Abstract: The present invention provides an electronic shelf label communication system, method and apparatus.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A method, an apparatus and a medium for optimizing allocation of switching resources in the polymorphic network. The method selects the ASIC switching chip, FPGA and PPK software switching on the polymorphic network element based on machine learning, and specifically comprises the following steps: manually pre-configuring, formulating basic rules for polymorphic software and hardware co-processing; offline learning, designing training configuration in the offline learning stage to capture different switching resource usage variables, running experiments to generate the original data of a training classifier, and using the generated performance indices to train the model offline; and online reasoning, obtaining switching resource allocation advises, and updating modality codes according to the switching resource allocation advises.

Abstract: This application relates to the field of wireless communications technologies, and discloses an encoding method and apparatus, to improve accuracy of reliability calculation and ordering for polarized channels. The method includes: obtaining a first sequence used to encode K to-be-encoded bits, where the first sequence includes sequence numbers of N polarized channels, the first sequence is same as a second sequence or a subset of the second sequence, the second sequence comprises sequence numbers of Nmax polarized channels, and the second sequence is the sequence shown in Sequence Q11 or Table Q11, K is a positive integer, N is a positive integer power of 2, n is equal to or greater than 5, K?N, Nmax=1024; selecting sequence numbers of K polarized channels from the first sequence; and performing polar code encoding on K the to-be-encoded bits based on the selected sequence numbers of the K polarized channels.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: A technique is described for extracting or constructing a three-dimensional (3D) model from multiple two-dimensional (2D) images. In an embodiment, a foreground segmentation mask or depth field may be provided as an additional supervision input with each 2D image. In an embodiment, the foreground segmentation mask or depth field is automatically generated for each 2D image. The constructed 3D model comprises a triangular mesh topology, materials, and environment lighting. The constructed 3D model is represented in a format that can be directly edited and/or rendered by conventional application programs, such as digital content creation (DCC) tools. For example, the constructed 3D model may be represented as a triangular surface mesh (with arbitrary topology), a set of 2D textures representing spatially-varying material parameters, and an environment map. Furthermore, the constructed 3D model may be included in 3D scenes and interacts realistically with other objects.

Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.

Abstract: The disclosure relates to a protein-type nanoparticle for multi-specific antibody delivery, a preparation method, and its application. The protein-type nanoparticle includes a polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interactions. The protein is at least one of albumin, globulin and cell wall protein. The protein-type nanoparticle of the present disclosure has excellent stability and biocompatibility. The protein-type nanoparticle is used to prepare a multi-specific antibody delivery platform (?Fc-NP) by binding anti-IgG-Fc antibody or anti-IgG-Fc antibody fragment, which can stably, quickly and easily bind to multiple specific antibodies through antigen-antibody interaction and enhance the therapeutic effect of specific antibodies.

Abstract: A method, system, electronic device and storage medium for constructing locally convex feasible space are provided. The method includes acquiring a plurality of initial motion trajectory points, size information and surrounding obstacle information of a target vehicle; generating a quadtree map according to the above information; determining a target distance corresponding to each initial motion trajectory point according to the quadtree map; allocating locally convex feasible space to a first-type initial motion trajectory point by using the quadtree map, and allocating locally convex feasible space to a second-type initial motion trajectory point by using an improved convex feasible set algorithm. The first-type initial motion trajectory point is an initial motion trajectory point with the target distance greater than or equal to a set threshold; and the second-type initial motion trajectory point is an initial motion trajectory point with the target distance less than the set threshold.

Abstract: A surgical instrument (10) includes a housing (20) defining a longitudinal axis and a first assembly (200) and a second assembly (300) operably coupled to the housing (20). The first assembly (200) includes a first function button (200b) pivotably coupled to the housing (20) about a first pivot (200p) and a first circuit (210) supported by the housing (20) and aligned with the first pivot (200p). The first function button (200b) includes a first arm (201) on a first side of the first pivot (200p) and a second arm (202) on a second side of the first pivot (200p). The first circuit (210) is aligned with the cutting picot between the first arm (201) and the second arm (202) and includes a first actuator (211) on the first side of the first pivot (200p) and a second actuator (212) on the second side of the first pivot (200p).

Abstract: A method and system for decomposing cross-domain path planning of an amphibious vehicle.

Abstract: The present invention discloses a extra thick hot rolled H section steel and a production method therefor. The extra thick hot rolled H section steel contains, by mass, the following chemical components: 0.04-0.11% of C, 0.10-0.40% of Si, 0.40-1.00% of Mn, 0.40-1.00% of Cr, 0.10-0.40% of Cu, 0.020-0.060% of Nb, 0.040-0.100% of V, 0.010-0.025% of Ti, 0.010-0.030% of Al, 0.0060-0.0120% of N, not more than 0.015% of P, not more than 0.005% of S, not more than 0.0060% of O, and the balance Fe and trace residual elements, wherein 0.090%?Nb+V+Ti?0.170%, 6.5?(V+Ti)/N?10.5, and 0.30%?CEV?0.48%. The extra thick hot rolled H section steel has a flange thickness of 90 mm-150 mm, has excellent comprehensive mechanical properties, and can well meet the needs for heavy supporting structural parts of high-rise buildings, large squares, bridge structures, etc.

Abstract: Disclosed is a polarization fusion orientation method for an occluded environment, which comprises: acquiring a sky polarization image through a polarization camera first, then taking a heading angle output by an E-vector polarization orientation method as a state quantity, taking a heading angle output by a symmetry axis polarization orientation method as an observed quantity, realizing heading angle fusion through a multi-frequency variational Bayesian strong tracking cubature Kalman filter (MF-VBSTCKF), and respectively selecting different methods for a sampling position and a sampling interval period to update an optimal heading angle. The method solves the problem that high-precision and high-robustness heading angle measurement of polarized light cannot be realized in the occluded environment, can improve the precision and robustness of a polarized light orientation method in the occluded environment, and ensures high-frequency output of the heading angle at the same time.

Abstract: A memory device is disclosed, including a memory array and a selection circuit. At least one first faulty cell and at least one second faulty cell that are in the memory array store data corresponding to, respectively, first and second fields of a floating-point number. The selection circuit identifies the at least one first faulty cell and the at least one second faulty cell based on a priority of a cell replacement operation which indicates that a priority of the at least one first faulty cell is higher than that of the at least one second faulty cell. The selection circuit further outputs a fault address of the at least one first faulty cell to a redundancy analyzer circuit for replacing the at least one first faulty cell.

Abstract: Apparatuses, systems, and techniques are presented to generate digital content. In at least one embodiment, one or more neural networks are used to generate one or more textured three-dimensional meshes corresponding to one or more objects based, at least in part, one or more two-dimensional images of the one or more objects.

Abstract: A brush for applying a product including a cosmetic, care, or pharmaceutical product onto the keratinous surface of a user. The applying member includes a support head and a plurality of bristles extends from a distal end face of the support head along a longitudinal axis of the support head. The distal end face of the support head comprises a first distal end face and a second distal end face. The first distal end face and the second distal end face are substantially flat surfaces that intersect each other to form a ridge on the distal end face. The ridge on the distal end face extends along an axis perpendicular to a longitudinal axis of the support head.

Abstract: Provided is a fusion protein, comprising a protein having a hydrophobic region, a peptide linker, a protein fusion receptor. The peptide linker links the protein having a hydrophobic region to the protein fusion receptor. The protein fusion receptor is an Fc receptor fragment that specifically recognizes an Fc fragment of an antibody, and the protein having a hydrophobic region is a serum albumin. Also provided is a nano-assembly consisting of the fusion protein and a hydrophobic degradable polyester and a derivative thereof. Also provided is an application of the nano-assembly having excellent stability in an antibody delivery platform. The constructed nano-assembly platform is creatively applied in the preparation of immunotherapeutic drugs or therapeutic drugs for tumors or autoimmune diseases or inflammations.

Abstract: A display device is a display device provided with a display region including a plurality of pixels and a frame region surrounding the display region, and includes: a thin film transistor layer; and a light-emitting element layer including a plurality of light-emitting elements, each including a first electrode, a function layer, and a second electrode, and each having a different luminescent color, wherein the function layer includes a light-emitting layer, and a pair of holding layers sandwiching the light-emitting layer and each including a photosensitive material and a conductive nanoparticle.

Abstract: Provided are a cathode catalyst layer and a preparation method and use thereof, and a fuel cell. The method includes: mixing a catalyst, water, and an alcohol with a pore-forming agent to obtain a mixture; dispersing the mixture into a Nafion solution to obtain a slurry; and coating the slurry onto a surface of a diffusion layer to obtain a coated diffusion layer, and subjecting the coated diffusion layer to calcination and freeze-drying in sequence to obtain the cathode catalyst layer.

Abstract: A refillable container for a stick type cosmetic product comprising a cap, a refill cartridge and a base assembly. The base assembly comprises an outer shell and a button member. The refill cartridge is configured to be detachably received at least partially within a cavity of the outer shell of the base assembly such that the refill cartridge may be removed and replaced from said base assembly by pressing the button member provided in the base assembly.