Patents by Inventor Julian A. Alexander

Julian A. Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 9603864
    Abstract: Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: March 28, 2017
    Assignee: Alios BioPharma, Inc.
    Inventors: Lawrence M. Blatt, Leonid Beigelman, Julian Alexander Symons, David Bernard Smith
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 9603863
    Abstract: Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: March 28, 2017
    Assignee: Alios BioPharma, Inc.
    Inventors: Lawrence M. Blatt, Leonid Beigelman, Natalia Dyatkina, Julian Alexander Symons, David Bernard Smith
  • Combination therapy
    Patent number: 9566318
    Abstract: The invention relates to producing humoral response to P2X7 receptors in individuals having cancer, and to minimizing the progression of cancer in said individuals.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: February 14, 2017
    Assignee: Biosceptre (Aust) Pty Ltd
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Companion animal treatments
    Patent number: 9562094
    Abstract: The invention relates to minimizing the progression of cancer in a companion animal using P2X7 immunotherapy.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: February 7, 2017
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • AIRFLOW ADAPTOR FOR A BREATH-ACTUATED DRY POWDER INHALER
    Publication number: 20170007787
    Abstract: An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
    Type: Application
    Filed: September 20, 2016
    Publication date: January 12, 2017
    Inventors: Julian Alexander Blair, Daniel Buck, Jan Geert Hazenberg, Xian-Ming Zeng
  • Antibodies to non-functional oligomeric P2X7 receptors and methods of use thereof
    Patent number: 9428587
    Abstract: The invention relates to purinergic receptors, to antibodies and related fragments thereof for binding to said receptors, to production of said antibodies and fragments and to sue of said antibodies and fragments for cancer detection and therapy. In particular the antibodies described bind specifically to non-functional P2X& receptors expressed by live cells.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: August 30, 2016
    Assignee: BIOSCEPTRE INTERNATIONAL LIMITED
    Inventors: Julian Alexander Barden, Angus Gidley-Baird, Glenn Ronald Pilkington
  • Anti- P2X7 Peptides and Epitopes
    Publication number: 20160199442
    Abstract: The invention relates to the identification of a novel epitope on non-function P2X7 receptors which are implicated in cancer. The epitope includes a region from two adjacent monomers within the three subunit receptor. Antibodies which bind to the epitope and peptides for generating the antibodies are described. The antibodies and peptides are useful in the diagnosis and treatment of cancer.
    Type: Application
    Filed: March 30, 2016
    Publication date: July 14, 2016
    Inventors: JULIAN ALEXANDER BARDEN, ANGUS GIDLEY-BAIRD
  • NOVEL P2X7 EPITOPES
    Publication number: 20160130342
    Abstract: The invention relates to purinergic (P2X) receptors, to generation of antibodies and to use of antibodies and immunogens for detection and treatment of a disease or condition, especially cancer.
    Type: Application
    Filed: October 7, 2015
    Publication date: May 12, 2016
    Applicant: BIOSCEPTRE INTERNATIONAL LIMITED
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Peptides for inducing antibodies to a non-functional P2Xreceptor
    Patent number: 9328155
    Abstract: The invention relates to a novel epitope on P2X7 receptors, to antibodies for binding to the epitope and to peptides for generating the antibodies.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: May 3, 2016
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Aircraft ice protection system and method
    Patent number: 9309001
    Abstract: A system and method for ice protection of a component, wherein the system is adapted to be adhesively bonded to a surface of the component. The system includes a heating element layer, at least one thermally conductive adhesive layer that adhesively bonds a first side of the heating element layer to the component, an insulation layer, at least one thermally insulating adhesive layer that adhesively bonds a second side of the heating element to the insulation layer, an electrical bus bar adapted to provide a connection between a power supply and the heating element layer, and at least one temperature sensor.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: April 12, 2016
    Assignees: MRA SYSTEMS INC., KELLY AEROSPACE THERMAL SYSTEMS, LLC
    Inventors: David Patrick Calder, Julian Alexander Opificius, Erik Thomas Pederson, David Cenit Flosdorf
  • HIGH PERFORMANCE PEROVSKITE-SENSITIZED MESOSCOPIC SOLAR CELLS
    Publication number: 20160086739
    Abstract: The present invention relates to methods for preparing sensitized solar cells using organic-inorganic perovskites as sensitizers.
    Type: Application
    Filed: November 5, 2014
    Publication date: March 24, 2016
    Applicant: Abengoa Research S.L.
    Inventors: Julian Alexander Burschka, Norman Pellet, Mohammad Khaja Nazeeruddin, Michael Graetzel, Shahzada Ahmad
  • SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
    Publication number: 20150366887
    Abstract: Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.
    Type: Application
    Filed: June 22, 2015
    Publication date: December 24, 2015
    Inventors: Lawrence M. Blatt, Leonid Beigelman, Natalia Dyatkina, Julian Alexander Symons, David Bernard Smith
  • SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
    Publication number: 20150366888
    Abstract: Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.
    Type: Application
    Filed: June 22, 2015
    Publication date: December 24, 2015
    Inventors: Lawrence M. Blatt, Leonid Beigelman, Julian Alexander Symons, David Bernard Smith
  • Aircraft ice protection system and method
    Patent number: 9193466
    Abstract: A system and method for ice protection of a component, wherein the system is adapted to be adhesively bonded to a surface of the component. The system includes a heating element layer, at least one thermally conductive adhesive layer that adhesively bonds a first side of the heating element layer to the component, an insulation layer, at least one thermally insulating adhesive layer that adhesively bonds a second side of the heating element to the insulation layer, an electrical bus bar adapted to provide a connection between a power supply and the heating element layer, and at least one temperature sensor.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: November 24, 2015
    Assignees: MRA Systems, Inc., Kelly Aerospace Thermal Systems, LLC
    Inventors: David Patrick Calder, Julian Alexander Opificius, Erik Thomas Pederson, David Cenit Flosdorf
  • AIRCRAFT ICE PROTECTION SYSTEM AND METHOD
    Publication number: 20150329211
    Abstract: A system and method for ice protection of a component, wherein the system is adapted to be adhesively bonded to a surface of the component. The system includes a heating element layer, at least one thermally conductive adhesive layer that adhesively bonds a first side of the heating element layer to the component, an insulation layer, at least one thermally insulating adhesive layer that adhesively bonds a second side of the heating element to the insulation layer, an electrical bus bar adapted to provide a connection between a power supply and the heating element layer, and at least one temperature sensor.
    Type: Application
    Filed: July 29, 2015
    Publication date: November 19, 2015
    Inventors: David Patrick Calder, Julian Alexander Opificius, Erik Thomas Pederson, David Cenit Flosdorf
  • Peptides for generating an antibody selectively binding to a non-ATP-binding P2X7 receptor but not to an ATP-binding P2X7 receptor
    Patent number: 9181320
    Abstract: The invention relates to purinergic (P2X) receptors, more specifically to P2X7 receptors, the generation of antibodies and the use of antibodies and immunogens that are capable of selectively binding to a non ATP-binding P2X7 receptor but not to an ATP-binding P2X7 receptor, for the detection and treatment of disease conditions, especially cancer.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 10, 2015
    Assignee: Biosceptre International Limited
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Antibodies to Non-Functional P2X7 Receptor
    Publication number: 20150274839
    Abstract: The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between function and non-functional P2X7 receptors, pharmaceutical compositions and kits containing the antibodies, and methods of using the antibodies for the detection, diagnosis and treatment of disease conditions.
    Type: Application
    Filed: May 29, 2015
    Publication date: October 1, 2015
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • ANTI P2X7 RECEPTOR ANTIBODIES AND FRAGMENTS THEREOF
    Publication number: 20150266969
    Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
    Type: Application
    Filed: March 27, 2015
    Publication date: September 24, 2015
    Applicant: BIOSCEPTRE INTERNATIONAL LIMITED
    Inventors: Julian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
  • Anti P2X7 receptor antibodies and fragments thereof
    Patent number: 9127059
    Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: September 8, 2015
    Assignee: Biosceptre International Limited
    Inventors: Julian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
  • Antibodies to Non-Functional Oligomeric P2X7 Receptors
    Publication number: 20150218283
    Abstract: The invention relates to purinergic receptors, to antibodies and related fragments thereof for binding to said receptors, to production of said antibodies and fragments and to sue of said antibodies and fragments for cancer detection and therapy. In particular the antibodies described bind specifically to non-functional P2X& receptors expressed by live cells.
    Type: Application
    Filed: August 11, 2014
    Publication date: August 6, 2015
    Applicant: BIOSCEPTRE INTERNATIONAL LIMITED
    Inventors: Julian Alexander Barden, Angus Gidley-Baird, Glenn Ronald Pilkington