Patents by Inventor Julian Becker

Julian Becker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9315537
    Abstract: In summary, the present invention concerns a method for multiple orthogonal labelling of oligonucleotides, preferably RNA or DNA, by simultaneously performing the inverse Diels-Alder reaction (DAinv) and the copper-catalyzed click reaction (CuAAC), wherein the method is employed in a single step by just adding the different reaction components together and incubating the aqueous reaction mixture preferably for one hour at room temperature. In detail, the reaction components are one or more N3-modified labels, a copper compound, a stabilizing ligand, a reducing agent and one or more electron-deficient label-modified dienes that are added together with an at least double-modified oligonucleotide having one more nucleotides containing one or more N3-reactive groups and one or more electron-rich dienophiles, wherein a terminal alkyne moiety is preferably used as N3-reactive group(s) and a frans-cyclooctene moiety or norbornene is preferably used as electron-rich dienophile(s), more preferably frans-cyclooctene.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: April 19, 2016
    Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG
    Inventors: Juliane Becker, Andres Jäschke, Ayan Samanta, Manfred Wiessler
  • Patent number: 9212590
    Abstract: An internal combustion engine has at least one combustion chamber and an exhaust gas system arranged on an exhaust gas outlet port. The exhaust gas system includes at least one secondary air injection device for injecting secondary air into the exhaust system between the combustion chamber and an exhaust emission control system arranged in the exhaust gas system. During operation of the internal combustion engine, a residual gas content in the combustion chamber can be changed. The secondary air injection site on the exhaust gas system is arranged so far from the combustion chamber that injected secondary air flows back into the exhaust gas outlet port due to back-flowing exhaust gas in the exhaust gas system but does not flow back into the combustion chamber. This makes it possible to comply with SULEV emission limits even for engines having many combustion chambers and/or exhaust gas turbochargers.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: December 15, 2015
    Assignee: Bayerische Motoren Werke Aktiengesellschaft
    Inventors: Manfred Miklautschitsch, Samuel Bucher, Stefan Babernits, Julian Becker
  • Publication number: 20150218203
    Abstract: In summary, the present invention concerns a method for multiple orthogonal labelling of oligonucleotides, preferably RNA or DNA, by simultaneously performing the inverse Diels-Alder reaction (DAinv) and the copper-catalyzed click reaction (CuAAC), wherein the method is employed in a single step by just adding the different reaction components together and incubating the aqueous reaction mixture preferably for one hour at room temperature. In detail, the reaction components are one or more N3-modified labels, a copper compound, a stabilizing ligand, a reducing agent and one or more electron-deficient label-modified dienes that are added together with an at least double-modified oligonucleotide having one more nucleotides containing one or more N3-reactive groups and one or more electron-rich dienophiles, wherein a terminal alkyne moiety is preferably used as N3-reactive group(s) and a frans-cyclooctene moiety or norbornene is preferably used as electron-rich dienophile(s), more preferably frans-cyclooctene.
    Type: Application
    Filed: August 31, 2012
    Publication date: August 6, 2015
    Applicant: Deutsches Krebsforschungszentrum
    Inventors: Juliane Becker, Andres Jäschke, Ayan Samanta, Manfred Wiessler
  • Publication number: 20120198842
    Abstract: An internal combustion engine has at least one combustion chamber and an exhaust gas system arranged on an exhaust gas outlet port. The exhaust gas system includes at least one secondary air injection device for injecting secondary air into the exhaust system between the combustion chamber and an exhaust emission control system arranged in the exhaust gas system. During operation of the internal combustion engine, a residual gas content in the combustion chamber can be changed. The secondary air injection site on the exhaust gas system is arranged so far from the combustion chamber that injected secondary air flows back into the exhaust gas outlet port due to back-flowing exhaust gas in the exhaust gas system but does not flow back into the combustion chamber. This makes it possible to comply with SULEV emission limits even for engines having many combustion chambers and/or exhaust gas turbochargers.
    Type: Application
    Filed: March 6, 2012
    Publication date: August 9, 2012
    Applicant: Bayerische Motoren Werke Aktiengesellschaft
    Inventors: Manfred Miklautschitsch, Samuel Bucher, Stefan Babernits, Julian Becker