Patents by Inventor Juergen Siekmann

Juergen Siekmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer-Von Willebrand Factor-Conjugates
    Publication number: 20120135462
    Abstract: The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
    Type: Application
    Filed: November 28, 2011
    Publication date: May 31, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann
  • Modified Blood Factors Comprising a Low Degree of Water Soluble Polymer
    Publication number: 20120076749
    Abstract: The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood factor but exhibit biological activity similar to or better than molecules having a higher number of water soluble polymer moieties.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 29, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Peter Turecek, Juergen Siekmann, Hanspeter Rottensteiner
  • von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
    Patent number: 8133865
    Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: March 13, 2012
    Assignees: Nektar Therapeutics, Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Mary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
  • NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
    Publication number: 20120035344
    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
    Type: Application
    Filed: July 29, 2011
    Publication date: February 9, 2012
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Juergen Siekmann, Stefan Haider, Hanspeter Rottensteiner, Andreas Ivens, Peter Turecek, Oliver Zoechling
  • Polymer-von Willebrand factor-conjugates
    Patent number: 8076463
    Abstract: The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: December 13, 2011
    Assignees: Baxter International, Inc., Baxter Healthcare S.A.
    Inventors: Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 8071727
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: December 6, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 8071724
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: December 6, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 8071728
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: December 6, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 8071725
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: December 6, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 8071726
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: December 6, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 8067543
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: November 29, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Pegylated factor VIII
    Patent number: 8053561
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: November 8, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Juergen Siekmann, Katalin Varadi, Herbert Gritsch, Peter Turecek
  • FACTOR VIII POLYMER CONJUGATES
    Publication number: 20110206651
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Application
    Filed: January 20, 2011
    Publication date: August 25, 2011
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 8003760
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: August 23, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 7985839
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: July 26, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 7985838
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: July 26, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 7982010
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: July 19, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • FACTOR VIII POLYMER CONJUGATES
    Publication number: 20110112025
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Application
    Filed: January 20, 2011
    Publication date: May 12, 2011
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Peter Turecek, Juergen Siekmann
  • Polymer-Von Willebrand Factor-Conjugates
    Publication number: 20110111455
    Abstract: The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
    Type: Application
    Filed: January 14, 2011
    Publication date: May 12, 2011
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann
  • FACTOR VIII POLYMER CONJUGATES
    Publication number: 20110112026
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Application
    Filed: January 20, 2011
    Publication date: May 12, 2011
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Peter Turecek, Juergen Siekmann