Abstract: Aspects of the disclosure relate to an article carrier (90; 290; 490) for packaging one or more articles and to a blank (10; 110; 210; 310; 410) for forming the carrier. The carrier comprises a main panel (12; 112; 212, 222; 312, 322A, 322B; 412, 422A, 422B) including an article retention structure (RT; RT1, RT2) having an article receiving opening defined in part by at least a pair of opposing engaging tabs (40, 42; 140, 142; 240, 242, 246, 248; 340, 342, 346, 348; 440, 442, 446, 448) each having a length (L1, L2) greater than a half of the distance (L3) between their hinged connections (13A, 41; 213, 215, 241, 247, 249; 313, 315, 341, 347, 349; 413, 415, 441, 447, 449) to the main panel (12; 112; 212, 222; 312, 322A, 322B; 412, 422A, 422B).

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: A foldable scooter includes a frame and a steering column provided with a front wheel and pivotably mounted on the frame, which has a first portion supporting a rear wheel and a footboard, and a second portion supporting the steering column. The first portion and the second portion are connected by a swivel joint along a folding axis, allowing movement between:—an unfolded configuration in which the steering column projects upwards with respect to the footboard by extending in a median plane; and—a folded configuration in which the steering column is on a first side face with respect to the median plane and extends away from the median plane, at least partially underneath the footboard, along a first side edge of the footboard and opposite a first side surface of the rear wheel.

Abstract: Described herein is a computer implemented method. The method comprises receiving a content item record in respect of a content item generated at a collaboration system and processing the received content item record to determine if the content item record includes any designated content. In response to determining that the received content item record includes designated content the method further comprises generating a designated content record in respect of the identified designated content and saving the designated content record to a data store.

Abstract: Described herein is a computer implemented method. The method comprises receiving a content item record in respect of a content item generated at a collaboration system and processing the received content item record to determine if the content item record includes any designated content. In response to determining that the received content item record includes designated content the method further comprises generating a designated content record in respect of the identified designated content and saving the designated content record to a data store.

Abstract: A scooter includes a frame which has a footboard and supports a rear wheel, a steering column provided with a front wheel pivotably mounted on the frame, and a motor provided with a drive shaft coupled to the rear wheel via a transmission system. The transmission system includes a rear transverse shaft having a first end portion and a second end portion rotatably coupled to the rear wheel; —a gear system having a sprocket coupled rotatably to the first end portion and in meshing engagement with a toothed gear rotatably coupled to the drive shaft; and —a rear structure attached to the frame, supporting the gear system and the rear transverse shaft, and extending laterally along one side only—right or left—of the rear wheel, such that the second end portion extends from the rear structure to support the rear wheel in a cantilevered fashion.

Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compounds in the treatment of various disorders.

Abstract: The invention describes a system for controlling the cyclic setting of blades (1) of a turbine engine propeller, the blades (1) being arranged in a plane normal to the axis of rotation (r) of the propeller, the system comprising: —a plate assembly (40) that can be tilted relative to the normal plane (P), —an articulation system (50) articulating the plate assembly (40) relative to the blades (1) such that tilting the plate assembly (40) modifies the setting of the blades (1), —a force sensor (5) designed to measure a force applied in the normal plane (P) by an air flow at the inlet of the propeller blades (1), —a cylinder (60) suitable for tilting the plate assembly (40) in response to a force measured by the force sensor (5).

Abstract: The invention concerns a device for helping a user fall asleep, comprising a light source designed to emit a substantially monochromatic red or quasi-monochromatic light encouraging the user to fall asleep, characterized in that it comprises a control unit designed to automatically control said light source according to a predefined law according to which the light power emitted by said light source decreases gradually over time in such a way as to change automatically between a maximum power value and a minimum power value, the light power emitted by said light source at a given time always being greater than or equal to the light power emitted at a subsequent time.

Abstract: A foldable scooter includes a frame and a steering column provided with a front wheel and pivotably mounted on the frame, which has a first portion supporting a rear wheel and a footboard, and a second portion supporting the steering column. The first portion and the second portion are connected by a swivel joint along a folding axis, allowing movement between: —an unfolded configuration in which the steering column projects upwards with respect to the footboard by extending in a median plane; and —a folded configuration in which the steering column is on a first side face with respect to the median plane and extends away from the median plane, at least partially underneath the footboard, along a first side edge of the footboard and opposite a first side surface of the rear wheel.

Abstract: An assembly for a turbomachine extending along an axis includes a combustion chamber having, at its downstream end, a downstream flange having a radially extending part. The assembly further includes a distributor disposed downstream of the combustion chamber and having a platform from which at least one vane extends radially. The platform includes an upstream flange extending radially and delimiting, with the radial part of the downstream flange disposed opposite it. An annular space for the circulation of cooling air opens into the combustion chamber at its radially internal end and has, at its radially external end, means of sealing attached to the distributor.

Abstract: Turbomachine ring as well as a turbomachine comprising such a ring and a method for repairing such a ring, the turbomachine ring comprising an essentially cylindrical support, including a frontal surface wherein a notch is formed, one or more sectors forming an annulus configured to embody a segment of air stream, each sector comprising a hook portion protruding in the direction of the support and engaging in the notch of the support, and an anti-wear device having a U shaped portion, provided in the notch of the support and pressed at least against the radially external surface of the notch, and a tab portion, continuously extending the U shaped portion, pressed and fastened against the frontal surface of the support.

Abstract: The invention describes a system for controlling the cyclic setting of blades (1) of a turbine engine propeller, the blades (1) being arranged in a plane normal to the axis of rotation (r) of the propeller, the system comprising: —a plate assembly (40) that can be tilted relative to the normal plane (P), —an articulation system (50) articulating the plate assembly (40) relative to the blades (1) such that tilting the plate assembly (40) modifies the setting of the blades (1), —a force sensor (5) designed to measure a force applied in the normal plane (P) by an air flow at the inlet of the propeller blades (1), —a cylinder (60) suitable for tilting the plate assembly (40) in response to a force measured by the force sensor (5).

Abstract: The present disclosure relates to relates to methods and products for assessing lysosomal system flux. In addition, the present disclosure also provides systems for assessing lysosomal system flux, and methods of identifying markers indicative of lysosomal system flux. In certain embodiments, the present disclosure provides a method of assessing lysosomal system flux in a subject. The method comprises determining the level of a lysosomal system marker in a sample of whole blood from the subject, the level of the lysosomal system marker being determined based on the level of the marker following treatment of the whole blood with an inhibitor of lysosomal system function.

Abstract: A scooter includes a frame which has a footboard and supports a rear wheel, a steering column provided with a front wheel pivotably mounted on the frame, and a motor provided with a drive shaft coupled to the rear wheel via a transmission system. The transmission system includes a rear transverse shaft having a first end portion and a second end portion rotatably coupled to the rear wheel; —a gear system having a sprocket coupled rotatably to the first end portion and in meshing engagement with a toothed gear rotatably coupled to the drive shaft; and—a rear structure attached to the frame, supporting the gear system and the rear transverse shaft, and extending laterally along one side only—right or left—of the rear wheel, such that the second end portion extends from the rear structure to support the rear wheel in a cantilevered fashion.

Abstract: A turbomachine includes a combustion chamber with a radially extending downstream flange at its downstream end. A distributor is disposed downstream of the combustion chamber and includes a platform from which at least one vane extends radially. The platform has an upstream edge extending radially and delimiting, with the downstream flange disposed opposite, a gap opening into the combustion chamber at its radially inner end and closed at its radially outer end by sealing means fixed to the distributor. The downstream flange of the combustion chamber has at least one rectilinear cooling orifice passing through the flange and opening into the gap opposite the platform of the distributor.

Abstract: A turbomachine includes a combustion chamber with a radially extending downstream flange at its downstream end. A distributor is disposed downstream of the combustion chamber and includes a platform from which at least one vane extends radially. The platform has an upstream edge extending radially and delimiting, with the downstream flange disposed opposite, a gap opening into the combustion chamber at its radially inner end and closed at its radially outer end by sealing means fixed to the distributor. The downstream flange of the combustion chamber has at least one rectilinear cooling orifice passing through the flange and opening into the gap opposite the platform of the distributor.

Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compounds in the treatment of various disorders.

Abstract: Described herein is a computer implemented method. The method comprises receiving a content item record in respect of a content item generated at a collaboration system and processing the received content item record to determine if the content item record includes any designated content. In response to determining that the received content item record includes designated content the method further comprises generating a designated content record in respect of the identified designated content and saving the designated content record to a data store.

Abstract: Described herein is a computer implemented method. The method comprises receiving a content item record in respect of a content item generated at a collaboration system and processing the received content item record to determine if the content item record includes any designated content. In response to determining that the received content item record includes designated content the method further comprises generating a designated content record in respect of the identified designated content and saving the designated content record to a data store.