Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An endoscope apparatus includes: an endoscope configured to acquire an image of an inside of a subject; and a processor including hardware. The processor generates three-dimensional model data of the subject; generates a three-dimensional model image visually confirmable in a predetermined line-of-sight direction, based on the three-dimensional model data; generates progress information enabling a progress state of endoscopic observation to be visually confirmed as a ratio; and associates the progress information with the three-dimensional model image and presents the progress information relative to the three-dimensional model image side by side.

Abstract: A control steered angle calculation unit includes: an end position determination unit that determines whether a rack shaft is located at either one of right and left rack end positions; a motor absolute angle calculation unit that detects a motor absolute angle; an end position-corresponding motor angle setting unit that, when the rack shaft is determined to be located at either one of the right and left rack end positions, sets the detected motor absolute angle as an end position-corresponding motor angle corresponding to the one of the right and left rack end positions; and a control steered angle origin setting unit that calculates an average value of right and left end position-corresponding motor angles as an offset angle, and sets an angle obtained by subtracting the offset angle from the detected motor absolute angle as an origin of the control steered angle represented by the motor ab solute angle.

Abstract: An information processing method of the present invention includes: a transmission control step of performing transmission control of data to a server; a storage control step of storing backup data for data to be transmitted to the server; and an acquisition step of acquiring a retention period of data transmitted to the server. In the transmission control step, in a case where the transmission control was stopped and is started again and the acquired retention period continues, the stored backup data is transmitted so as to be continued from data that was transmitted to the server until the transmission control was stopped.

Abstract: The purpose of the present invention is to provide a substance having superior antibacterial activity against Pseudomonas aeruginosa, and a pharmaceutical composition for treatment and/or prophylaxis of pseudomonal infections. A pharmaceutical composition is provided, containing an antibody which specifically binds to the LPS O11 antigen of Pseudomonas aeruginosa, and which has superior antibacterial activity.

Abstract: A tubular insertion system includes an insertion unit including a bendable portion, a bending operation mechanism that operates the bendable portion. The tubular insertion system further includes a bending operation amount detection/calculation device that calculates bending operation amount information, a bent shape detection/calculation device that calculates bent shape information, and a first operation support information acquisition unit that acquires first operation support information based on at least one of the bending operation amount information and the bent shape information.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An ECU includes a deviation calculating circuit an assist control circuit, an automatic steering control circuit including an intervention determination switching circuit, an adder, a current command value calculating circuit The intervention determination switching circuit includes a count amount calculating circuit, an adder, an immediately-preceding count amount output circuit, a switching determination circuit, and an output switching circuit. The count amount calculating circuit calculates a count amount having a positive value or a negative value based on a steering torque absolute value calculated by an absolute value switching circuit. The adder calculates a total count amount that is the total sum of a presently calculated count amount and an immediately-preceding count amount calculated in an immediately-preceding calculation cycle.

Abstract: A steering control device includes a feedback processing portion configured to control a current flowing through a motor to a current command value; an end determination processing portion configured to determine whether a turning angle of steered wheels has reached a limit angle; and an end-time limit processing portion configured to limit a magnitude of the current command value to a magnitude of a limited current value or smaller, when the end determination processing portion determines that the turning angle has reached the limit angle. The limited current value is a value obtained by performing correction to decrease a magnitude of a detected value of the current flowing through the motor at a time when the end determination processing portion determines that the turning angle has reached the limit angle, based on a degree of a decrease in a magnitude of a rotational speed of the motor.

Abstract: A steering control device includes a command value setting processing portion configured to set a current command value based on a detection value of steering torque; a feedback processing portion configured to control a voltage applied to a motor so as to control a current flowing through the motor to the current command value, based on an output value of an integral element obtained by using a difference between the current and the current command value; an end determination processing portion configured to determine whether a turning angle of steered wheels has reached a limit angle; and an end-time limit processing portion configured to perform correction to increase a magnitude of the difference, based on a degree of a decrease in a magnitude of a rotational speed of the motor when the end determination processing portion determines that the turning angle has reached the limit angle.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A semiconductor circuit has circuit units in a plurality of stages which units are continuously connected, each of the circuit units in the plurality of stages including: a first register; a second register; a first outputter; and a second outputter. The first outputter is connected to the first register and the second register, and selects and outputs one of a first input signal inputted from the first register and a second input signal inputted from the second register. The second outputter outputs at least one of the second input signal and a third input signal to a second register in a next stage, the third input signal being outputted from a logic circuit unit that performs logic operation on the basis of an input signal containing at least one of a signals outputted from the first outputters.

Abstract: An image processing apparatus for scanning endoscope includes: a number-of-interpolations determination section that receives detection signals from a detector for sequentially sampling return light from a subject and determines a number of detection signals used in an interpolation process by an interpolation section based on distances between a coordinate position of a predetermined lattice point in pixel data of a raster scan system and sampling coordinate positions of the detection signals around the coordinate position of the predetermined lattice point; and the interpolation section that generates pixel data of the predetermined lattice point by using signals of the sampling coordinate positions, wherein a number of the signals is equal to the number of detection signals determined by the number-of-interpolations determination section near the sampling coordinate position corresponding to the coordinate position of the predetermined lattice point.

Abstract: The present invention provides an antibody which binds to a fibroblast growth factor receptor.

Abstract: The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Abstract: A vehicle handle device includes: a handle support member; a handle rotatably supported by the handle support member and causing a locking device to perform a transition from a latched state to an unlatched state; a rotary member rotatable around a rotary shaft with respect to the handle support member; and a torsion coil spring having a main body portion extending to have a spiral shape and disposed on the periphery of the rotary shaft, and first and second engagement pieces extending from both ends of the main body portion, respectively, and generating a bias force causing the rotary member to rotate around the rotary shaft when the first and second engagement pieces engage with the rotary member and the handle support member, respectively, in a state where the main body portion is elastically deformed.

Abstract: A vehicle handle device: a resin handle support member having one surface in a vehicle width direction which faces one surface of a metal panel of a vehicle door; a handle rotatably supported by the handle support member and causing a locking device to perform a transition from a latched state to an unlatched state; a metal bolt penetrating through a through-hole and a bolt inserting hole, and having a head portion facing the other surface of the handle support member; a metal nut facing the other surface of the panel and screwed with the bolt; and a metal spacer positioned between the head portion and the other surface of the panel, and whose both end portions come into contact with the head portion and the one surface of the panel.

Abstract: The endoscope system includes: an endoscope including an insertion portion to be inserted into a subject, and an image pickup portion that picks up an image of inside of the subject; an image pickup information acquisition portion that acquires positional information of the image pickup portion; an insertion form information acquisition portion that acquires insertion form information of the insertion portion inside the subject; and a control portion that, on a stereoscopic model image that simulates a predetermined organ inside the subject, superimposes an insertion form image that is based on insertion form information that is acquired by the insertion form information acquisition portion, and based on positional information of the image pickup portion that is acquired by the image pickup information acquisition portion, also pastes an image pickup image that is picked up by the image pickup portion, and presents the resulting stereoscopic model image.

Abstract: A medical apparatus includes: an information acquisition section configured to acquire position information and visual line information in an endoscope inserted into a predetermined organ; an image acquisition section configured to acquire an image obtained by observing inside of the predetermined organ from a predetermined viewpoint; an alignment section configured to convert the position information and the visual line information to a coordinate system of a model of the predetermined organ; a position calculation section configured to calculate position information of an inner wall of the predetermined organ opposing in a visual line direction from the predetermined viewpoint; an index generation section configured to generate an index defined based on a predetermined feature; and an image generation section configured to generate an image in which the index and position information of the inner wall are associated, for the image acquired by the image acquisition section.

Abstract: A semiconductor circuit has circuit units in a plurality of stages which units are continuously connected, each of the circuit units in the plurality of stages including: a first register; a second register; a first outputter; and a second outputter. The first outputter is connected to the first register and the second register, and selects and outputs one of a first input signal inputted from the first register and a second input signal inputted from the second register. The second outputter outputs at least one of the second input signal and a third input signal to a second register in a next stage, the third input signal being outputted from a logic circuit unit that performs logic operation on the basis of an input signal containing at least one of a signals outputted from the first outputters.