Abstract: A microapplicator for dispensing and applying an adhesive or sealant material comprises a handle portion, an applicator tip connected to the handle portion, and a microreservoir at the applicator tip arranged to hold a small amount, about 20 microliters or less, of an adhesive/sealant material until dispensing. In embodiments, the applicator tip has a width of about 1 mm. The microapplicator may include a second reservoir, containing the adhesive/sealant material, that is arranged to supply the adhesive/sealant material to the microreservoir at the applicator tip. The second reservoir may comprise a frangible ampoule disposed in the handle portion, a container, such as a syringe, connected to the handle portion, or the handle portion itself. The applicator tip may comprise one of a polymer loop, a spatula, a rolling ball, a grate, a porous material, such as a swab, a foam pad or a mesh, and a brush.

Abstract: A microapplicator for dispensing and applying an adhesive or sealant material comprises a handle portion, an applicator tip connected to the handle portion, and a microreservoir at the applicator tip arranged to hold a small amount, about 20 microliters or less, of an adhesive/sealant material until dispensing. In embodiments, the applicator tip has a width of about 1 mm. The microapplicator may include a second reservoir, containing the adhesive/sealant material, that is arranged to supply the adhesive/sealant material to the microreservoir at the applicator tip. The second reservoir may comprise a frangible ampoule disposed in the handle portion, a container, such as a syringe, connected to the handle portion, or the handle portion itself. The applicator tip may comprise one of a polymer loop, a spatula, a rolling ball, a grate, a porous material, such as a swab, a foam or a mesh, and a brush.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by providing one or more cuts in the applicator tip to alter flow properties of the adhesive material through the applicator tip.

Abstract: An applicator for dispensing adhesive material includes a container body holding the adhesive material and an applicator tip configured to permit improved control and economy in application of the adhesive.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by providing one or more cuts in the applicator tip to alter flow properties of the adhesive material through the applicator tip.

Abstract: A method of treating living tissue includes applying to living tissue a biocompatible adhesive composition, where the adhesive composition contains at least one alkyl ester cyanoacrylate monomer and a polymerization initiator or accelerator, wherein the polymerization initiator or accelerator is a quaternary amine, or where the adhesive composition contains a mixture of two monomer species having different absorption rates.