Abstract: The invention relates to novel derivatives of thapsigargin that are chemically modified with a group that targets a cell surface-expressed receptor, and pharmaceutical preparations thereof. The invention further relates to methods of treating diseases such as cancer using the compounds of the invention.

Abstract: A system and method of optimizing tree pruning for a decision tree may include splitting, a first dataset into a training dataset and a testing dataset, growing the training dataset into a first decision tree, sampling the training dataset by creating a plurality of sampling datasets from the training dataset, pruning the first decision tree using the plurality of sampling datasets, creating a plurality of models, at least one for each of the plurality of sampling datasets, and verifying the accuracy of each of the plurality of models, using the testing dataset.

Abstract: The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hh signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a backlight unit. The backlight unit may include a printed circuit board, a plurality of light-emitting diodes mounted on the printed circuit board, at least one light spreading layer formed over the printed circuit board that spreads light received from the plurality of light-emitting diodes, a partially reflective layer formed over the at least one light spreading layer, a color conversion layer formed over the partially reflective layer, a collimating layer formed over the color conversion layer, a brightness enhancement film formed over the collimating layer, and a diffuser formed over the brightness enhancement film. The at least one light spreading layer may include two light spreading layers with elongated protrusions that are rotated relative to each other.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a backlight unit. The backlight unit may include a printed circuit board, a plurality of light-emitting diodes mounted on the printed circuit board, at least one light spreading layer formed over the printed circuit board that spreads light received from the plurality of light-emitting diodes, a partially reflective layer formed over the at least one light spreading layer, a color conversion layer formed over the partially reflective layer, a collimating layer formed over the color conversion layer, a brightness enhancement film formed over the collimating layer, and a diffuser formed over the brightness enhancement film. The at least one light spreading layer may include two light spreading layers with elongated protrusions that are rotated relative to each other.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a backlight unit. The backlight unit may include a printed circuit board, a plurality of light-emitting diodes mounted on the printed circuit board, at least one light spreading layer formed over the printed circuit board that spreads light received from the plurality of light-emitting diodes, a partially reflective layer formed over the at least one light spreading layer, a color conversion layer formed over the partially reflective layer, a collimating layer formed over the color conversion layer, a brightness enhancement film formed over the collimating layer, and a diffuser formed over the brightness enhancement film. The at least one light spreading layer may include two light spreading layers with elongated protrusions that are rotated relative to each other.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a backlight unit. The backlight unit may include a printed circuit board, a plurality of light-emitting diodes mounted on the printed circuit board, at least one light spreading layer formed over the printed circuit board that spreads light received from the plurality of light-emitting diodes, a partially reflective layer formed over the at least one light spreading layer, a color conversion layer formed over the partially reflective layer, a collimating layer formed over the color conversion layer, a brightness enhancement film formed over the collimating layer, and a diffuser formed over the brightness enhancement film. The at least one light spreading layer may include two light spreading layers with elongated protrusions that are rotated relative to each other.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a backlight unit. The backlight unit may include a printed circuit board, a plurality of light-emitting diodes mounted on the printed circuit board, at least one light spreading layer formed over the printed circuit board that spreads light received from the plurality of light-emitting diodes, a partially reflective layer formed over the at least one light spreading layer, a color conversion layer formed over the partially reflective layer, a collimating layer formed over the color conversion layer, a brightness enhancement film formed over the collimating layer, and a diffuser formed over the brightness enhancement film. The at least one light spreading layer may include two light spreading layers with elongated protrusions that are rotated relative to each other.

Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).

Abstract: Embodiments related to an electronic device having an adaptive input row. The adaptive input row may be positioned within an opening of a device and include a cover for receiving a touch and a display that is configured to present an adaptable set of indicia. The adaptive input row may also include one or more sensors for detecting the location of a touch and/or the magnitude of a force of the touch. The adaptive input row may be positioned adjacent or proximate to a keyboard of the electronic device.

Abstract: A die attachment apparatus for attaching a semiconductor die onto a substrate having a metallic surface comprises a material dispensing station for dispensing a bonding material onto the substrate and a die attachment station for placing the semiconductor die onto the bonding material which has been dispensed onto the substrate. An activating gas generator positioned before the die attachment station introduces activated forming gas onto the substrate in order to reduce oxides on the substrate.

Abstract: An electronic device may have a display with a backlight. The backlight provides backlight illumination for an array of pixels that is displaying images. The backlight may include an array of cells. Each cell may contain a light source with one or more light-emitting diodes and a cavity reflector that reflects light from the light source outwardly through a diffuser for use in forming the backlight illumination. The light sources may be mounted to a printed circuit. Support posts on the printed circuit may be used to maintain the diffuser at a fixed distance from the printed circuit. Sensors on the printed circuit may be used to measure separation distances between the printed circuit and diffuser. Adjustments to pixel gain profiles can be made based on the measured separation distances.

Abstract: An array of pixels in a display may be illuminated by a backlight having an array of light-emitting diodes in an array of respective cells. A reflector is used to reflect light from the light-emitting diodes through the array of pixels. Within the cells, the reflector has cross-sectional profiles that help distribute light emitted from the light-emitting diodes toward edges of the cells. A light diffuser layer for the backlight may have a partially reflective layer such as a thin-film interference filter with an angularly dependent transmission. Within each cell, the reflector may have cross-sectional profiles with portions that are parabolic or elliptical.

Abstract: Aspects of the subject technology relate to control circuitry for light-emitting diodes. The control circuitry may operate a light-emitting diode using a multi-peak pulse-width-modulation signal. The control circuitry may include a multi-stage driver having a relatively larger driver stage for providing a direct current through a light-emitting diode and a relatively smaller driver stage configured to cooperate with a pulse-width-modulation controller to pulse-width-modulate a current through the light-emitting diode.

Abstract: A ball cutter includes a cutter bar and a cutter head. The cutter head has one end mounted to the cutter bar. The cutter head includes a main body and a number of cutter teeth mounted on the main body. A quantity of the cutter teeth is equal to a positive integer within a range from 8 to D*15. D is equal to a diameter of the main body of the cutter head in millimeters.

Abstract: A molding cutter includes a cutter bar and a cutter head. The cutter head is mounted on one end of the cutter bar. The cutter head includes a main body and a number of cutter teeth. The main body includes a first end face, a second end face, and a curved surface. The first end face is coupled to the cutter bar, and the curved surface is coupled between the first end face and the second end face. The cutter teeth are mounted on the curved surface. A quantity of the number of cutter teeth is equal to a positive integer within a range from 8 to D*15. D is equal to a diameter of the main body of the cutter head in millimeters.

Abstract: An electronic device may generate content that is to be displayed on a display. The display may have an array of liquid crystal display pixels for displaying image frames of the content. The display may be operated in at least a normal viewing mode, a privacy mode, an outdoor viewing mode, and a power saving mode. The different view modes may exhibit different viewing angles. In one configuration, the display may include a backlight unit that generates a collimated light source and that includes a switchable diffuser film for selectively scattering the collimated light source depending on the current viewing mode of the display. In another configuration, the display may include a backlight unit that generates a scattered light source that includes a switchable microarray structure such as a switchable mirror structure or a tunable microlens array for selectively collimating the scattered light source depending on the current viewing mode.

Abstract: Described is an illumination structure for a key of a keyboard. The illumination structure is used to uniformly illuminate the key and any glyphs that are present on the key. The illumination structure includes a light guide having various features that increase total internal reflection and also illuminate the glyphs of the key.

Abstract: A bull mill cutter includes a cutter bar and a cutter head. The cutter head has one end mounted to the cutter bar. The cutter head includes a main body and a number of cutter teeth mounted on the main body. A quantity of the cutter teeth is equal to a positive integer within a range from 8 to D*15. D is equal to a diameter of the main body of the cutter head in millimeters.