Abstract: The liquid feeding device includes a discharge speed calculation part configured to calculate a discharge speed v of the plunger pump so that a converted value LATM under an atmospheric pressure of a flow rate LPRE of the mobile phase discharged to the discharge channel from the pump part becomes a set flow rate LSET using a volume V of the mobile phase in the pump chamber of the closing pump immediately before the precompression process is started, a volume ?V reduced due to the precompression process of the mobile phase in the pump chamber of the closing pump, and a feeding pressure P; and a discharge operation controller configured to control a discharge speed of the plunger pump to a discharge speed v calculated by the discharge speed calculation part.

Abstract: A liquid delivery device includes a pump head having a pump chamber provided in the inside, a plunger whose tip is slidably inserted into the pump chamber, and at least one plunger pump having a drive mechanism that reciprocates the plunger in its axial direction. Then, at least one of the plunger pumps is a pressurizing pump that pressurizes a mobile phase including a compressible fluid sucked into the pump chamber and then discharges the mobile phase from the pump chamber, and at least the pump head of the pressurizing pump includes a cooling part that is connected to an outlet channel from the pump chamber, and allows the pump head to absorb heat of the mobile phase discharged from the pump chamber to cool the mobile phase.

Abstract: A resin tube is prepared. Further, a formation tool having a pressing surface and a projection that projects from the pressing surface and is insertable into the resin tube is prepared. The projection of the formation tool is inserted from an end of the resin tube into the resin tube. The pressing surface of the formation tool is pressed against an end surface of the resin tube. Thermal energy is applied to the end of the resin tube, whereby a shape of the pressing surface of the formation tool is transferred to the end surface of the resin tube, and the end of the resin tube is formed into a flange shape.

Abstract: A first flow path is connected to an inlet for introducing gas into a microvalve. A second flow path is connected to an outlet for allowing gas to flow out of the microvalve. A third flow path is for introducing a pneumatic fluid into the microvalve. A negative pressure generation mechanism (a pump) is for generating a negative pressure on the second flow path to suck gas from the first flow path forward the second flow path via the microvalve. A pressure adjustment mechanism (a connection flow path and a valve) is for reducing a pressure difference between the second flow path and the third flow path to prevent the inlet and the outlet from being blocked by a diaphragm layer in response to the negative pressure generated on the second flow path side.

Abstract: An autosampler sets an injection valve to be in a sample filling state when a sample loop is filled with a sample, and, after completion of filling with the sample, switches the injection valve to an intermediate state and first connects only one end of the sample loop to a liquid delivery channel and an analysis channel. After the above, the injection valve is switched to the sample injection state and the sample loop is interposed between the liquid delivery channel and the analysis channel, so that the sample is injected into the analysis channel.

Abstract: A field-flow fractionation device includes a separation channel, a carrier fluid supplier, a separation membrane, a waste liquid chamber, a cross-flow flow rate adjuster, and a carrier fluid adder. The carrier fluid adder is configured to add, to a flow of a carrier fluid having passed through the separation membrane, a flow of another carrier fluid at a carrier fluid adding position set on an upstream side of the cross-flow flow rate adjuster so that the flow rate of the carrier fluid flowing into the cross-flow flow rate adjuster is larger than the flow rate of the carrier fluid having passed through the separation membrane.

Abstract: A switching valve is used in a binary pump. The switching valve is provided with a first liquid delivery port to which a first pump unit is connected, a second liquid delivery port to which a second pump unit is connected, and an output port leading to an output unit that outputs a liquid to be delivered. The switching valve is configured so as to be switched to any one of the following states: a first state in which the first liquid delivery port is connected to the output port and the second liquid delivery port is not connected to any port; a second state in which the second liquid delivery port is connected to the output port and the first liquid delivery port is not connected to any port; and a third state in which both the first liquid delivery port and the second liquid delivery port are connected to the output port.

Abstract: A liquid feeding apparatus includes: a plurality of plunger pumps fluidly connected in series or in parallel between a suction flow path and a discharge flow path; and a control unit configured to control an operation of the plunger pump. The control unit includes a compensation flow rate calculation unit configured to calculate a positive compensation flow rate which changes with time in synchronization with the period with respect to a set flow rate. The compensation flow rate is a flow rate which compensates for a loss of the flow rate caused by cooling and contraction in a discharge stroke after the fluid in the plunger pump is compressed and heated in a pre-compression stroke. The compensation flow rate calculation unit is configured to calculate the compensation flow rate.

Abstract: The liquid feeding device includes a discharge speed calculation part configured to calculate a discharge speed v of the plunger pump so that a converted value LATM under an atmospheric pressure of a flow rate LPRE of the mobile phase discharged to the discharge channel from the pump part becomes a set flow rate LSET using a volume V of the mobile phase in the pump chamber of the closing pump immediately before the precompression process is started, a volume ?V reduced due to the precompression process of the mobile phase in the pump chamber of the closing pump, and a feeding pressure P; and a discharge operation controller configured to control a discharge speed of the plunger pump to a discharge speed v calculated by the discharge speed calculation part.

Abstract: Even though a pump head part is finally fixed to a pump body with a fixing member, the pump head part is movable relative to the pump body perpendicular to the axial direction of a plunger at a stage before the pump head part is fixed with the fixing member. In this state, if a plunger driving part is moved to a predetermined location on the front end side of the pump body and the pump head part and the plunger driving part are fitted to each other, the pump head part is positioned where the center axis of the plunger and the center axis of the pump chamber are substantially aligned. By fixing the pump head part to the pump body with the fixing member at this location, it is possible to assemble a plunger pump with the center axis of the plunger and the center axis substantially aligned.

Abstract: A liquid feeding device includes a discharge channel, a pump part, a feeding pressure sensor, a non-discharge pressure sensor, a pre-compression part, and a pre-compression speed determination part. The pump part has plunger pumps connected in series or parallel. At least one of the plunger pumps is a closed pump in which communication with the discharge channel is disconnected during a non-discharge time. The pre-compression part causes the closed pump that is after the suction process for sucking the liquid into a pump chamber is completed and during the non-discharge time to execute a pre-compression process to perform a discharge operation until a non-discharge pressure is substantially the same as a feeding pressure based on output of the feeding pressure sensor and output of the non-discharge pressure sensor. The pre-compression speed determination part determines a pre-compression speed of the closed pump in the pre-compression process.

Abstract: A liquid delivery device includes at least one liquid delivery pump that delivers liquid, at least one main channel communicating with an outlet of the liquid delivery pump, at least one branch channel branched from the main channel, and a switching valve that has, as a port for connecting channels, at least a port to which the main channel is connected, a port to which the branch channel is connected, at least one output port for outputting liquid delivered by the liquid delivery pump through the main channel, and at least one drain port leading to a drain, and is configured to be selectively switched to a first state, in which the main channel is connected to the output port while the branch channel is not connected to any channel, and a second state in which the branch channel is connected to the drain port while the main channel is not connected to any channel.

Abstract: A liquid delivery device includes a pump head having a pump chamber provided in the inside, a plunger whose tip is slidably inserted into the pump chamber, and at least one plunger pump having a drive mechanism that reciprocates the plunger in its axial direction. Then, at least one of the plunger pumps is a pressurizing pump that pressurizes a mobile phase including a compressible fluid sucked into the pump chamber and then discharges the mobile phase from the pump chamber, and at least the pump head of the pressurizing pump includes a cooling part that is connected to an outlet channel from the pump chamber, and allows the pump head to absorb heat of the mobile phase discharged from the pump chamber to cool the mobile phase.

Abstract: The present invention relates to a particle manipulation method to disperse magnetic particles 70 in a liquid 35 filling up a tube container 10, wherein a circumferential direction moving step to move the magnetic particles 70 along the circumferential direction of the container 10 in the liquid 35 and in a radial direction moving step to move the magnetic particles 70 as crossing the radial direction of the container 10 in the liquid 35 are implemented repeatedly. Such manipulations can be achieved by combining rotation of the container and gravity force and magnetic field manipulations.

Abstract: A first flow path is connected to an inlet for introducing gas into a microvalve. A second flow path is connected to an outlet for allowing gas to flow out of the microvalve. A third flow path is for introducing a pneumatic fluid into the microvalve. A negative pressure generation mechanism (a pump) is for generating a negative pressure on the second flow path to suck gas from the first flow path forward the second flow path via the microvalve. A pressure adjustment mechanism (a connection flow path and a valve) is for reducing a pressure difference between the second flow path and the third flow path to prevent the inlet and the outlet from being blocked by a diaphragm layer in response to the negative pressure generated on the second flow path side.

Abstract: A switching valve is used in a binary pump. The switching valve is provided with a first liquid delivery port to which a first pump unit is connected, a second liquid delivery port to which a second pump unit is connected, and an output port leading to an output unit that outputs a liquid to be delivered. The switching valve is configured so as to be switched to any one of the following states: a first state in which the first liquid delivery port is connected to the output port and the second liquid delivery port is not connected to any port; a second state in which the second liquid delivery port is connected to the output port and the first liquid delivery port is not connected to any port; and a third state in which both the first liquid delivery port and the second liquid delivery port are connected to the output port.

Abstract: A liquid feeding apparatus includes: a plurality of plunger pumps fluidly connected in series or in parallel between a suction flow path and a discharge flow path; and a control unit configured to control an operation of the plunger pump. The control unit includes a compensation flow rate calculation unit configured to calculate a positive compensation flow rate which changes with time in synchronization with the period with respect to a set flow rate. The compensation flow rate is a flow rate which compensates for a loss of the flow rate caused by cooling and contraction in a discharge stroke after the fluid in the plunger pump is compressed and heated in a pre-compression stroke. The compensation flow rate calculation unit is configured to calculate the compensation flow rate.

Abstract: The present invention relates to a particle manipulation method to disperse magnetic particles 70 in a liquid 35 filling up a tube container 10, wherein a circumferential direction moving step to move the magnetic particles 70 along the circumferential direction of the container 10 in the liquid 35 and in a radial direction moving step to move the magnetic particles 70 as crossing the radial direction of the container 10 in the liquid 35 are implemented repeatedly. Such manipulations can be achieved by combining rotation of the container and gravity force and magnetic field manipulations.

Abstract: A pressure controller is provided with an insulating substrate having a gas inlet and a gas outlet and including an inner channel, a valve mechanism including an MEMS valve element that is attached directly to a front surface or a back surface of the insulating substrate and that is connected to the inner channel via a port communicating with the inner channel, a pressure sensor section including an MEMS pressure sensor element that is attached directly to the front surface or the back surface of the insulating substrate and that is connected to the inner channel via a port communicating with the inner channel, and a control section for feedback-controlling the valve mechanism based on a detection signal of the pressure sensor section.