Abstract: This invention relates to compounds of formula 1; and their use as STING antagonists e.g. for the treatment of a disease selected from the group consisting of systemic lupus erythematosus (SLE), (monogenic and digenic) interferonopathies (including STING-associated vasculopathy with onset in infancy (SAVI).

Abstract: In accordance with embodiments of the present disclosure, an anode is presented. The anode includes a first anode material, the first anode material having a flat side and an embossed side that is embossed with a first embossing pattern; and a second anode material, the second anode material having a flat side and an embossed side that is embossed with a second embossing pattern, wherein the embossed side of the first anode material is positioned against the embossed side of the second anode material, and wherein the first anode material and the second anode material are coupled on one edge.

Abstract: A door body assembly for a refrigeration appliance includes an enclosure door rotatably connected to an appliance main body for opening or closing a storage compartment, a door panel slidably mounted on an outer side of the enclosure door, and a transmission mechanism configured to drive relative movement of the door panel during rotation of the enclosure door. The transmission mechanism enables the door panel to shift laterally as the door is opened or closed, allowing the enclosure door to avoid interference with adjacent cabinet structures. This configuration improves clearance during operation, prevents collisions between the door panel and surrounding objects, and enhances usability across various installation environments.

Abstract: Disclosed herein is a composition comprising an amount of water; a hyaluronic acid; and a first excipient, wherein the composition is configured to be formed into a ‘flowable cold slum’ when the composition is exposed, to a temperature of 0° C. or less.

Abstract: A method, an apparatus, and a system for generating a layout diagram of a photovoltaic power generation system, and a storage medium are provided. The method includes: acquiring device information and first physical location information of each photovoltaic device; acquiring physical location information of each photovoltaic module and second physical location information of a photovoltaic device connected to the photovoltaic module; and generating a layout diagram of the photovoltaic power generation system based on the device information, the first physical location information, the second physical location information of each photovoltaic device, and the physical location information of each photovoltaic module. The first physical location information and the second physical location information of each photovoltaic device at least partially correspond to each other and at least include an arrangement number of the photovoltaic device in a photovoltaic device array.

Abstract: Systems and methods are disclosed to shape optical fiber lenses through surface grinding. The method involves rotating the optical fiber using a rotation-driving module, swinging the fiber through a swing module to fine-tune the grinding angle radially, and performing the grinding at the fiber's end to achieve the specified lens contour. The apparatus integrates a rotation module for consistent axial spinning, a swing device for managing the radial angle of grinding, and an expedited load and unload system.

Abstract: Heterocyclic compound drugs with a nitrogen atom as a heterocyclic atom may be used as a kinase inhibitor. The preparation of a free base crystal form of the compound is also provided. The compound used as a kinase inhibitor is a compound as shown in formula I, or a deuterated compound thereof, or a pharmaceutically acceptable salt, solvate or prodrug. Biological activity experiments prove that the compound has a good inhibitory activity on exon 20 insertion mutations in EGFR and HER2, exon 19 deletion in EGFR and exon 21 point mutation in EGFR, and can be used as the bulk drug in relevant drugs.

Abstract: Systems and methods are disclosed for clamping an optical fiber for lens grinding by inserting an optical fiber into an optical fiber core dimension matching ferrule tube; aligning the optical fiber using a rotatable optical fiber guide tube; engaging a front optical fiber clamp mechanism to secure a front portion of the optical fiber; engaging a rear optical fiber clamp mechanism to secure a rear portion of the optical fiber; and performing a lens grinding operation on an end of the optical fiber. The method is tailored for working with multiple fibers simultaneously and also supports precise alignment for polarization-maintaining fibers. This innovation streamlines the formation of lens-equipped fiber ends, boosting production efficiency and lens quality.

Abstract: There is a provided a pointing device, for example a remote pen which includes a multimode switch or button for transitioning the pointing device between three or more modes of operation. The mode of operation can include a first mode, an annotation mode and an air mouse mode. The remote point device further includes an inertial measurement unit configured for determination orientation information associated with the pointing device, which provides a means for determination of changes in x and y with respect to a cursor associated with a screen of a display device being controlled by the pointing device. The pointing device is further configured to provide different control/display (C/D) gains depending on the action being performed by the pointing device.

Abstract: A door body assembly for a refrigeration device includes a box door rotatably connected to a box body to open or close a storage space, with a first mounting slot formed on an outer side of the box door. A door panel is slidably arranged on the outer side of the box door. A first sliding door mechanism is disposed within the first mounting slot and has one end connected to the box body via a traction mechanism and another end connected to the door panel. The first sliding door mechanism is configured to drive the door panel to move in the width direction of the box door during rotation of the box door. The sliding structure enables relative movement between the door panel and the box door, with the mechanism housed within the door structure.

Abstract: Embodiments of the present disclosure provide an image processing method, an electronic device, and a storage medium. The method includes: determining a target resolution in response to a shooting instruction; and controlling a camera to shoot a first image with the target resolution for a current environment, where the target resolution is a first resolution or a second resolution, and the first resolution is greater than the second resolution.

Abstract: In an illustrative embodiment, a system includes consolidating location feature data sets for multiple geographic regions defined at multiple levels of granularity, transforming feature data values from an original granularity level to another granularity level, and training, for each geographic area, a machine learning data model to predict an average rental income per unit value within the respective geographic area and a set of feature-level scores indicating a contribution strength of each location feature to the average rental income per unit value. The system may determine a location score calculation data set representing geographic location(s) and a portion of the location features, and apply the location score calculation data set to the machine learning model(s) to obtain a respective average rental income per unit value within the geographic location(s) and a respective set of feature-level scores within the geographic location(s).

Abstract: A method and an apparatus for generating an electrical topology diagram of a power system, and a medium are provided. The method includes identifying at least one information identification diagram corresponding to each of the at least one convergence device to obtain electrical topology location information and device information of power devices connected to each of the at least one convergence device; and generating an electrical topology diagram of the power system based on the electrical topology location information and the device information of the power devices connected to each of the at least one convergence device. The information identification diagram includes at least one cell, and each of the at least one cell has a device identifier of corresponding one of the plurality of power devices and electrical topology location information of the one of the plurality of power devices.

Abstract: This application discloses a VXLAN packet transmission method, a network device, and a system. After receiving a first packet, a first network device obtains a VNI corresponding to the first packet. The first network device encapsulates the VNI in an IPV6 header by encapsulating the IPV6 header in the first packet, to obtain a second packet. The first network device sends the second packet to a second network device, so that the second network device forwards the packet based on the VNI included in the IPV6 header. In this application, the IPV6 header is used to carry the VNI, and no additional UDP header needs to be encapsulated to carry the VNI.

Abstract: The present disclosure provides an automatic door opening and closing actuator, belonging to the technical field of automobile components. The actuator includes a mounting housing and a push rod, wherein one end of the push rod extends out of a channel arranged on the mounting housing, and the other end of the push rod is arranged in the mounting housing to slide reciprocally, and further includes a sealing tube, wherein the sealing tube is sleeved outside the push rod, one end of the sealing tube is provided with an elastic covering ring wrapping the push rod, and the other end of the sealing tube is sealed and fixed to an inner wall of the channel or an end portion of the channel.

Abstract: A compound can prevent and/or treat a neurodegenerative disease. Specifically, the compound has a structure as shown in formula I. A preparation method for the compound and a use of the compound in preventing and/or treating a neurodegenerative disease are provided.

Abstract: A self-referencing spectral constraint-based spectral reconstruction method and apparatus, a device, and a medium are provided. The method includes: acquiring a total transmission matrix through a calibration; acquiring each observed speckle generated after target light passes through each filtering interval of a spectral filter to enter a scattering medium, where all observed speckles form a total observed speckle; forming a self-referencing spectrum based on total intensities of each observed speckle; and constructing a spectral reconstruction model based on a neural network and a physical forward process of the total transmission matrix, constructing a composite loss function based on a speckle intensity estimation error and a self-referencing spectrum error, and optimizing the parameters of the neural network via the composite loss function until convergence, thereby yielding an optimized neural network for spectral reconstruction for a given total observed speckle.