Abstract: Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.

Abstract: Hydroxide-exchange membranes (HEMs) and hydroxide-exchange ionomers (HEIs) are provided which include polymers with oxidation resistant groups. The attachment of the oxidation resistant groups to the polymer backbone allows fine-tuning of the mechanical properties of the membrane and incorporation of alkaline stable cations, such as imidazoliums, phosphoniums and ammoniums, and provides enhanced stability to the polymer. HEMs/HEIs formed from these polymers exhibit superior chemical stability, anion conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional HEM/HEIs. The HEMs exhibit enhanced stability in a highly oxidative environment.

Abstract: Provided is a GABAA receptor agonist phenol derivative that has a novel structure and better efficacy, can effectively reduce side effects, and is safer for clinical use. Specifically disclosed are a compound as represented by the following formula (I), a stereoisomer and pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and an application of the compound or composition of the present invention in the central nervous field, thereby providing more and better choices for medicaments for inducing and/or maintaining anesthesia in animal or human bodies, facilitating sedation and hypnosis, and treating and/or preventing anxiety, nausea, vomiting, migraine, convulsion, epilepsy, neurodegenerative diseases, and central nervous system-related diseases.

Abstract: An upper limb rehabilitation training system in two-person standing type and an application method thereof are provided. The upper limb rehabilitation training system includes an upper limb rehabilitation training platform, two weight-reducing suspending support structures arranged oppositely, and two standing frames arranged oppositely; the upper limb rehabilitation training platform includes an all-in-one computer which includes a computer and a touch display screen, and a periphery of the touch display screen is provided with a grating structure; the upper limb rehabilitation training platform is provided with a two-person interactive upper limb training module including two control handles, a virtual training prop and a virtual training scene. The two control handles are suspended from the two weight-reducing suspending support structures, respectively; the grating structure is configured to identify the control handles and positions thereof.

Abstract: The present disclosure discloses a method and device for sampling a pulse signal, and a computer program medium.

Abstract: A method of extracting myricetin from Xanthoceras sorbifolia Bunge is provided. The method includes: step 1, baking obtaining Xanthoceras sorbifolia Bunge crude powder; step 2, mixing the crude powder with a counter-current extraction solution to perform a counter-current extraction to obtain a filtrate and a filter residue; step 3, mixing the filter residue with a solvent to obtain a first mixture, and heating the first mixture to reflux for extraction to obtain an extraction liquid; step 4, mixing the extraction liquid and the filtrate, and concentrating under reduced pressure to obtain a concentrated solution; and step 5, separating and eluting the concentrated solution to obtain an eluent, then drying the eluent to obtain the myricetin.

Abstract: The disclosure relates to the technical field of extraction of an active ingredient from traditional Chinese medicine, and provides a method of extracting myricetin from Xanthoceras sorbifolia Bunge.

Abstract: Various methods and systems are provided for accelerated image rendering with motion compensation. In one embodiment, a method comprises calculating motion between a preceding image frame and a target image frame to be rendered, rendering a small image with a size smaller than a target size of the target image frame based on the calculated motion, and generating the target image frame at the target size based on the small image, the calculated motion, and a reference image frame. In this way, high-quality image frames for a video stream may be generated with a reduced amount of rendering for each frame, thereby reducing the overall processing resources dedicated to rendering as well as the power consumption for image rendering.

Abstract: A method for harmonic detection includes: acquiring a ripple component of a direct-current bus voltage; acquiring a harmonic component of the direct-current bus voltage based on the ripple component; acquiring a quadrature component of the harmonic component based on the harmonic component; acquiring a characteristic parameter of the harmonic component based on the quadrature component, in which the characteristic parameter includes a phase; and acquiring and outputting a voltage amplitude of the harmonic component based on the quadrature component and the phase of the harmonic component.

Abstract: The invention discloses a method and system for traffic clearance at signalized intersections based on lidar and trajectory prediction, belonging to the field of intelligent transportation systems. The invention obtains live vehicle trajectory data at the entrance of the intersection based on 3D LiDAR, and predicts whether a motor vehicle will enter at the signalized intersection when traffic light changes from green to red (which normally involves the yellow change interval). It uses the 3D LiDAR installed at the intersection covering the entrance to collect the trajectory data of the vehicle, and further judges whether the vehicle will enter the intersection after the yellow change interval; it also predicts the driving time of the entered vehicle in the intersection, and determines the all-red time of the intersection on this basis, so as to achieve the purpose of clearing the traffic within the intersection in time and reducing traffic conflicts.

Abstract: Poly(aryl alkylene) polymers or poly(aryl-crown ether-alkylene) polymers with pendant cationic groups are provided which have an alkaline-stable cation, such as imidazolium, introduced into a rigid aromatic polymer backbone free of ether bonds. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells and hydroxide exchange membrane electrolyzers comprising the poly(aryl alkylene) polymers or poly(aryl-crown ether-alkylene) polymers with pendant cationic groups exhibit enhanced performance and durability at relatively high temperatures.

Abstract: A low cost biodegradable drinking straw comprising structurally non-altered corn starch mixed with one or more than one improver. The improver comprises a biological enzyme preparation and a colloid preparation. The low cost biodegradable drinking straw is made by providing 98% structurally non-altered corn starch mixed with one or more than one improver to make a biodegradable powder. The edible biodegradable powder is formed into a drinking straw shape and extruded to a drinking straw shape. When the extruded drinking straw shapes are cooled, they are cut into an appropriate drinking straw length. The cut drinking straws are then dried and packaged.

Abstract: The present disclosure discloses a method for lane alignment detection based on millimeter wave radar data. An embodiment of the method comprises: acquiring the vehicle trajectory data and radar reflection data detected by the millimeter wave radar which are installed on the road to sense the moving vehicles; setting up two datasets in the database, including vehicle track dataset and waypoint dataset obtained after rasterizing the road; filtering vehicle track data and vehicle radar reflection data detected by millimeter-wave radar and eliminate erroneous data; performing radial clustering and horizontal initial stable point clustering on the filtered data; extracting and outputting the lane alignment. Compared with the prior art, the invention possesses the advantages of obtaining more accurate lane alignments, low cost and good adaptability, etc.

Abstract: Fluoride-containing nickel iron oxyhydroxide electrocatalysts for use as anodes in anion exchange membrane electrolyzers for generating hydrogen gas.

Abstract: An apparatus and method for purification and recovery of an organic liquid. The apparatus includes a distillation kettle and a receiver tank connected by a distillation pipe, and a vacuum pump, wherein a vacuum storage tank is arranged between the receiver tank and the vacuum pump; the vacuum storage tank is connected to the receiver tank by a vacuum regulating pipe, a first vacuum regulating valve being arranged on the vacuum regulating pipe; and the vacuum storage tank is connected to the vacuum pump by an evacuation pipe, a second vacuum regulating valve being arranged on the evacuation pipe. By arranging a vacuum storage tank between the receiver tank and the vacuum pump, the vacuum degree in the receiver tank is regulated by the vacuum storage tank, such that the organic liquid is recovered in a sealed environment under reduced pressure.

Abstract: Poly(aryl piperidinium) polymers with pendant cationic groups are provided which have an alkaline-stable cation, piperidinium, introduced into a rigid aromatic polymer backbone free of ether bonds. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells comprising the poly(aryl piperidinium) polymers with pendant cationic groups exhibit enhanced performance and durability at relatively high temperatures.

Abstract: Certain embodiments provide a method of detecting one or more biomarkers in a subject having a lysosomal storage disorder, the method comprising: 1) measuring the concentration of a combination of two or more lipids in a sample from the subject, wherein the combination of lipids is selected from the group consisting of: a) a bis(monoacylglycero)phosphate (BMP); b) a GM2 ganglioside and/or a GM3 ganglioside; c) a GD3 ganglioside; d) a GD1a/b ganglioside; and e) a glucosylceramide (GlcCer); 2) measuring the concentration of GlcCer in a sample from the subject; 3) measuring the concentration of neurofilament light chain (Nf-L) in a sample from the subject; and/or 4) measuring the concentration of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in a sample from the subject.

Abstract: The present disclosure provides methods and materials for screening a compound or monitoring a subjects response to a compound or dosing regimen for treating a PGRN-associated disorder. Methods and materials for identifying and treating a subject having a PGRN-associated disorder are also provided.

Abstract: An upper limb rehabilitation training system in two-person standing type and an application method thereof are provided. The upper limb rehabilitation training system includes an upper limb rehabilitation training platform, two weight-reducing suspending support structures arranged oppositely, and two standing frames arranged oppositely; the upper limb rehabilitation training platform includes an all-in-one computer which includes a computer and a touch display screen, and a periphery of the touch display screen is provided with a grating structure; the upper limb rehabilitation training platform is provided with a two-person interactive upper limb training module including two control handles, a virtual training prop and a virtual training scene. The two control handles are suspended from the two weight-reducing suspending support structures, respectively; the grating structure is configured to identify the control handles and positions thereof.