Abstract: Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.

Abstract: Enhanced vectorization of raster images is described. An image vectorization module converts a raster image with bitmapped data to a vector image with vector elements based on mathematical formulas. In some embodiments, spatially-localized control of a vectorization operation is provided to a user. First, the user can adjust an intensity of a denoising operation differently at different areas of the raster image. Second, the user can adjust an automated segmentation by causing one segment to be split into two segments along a zone marked with an indicator tool, such as a brush. Third, the user can adjust an automated segmentation by causing two segments to be merged into a combined segment. The computation of the vector elements is based on the adjusted segmentation. In other embodiments, semantic information gleaned from the raster image is incorporated into the vector image to facilitate manipulation, such as joint selection of multiple vector elements.

Abstract: One aspect of the invention relates to novel isatin derivative compounds and the pharmaceutical composition thereof. Another aspect of the invention relates to methods of using the isatin derivative compounds disclosed herein and the pharmaceutical compositions thereof. In certain embodiments, the method is used to treat a cancer or a tumor in a subject including, without limitation, prostate cancer, melanoma, pancreatic cancer, ovarian cancer, and lymphoma. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the activation of one or more proteins such as EGFR, Erk1/2, Her2/Neu, Jak2, Src, Stat3, Akt, Cyclin B1, and Cdc25C. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the disruption of microtubule formations.

Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.

Abstract: A method of validating rules configured to be utilized in an information extraction application, including: receiving a plurality of labeled samples in a training database; for each of the rules in the rule database: (a) determining, for each of the data points of the plurality of labeled samples in the training database to which the rule applies, whether applying the rule to the data point has a positive or negative impact on matching an output for the data point based on the rule to the assured output of the labeled sample corresponding to the data point; (b) generating positive impact information for the rule based on the positive voters; (c) generating negative impact information for the rule based on the negative voters; and (d) determining a metric for the rule based on the quantity of the negative voters and the quantity of the positive voters; ranking the rules based on the metrics corresponding to the rules; and sending to a user for refinement one or more flagged rules of the rules that have a lowes

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: A fluorophor includes: ?-type sialon crystal which is expressed by a general formula: (Lix1, Eux2)(Si12?(m+n)Alm+n)(OnN16?n), wherein x1 is an amount of solid solution of Li in a sialon unit cell, and x2 is an amount of solid solution of Eu in the sialon unit cell, wherein the parameters x1, x2, m, and n satisfy: 1.6?x1?2.4 (1), 0.001?x2?0.4 (2), 1.8?m?2.4 (3), 0.8?n?1.2 (4), wherein the ?-type sialon crystal emits fluorescence with a peak in a wavelength region of from 550 nm to 575 nm upon irradiation of an excitation source.

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Abstract: Some aspects of this invention provide nucleic acid constructs for transgene expression. Some aspects of this invention provide multicistronic nucleic acid constructs, for example, comprising an expression cassette encoding a hairpin RNA and a reporter expression cassette. Some aspects of this invention provide nucleic acid constructs comprising two or more self-complementary nucleic acid sequences, for example, hairpin RNA encoding nucleic acid sequences and AAV inverse terminal repeats. Methods for the use of the constructs in therapy and research are also provided.

Abstract: Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.

Abstract: Methods for providing drawing assistance to a user sketching an image include geometrically correcting adjusting user strokes to improve their placement and appearance. In particular, one or more guidance maps indicate where the user “should” draw lines. As a user draws a stroke, the stroke is geometrically corrected by moving the stroke toward a portion of the guidance maps corresponding to the feature of the image the user is intending to draw based feature labels. To further improve the user drawn lines, parametric adjustments are optionally made to the geometrically-corrected stroke to emphasize “correctly” drawn lines and de-emphasize “incorrectly” drawn lines.

Abstract: Some aspects of this invention provide nucleic acid constructs for transgene expression. Some aspects of this invention provide multicistronic nucleic acid constructs, for example, comprising an expression cassette encoding a hairpin RNA and a reporter expression cassette. Some aspects of this invention provide nucleic acid constructs comprising two or more self-complementary nucleic acid sequences, for example, hairpin RNA encoding nucleic acid sequences and AAV inverse terminal repeats. Methods for the use of the constructs in therapy and research are also provided.

Abstract: Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.

Abstract: A method and device for recording data of a terminal are disclosed. The method includes: setting a relation condition list for triggering recording among function modules, and setting a corresponding random probability generator for each function module; determining whether to start recording data, and whether to end the data recording operation in accordance with the relation condition list or the random probability generator, during the operation process of each function module; and sending the respective data packets obtained by recording to a data management module for storage after the data record operation of each function module is ended. By adopting the method and device, fuzzy recording can be performed on data of the terminal, and data of different function modules can be stored centrally, and a query operation is simplified.

Abstract: Methods for providing drawing assistance to a user sketching an image include geometrically correcting adjusting user strokes to improve their placement and appearance. In particular, one or more guidance maps indicate where the user “should” draw lines. As a user draws a stroke, the stroke is geometrically corrected by moving the stroke toward a portion of the guidance maps corresponding to the feature of the image the user is intending to draw based feature labels. To further improve the user drawn lines, parametric adjustments are optionally made to the geometrically-corrected stroke to emphasize “correctly” drawn lines and de-emphasize “incorrectly” drawn lines.

Abstract: A device for reading data from a first memory to a second memory based on real-time blank page detection includes a memory controller for reading a page of data from the first memory, a buffer for buffering a portion of the page data, a blank page pre-detection unit for generating a pre-detection result that indicates whether the page is a blank page based on a pre-determined part of the page data, a data processing unit for processing all of the page data to identify a page type, and a control unit for signaling the memory controller to read the page of data from the first memory and enabling the data processing unit based on the pre-detection result.

Abstract: Systems and methods are disclosed herein for rule-based item classification. The methods include receiving, by a computing device, an item record for analysis. The computing device may determine ranked lists of item types using rule-based classifiers and machine learning-based classifiers. Then, the computing device may aggregate the ranked lists of item types to generate a combined ranked list of item types.

Abstract: An logging method for locating a watered zone in a horizontal well with high watercut problem by isotope labeling is disclosed, which successively includes the following steps: a. solidifying an isotope used in an isotope releasing device into a water-soluble carrier; b. connecting the isotope releasing device with a tubing and setting them to a horizontal segment of the well; c. dissolving the water-soluble carriers in the water at the bottom of the well to release the isotope, wherein the releasing rate is proportional to the flow rate of the water; d. starting a lift-up pump and beginning a production logging; and e. continuously performing y-ray energy-spectrum analysis on produced water on the ground, so as to locate the watered zone of the horizontal well with high watercut problem by the detected species and characteristic content of the isotope.

Abstract: A control method and a control apparatus are provided. The method includes: monitoring whether a first trigger event is generated when a first electronic device outputs, based on display data, a first display content via a first display unit coupling the first electronic device, wherein the display data is transmitted to the first electronic device by a second electronic device and corresponds to a second display content of the second electronic device, wherein the second display content is same as the first display content; mapping the first trigger event to first information that can be recognized by the second electronic device, if it is detected that the first trigger event is generated; and transmitting the first information to the second electronic device, to instruct the second electronic device to perform a first operation. An electronic device is further provided.

Abstract: A method for reducing vehicle bias when testing a tire for use with a market segment of vehicles by creating a vehicle model that is scalable by vehicle weight. A market segment of vehicles is defined, at least one of a vehicle model parameter is defined, data is collected for the at least one vehicle model parameter from at least one vehicle in the market segment, the at least one vehicle model parameter is characterized through regression analysis as a function of total weight of a scalable vehicle model, the scalable vehicle model parameter is applied to a multibody vehicle dynamics simulation, at least one maneuver is applied to the scalable vehicle model, and the tire load histories generated by the multibody vehicle dynamics simulation are provided to a tire test machine to obtain tire wear data representative of the vehicles in the market segment.