Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A data feature processing method and a data feature processing apparatus are provided, which perform the following operations: sorting a plurality of groups of business data to obtain a business data sorting sequence, and determining a cross-time validation set and modeling sample data to establish a recognition model by using a preset classifier; calculating feature importance values of data features in the business data based on the recognition model and a gain indicator of the recognition model, and calculating a correlation matrix by taking the modeling sample data as a benchmark; determining to-be-selected model features based on the correlation matrix; and importing the to-be-selected model features into the preset classifier in batches to determine model benchmark performance data. In this way, a highly-correlated feature can be deleted based on an order of the feature importance values. This can reduce operation time and memory demands in a model establishment process.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A method of jitter detection and image restoration for high-resolution TDI CCD satellite images. The method includes: obtaining a parallax image after a sub-pixel matching method relying on a correlation coefficient and least squares algorithm; transferring a jitter offset from an image space to an object space by an integral transformation function (ITF); dealing with a continuous push-broom mode of cameras in a discrete way with a denser sampling strategy according to a continue dynamic shooting model (CDSM), obtaining a specialized CDSM and feeding it back to the ITF; applying the accurate ITF to the obtained parallax image and conducting the jitter curve fitting to achieve the jitter detection; estimating a correspondent partial PSF according to the CDSM and the obtained jitter curve; carrying out an adaptive restoration based on context through optimal window Wiener filtering, by means of multiple input and single output to completes the image restoration.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Described herein are compositions and methods relating to light converting luminescent Zero-D perovskite composite materials.

Abstract: Provided in the present disclosure are anti-TIM-3 antibodies, the methods of hybridoma generation, the nucleic acid molecules encoding the anti-TIM-3 antibodies, expression vectors and host cells used for the expression of anti-TIM-3 antibodies. The disclosure further provides the methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies of the disclosure provide a very potent agent for the treatment of cancers via modulating immune functions.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: Embodiments of the present disclosure provide for passivated quantum dots, methods of making passivated quantum dots, methods of using passivated quantum dots, and the like.

Abstract: Disclosed are compounds of Formula (I): or a pharmaceutically acceptable salt thereof. Also provided are methods of using the compounds of Formula (I) for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Technologies relating to generation of training data for use in training a computer-implemented ranker are described. A product name extracted from a URL in a log entry of a search log of a search engine is mapped to a catalog product name from a catalog of a website, wherein the catalog product name identifies a product that is available for acquisition by way of a webpage of a website. A query assigned to the URL in the log entry is assigned to the catalog product name due to the product name being mapped to the catalog product name. The computer-implemented ranker is trained based upon the query being assigned to the catalog product name.

Abstract: A gradient coil assembly of a magnetic resonance imaging system includes at least one gradient coil, a cooling arrangement for cooling the gradient coil, and an RF shield. The cooling arrangement includes at least one cooling tube that is configured to transport a cooling fluid and which is disposed on and in thermal contact with the gradient coil, wherein the assembly further comprises a thermal connector arrangement with at least one of a first thermal connector disposed between the RF shield and the at least one cooling tube, which provides a radially extending connection between the RF shield and the at least one cooling tube.

Abstract: A gradient coil assembly (62) for use in a Magnetic Resonance Imaging (MRI) system includes primary coils (68), shield coils (72) and a supporting structure (10) arranged between the primary coils (68) and the shield coils (72). The supporting structure (10) includes at least a supporting element (12) including a first end face (14) and at least a first recess (24) with an opening (26) in the first end face (14). The first recess (24) extends in a longitudinal direction (18) of the supporting element (12) forming a tray for receiving a passive shim bar.

Abstract: A method of jitter detection and image restoration for high-resolution TDI CCD satellite images. The method includes: obtaining a parallax image after a sub-pixel matching method relying on a correlation coefficient and least squares algorithm; transferring a jitter offset from an image space to an object space by an integral transformation function (ITF); dealing with a continuous push-broom mode of cameras in a discrete way with a denser sampling strategy according to a continue dynamic shooting model (CDSM), obtaining a specialized CDSM and feeding it back to the ITF; applying the accurate ITF to the obtained parallax image and conducting the jitter curve fitting to achieve the jitter detection; estimating a correspondent partial PSF according to the CDSM and the obtained jitter curve; carrying out an adaptive restoration based on context through optimal window Wiener filtering, by means of multiple input and single output to completes the image restoration.

Abstract: Disclosed are compounds of Formula (I?) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: Embodiments of the present disclosure provide for passivated quantum dots, methods of making passivated quantum dots, methods of using passivated quantum dots, and the like.