Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: An insulation light-conversion film for a photovoltaic assembly and a preparation method thereof and a photovoltaic assembly. The preparation process of the insulation light-conversion film for the photovoltaic assembly in the present disclosure includes insulation coating of the carbon quantum dots, material mixing and preparation and film formation by cast. The carbon quantum dots used by the present disclosure come from various sources, are safe and environment-friendly and simple to modify. The insulation-modified siloxane-coated carbon quantum dots can be better dispersed in the resin substrate, showing good binding. The present disclosure improves the light-conversion rate of the adhesive film for the ultraviolet light, increases the power generation efficiency and reduces the attenuation of the power generation efficiency of the aged assembly. The preparation process is simple, and environment-friendly and can be applied to the existing photovoltaic production process.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: A method and system of host to guest (H2G) notification are disclosed. H2G is provided via an instruction. The instruction is a send user inter-processor interrupt instruction. An exemplary processor includes decoder circuitry to decode a single instruction and execute the decoded single instruction according to the at least the opcode to cause a host to guest notification from a virtual device running in a host machine on the first physical processor to a virtual device driver running on a virtual processor in a guest machine on a second physical processor.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: The present invention discloses a method, equipment, and readable storage medium for tracking and evaluating the life cycle EUR of horizontal wells, and relates to the field of oil and gas development technology. The present invention divides the life cycle stages of fractured horizontal wells in unconventional oil and gas reservoirs, provides corresponding EUR evaluation steps for different life cycle stages based on the production performance characteristics of fractured horizontal wells in unconventional oil and gas reservoirs in the drilling and fracturing stage, extraction and testing stage, rapid production decline stage, and low pressure and small volume production stage, and establishes the EUR tracking and evaluation process of fractured horizontal wells in unconventional oil and gas reservoirs throughout their life cycle from drilling to abandonment.

Abstract: Embodiments of exitless guest to host (G2H) notification are described. In some embodiments, G2H is provided via an instruction. An exemplary processor includes decoder circuitry to decode a single instruction, the single instruction to include a field for an opcode; and execution processing resources to execute the decoded single instruction according to the at least the opcode to cause an exitless guest to host notification from a virtual processor to a physical or virtual processor.

Abstract: Disclosed are compounds of Formula (I?) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A constant current generation circuit for optocoupler isolation amplifier and a current precision adjustment method are provided. The constant current generation circuit includes a start circuit, a current generation circuit and a precision adjustment and output circuit integrated into a same substrate. The start circuit can generate and output a first start current and a second start current. The current generation circuit includes a negative temperature change rate current generation circuit connected to a first start current output and a positive temperature change rate current generation circuit connected to a second start current output. The precision adjustment and output circuit outputs constant current meeting application requirements of optocoupler isolation amplifier by adjusting proportional precision of two currents output from a current generation circuit.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: Disclosed is a circuit for shifting a fixed ground level to a floating ground level in a motor drive system, including a floating ground high level line, a floating ground output level line, a floating ground low level line, a normal input level line, and a normal ground line that are used for characterizing an application detail. The circuit includes a controlled switching current source, a first upper current rectifier, a second upper current rectifier, a lower current rectifier, and an amplifying and shaping circuit that are integrated on a same substrate.

Abstract: Disclosed is a circuit for converting a temperature change amount into a voltage change amount in a motor drive system, including a positive temperature change rate voltage generation module, a circuit bias module, and a temperature detection module that are integrated on a same substrate. An external power supply voltage is processed by the positive temperature change rate voltage generation module and the circuit bias module, and then inputted to the temperature detection module. The temperature detection module detects in real time the temperature change amount in the motor drive system, convert the temperature change amount into the voltage change amount, and transfer the voltage change amount to the circuit bias module, to allow the circuit bias module to output the voltage change amount. In this way, the conversion from the temperature change amount into the voltage change amount is realized.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.