Abstract: Present application relates to a strategy for compensating for transesterification degradation of lipid-encapsulated RNA, such as mRNA-LNP, in liquid formulations for high-volume distribution. This involves determining the rate of degradation of the encapsulated RNA and calculating an appropriate overage relative to the intended dose. Alternatively, a higher dose of the RNA may be administered to compensate for loss of effective RNA or the RNA may be formulated in higher purity in anticipation of degradation. The strategy provides a balance between supplying effective and safe products and the need for costly manufacturing processes or transportation hurdles, such as cold-chain supply.

Abstract: The application relates to a method for creating a user-augmented index, including: receiving information identifying data, a first user-created category and a first user-designated value from the first user. The data, the first user-created category, and the first user-designated value are associated together in a data entry in the user-augmented index. A second user-created category and a second user-designated value are received from the second user. The second user-created category and the second user-designated value are also associated with the data entry in the user-augmented index. The application further relates to ranking one or more related data entries in response to a query of a user-augmented index.

Abstract: Systems and methods describe improvements in the automated production of meat analogues. Ingredients are provided, including oil, water, binding agent(s), and one or more forms of protein to be separately and continuously conveyed through a facility. Concurrently to the ingredients being conveyed through the facility, a number of actions occur. The system emulsifies the oil, water, and binding agent(s) within an emulsifying machine to form a final emulsion. A hydration process is separately applied to at least one of the forms of protein. The system mixes and conveys the protein(s) with the final emulsion in a final mixer to form a final dough.

Abstract: A system configured to hydrate and process foodstuff materials can include an exterior tube, an inner shaft, and multiple water inlets. The exterior tube can have a foodstuff inlet, an outlet, and a longitudinal axis, and can facilitate the conveyance of foodstuff materials along a material passage from the foodstuff inlet to the outlet. The inner shaft can be located within the exterior tube, can extend along the longitudinal axis, and can combine with the exterior tube to define the material passage. The inner shaft can be configured to be rotationally driven and can include one or more particle resizing features extending therefrom. The multiple water inlets can be spaced apart along the length of the material passage and can be configured to provide water to the foodstuff materials at different locations along the length of the material passage as the foodstuff materials are being conveyed along the material passage.

Abstract: An apparatus configured to process foodstuff materials can include an exterior tube, an inner shaft, and multiple differently shaped protrusions. The exterior tube can have a foodstuff inlet, an outlet, and a longitudinal axis, and can be configured to facilitate the conveyance of foodstuff materials along a material passage from the foodstuff inlet to the outlet. The inner shaft can be located within the exterior tube, can extend along the longitudinal axis, and can combine with the exterior tube to define the material passage. The inner shaft can be configured to be rotationally driven. The multiple differently shaped protrusions can be coupled to and extend from the inner shaft, and these differently shaped protrusions can be configured to process the foodstuff materials when the inner shaft is rotationally driven. Processing can include conveying, agitating, and/or hydrating the foodstuff materials.

Abstract: Systems and methods describe continuously and progressively hydrating and post-processing material, such as food material for meat analogue products. First, material is provided to be conveyed through a material passage between an exterior tube and a rotating inner shaft, with the rotating inner shaft including one or more particle resizing features extending around the rotating inner shaft. Concurrently, the material is post-processed, via the particle resizing features, to reduce the material into a plurality of smaller material particles. Also concurrently, water is continuously and progressively provided to the material to produce hydrated material particles.

Abstract: Systems and methods describe continuously and progressively hydrating material, such as food material for meat analogue products. First, material is provided to be conveyed through a material passage between an exterior tube and a rotating inner shaft, with the rotating inner shaft including one or more agitation and/or progression features. The progression features could be, e.g., a series of imbricated protruding filled paddles arranged in a helical pattern, while the agitation features could take the form of, e.g., unfilled hoops, hooks, or paddles. Concurrent to conveying and hydrating the material through the material passage, a number of lumps, clumps, and/or unhydrated pieces of the material are broken up via one or more agitation features configured to produce uniform hydration and consistent dispersal of the material. Also concurrently or subsequently, water is continuously and/or progressively provided to the material to produce hydrated material particles.

Abstract: Systems and methods describe continuously and progressively hydrating material, such as food material for meat analogue products. First, material is provided to be conveyed through a material passage between an exterior tube and a rotating inner shaft, with the rotating inner shaft including one or more agitation and/or progression features. The progression features could be, e.g., a series of imbricated protruding filled paddles arranged in a helical pattern, while the agitation features could take the form of, e.g., unfilled hoops, hooks, or paddles. Concurrent to conveying and hydrating the material through the material passage, a number of lumps, clumps, and/or unhydrated pieces of the material are broken up via one or more agitation features configured to produce uniform hydration and consistent dispersal of the material. Also concurrently or subsequently, water is continuously and/or progressively provided to the material to produce hydrated material particles.

Abstract: Systems and methods describe continuously and progressively hydrating and post-processing material, such as food material for meat analogue products. First, material is provided to be conveyed through a material passage between an exterior tube and a rotating inner shaft, with the rotating inner shaft including one or more particle resizing features extending around the rotating inner shaft. Concurrently, the material is post-processed, via the particle resizing features, to reduce the material into a plurality of smaller material particles. Also concurrently, water is continuously and progressively provided to the material to produce hydrated material particles.

Abstract: Systems and methods describe improvements in the automated production of meat analogues. Ingredients are provided, including oil, water, binding agent(s), and one or more forms of protein to be separately and continuously conveyed through a facility. Concurrently to the ingredients being conveyed through the facility, a number of actions occur. The system emulsifies the oil, water, and binding agent(s) within an emulsifying machine to form a final emulsion. A hydration process is separately applied to at least one of the forms of protein. The system mixes and conveys the protein(s) with the final emulsion in a final mixer to form a final dough.

Abstract: A progressive shear emulsifier can include an outer body and an inner body. The outer body can have a central opening therethrough, an inlet, an outlet, and an inner surface along the central opening defining a first three-dimensional contour. The inner body can be positioned within the central opening and configured to rotate with respect to the outer body about an axis of rotation along the central opening. The inner body can have an outer surface defining a second three-dimensional contour that correlates to the first three-dimensional contour to form a material passage between the outer body and inner body. Rotation of the inner body within the outer body can create progressive amounts of shear across materials passing through the material passage, which can result in emulsified material. Conic transitions can create turbulent regions that mix the materials passing therethrough. Collective geometry can create conveyance and/or pumping of materials, which can be methylcellulose and free water.

Abstract: Methods, systems, computer programs, and electronically readable media storing computer programs are provided for providing access to a plurality of structured data stores based on a plurality of personal authentication information. A first personal authentication information is received. Upon authenticating the first personal authentication information, access to a first level data store is provided. A second personal authentication information is received, and upon authenticating the second personal authentication information, and after authenticating the first personal authentication information, access is provided to a second level data store.

Abstract: The present invention relates to a method of providing a timeline display with a first dynamically sized display area and a second dynamically sized display area. The timeline display is displayed with a timeline scroll axis and a category axis, the first dynamically sized display area is displayed in the timeline display with a first length parallel to the category; axis, the first dynamically sized display area associated with a first category associated with one or more first category events, the first length being proportionate to a first user-directed variable, and the second dynamically sized display area is displayed in the timeline display with a second length parallel to the category axis, the second dynamically sized display area associated with a second category including one or more second category events, the second length being proportionate to a second user-directed variable.

Abstract: Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.

Abstract: The application relates to a method for creating a user-augmented index, including: receiving information identifying data, a first user-created category and a first user-designated value from the first user. The data, the first user-created category, and the first user-designated value are associated together in a data entry in the user-augmented index. A second user-created category and a second user-designated value are received from the second user. The second user-created category and the second user-designated value are also associated with the data entry in the user-augmented index. The application further relates to ranking one or more related data entries in response to a query of a user-augmented index.

Abstract: Methods, systems, computer programs, and electronically readable media storing computer programs are provided for providing access to a plurality of structured data stores based on a plurality of personal authentication information. A first personal authentication information is received. Upon authenticating the first personal authentication information, access to a first level data store is provided. A second personal authentication information is received, and upon authenticating the second personal authentication information, and after authenticating the first personal authentication information, access is provided to a second level data store.

Abstract: The present invention relates to methods, systems, and programs, for facilitating the creation and coordination of a project. In a first embodiment, the project is received from a project creation interface and a first task is received from a task creation interface. The first task includes first task authorized users permitted to change a first task status. The project and the task are sent to a project facilitation interface. In a second embodiment, for a project including at least a first task and a first user, a first task status is received. The task includes first task authorized users that include the first user exclusive of a second user. The first task status is saved to a project facilitation database.

Abstract: The instant invention is drawn to the methods and compositions necessary to provide recombinant proteins with a substantially reduced or eliminated content of norleucine or other non-standard amino acids. Various embodiments of the invention provide for the substantial elimination of the incorporation of non-standard amino acids into recombinant proteins by the co-expression or enhanced expression of a protein (or the enzymatically active portion thereof) capable of degrading norleucine or other non-standard amino acids, including norvaline, beta-methylnorleucine, and homoisoleucine. In certain particular embodiments of the invention, the norleucine is degraded by a glutamate dehydrogenase, a leucine dehydrogenase, a valine dehydrogenase, a phenylalanine dehydrogenase, a glutamate/leucine/phenylalanine/valine dehydrogenase, or an opine dehydrogenase. Also provided are the cells and DNA constructs for carrying out these methods.

Abstract: The present invention provides methods of making sticky powder comprising mixing one or more resin or (co)polymer powders in one or more mixing devices without agglomerating the powders and while measuring the power, work or torque drawn by the mixing devices, the mixing continuing until the measure of the power or torque drawn indicates that the powders have become sticky. The mixing further comprises adding to the powders one or more dry materials and mixing to so that the dry materials adhere or “bond” to the sticky powders. Alternatively, the methods further comprise slowing or stopping the mixing, or cooling while mixing once the said sticky powders have been formed, adding one or more dry materials to form a sticky powder mixture, and further mixing to bond the sticky powders and the dry materials together. The dry materials may comprise one or more flake materials, e.g.