Abstract: In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.

Abstract: Methods and systems are provided for facilitating access to a cloud-based logging service. According to one embodiment, access to a cloud-based logging service is integrated within a network security appliance by automatically configuring access settings for the logging service and creating an account for the security appliance with the logging service. A log is created within the logging service by making use of the automatically configured access settings and the account. A request is received by the security appliance to access data associated with the log. Responsive thereto and without requiring separate registration of a network administrator with the cloud-based logging service, the data is retrieved by the security appliance from the logging service and is presented via a graphical user interface of the security appliance.

Abstract: The present invention relates to a compound based on cyanine scaffold for diagnosing sepsis by selectively detecting glutathione. The compound based on cyanine scaffold according to the present invention has the advantages of maintaining its structure in intracellular environment and of reacting selectively to glutathione only among many amino acids containing thiol group (R—SH) such as cysteine, homocysteine, and glutathione, to produce changes in absorption or fluorescence spectrum, making the compound useful for the detection of in vivo glutathione in biosamples and also for the diagnosis of sepsis characteristically displaying the changes of glutathione concentration.

Abstract: A process for producing an anode layer, comprising: (a) dispersing catalyst metal-coated Si particles, graphene sheets, and an optional blowing agent in a liquid medium to form a graphene/Si dispersion; (b) dispensing and depositing the dispersion onto a supporting substrate to form a wet layer and removing the liquid medium from the wet layer to form a dried layer of graphene/Si mixture material; and (c) exposing the dried layer to a high temperature environment, from 300° C. to 2,000° C., to induce volatile gas molecules from graphene sheets or to activate the blowing agent for producing the graphene foam and, concurrently, to enable a catalyst metal-catalyzed growth of multiple Si nanowires emanated from Si particles as a feed material in pores of the foam to form the anode layer; wherein the Si nanowires have a diameter of 5-100 nm and a length-to-diameter aspect ratio of at least 5.

Abstract: The present invention discloses a method and system for managing a database. According to embodiments of the present invention, there is provided a method for managing a database, each item of data in the database being associated with a timestamp and a data point, the timestamps being used as row keys for rows of a table in the database, the method comprising: obtaining a behavior characteristic of a user based on a previous data access to the database by the user; partitioning columns in the table into column families based on the obtained behavior characteristic and system configuration of the database; and causing data in the database to be stored in respective column families at least in part based on the associated data point. There is further disclosed a corresponding system.

Abstract: A data entry and scanning apparatus that includes a commercially available mobile device wherein said commercially available mobile device with a touch screen display, a processor, and a wireless communications network access point, a scanning device, an interface, and a power source that external to the commercially available mobile device and connected to the interface, and a casing that does not cover the touch screen display.

Abstract: A method, system, and computer program product, include identifying a plurality of pollution process sets and determining pollution sources based on pollution start times of target pollution processes with matched features in the plurality of pollution process sets within a time window.

Abstract: Methods and systems are provided for creation and implementation of firewall policies. According to one embodiment, a firewall maintains a log of observed network traffic flows. An administrator may request the firewall to generate a customized report based on the logged network traffic by extracting information from the log based on specified report parameters. The report includes aggregated network traffic items and one or more corresponding action objects. Responsive to receipt of a directive to implement an appropriate firewall policy for one or more network traffic items based on interaction with one or more action objects by the administrator, the firewall then automatically defines and establishes an appropriate firewall policy.

Abstract: Provided in embodiments of the present invention are a method and device for implementing high-definition image capturing, comprising: collecting and acquiring image data of a first set format by using an image sensor, image processing the image data then encoding into modulated data of a second set format, converting the modulated data into an analog electric signal of a third set format by using a synchronous clock, and filtering the analog electric signal by using a filter circuit then transmitting via a coaxial cable. The above series of operations is capable of implementing the collection and processing of a high-resolution video, and solves the problem that existing high-definition camera are incapable of ensuring timeliness during a video transmission process and provides poor stability and reliability, while at the same time, employment of the present invention also allows an existing analog camera to use a cable device for video transmission, thus implementing full utilization of existing resources.

Abstract: Systems and methods for facilitating offloading of communication sessions from layer 3 network devices are provided. According to one embodiment, session information pertaining to a session capable of being offloaded is received from a layer 3 network device by a layer 2 network device that includes multiple network processing units (NPUs). The session is assigned to one of the NPUs. Subsequently, responsive to receiving, by the layer 2 network device, a packet associated with the session, the packet is processed by the assigned NPU and forwarded on behalf of the layer 3 network device to a destination specified by the processed packet.

Abstract: An imaging scanner is provided. The image scanner has a housing. The housing contains a mirror, a camera, a transparent window for scanning, a transparent window for viewing positioned above the transparent window for scanning such that anything presented below the transparent window for scanning is visible in the transparent window for viewing. The transparent window for viewing has an electronic display embedded therein. The imaging scanner also includes an image decoder linked to the camera and to the electronic display. The mirror is positioned such that incident light on the mirror from the transparent scanning window will be reflected within the camera's field of view. The camera is configured to scan images presented at the transparent window for scanning. The image decoder is configured to decode the scanned images. The electronic display is configured to display the decoded information on the transparent window for viewing.

Abstract: Barcode reading devices for creating an easy-to-use experience are provided. In one implementation, a barcode reading apparatus comprises a housing having at least a scan body and an image sensor disposed within the housing. The image sensor is configured to read the barcode. The apparatus further includes a scanning frame and a viewing frame. The scanning frame is formed in a first bottom surface of the scan body and is configured to enable the image sensor to visually detect the barcode when the barcode is placed in a scanning zone at least partially below the scan body. The viewing frame is formed in a first top surface of the scan body and is configured to enable a user to view the barcode through both the viewing frame and scanning frame when the barcode is placed in the scanning zone.

Abstract: The present disclosure relates to a system and a method of allocating orders. The system may include a non-transitory computer readable storage medium and a processor. The non-transitory computer may store an executable module. The processor may execute the executable module stored in the computer readable storage medium. The non-transitory computer readable storage medium may include a receiving unit (231) and an order allocation unit (361). The receiving unit (231) may receive order information and user information. The user information may include location information and/or time information. The order allocation unit (361) may allocate an order based on the location information and/or the time information. The method may include receiving order information and user information, wherein the order information and the user information may include location information and/or time information, and allocating an order based on the location information and/or the time information.

Abstract: Methods and systems are provided for facilitating access to a cloud-based logging service. According to one embodiment, access to a cloud-based logging service is integrated within a network security appliance by automatically configuring access settings for the logging service and creating an account for the security appliance with the logging service. A log is created within the logging service by making use of the automatically configured access settings and the account. A request is received by the security appliance to access data associated with the log. Responsive thereto and without requiring separate registration of a network administrator with the cloud-based logging service, the data is retrieved by the security appliance from the logging service and is presented via a graphical user interface of the security appliance.

Abstract: An electrical connector has an insulating body which comprises a housing and a tongue; a plurality of conductive terminals, each conductive terminal has a mating portion and a soldering portion; a metal inner shell which surrounds to form a first frame, the first frame is fixed on the insulating body and surrounds a rear portion of the tongue to form a mating cavity; a metal outer shell which surrounds to form a second frame, the second frame encircles an outside of the first frame, a plurality of soldering legs extend out from two sides of the metal outer shell; and an insulating outer shell which is engaged with the metal outer shell integrally, a rear portion of the insulating outer shell is formed with a receiving cavity; the metal inner shell is correspondingly inserted in the receiving cavity, the insulating outer shell surrounds a front portion of the tongue and forms an insertion opening, the insertion opening is integrally communicated with the mating cavity along a front-rear direction.

Abstract: A service maintains information regarding one or more aspects of Web content, such as Web pages, that can be accessed by a computing device. The same service or a different service (e.g., a digital assistant) also maintains information regarding the user of the computing device. When a user navigates to Web content using a Web application, such as a Web browser, the services are accessed to obtain information regarding the Web content navigated to, information regarding the user, and/or user selectable tasks or actions. The Web application displays the obtained information to the user along with the Web content. The Web application displays the obtained information without altering the obtained Web content. Optionally, the Web application displays an indication that additional information regarding the Web content is available, and displays the obtained information (e.g., automatically or in response to receiving a user input request to display that additional information).

Abstract: Provided in embodiments of the present invention are a method and device for transmitting a high-definition video signal, comprising: isolating from the high-definition video signal a brightness signal and a chrominance signal, and, by using an analog signal transmission mode, using non-overlapping frequency hands to transmit respectively the brightness signal and the chrominance signal. The solution of the present invention employs the analog signal transmission method, utilizes independent frequency bands to transmit respectively the brightness signal and the chrominance signal, and ensures that the brightness signal and the chrominance signal do not affect each other, thus ensuring video quality and timeliness of the high-definition video signal when transmitted over a long distance.

Abstract: Described herein are methods and systems for texturing a three-dimensional (3D) model using photogrammetry. A sensor captures scans of a physical object, including related pose information, and color images corresponding to each scan. A computing device generates a 3D mesh of the physical object. The computing device preprocesses the color images to remove blurry images and detect textured regions of the object in each non-blurry image. The computing device optimizes the pose information for each color image by generating associations between the color images and vertices in the 3D mesh and classifying the vertices as textured or non-textured. The computing device generates texture coordinates for the 3D mesh by segmenting the mesh, parameterizing the segments, and packing the parameterized segments into a texture atlas. The computing device paint the texture atlas using the color images that have optimized pose information to generate a model having texture coordinates for each vertex.

Abstract: Methods and systems are provided for creation and implementation of firewall policies. According to one embodiment, a firewall maintains a log of observed network traffic flows. An administrator may request the firewall to generate a customized report based on the logged network traffic by extracting information from the log based on specified report parameters. The report includes aggregated network traffic items and one or more corresponding action objects. Responsive to receipt of a directive to implement an appropriate firewall policy for one or more network traffic items based on interaction with one or more action objects by the administrator, the firewall then automatically defines and establishes an appropriate firewall policy.

Abstract: A method for paving a steel bridge deck comprises laying consecutively a 0.6 mm-0.8 mm epoxy waterproofing bond material layer, a 30 mm-40 mm injectable self-flowing asphalt concrete material layer, a 0.4 mm-0.6 mm epoxy asphalt bond material layer, and a 25 mm-40 mm latex cement mortar poured asphalt concrete material layer onto the top of the steel bridge deck to form the steel bridge deck pavement structure.