Abstract: A system for correcting malocclusions may include a maxillary appliance having tooth receiving cavities shaped to receive teeth of a maxilla and a first elastic coupling at gingival line of the maxillary appliance. The first elastic coupling may be configured for receiving an elastic. The system may also include mandibular appliance having tooth receiving cavities shaped to receive teeth of a mandible. The system may also include a corrective appliance having a first coupling configured to be coupled to the mandibular appliance at a first location on a first side of incisors of a patient and a second coupling configured to be coupled to the mandibular appliance on a second side of the incisors, and having an arm extending from the corrective appliance towards the gingival line of the maxillary appliance and being shaped to receive the elastic.

Abstract: A handheld gaming device in which configurations allow for default-open, force-close systems and separate the user's insertion of the mobile device and closure of the handles around the mobile device.

Abstract: Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer.

Abstract: A method for improving wheat resistance to Fusarium head blight (FHB) by genome editing is provided, and further provided is use of TaCIPK14 protein or related biomaterial thereto in the regulation of plant resistance to FHB; the TaCIPK14 protein is TaCIPK14-4A protein (SEQ ID NO: 4), TaCIPK14-4B protein (SEQ ID NO: 5), and/or TaCIPK14-4D protein (SEQ ID NO: 6). TaCIPK14 knockout mutant plants are successfully obtained by simultaneously editing three alleles of TaCIPK14 in wheat using CRISPR-Cas9 gene editing technology. The TaCIPK14 knockout mutant shows resistance to inoculation with FHB pathogens, and the results of evaluation of major agronomic traits confirm that the TaCIPK14 knockout mutant reserves the major agronomic traits.

Abstract: A system for use in a well comprises: a well string; a cable deployed along well tubing; and a cable protector securing the cable to the well tubing, the cable protector comprising: a first cable protector body; a second cable protector body comprising: a cut-out extending from an end surface of the second protector body, the cut-out bordered or defined by a base and two side walls; and a J or L shaped slot formed in each side wall of the cut-out; and a fastening mechanism comprising: a pivot comprising a body having a bore extending axially therethrough; and a connection bolt configured to be inserted through the bore of the pivot.

Abstract: The present disclosure relates to the technical field of lithium-ion batteries, and discloses a lithium-rich manganese oxide cathode material, a preparation method and use thereof, and a positive electrode plate and use thereof. The cathode material has a chemical composition of xLi[Li1/3(Mn1-aMa)2/3]O2·(1?x)LiMn1-bM?bO2. An XRD spectrum of the cathode material has a diffraction peak P(1) in a range of a diffraction angle 2?1 satisfying [43.5(1?x)+44x]°?2?1?[44(1?x)+45x]°; and the XRD spectrum of the cathode material has a diffraction peak P(2) in a range of a diffraction angle 2?2 satisfying [17.7(1?x)+18.3x]°?2?2?[19.2(1?x)+19.8x]°, where 0.35?x?0.63. The cathode material has high first-cycle efficiency, high discharge capacity, high energy efficiency, high rate performance, and high cycle performance.

Abstract: A display substrate has a fan-out area and includes a plurality of conductive layers. The plurality of conductive layers include data lines, connection lines and fan-out lines. A connection line is electrically connected to a first data line, and crosses at least one data line and is insulated from the crossed data line. A first fan-out line is electrically connected to the connection line. A second fan-out line is electrically connected to a second data line. The first fan-out line includes a transfer line, and is located in a different conductive layer from second fan-out lines and crosses at least one second fan-out line. An order of arrangement of ends of the fan-out lines away from the display area in a first direction is same as an order of arrangement of the data lines in the first direction.

Abstract: A system and method for determining a likelihood of response to a Balance Transfer (“BT”) offer includes developing a pattern recognition model based on BT response information contained in tradeline level data that has external tradeline information of a plurality of customers of a host financial institution, applying the pattern recognition model to the external tradeline information of the customers to determine a probability of whether the external tradeline information indicates that an BT offer was accepted by a customer, developing an overall customer account level model based on desired historical account behavior, applying the account level model to historical account behavior information of the customers to determine a likelihood of whether each customer will accept a BT offer from an external financial institution, and ranking the customers based on the determined probability and the likelihood that each customer would accept a BT offer from an external financial institution.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: The present invention relates to the technical field of microbial engineering. Specifically disclosed are a recombinant microorganism, a method for constructing same and use thereof. According to the present invention, by means of constructing a phosphate acetyltransferase-inactivated strain and applying the strain to the production of threonine, the threonine-producing ability of the strain is remarkably improved, and the strain has a remarkably increased production of threonine as compared to an unmodified strain. Combined with attenuated expression or inactivation of acetate kinase, HTH-type transcriptional regulator and the like, as well as improved activity of pyruvate carboxylase and enzymes involved in a threonine synthesis-related pathway, the production of threonine is further improved. The described modifications can be used in the fermentative production of threonine and have relatively good application value.

Abstract: Provided by the present disclosure is a power distribution box having a data interaction function, comprising a moving mechanism, a control mechanism and a data interaction mechanism. The moving mechanism comprises an electric valve and an electric telescopic rod. The control mechanism comprises a main control single-chip microcomputer and a control panel. The data interaction mechanism comprises a power distribution box tester and an output port. The electric valve is electrically connected to the main control single-chip microcomputer and is arranged at the bottom of the power distribution box. The control panel is arranged on a support rod and is electrically connected to the main control single-chip microcomputer. The power distribution box tester is electrically connected to the main control single-chip microcomputer and is arranged in the power distribution box, and the power distribution box tester is used for testing electrical devices of the power distribution box.

Abstract: Disclosed are a method and a device for identifying full-section excavation parameters of large-section tunnel with broken surrounding rock, which is capable of solving the problem of inaccurate arrangement of blasting hole points in tunnel excavation engineering, including following steps: establishing a three-dimensional finite element model based on a blasting section design of a tunnel; performing a simulation with the three-dimensional finite element model based on blasting design parameters to obtain blasting quality parameters; selecting a group closest to a preset quality parameter from multiple groups of the blasting design parameters as target blasting design parameters, wherein the preset quality parameter is an acceptance grade standard of the tunnel; obtaining first thermal imaging information of a first hot spot of a surface to be blasted; calibrating actual hole spacing parameters based on the first thermal imaging information and the target blasting design parameters.

Abstract: The present disclosure provides a two-stroke pumping method and oil production device, and relates to the technical field of oil production. The oil production device comprises a pump body, wherein the oil production device further comprises a central tube of a hollow structure, and the central tube is partially located in the pump body and coaxially arranged with the pump body; a traveling valve and a standing valve are arranged on the left side and the right side of the outer wall of the central tube respectively, and the traveling valve is arranged between the pump body and the central tube; the standing valve is located outside the pump body; the traveling valve and the standing valve are matched with the pump body and the central tube to form an oil pumping space; and an oil pumping assembly is further arranged in the oil pumping space.

Abstract: This application relates to the field of wireless communication technologies, and in particular, to a time control, an apparatus, and a system. This application provides a timer control method, including: When downlink control information indicates data transmission of N hybrid automatic repeat request (HARQ) processes and a terminal device is configured with the N HARQ processes, where N is an integer greater than or equal to 2, a discontinuous reception inactivity timer is not started or the discontinuous reception inactivity timer is stopped. This application reduces time required by the terminal device to monitor a downlink channel or downlink data through control by the timer, thereby reducing power consumption of the terminal device.

Abstract: A use of a FAK inhibitor in the preparation of a drug for preventing and/or treating tumors having an NRAS mutation. A method for treating tumors that have experienced an NRAS mutation, which comprises administering an effective dose of a FAK inhibitor to an individual. A FAK inhibitor for treating tumors having an NRAS mutation. The FAK inhibitor is B1853520, defactinib, GSK2256098, PF-00562271, VS-4718 or a pharmaceutically acceptable salt thereof.

Abstract: A scheduling method, scheduling algorithm training method, related system, and storage medium are provided including the scheduling method being applied to a scheduling control system, which includes K network devices, and K is an integer greater than 1. The method further includes a first network device that obtains target state information of a first area, where the target state information includes network state information and user data packet cache information. The first network device generates first scheduling information based on the target state information of the first area and a first target sub-policy network, where the first target sub-policy network is a target sub-policy network that is in K target sub-policy networks and that corresponds to the first network device. The first network device delivers the first scheduling information to a terminal in the first area.

Abstract: A communication method and apparatus are applied to fields such as V2X, vehicle to everything, an intelligent connected vehicle, assisted driving, and intelligent driving. The method includes: a first terminal device determines a first new data indicator NDI based on an identifier of a first destination address and an identifier of a first hybrid automatic repeat request HARQ process, where the first NDI is included in first sidelink control information SCI, and the first SCI is used to schedule first data; and the first terminal device sends, through a sidelink, the first SCI and/or the first data to a second terminal device.

Abstract: Implementations of this specification provide query optimization methods, apparatuses, and systems for secure multi-party databases. In an implementation, a method includes: receiving a current query associated with a plurality of target database of a multi-party database system, generating a plurality of execution plans for the current query, determining, for each execution plan, a respective cost computation formula of a plurality of cost computation values for computing an execution cost of jointly executing the execution plan by the plurality of target databases, receiving a secure computation result from each of a plurality of query engines corresponding to the plurality of target databases, and determining an optimal execution plan having a lowest cost value in the plurality of cost computation formulas based on the secure computation result.

Abstract: A multi-mode three-dimensional scanning method includes: obtaining intrinsic parameters and extrinsic parameters of a calibrated camera in different scanning modes, and upon switching between the different scanning modes, triggering a change of parameters of the camera to the intrinsic parameters and the extrinsic parameters in a corresponding scanning mode; and a user selecting to execute a laser-based scanning mode, a speckle-based scanning mode or a transition scanning mode according to a scanning requirement. In the continual fusion and conversion during the whole scanning process, the speckle reconstruction and the laser line reconstruction are unified to the same coordinate system, and the surface point cloud of the object being scanned is output. The present disclosure also provides a multi-mode three-dimensional scanning system.