Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: A coffee roasting apparatus is disclosed that comprises a compartment for holding coffee beans, a heating arrangement for directing a heated air flow through the compartment during a roasting process of the coffee beans, a particulate matter sensor for detecting a peak amount of particulate matter released by the coffee beans, a timer for determining an amount of time lapsed from a start of the roasting process until the detection of the peak amount, and a controller arranged to control the heating arrangement. The controller is adapted to select a defined control time as a function of the lapsed amount of time and apply the defined control time to the heating arrangement after first cracking of the coffee beans to complete the roasting process. A coffee brewing apparatus including such a coffee roasting apparatus and a method of controlling such a coffee roasting apparatus are also disclosed.

Abstract: A shroud for radially encasing a turbine in a gas turbine engine is provided. The shroud comprises a carrier which defines a pin-receiving carrier bore, and a ceramic matrix composite (CMC) seal segment comprising an arcuate flange with a surface facing the turbine and a part that defines a pin-receiving seal segment bore. The seal segment bore is radially spaced from the arcuate flange by a spacing flange which extends radially outward from the arcuate flange to effect receipt within the seal segment bore of an elongated pin. The elongated pin extends through the carrier bore and the seal segment bore, and the elongated pin has a lateral cross-sectional dimension of at least three-eighths of an inch.

Abstract: Various approaches for attaching tracking devices to pallets allow pallets to be remotely tracked through any phase of a transportation lifecycle. In a first approach, one or more electronic components of a tracking device may be disposed within a cavity of a block of a pallet. In a second approach, one or more electronic components of a tracking device may be disposed within a strut that interfaces between two beams of a pallet. In a third approach, one or more electronic components of a tracking device may be disposed within a cavity of a beam.

Abstract: The present invention relates to a method for Agrobacterium-mediated transformation and regeneration of Stevia plants. In particular, the method involves co-culturing leaf explants with Agrobacterium in a medium comprising acetosyringone and 2,4-dichlorophenoxyacetic acid in the dark, callus induction and shoot regeneration in a medium comprising 6-benzylaminopurine, 3-indoleacetic acid, a selective agent and an Agrobacterium eradicant in the dark, and root regeneration in a medium comprising 3-indoleacetic acid in a light/dark cycle. The present invention also relates to the overexpression of SrDXS1 and SrKAH in transgenic plants, resulting in the enhancement of steviol glycosides in the transgenic plants. The present invention further relates to the overexpression SrUGT76G1 in transgenic plants, resulting in higher Rebaudioside A (Reb A) to stevioside ratios in the transgenic plants.

Abstract: A ceramic matrix composite (CMC) seal segment for use in a segmented turbine shroud for radially encasing a turbine in a gas turbine engine. The CMC seal segment comprises an arcuate flange having a surface facing the turbine and a portion defining a bore for receiving an elongated pin, with the bore having a length that is at least 70% of the length of the elongated pin received therein. The CMC seal segment is carried by the carrier by at least one of the elongated pins being received within the bore. The CMC seal segment portion defining a pin-receiving bore is radially spaced from the arcuate flange by a spacing flange extending radially outward from the arcuate flange.

Abstract: An example high-performance system includes an example high-performance component including a substrate and a multilayer abradable track adjacent to the substrate. The abradable track includes a plurality of alternating layers along a thickness of the abradable track. The plurality of alternating layers includes at least one relatively porous abradable layer and at least one relatively dense layer. A porosity of the relatively dense layer is lower than that of the at least one relatively porous abradable layer. The example high-performance system may include a rotating component configured to contact and abrade the multilayer abradable track. An example technique for forming the multilayer abradable track includes thermal spraying a first precursor composition toward the substrate to form a relatively porous abradable layer of a layer pair of a plurality of layer pairs of the multilayer abradable track, and a second precursor composition to form a relatively dense layer of the pair.

Abstract: According to some embodiments of the invention, data may be collected from multiple tagged pallets by a mobile reader pallet. The tagged pallets may include components capable of short range communication with the mobile reader pallet. The reader pallet may include components capable of long range communication that allow the reader pallet to transmit the data to another device or server. This may result in reduced costs and battery preservation, as each pallet does not need to include costly and power intensive long range communication components. Further, because the reader pallet is mobile, movement of the tagged pallets within range of a stationary reader is not needed.

Abstract: The disclosure provides an online test data record and offline data conversion analysis system and a method thereof. In the present disclosure, the test process information of the production line testing system performed on the circuit board to be tested is generated into online test result data in a database file format, and the offline analysis system receives the online test data from the production line testing system. The offline analysis system reads the corresponding data in the online test result data according to the designated data in the data designated instruction, and generates the offline test result data in the designated file format of the data designated instruction, and the offline analysis system perform the data analysis for the offline test result according to the analysis instruction.

Abstract: A system and method for generating configuration files and performing test by using the configuration files are disclosed. The configuration generation system configures the identification code corresponding to each testing mode as a comparison table, and configures at least one set of identification codes corresponding to each testing collection and the execution configuration of the identification code to generate the configuration files, and the production line testing system parses the test script to obtain the testing mode and the execution configuration of the testing mode according to the identification comparison table and the configuration files, so as to execute the test. The test program is convenient by providing the configuration files.

Abstract: An article may include a substrate, a plurality of cooling holes in the substrate, wherein each of the plurality of cooling holes defines substantially the same diameter measured parallel to an outer surface of the substrate, and a coating on the surface of the substrate. In accordance with these examples, the coating covers and substantially blocks a first set of cooling holes from the plurality of cooling holes and leaves a second set of cooling holes from the plurality of cooling holes substantially uncovered. In some examples, an article including a substrate, a plurality of cooling holes in the substrate, and a coating on the substrate. In accordance with these examples, the coating covers and partially occludes each cooling hole of the plurality of cooling holes, and the coating does not extend into any of the plurality of cooling holes.

Abstract: A semiconductor device is provided, which includes an active region, a first structure, a second gate structure, a first gate dielectric sidewall, a second gate dielectric sidewall, a first air gap region, a second air gap region and a contact structure. The active region is formed over a substrate. The first and second gate structures are formed over the active region and between the first gate structure and the second gate structure are the first gate dielectric sidewall, the first air gap region, the contact structure, the second air gap region and a second gate dielectric sidewall.

Abstract: A method of processing a CMC component includes preparing a fiber preform having a predetermined shape, and positioning the fiber preform with tooling having holes facing one or more surfaces of the fiber preform. After the positioning, a clamping pressure is applied to the tooling to force portions of the one or more surfaces of the fiber preform into the holes, thereby forming protruded regions of the fiber preform. During the application of the clamping pressure, the fiber preform is exposed to gaseous reagents at an elevated temperature, and a matrix material is deposited on the fiber preform to form a rigidized preform including surface protrusions. After removing the tooling, the rigidized preform is infiltrated with a melt for densification, and a CMC component having surface bumps is formed. When the CMC component is assembled with a metal component, the surface bumps may reduce diffusion at high temperatures.

Abstract: A segmented turbine shroud for radially encasing a rotatable turbine in a gas turbine engine comprising a carrier, a ceramic matrix composite (CMC) seal segment, and an elongated pin. The carrier defines a pin-receiving carrier bore and the CMC seal segment defines a pin-receiving seal segment bore. The elongated pin extends through the carrier bore and the seal segment bore. The pin-receiving carrier bore includes a cantilevered member such that the carrier bore has a length sufficient to effect radial flexion between the carrier bore and the pin received within the carrier bore during operation of the turbine.

Abstract: An example article includes a substrate and a barrier coating on the substrate extending from an inner interface facing the substrate to an outer surface opposite the inner interface. The barrier coating includes a bulk matrix and a plurality of discrete plugs inset within the bulk matrix and dispersed across the outer surface of the barrier coating. An example technique includes forming the barrier coating on the substrate of a component.

Abstract: A lubrication system includes an engine oil pump, a lubricating oil tank, a breathing pipe, a machine body, and an oil pan. The engine oil pump is formed by superposing upper and lower layers being a lubricating pump and an oil return pump. An oil inlet of the oil return pump leads to a cavity of the oil pan, and an oil outlet leads to an interior of the lubricating oil tank. An oil inlet of the lubricating pump leads to the interior of the lubricating oil tank, and an oil outlet leads to a machine filter. The machine filter is communicated with a main oil path of the machine body. An oil tank cover of the lubricating oil tank is provided with a breathing one-way valve and an oil filling port. The breathing one-way valve communicates one end of the breathing pipe, and the other end thereof communicates a crankcase.

Abstract: An example high-performance system may include an example high-performance component. The high-performance component may include a substrate defining a channel. The channel defines a leading ramp and a trailing ramp. The example high-performance component includes an abradable track between the leading and the trailing ramps. The abradable track includes a porous abradable composition. The example high-performance system may include a rotating component configured to contact and abrade the abradable track. An example technique for forming the abradable track includes thermal spraying a precursor composition at the channel to form the abradable track.

Abstract: In one example, a method for forming an environmental barrier coating (EBC) on a substrate. The method may include heating the substrate before and/or during deposition of EBC on the substrate using an external burner and/or resistive electrical heating. Additionally, or alternatively, the as-deposited EBC may be heat treated using an external burner and/or resistive electrical heating. In some examples, the techniques of the disclosure are configured to increase or otherwise tailor the amount of crystalline phase in the EBC.

Abstract: A CMC article may include a CMC substrate defining a major surface and a plurality of CMC reinforcing pins at least partially embedded in the CMC substrate. Each CMC reinforcing pin of the plurality of CMC reinforcing pins defines a respective long axis. The respective long axes may be oriented at an angle substantially perpendicular to the major surface of the CMC substrate. A method may include inserting a plurality of CMC reinforcing pins into a major surface of a ceramic fiber preform. Each CMC reinforcing pin of the plurality of CMC reinforcing pins defines a respective long axis. As the plurality of CMC reinforcing pins are inserted into the major surface, the respective long axes may be oriented at an angle substantially perpendicular to the major surface. The method also includes forming a matrix of material within pores of the ceramic fiber preform to form a CMC article.