Abstract: This application relates to the field of computer information processing, and provides a method for constructing a geographic information system (GIS) application system for digital agriculture, and a computer program product. The method includes: integrating a GIS function with a digital agriculture application demand, and dividing a GIS application for digital agriculture into a plurality of components based on an integration relationship; developing the components separately and constructing a digital agricultural GIS application component library; and selecting a component from the digital agricultural GIS application component library for assembling, and building a navigation module and various functional modules for the GIS application system for digital agriculture to complete construction of the GIS application system for digital agriculture. This application can adapt to various different digital agriculture application scenarios and personalized user demands.

Abstract: The present inventive concept relates to a method and device for monitoring cardiopulmonary function using electrical impedance tomography, and more specifically, to a method and system for monitoring cardiopulmonary function using electrical impedance tomography, whereby lung collapse and hyperinflation are monitored in real-time during a mechanical ventilation treatment process by using a single monitoring device, and information on a plurality of hemodynamic diagnostic parameters changing in real-time during the mechanical ventilation treatment process can be provided. According to the present inventive concept, it is possible to take selectively electrical impedance tomography of blood vessels at any part of a body such as the chest, neck, arms, legs, etc., and to monitor hemodynamic diagnostic parameters including a stroke volume, a cardiac output, a peripheral vascular resistance, etc.

Abstract: Provided is a method for calculating a hemodynamic variable for a subject based on electrical impedance tomography (EIT). The method may include: obtaining EIT images at discrete time points in a cardiac cycle of a subject by targeting a chest portion of the subject; identifying, in the EIT images, values of a first pixel in a region corresponding to the heart and values of a second pixel in a region corresponding to a lung, wherein the values of the first pixel are associated with the discrete time points, respectively, and the values of the second pixel are associated with the discrete time points, respectively; and calculating at least one hemodynamic variable on the basis of a first time point associated with a minimum value among the identified values of the first pixel and a second time point associated with a maximum value among the identified values of the second pixel.

Abstract: Disclosed are a furaneone glycoside compound, a pharmaceutical composition thereof, a preparation method therefor, and an application thereof. Specifically disclosed are a compound as represented by formula A-1, a pharmaceutically acceptable salt thereof or a crystal form thereof. Also disclosed is a pharmaceutical composition, which comprises the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof, and a pharmaceutical adjuvant. Also disclosed is an application of the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof, the crystal form thereof, or the pharmaceutical composition in the preparation of drugs. The drugs are drugs for treating inflammatory bowel diseases. The furaneone glycoside compound has a good effect of treating inflammatory bowel diseases, particularly ulcerative colitis.

Abstract: Disclosed are a furaneol glycoside compound, a pharmaceutical composition thereof, a preparation method therefor, and an application thereof. Specifically disclosed are a compound as represented by formula A-1, a pharmaceutically acceptable salt thereof or a crystal form thereof. Also disclosed is a pharmaceutical composition, which comprises the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof, and a pharmaceutical adjuvant. Also disclosed is an application of the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof, the crystal form thereof, or the pharmaceutical composition in the preparation of drugs. The drugs are drugs for treating inflammatory bowel diseases. The furaneol glycoside compound has a good effect of treating inflammatory bowel diseases, particularly ulcerative colitis.

Abstract: A body fat measurement device, disclosed according to the present ion, comprises: at least one electrode unit which supports at least one EIT electrode and is tightly attachable to skin; and a sensor unit which measures electrical impedance tomography information by sensing a signal measured from the electrode unit, wherein, after being connected to the sensor unit and used once, the electrode unit may be separated from the sensor unit and replaced. According to such configuration, the one-time used electrode unit can be replaced from the sensor unit, and thus economic efficiency can be achieved, and convenience of use can be increased.

Abstract: A connecting terminal is disclosed having a wire connection portion with at least one pair of side arms, and an abutting portion attached at a second end to the wire connection portion. The Abutting portion includes at least one mating terminal receiving chamber and a locking structure. The locking structure includes a locking surface facing the wire connection portion and extending perpendicularly to an insertion direction of the connecting terminal, a first locking surface formed on an upper side of the abutting portion and a second locking surface formed on a lower side of the second end of the abutting portion.

Abstract: A connecting terminal is disclosed having a wire connection portion with at least one pair of side arms, and an abutting portion attached at a second end to the wire connection portion. The Abutting portion includes at least one mating terminal receiving chamber and a locking structure. The locking structure includes a locking surface facing the wire connection portion and extending perpendicularly to an insertion direction of the connecting terminal, a first locking surface formed on an upper side of the abutting portion and a second locking surface formed on a lower side of the second end of the abutting portion.

Abstract: A navigation apparatus for updating objects by category and updating map information of the navigation from a data center, includes a version manager configured to manage a version of a data group in which object data is provided in units at a group; and an update manager configured to perform an update in response to an update request and when the update is completed, transmitting updated version information to the version manager. Further, the navigation includes a controller configured to receive a list of data group versions to update from the data center storing the map information, select a data group version to update from the data group version list, request and receive the selected data group version from the data center, and request an update from the update manager. Further, the update request is received from the controller.

Abstract: A method for updating map data of a navigation includes downloading map data for update from a map data server to an update database (DB); determining whether the update manager uses a map data DB; and postponing, by the update manager, update of the map data DB when the map data DB is used. Further, the method includes updating, by the update manager, the map data DB with the map data for update when a vehicle-start end message is received from a vehicle controller, the map data being stored in the update DB.

Abstract: The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL- 12p70 by making mutation at Asn-222 (human) or Asn- 220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.

Abstract: The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222 (human) or Asn-220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.

Abstract: The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12(interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222(human) or Asn-220(mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.

Abstract: Disclosed is a method of bonding upper and lower substrates for manufacturing a plastic micro chip comprising the upper substrate, the lower substrate and a sample filling space having a predetermined height for filling a sample between the upper and lower substrates. According to the method, the upper and lower substrates are bonded by introducing an organic solvent between the upper and lower substrates. In addition, the invention provides a method of manufacturing a micro chip using the method and a micro chip manufactured according to the method. According to the invention, it is possible to easily and precisely bond the upper and lower substrates of the plastic micro chip.

Abstract: Disclosed herein is an integrated-type polarizer comprising a polarizing film provided with a biaxial retardation film as a protective film on a first side thereof, the polarizing film having an absorption axis perpendicular to the optical axis of the biaxial retardation film. Also is provided a vertically aligned liquid crystal display comprising a liquid crystal cell filled with liquid crystal molecules of negative dielectric anisotropy between a first and a second polarizer, the respective absorption axes of which are perpendicular to each other, wherein the integrated-type polarizer acts as the first polarizer.

Abstract: An IPS-LCD, in which the direction of an optical axis and retardation values are adjusted according to the disposition of a phase retardation film replacing one protective film, obtains a contrast ratio similar to that of an IPS-LCD having upper and lower protective films, and has a small thickness. The IPS-LCD includes first and second polarizing plates (1, 2), an IPS panel (3), and a first protective film. Absorption axes (4, 5) of the first and second polarizing plates (1, 2) are orthogonal to each other, and an optical axis of a liquid crystal in the IPS panel (3) and the absorption axis (4) are parallel with each other. A second phase retardation film, obtained by coating a biaxial film (17) with a uniaxial C film (11), is disposed between the second polarizing plate (2) and the IPS panel (3) and is used as a second protective film.

Abstract: Disclosed is a vaccine composition including a pathogenic antigen and IL-12 encapsulated in controlled release microspheres. Also, the present invention discloses a method of enhancing the adjuvant effect of IL-12 by employing an IL-12 adjuvant encapsulated in controlled release microspheres. IL-12, used as an adjuvant for a co-administered vaccine antigen in the vaccine composition, is released in vivo for a prolonged period of time by being encapsulated in controlled release microspheres, thereby maximizing its adjuvant effect.

Abstract: Disclosed herein is an IPS-LCD using two sheets of negative (?) biaxial retardation films and one +C-plate. The IPS-LCD has a superior contrast ratio at the surface-facing angle and tilt angles and undergoes a minimal color change with viewing angles in a black state, thereby providing a wider viewing angle.

Abstract: Disclosed are a device for counting cells and a method for manufacturing the device. The device comprises a transparent upper substrate and a transparent lower substrate. Fine lattice patterns for counting cells are formed on the lower substrate. A space for filling the sample, including cells, is provided between the upper substrate and the lower substrate. A hole for injecting the samples into the space for filling the samples is provided in the upper substrate. The device is disposable, and the cost of manufacturing the device is low. It is easy to fill the samples into the filling space and to count cells by using the device. The upper substrate and the lower substrate are bonded, and thus, no cover is required.

Abstract: A device for counting micro particles is presented. The device comprises a light source; a chip containing micro particles; an object lens; a CCD camera; a counting part; and a shifter for shifting the position of the chip. It is easy to count the number of micro particles, such as red blood cells or somatic cells, by using the device. The shifter shifts the position of the chip by a predetermined distance at every predetermined time interval in order that a certain area adjacent to the area photographed just before is shifted to the point where the light is incident. Therefore, sub-areas on the chip are photographed successively. The counting part counts the number of micro particles in each sub-area, and adds them together to calculate the total number of micro particles in the samples.