Abstract: An encoding parameter adjustment method is performed at a computer device. The method includes: obtaining a first audio signal, and determining a psychoacoustic masking threshold within a service frequency band in the first audio signal; obtaining a second audio signal, and determining a background environmental noise estimation value of the frequency within the service frequency band in the second audio signal; determining a masking tag corresponding to the service frequency band according to the psychoacoustic masking threshold of the first audio signal and the background environmental noise estimation value of the second audio signal; determining a masking rate of the service frequency band according to the masking tag corresponding to the frequency within the service frequency band; determining a first reference bit rate according to the masking rate of the service frequency band; and configuring an encoding bit rate of an audio encoder based on the first reference bit rate.

Abstract: A method for improving speech signal intelligibility is performed at a device. A speech signal is obtained. A correspondence between the speech signal and a respective user group among different user groups having distinct voice characteristics is identified. Pre-encoding signal augmentation is performed on the speech signal with a respective pre-augmentation filtering coefficient that corresponds to the respective user group to obtain a group-specific pre-augmented speech signal. The device encodes the pre-augmented speech signal for subsequent transmission through the voice communication channel. An encoded version of the pre-augmented speech signal has reduced loss of signal quality as compared to an encoded version of the speech signal that is obtained without the pre-encoding signal augmentation.

Abstract: Provided in the present invention is a method for constructing a high-resolution single cell Hi-C library with a large amount of information, comprising the following steps: Step B: obtain a small amount of fixed chromatin; Step C: digest the fixed chromatin in Step B to obtain fragments of the fixed chromatin; Step D: reconnect the fragments of the fixed chromatin in Step C directly to obtain reconnected fragments of the fixed chromatin; Step E: de-fix the reconnected fragments of the fixed chromatin in Step D to release DNA fragments; Step F: amplify the released DNA fragments in Step E to obtain amplified products; and Step H: construct a sequencing DNA library by using the amplified products as the DNA fragments to be sequenced.

Abstract: An echo delay tracking method includes obtaining, by a computing terminal, a current frame reference signal and a current frame collection signal; and identifying target frequency information in the current frame collection signal according to signal-to-noise ratios of the current frame collection signal at a plurality of frequencies. The target frequency information includes at least one target frequency that corresponds to a signal-to-noise ratio greater than a first preset threshold. The method also includes determining whether the current frame collection signal is a valid frame signal based on the target frequency information; and if yes, performing a cross-correlation operation of a signal component of the current frame reference signal corresponding to the target frequency and a signal component of the current frame collection signal corresponding to the target frequency. An echo delay value can be obtained according to a result of the cross-correlation operation.

Abstract: A method for improving speech signal intelligibility is performed at a device. A speech signal is obtained. A correspondence between the speech signal and a respective user group among different user groups having distinct voice characteristics is identified. Pre-encoding signal augmentation is performed on the speech signal with a respective pre-augmentation filtering coefficient that corresponds to the respective user group to obtain a group-specific pre-augmented speech signal. The device encodes the pre-augmented speech signal for subsequent transmission through the voice communication channel. An encoded version of the pre-augmented speech signal has reduced loss of signal quality as compared to an encoded version of the speech signal that is obtained without the pre-encoding signal augmentation.

Abstract: Described is an echo cancellation method including buffering the at least one frame of a first voice signal, the at least one frame of the first voice signal including an echo signal, when the at least one frame of signal is preprocessed, separately obtaining, in a first timing period, the at least one frame of the first voice signal from a buffer and at least one frame of a reference signal matching the at least one frame of first voice signal from a reference signal queue, so that an estimated latency value, between each frame of first voice signal and a corresponding reference signal, remains within a preset range, performing echo cancellation processing on the echo signal in the at least one frame of first voice signal using the at least one frame of reference signal, to obtain a second voice signal, and outputting the second voice signal.

Abstract: A voice data transmission method performed by at least one processor, includes placing multiple voice data frames in a target sending queue, sequentially sending the multiple voice data frames to a data receiving party, and identifying one or more important voice frames among the multiple voice data frames placed in the target sending queue. The method further includes placing the one or more important voice frames that are identified, in a retransmission processing queue, and for the multiple voice data frames that are sent, performing retransmission processing on only the one or more important voice frames placed in the retransmission processing queue.

Abstract: Provided are a method and a device for detecting a genetic mutation, and a kit for typing genotypes of a pregnant woman and a fetus. The method comprises: performing high-throughput sequencing on free DNA in a pregnant woman's peripheral blood to obtain sequencing data; comparing the sequencing data with reference genome to obtain SNP sites; performing mixed genotyping on each SNP site to obtain target genotypes for each SNP site; and selecting a mutation site that causes the gene mutation from the genotype of the fetus in the target genotypes.

Abstract: A howling detection method is provided. A window separation processing is processed on an audio signal to obtain a plurality of analysis windows. A signal energy indicator value of each preset frequency in at least one analysis window is obtained by using a preset perceptual coefficient corresponding to each frequency, to obtain a perceptual energy indicator value of each frequency, the preset perceptual coefficient corresponding to each frequency indicating a sensitivity of a human ear to a sound of each frequency. It is determined whether howling occurs according to the perceptual energy indicator value of each frequency in the at least one analysis window.

Abstract: An audio frame loss recovery method and apparatus are disclosed. In one implementation, data from some but not all audio frames is included in a redundant frame. The audio frames whose data is not included in the redundant frame may include multiple audio frames but may not include more than two consecutive audio frames. Because not all audio frames are used in the redundant frame, the amount of information needed to be transmitted in the redundant frame is reduced. A lost audio frame during transmission may be recovered from either the redundant frame when the redundant frame include data of the lost frame, or from at least one neighboring frame of the lost frame derived from either the redundant frame or the successfully transmitted audio frames when the redundant frame does not include data of the lost frame.

Abstract: Described is an echo cancellation method including buffering the at least one frame of a first voice signal, the at least one frame of the first voice signal including an echo signal, when the at least one frame of signal is preprocessed, separately obtaining, in a first timing period, the at least one frame of the first voice signal from a buffer and at least one frame of a reference signal matching the at least one frame of first voice signal from a reference signal queue, so that an estimated latency value, between each frame of first voice signal and a corresponding reference signal, remains within a preset range, performing echo cancellation processing on the echo signal in the at least one frame of first voice signal using the at least one frame of reference signal, to obtain a second voice signal, and outputting the second voice signal.

Abstract: An echo delay tracking method includes obtaining, by a computing terminal, a current frame reference signal and a current frame collection signal; and identifying target frequency information in the current frame collection signal according to signal-to-noise ratios of the current frame collection signal at a plurality of frequencies. The target frequency information includes at least one target frequency that corresponds to a signal-to-noise ratio greater than a first preset threshold. The method also includes determining whether the current frame collection signal is a valid frame signal based on the target frequency information; and if yes, performing a cross-correlation operation of a signal component of the current frame reference signal corresponding to the target frequency and a signal component of the current frame collection signal corresponding to the target frequency. An echo delay value can be obtained according to a result of the cross-correlation operation.

Abstract: The present invention provides a method for constructing a next-generation sequencing library for detecting low-frequency mutations, and a kit thereof. The constructing method comprises steps of obtaining blunt-end DNA fragments, obtaining DNA fragments with A-tail at the 3? end, obtaining adapter-added DNA fragments using a specific nucleotide sequence and obtaining amplification products using a specific nucleotide sequence.

Abstract: A howling detection method is provided. A window separation processing is processed on an audio signal to obtain a plurality of analysis windows. A signal energy indicator value of each preset frequency in at least one analysis window is obtained by using a preset perceptual coefficient corresponding to each frequency, to obtain a perceptual energy indicator value of each frequency, the preset perceptual coefficient corresponding to each frequency indicating a sensitivity of a human ear to a sound of each frequency. It is determined whether howling occurs according to the perceptual energy indicator value of each frequency in the at least one analysis window.

Abstract: Provided is a method for constructing a DNA library for sequencing. The method comprises A-tailing of a single 3? end to at least a portion of blunt-end DNA fragments, and a step of blunt-end ligating the obtained DNA fragments having A tailing to the single 3? end. Also provided are a DNA library for sequencing constructed with the method and a corresponding sequencing method.

Abstract: Provided in the present invention is a method for constructing a high-resolution single cell Hi-C library with a large amount of information, comprising the following steps: Step B: obtain a small amount of fixed chromatin; Step C: digest the fixed chromatin in Step B to obtain fragments of the fixed chromatin; Step D: reconnect the fragments of the fixed chromatin in Step C directly to obtain reconnected fragments of the fixed chromatin; Step E: de-fix the reconnected fragments of the fixed chromatin in Step D to release DNA fragments; Step F: amplify the released DNA fragments in Step E to obtain amplified products; and Step H: construct a sequencing DNA library by using the amplified products as the DNA fragments to be sequenced.

Abstract: A method for improving speech signal intelligibility is performed at a device. A speech signal is obtained. A correspondence between the speech signal and a respective user group among different user groups having distinct voice characteristics is identified. Pre-encoding signal augmentation is performed on the speech signal with a respective pre-augmentation filtering coefficient that corresponds to the respective user group to obtain a group-specific pre-augmented speech signal. The device encodes the pre-augmented speech signal for subsequent transmission through the voice communication channel. An encoded version of the pre-augmented speech signal has reduced loss of signal quality as compared to an encoded version of the speech signal that is obtained without the pre-encoding signal augmentation.

Abstract: A voice data transmission method performed by at least one processor, includes placing multiple voice data frames in a target sending queue, sequentially sending the multiple voice data frames to a data receiving party, and identifying one or more important voice frames among the multiple voice data frames placed in the target sending queue. The method further includes placing the one or more important voice frames that are identified, in a retransmission processing queue, and for the multiple voice data frames that are sent, performing retransmission processing on only the one or more important voice frames placed in the retransmission processing queue.

Abstract: A kit, an apparatus, and a method for detecting chromosome aneuploidy.

Abstract: Embodiments of the present invention provide a voice identification method, which includes: obtaining voice data; obtaining a confidence value according to the voice data; obtaining a noise scenario according to the voice data; obtaining a confidence threshold corresponding to the noise scenario; and if the confidence value is greater than or equal to the confidence threshold, processing the voice data. An apparatus is also provided. The method and apparatus that flexibly adjust the confidence threshold according to the noise scenario greatly improve a voice identification rate under a noise environment.