Abstract: A control device in an electric power steering device calculates a first assist component based on steering torque and a vehicle speed. The control device also calculates a compensation component associated with an reverse input and calculates a steered angle command value based on an addition value of the compensation component and basic drive torque that is an addition value of the steering torque and the first assist component, produces a second assist component by performing steered angle feedback control that causes the steered angle of a vehicle to follow the steered angle command value. The control device controls drive of a motor based on an assist command value that is an addition value of the first assist component and the second assist component.

Abstract: Problem to be Solved The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Abstract: A conditioner composition that increases the deposition and retention of benefit agent containing polyacrylate microcapsules onto hair. The conditioner composition is based on the combination of anionic charged polyacrylate microcapsules, deposition aids, conditioner agents, and a carrier.

Abstract: An endoscope system includes an image pickup device that is inserted into a subject and picks up an image inside the subject and a memory that records an intra-subject image acquired by the image pickup device and position information of the image pickup device in association with each other. The endoscope system includes an image generating section that applies, to the intra-subject image, when it is determined that a release signal is generated as a predetermined trigger signal, predetermined processing for distinguishably displaying the intra-subject image at a time when the release signal is generated and generates an image obtained by pasting the intra-subject image onto a model image of a predetermined organ.

Abstract: An endoscope system includes a determining section that determines whether or not an image pickup device is moving at a predetermined speed or higher based on position/direction information and determines, when the image pickup device is not moving at the predetermined speed or higher, that a subject internal image is an image that can be pasted onto a model image of a predetermined organ in a state where the position/direction information of an objective optical window and position/direction information in a coordinate system of the predetermined organ model image are associated with each other, and an image pasting section that reads the subject internal image determined to be the image that can be pasted from the memory and pastes the subject internal image onto the model image of the predetermined organ based on the position/direction information.

Abstract: The present invention provides an antibody which binds to a fibroblast growth factor receptor.

Abstract: The purpose of the present invention is to provide a substance having superior antibacterial activity against Pseudomonas aeruginosa, and a pharmaceutical composition for treatment and/or prophylaxis of pseudomonal infections. A pharmaceutical composition is provided, containing an antibody which specifically binds to the LPS O11 antigen of Pseudomonas aeruginosa, and which has superior antibacterial activity.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A door handle device for a vehicle includes a door opening prevention mechanism that is provided with an inertia lever being rotatably supported at a base frame, an inertia body being mounted to the inertia lever, and an elastic member elastically biasing the inertia lever toward an initial position where the movement of a link mechanism is not restricted by the inertia lever. The inertia lever includes a center of gravity of the inertia lever being set at a same position as a position of a center of gravity of the outside handle in an extending direction of the outside handle, the center of gravity of the inertia lever being set at a same position as a position of the center of gravity of the outside handle in vehicle upper-lower directions, or being set at a lower position relative to the center of gravity of the outside handle.

Abstract: In a state in which the energization in the first direction is possible between the motor and the drive circuit and the motor is not rotating at high speed, when the phase induced voltage value of the specific phase that is the target of determination is continuously equal to or smaller than the abnormality determination threshold, the abnormality detecting unit determines that an open malfunction has occurred in the relay FET of the specific phase.

Abstract: An endoscope system includes an insertion portion, an objective optical window, an image pickup device, a position/direction detection section that acquires position information of the objective optical window, and a memory that records the subject internal image acquired by the image pickup device in association with the position information of the objective optical window. The endoscope system aligns the position information of the objective optical window with a reference position of a predetermined organ in the subject in a coordinate system of a three-dimensional model image based on an amount of change or the like of the subject internal image information in the subject and generates an image with the subject internal image pasted onto the two-dimensional model image of the predetermined organ which is the three-dimensional model image two-dimensionally developed in which the position of the objective optical window is associated with the position in the coordinate system.

Abstract: An endoscope system includes: an insertion portion to be inserted into a predetermined luminal organ in a subject; an image pickup section provided in a vicinity of a distal end of the insertion portion, the image pickup section picking up an image of a predetermined range; an image pickup information acquiring section acquiring position information and gaze information about the image pickup section; a model image generating section generating a planar model image of the predetermined luminal organ; an image pasting processing section generating a pasted image obtained by pasting a subject image of an inside of the predetermined luminal organ onto the planar model image based on the position information and gaze information about the image pickup section; and an image pasting/presentation processing section presenting an image pickup range of the image pickup section on the pasted image based on the position information about the image pickup section.

Abstract: An image processing apparatus for scanning endoscope includes: a number-of-interpolations determination section that receives detection signals from a detector for sequentially sampling return light from a subject and determines a number of detection signals used in an interpolation process by an interpolation section based on distances between a coordinate position of a predetermined lattice point in pixel data of a raster scan system and sampling coordinate positions of the detection signals around the coordinate position of the predetermined lattice point; and the interpolation section that generates pixel data of the predetermined lattice point by using signals of the sampling coordinate positions, wherein a number of the signals is equal to the number of detection signals determined by the number-of-interpolations determination section near the sampling coordinate position corresponding to the coordinate position of the predetermined lattice point.

Abstract: A scanning endoscope system has a light guide portion that guides an illuminating light, a drive portion capable of causing the light guide portion to swing so that an irradiation position of the illuminating light draws a locus corresponding to a predetermined scanning pattern, a light detecting portion that receives a return light of the illuminating light and outputs a signal, a control portion that drives the drive portion to perform scan so that the irradiation position of the illuminating light becomes a locus in a spiral shape, and an image generating portion that generates an image of an object based on a signal outputted from the light detecting portion in a predetermined timing, wherein the control portion further performs control for driving the drive portion so that the irradiation position of the illuminating light circles on a same circumference in the predetermined timing.

Abstract: There is provided an electric power steering system that makes it possible to improve the driver's steering feel, and that includes a controller that controls driving of a motor. The controller computes a first assist component based on a steering torque. The controller computes a torque command value based on a basic drive torque that is the sum of the steering torque and the first assist component, and computes an assist compensation component through feedback control based on the torque command value. The controller computes a steered angle command value based on a value obtained by adding the assist compensation component to the basic drive torque, and computes a second assist component through feedback control based on the steered angle command value. The controller controls driving of the motor based on an assist command value that is the sum of the first assist component and the second assist component.

Abstract: Problem to be Solved The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Abstract: A medical instrument includes an insertion portion, first transmitting coils, second transmitting coils, a signal control unit, a position detection unit, a memory, and a position estimating unit. The signal control unit controls the first transmitting coils to transmit magnetic fields during a first predetermined period and controls the second transmitting coils to transmit magnetic fields during a second predetermined period. The position detection unit detects positions of the first transmitting coils during the first predetermined period and detects positions of the second transmitting coils during the second predetermined period. The memory stores the positions of the first transmitting coils. The position estimating unit estimates a shape of the insertion portion based on the positions of the second transmitting coils and the positions of the first transmitting coils stored in the memory.

Abstract: A position detecting apparatus for a medical device includes a transmission unit configured to transmit a magnetic field in each of a plurality of frame periods. A reception unit detects the magnetic field transmitted from the transmission unit and output a detection signal corresponding to a position of the transmission unit. A signal control unit causes the transmission unit to transmit the magnetic field by a multiplexed signal including at least two or more different frequencies in a certain frame period among the frame periods, and causes the transmission unit to transmit the magnetic field by the multiplexed signal in the frame periods other than the certain frame period when the detection signal output from the reception unit has changed to a certain threshold or higher.

Abstract: The endoscope system includes: an endoscope including an insertion portion to be inserted into a subject, and an image pickup portion that picks up an image of inside of the subject; an image pickup information acquisition portion that acquires positional information of the image pickup portion; an insertion form information acquisition portion that acquires insertion form information of the insertion portion inside the subject; and a control portion that, on a stereoscopic model image that simulates a predetermined organ inside the subject, superimposes an insertion form image that is based on insertion form information that is acquired by the insertion form information acquisition portion, and based on positional information of the image pickup portion that is acquired by the image pickup information acquisition portion, also pastes an image pickup image that is picked up by the image pickup portion, and presents the resulting stereoscopic model image.

Abstract: The present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.