Abstract: The present application provides tricyclic heteroaryl compounds that modulate the activity of the JAK1 and/or TYK2, which are useful in the treatment of various disorders and diseases, including skin, respiratory, ophthalmic, and rectal diseases and disorders, cancer, and neuroinflammation.

Abstract: A health detection device may determine a first data sampling interval based on a data amount of a first user health data set, a data transmission rate, and expected transmission waiting duration, sample the to-be-transmitted first user health data set at the first data sampling interval, to obtain first transmission data, and preferentially transmit the first transmission data in the first user health data set, so that a terminal device can output user health data and/or a related health indicator without waiting for a long time. Therefore, a user can view the user health data and/or the related health indicator as soon as possible, thereby effectively improving user experience.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: A sample processing module and a method for processing information of sample processing module are provided. The sample processing module includes: a sample storage device, the sample storage device including a plurality of drawers for storing sample tubes; a state detection device of each drawer, configured to detect a state of the drawer corresponding to the state detection device; a human-computer interaction device, wherein a display interface of the human-computer interaction device at least includes a first area, configured to display information of the drawer; and a processor, configured to acquire the state of the drawer, and switch from the currently displayed information of the drawer to highlighting the information of a first drawer in the first area in response to detecting that the first drawer is opened, wherein the first drawer is any drawer of the sample storage device.

Abstract: Disclosed are compounds of Formula (I?) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: The present disclosure relates to an siRNA for inhibiting the expression of an angiopoietin-like protein 3 (ANGPTL3) gene, an siRNA conjugate, and a pharmaceutical composition thereof, and a method for reducing the expression of the ANGPTL3 gene by using the siRNA, the siRNA conjugate, and the pharmaceutical composition thereof. The siRNA, the siRNA conjugate, and the pharmaceutical composition thereof of the present disclosure can be used for treating and/or preventing an ANGPTL3 gene-mediated disease or disorder.

Abstract: A knowledge base updating method includes: obtaining a plurality of question messages processed by a task processing model without relying on a knowledge base and a plurality of satisfaction results corresponding to the plurality of question messages; determining at least one target document in the knowledge base matching a question message of the plurality of question messages; based on a satisfaction result of the plurality of satisfaction results corresponding to each question message of at least one question message of the plurality of question messages associated with a target document of the at least one target document, determining a comprehensive satisfaction degree of the user with at least one feedback message corresponding to the at least one question message associated with the target document; and when the comprehensive satisfaction degree corresponding to the target document exceeds a set threshold, compressing the target document.

Abstract: A response information generation method includes obtaining first query information of a user, retrieving a first sub-text block matching the first query information, and determining a target parent text block corresponding to the first sub-text block. The target parent text block includes the first sub-text block and a second sub-text block associated with the first sub-text block. The method also includes determining first response information corresponding to the first query information based on the target parent text block using a target model.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: This disclosure discloses a method and system of hue-distance constrained relative radiometric correction considering Helmholtz-Kohlrausch (H-K) effect for multiple remote sensing images. The method comprises: first converting the image from the RGB color space to the CIELAB color space, then performing relative radiometric correction using adaptive constraint based on hue-distance, and quantitatively describing the H-K effect to apply global lightness mapping to the corrected image. Based on the limitations of the RGB color space, this disclosure proposes a relative radiometric correction strategy that maintains hue distance, which suppresses radiometric anomalies in local regions and optimizes correction results. By implementing global lightness mapping based on the H-K effect and introducing perceived lightness into the relative radiometric correction of remote sensing images, this method effectively enhances the radiation consistency of multi-temporal images.

Abstract: The present disclosure provides compounds, compositions, and methods useful for inhibiting PI3K?, and/or treating a disease, disorder, or condition associated with PI3K?, and/or treating cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: A green, safe and efficient mining device for a mine is provided. The device includes a support frame, a crushing bin, a fixed jaw plate, a movable jaw plate, a cam roller, a movable jaw back plate, first springs and a driving device. The support frame is provided with an opening, the crushing bin is installed on the support frame; the fixed jaw plate is vertically installed on a left side of an inside of the crushing bin, the movable jaw back plate is installed at one side of the movable jaw plate; a top end of the movable jaw plate is hinged to a right side of the crushing bin, the cam roller is rotatably connected with the inside of the crushing bin and is slidably connected with the movable jaw back plate.

Abstract: The present disclosure provides compounds, compositions, and methods useful for inhibiting PI3Ka, and/or treating a disease, disorder, or condition associated with PI3Ka, and/or treating cancer.

Abstract: There are provided inhibin subunit beta E (INHBE) inhibitors such as RNAi agents and RNAs useful for inhibiting the expression of INHBE, pharmaceutical compositions thereof, and applications thereof in the prevention and/or treatment of INHBE-associated disorders, e.g., metabolic disorders such as metabolic syndrome. In some embodiments the RNAi agents and RNAs comprise at least one non-canonical base pairing nucleotide.

Abstract: The present disclosure provides compounds, compositions, and methods useful for inhibiting PARP1, and/or treating a disease, disorder, or condition associated with PARP1, and/or treating cancer.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: An insulation light-conversion film for a photovoltaic assembly and a preparation method thereof and a photovoltaic assembly. The preparation process of the insulation light-conversion film for the photovoltaic assembly in the present disclosure includes insulation coating of the carbon quantum dots, material mixing and preparation and film formation by cast. The carbon quantum dots used by the present disclosure come from various sources, are safe and environment-friendly and simple to modify. The insulation-modified siloxane-coated carbon quantum dots can be better dispersed in the resin substrate, showing good binding. The present disclosure improves the light-conversion rate of the adhesive film for the ultraviolet light, increases the power generation efficiency and reduces the attenuation of the power generation efficiency of the aged assembly. The preparation process is simple, and environment-friendly and can be applied to the existing photovoltaic production process.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.