Abstract: Provided are a fused bicyclic derivative, a pharmaceutically acceptable salt, a crystal form thereof and a preparation method therefor. Specifically, provided are a hydrochloride, a mesylate, an acetate and a tartrate of the compound of formula (I), and a preparation method therefor and a crystal form thereof.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, L1, L2, L3, A1, A2, A3, A4, G1, G2, E, W, X, Y, Z, m, and n are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: In an approach to improve the privacy of chat groups within a virtual world, in response to identifying a private chat group has been created between two or more users, embodiments collect, by an internet of things (IoT) sensor set, a voice for each user in the private chat group. Further, embodiments analyze, by an analysis module, the collected voice, an intonation associated with the collected voice and an original pronunciation associated with the collected voice, and generate a de-content pronunciation based on the analysis of the collected voice, the intonation, and the original pronunciation. Additionally, embodiments output, by the IoT sensor set, the intonation and the original pronunciation to the two or more users in the private chat group and output, by the IoT sensor set and a client computer, the intonation and the de-content pronunciation to one or more users outside the private chat group.

Abstract: The present disclosure relates to a crystal form of a pyridopyrimidine derivative and a preparation method thereof, and specifically relates to the crystal form of the compound of formula (I) and a preparation method thereof. The new crystal form has good physical and chemical properties, thereby facilitating clinical treatments.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Embodiments of the disclosure provide a method for manufacturing a photovoltaic module, including: providing at least one cell string, an end portion of each cell overlaps with an end portion of an adjacent cell to form a corresponding overlapping welding region; for each overlapping welding region, forming a film insertion opening between stacked end portions of the two adjacent cells forming the each overlapping welding region; providing at least one film strip, and inserting a part of each film strip into a corresponding film insertion opening, such that a width of the part of the each film strip inserted into the corresponding film insertion opening is larger than a width of the remaining part of the each film strip; and closing each film insertion opening.

Abstract: The present disclosure relates to the technical field of photovoltaic modules, and in particular, to a solar cell and a photovoltaic module. The solar cell includes a substrate and a positive gate line and a negative gate line that are arranged on a back surface of the substrate, wherein the positive gate line and the negative gate line are alternately arranged and are not connected. An edge portion of at least one side of the back surface in at least one direction is an insulating portionoverlap with one anotheroverlap with one another.

Abstract: A computer-implemented method to automatically adjust a view of a video stream to focus on a relevant item. The method includes monitoring activity in video feed of a video conference. The method further includes identifying, in the video feed, an item that a user is interacting with during the video conference. The method also includes determining a relevance score for to the item, where the relevance score represents a likelihood the item is a focus of the video conference. The method includes determining the relevance score is above a relevance threshold for the item. The method also includes adjusting, in response to the relevance score being above the relevance threshold, a focus the video feed, where the adjusting is configured to focus on the item.

Abstract: In accordance with an embodiment, a drive apparatus includes a substrate, a first movable structure, a second movable structure, a first fastening structure, a second fastening structure, a first connecting piece, a second connecting piece, and a drive structure. The first fastening structure is fastened to the substrate, and the first movable structure is connected to the first fastening structure by using the first connecting piece. The second movable structure is connected to the second fastening structure by using the second connecting piece, and the second movable structure is fastened to the first movable structure. A thickness of a first area on the first fastening structure is less than a thickness of a second area. A thickness of a third area on the second fastening structure is less than a thickness of a fourth area.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds, or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, have the following structure: wherein A, L1, L2, Q, R1, R2a, R3a, R3b, R4a, R4b, R9, R10, Y, and Z are as exemplified herein. Pharmaceutical compositions comprising such compounds, methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, and methods associated with preparation of such compounds are also provided.

Abstract: Embodiments of the disclosure provide a method for manufacturing a photovoltaic module, including: providing at least one cell string an end portion of each cell is stacked with an end portion of an adjacent cell to form a corresponding overlapping welding region; for each overlapping welding region, forming a film insertion opening between stacked end portions of the two adjacent cells corresponding to the each overlapping welding region; providing at least one film strip, and inserting a part of each film strip into a corresponding film insertion opening; moving the at least one cell string relative to the at least one film strip; and closing the film insertion openings so that the each film strip is inserted between the two adjacent cells of the corresponding overlapping welding region.

Abstract: The present invention relates to a heat sink manufacturing method and system and, more specifically, to a heat sink manufacturing method and system for providing support so that a heat sink with enhanced heat dissipation efficiency can be quickly and efficiently manufactured.

Abstract: A method for maintaining an intelligent self-growing avatar (ISGA) in a metaverse is presented including supporting the ISGA with an ISGA server communicating with an ISGA client, collecting, via an ISGA data structure, personal characteristics and activities of a person in a real world, creating, via an avatar creator, an avatar having the personal characteristics of the person in the real world, training, via an ISGA trainer, the avatar to recognize and respond to the activities and relationships of the real person, and changing, via an ISGA adjuster, a behavior and personality of the avatar based on the activities and relationships of the real person in the real world to allow the avatar to continuously grow and evolve in the metaverse.

Abstract: Provided are a pharmaceutically acceptable salt and a crystalline form of a GLP-1 receptor agonist and a preparation method therefor. Specifically, provided are a pharmaceutically acceptable salt and a crystalline form of a compound 2-((4-((S)-3-(4-chloro-2-fluorophenyl)-2,3-dihydrobenzo[b][1,4]dioxane-5-yl)piperidin-1-yl)methyl)-1-(((S)-oxe-tane-2-yl)methyl)-1H-benzo[d]imidazole-6-formic acid.

Abstract: A camera module is provided. The camera module may be separately used as a camera, or may be applied to a terminal device such as a mobile phone or a tablet computer, or a vehicle-mounted device. The camera module includes an optical lens component, a light filtering layer, an image sensor and a drive module. The optical lens component is configured to receive a light beam from a photographed object, and transmit the light beam to the light filtering layer. The light filtering layer is configured to move a position under the drive of the drive module, and respectively transmit light signals filtered at different positions to the image sensor. The image sensor is configured to receive the light signals at the different positions from the light filtering layer, and determine image information based on the light signals at the different positions.

Abstract: Disclosed is NOR memory device. The NOR memory device comprises: at least two source/drain contact layers and at least one isolation layer alternately stacked in a vertical direction; a gate structure vertically extending through the source/drain contact layers and the isolation layer; and a semiconductor layer on the periphery of the gate structure; wherein, two of the source/drain contact layers located immediately above and below the isolation layer are respectively connected to two bit/source lines, and form a memory transistor together with the gate structure and the semiconductor layer.

Abstract: A button assembly is adapted to be installed at a conductive casing. Two opposite sides of the conductive casing respectively have first and second openings, and the first opening is communicated with the second opening. The button assembly includes a conductive button, a first insulating sleeve, and a second insulating sleeve. The conductive button includes a button part corresponding to the first opening and a shaft part connected to the button part and passing through the second opening from the first opening. The first insulating sleeve includes a first shaft hole and a first lateral slit. The second insulating sleeve includes a second shaft hole and a second lateral slit. The first insulating sleeve is sleeved on the shaft part and located at the first opening. The second insulating sleeve is sleeved on the shaft part and located at the second opening. An electronic device is also provided.

Abstract: A compound of Formula (I) is provided: where the variables are defined herein.

Abstract: A photovoltaic module and a method for manufacturing photovoltaic module. The photovoltaic module includes a solar cell, a pad, fasteners, and a solder strip. The pad is arranged on the solar cell and includes first, second, and third parts, the first part is connected to the third part through the second part, and along a length direction of the solder strip, a width of the second part is less than a width of the first part and a width of the third part. The fasteners are arranged on a side of the first part facing away from the solar cell and a side of the third part facing away from the solar cell, the solder strip is provided between the fastener in the first part and the fastener in the third part, and the solder strip is connected to the pad through the fastener to form a solar cell string.

Abstract: A computer implemented method performs a task for a vehicle. A number of processor units detects a presence of the vehicle on a road. The number of processor units divides the task to be performed for the vehicle into subtasks. The number of processor units assigns the subtasks to Internet of Things nodes on possible paths that the vehicle can travel on the road. The number of processor units processes the subtasks using a set of the Internet of Things nodes on a selected path in the possible paths in real time as the vehicle moves on the selected path to form subtask results. The number of processor units combines the subtask results from the processed subtasks to form a task result for the task.