Abstract: The present invention relates to a novel lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can be effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.

Abstract: The present invention pertains to a novel lappaconitine derivative, a method for producing same, and a pharmaceutical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into osteoblasts, increases bone mineral density when administered to animal models of osteoporosis, and induces bone formation in animal models of bone fracture, and thus can be advantageously used for preventing, ameliorating, or treating bone-related diseases such as osteoporosis, as well as treating non-disease fractures caused by physical trauma.

Abstract: An interfering assembly of a hinge includes a male element including a first raised portion and a second raised portion, and a female element defining a through hole. A sliding surface apart from a center of the through hole protrudes from the female element. An inner slot and an outer slot are formed beside the sliding surface. The female element defines a first depressed portion and a second depressed portion correspondingly engaged with the first and second raised portions. Widths of the inner slot and the outer slot are gradually varied. During rotation of the rotating member, the first and second raised portions are slid out from the first and second depressed portions, respectively, and then in frictional engagement with the sliding surface, together with partial portions covering the inner and outer slots, correspondingly.

Abstract: A hinge includes a fixing member, a shaft fixed to the fixing member, a rotating member, an interfering member, and a fastener. The shaft includes a shaft post, and the fastener is fixed to a distal end of the shaft post. The interfering member defines a fixing hole departing from a center of the interfering member, and includes two guiding surfaces. The rotating member defines an oblong adjusting hole, through which the shaft post rotatably passes. A first resisting stub and a second resisting stub extend from the rotating member, to resist against the corresponding guiding surfaces. The shaft post is fixedly received in the fixing hole. When the rotating member is rotated relative to the shaft post, the first and second resisting stubs always resist against and move along the corresponding guiding surfaces, to urge the shaft post to relatively move in the adjusting hole.

Abstract: An interfering assembly of a hinge includes a male element including a first raised portion and a second raised portion, and a female element defining a through hole. A slot apart from a center of the through hole is defined in the female element. An inner ring and an outer ring are formed beside the slot. The inner ring defines a first depressed portion engaged with the first raised portion, and the outer ring defines a second depressed portion engaged with the second raised portion. Widths of the inner ring and the ring slot are gradually varied. During rotation of the rotating member, the first and second raised portions are slid out from the first and second depressed portions, respectively, and then in frictional engagement with the inner and outer rings, together with partial portions of the first and second raised portions covering the slot, correspondingly.

Abstract: A hinge includes a fixing member, a bolt non-rotatably fixed to the fixing member, a rotating member rotatably sleeved on the bolt, a lock washer not-rotatably sleeved on the bolt, an elastic assembly rotatably sleeved on the bolt, and a fastener fixed to a distal end of the bolt. The lock washer abuts against the rotating member. The lock washer includes a number of friction portions formed on an engaging side of the lock washer. Each friction portion includes a friction surface, and a slanting connecting surface smoothly connected to a first edge of the friction surface. A pitch is connected to a second edge of the friction surface and the connecting surface of the adjacent friction portion.

Abstract: A hinge includes a fixing member, a shaft non-rotatably fixed to the fixing member, a rotating member, an adjusting member, an elastic assembly, and a fastener. The shaft includes a shaft post, and the fastener fixed to a distal end of the shaft post. The rotating member and the elastic assembly are rotatably sleeved on the shaft post. The rotating member defines a depressed slot. The adjusting member is fixed to the shaft post, and abuts against the rotating member. The adjusting member defines a groove. When the rotating member is rotated relative to the fixing member, the depressed slot can be rotated to align with the groove, or away from the groove.

Abstract: A hinge includes a fixing member, a shaft non-rotatably fixed to the fixing member, two shaft sleeves, and a rotating member. The shaft includes a shaft rod. Each shaft sleeve includes a sleeve portion rotatably fitting about the shaft rod, and a fixing board. A protrusion protrudes from each fixing board. The rotating member defines a receiving hole to fixedly accommodate the fixing boards, and a T-shaped fixing slot communicating with the receiving hole. The shaft rod is rotatably inserted into the receiving hole, together with the shaft sleeves, and the protrusions of the shaft sleeves overlap with each other, and are fixedly engaged in the fixing slot.

Abstract: A hinge includes a fixing member, a shaft non-rotatably fixed to the fixing member, and a rotating member. The shaft rod defines a flat surface. The rotating member includes a pivoting portion rotatably fitting about the shaft rod. The pivoting portion defines a cutout. When the rotating member is rotated relative to the fixing member, the flat surface is relatively rotated to align with the cutout, or face an inner wall of the pivoting portion.

Abstract: A hinge includes a fixing member, a shaft fixed to the fixing member, a rotating member, an interfering member, and a fastener. The shaft includes a shaft post, and the fastener is fixed to a distal end of the shaft post. The interfering member defines a fixing hole departing from a center of the interfering member, and includes two guiding surfaces. The rotating member defines an oblong adjusting hole, through which the shaft post rotatably passes. A first resisting stub and a second resisting stub extend from the rotating member, to resist against the corresponding guiding surfaces. The shaft post is fixedly received in the fixing hole. When the rotating member is rotated relative to the shaft post, the first and second resisting stubs always resist against and move along the corresponding guiding surfaces, to urge the shaft post to relatively move in the adjusting hole.

Abstract: A hinge includes a first bracket, a second bracket, a shaft, and first and second interference elements. The shaft is fixed to the first bracket. The second bracket rotationally fit about the shaft. The first interference element is rotationally mounted on the shaft and fixed to the second bracket, and defines two unleveled surfaces at one side. The second interference element is immovably mounted on the shaft beside the first interference element, and defines two unleveled surfaces at one side facing and corresponding to the unleveled surfaces of the first interference element.

Abstract: A hinge includes a first bracket, a second bracket, a shaft, and first and second interference elements. The shaft is fixed to the first bracket. The second bracket rotationally fit about the shaft. The first interference element is rotationally mounted on the shaft and fixed to the second bracket, and defines two unleveled surfaces at one side. The second interference element is immovably mounted on the shaft beside the first interference element, and defines two unleveled surfaces at one side facing and corresponding to the unleveled surfaces of the first interference element.

Abstract: An interfering assembly of a hinge includes a male element including a first raised portion and a second raised portion, and a female element defining a through hole. A sliding surface apart from a center of the through hole protrudes from the female element. An inner slot and an outer slot are formed beside the sliding surface. The female element defines a first depressed portion and a second depressed portion correspondingly engaged with the first and second raised portions. Widths of the inner slot and the outer slot are gradually varied. During rotation of the rotating member, the first and second raised portions are slid out from the first and second depressed portions, respectively, and then in frictional engagement with the sliding surface, together with partial portions covering the inner and outer slots, correspondingly.

Abstract: An interfering assembly of a hinge includes a male element including a first raised portion and a second raised portion, and a female element defining a through hole. A slot apart from a center of the through hole is defined in the female element. An inner ring and an outer ring are formed beside the slot. The inner ring defines a first depressed portion engaged with the first raised portion, and the outer ring defines a second depressed portion engaged with the second raised portion. Widths of the inner ring and the ring slot are gradually varied. During rotation of the rotating member, the first and second raised portions are slid out from the first and second depressed portions, respectively, and then in frictional engagement with the inner and outer rings, together with partial portions of the first and second raised portions covering the slot, correspondingly.

Abstract: A hinge includes a first leaf, a pivot shaft mounted to the first leaf, a first knuckle rotatably mounted to the shaft, a second leaf rotatably mounted to the shaft, a resilient assembly mounted to the shaft, and a fastener fixed to the shaft. One end of the first knuckle forms an engaging portion, and the second leaf correspondingly forms a tab to engage with the engaging portion. Upon the condition that the tab engages with the engaging portion such that the first knuckle can rotate with the second leaf, a larger twisting force is needed for the second leaf, together with the first knuckle, to rotate relative to the pivot shaft due to further overcome a friction between the first knuckle and the pivot shaft.

Abstract: A hinge includes a first leaf, a second leaf, and a pivot shaft. The pivot shaft includes a first pivot pin pivotably mounted to the first leaf and a second pivot pin pivotably mounted to the second leaf. A friction between the second leaf and the pivot shaft is smaller than a friction between the first leaf and the pivot shaft. The pivot shaft forms a ledge, and the second leaf correspondingly forms a tab to engage with the ledge. Upon the condition that the tab engages with the ledge such that the pivot shaft can rotate with the second leaf, a larger twisting force is needed for the second leaf, together with the pivot shaft, to rotate relative to the first leaf due to the larger friction between the first leaf and the pivot shaft.

Abstract: A hinge includes a shaft defining a positioning depression, a rotation bracket rotatably mounted to the shaft, and a positioning member. A first end of the positioning member is fixedly mounted to the rotation bracket, and a second end of the positioning member defines a protuberance engagable in the positioning depression.

Abstract: A hinge includes a first leaf, a pivot shaft fixedly mounted to the first leaf, a second leaf rotatably mounted to the pivot shaft, a retention assembly mounted to the pivot shaft, a resilient assembly mounted to the pivot shaft; and two limiting members unrotatably mounted to the pivot shaft and located at opposite sides of the second leaf. Each limiting member forms two limiting surfaces at a circumference of the limiting member. The retention assembly defines a positioning column passing through the second leaf. The positioning column of the retention assembly is operable to engage with one of the limiting surfaces of each of the limiting members.

Abstract: A hinge includes a shaft, a rotation bracket rotatably mounted to the shaft, an interference element fixedly mounted to the shaft, a biasing member mounted to the shaft, and a fastener fixed to a distal end of the shaft. The rotation bracket includes a combination portion engaging and capable of rotating relative to the interference element. The interference includes a first end surface located on a first cone angling down from a center towards a side of the first end surface, the combination portion includes a second end surface located on a second cone angling down from a side towards a center of the second end surface, to engage the first end surface of the interference element.

Abstract: A hinge includes a shaft, a rotation bracket rotatably mounted to the shaft, an interference assembly mounted to the shaft, a biasing member mounted to the shaft, and a fastener fixed to a distal end of the shaft, to prevent the interference assembly and the biasing member from disengaging from the shaft. The interference assembly includes a first element and a second element. The first element includes a first end face located on a first cone tiling down from a circumference towards a center of the first element, and the second element includes a second end face located on a second cone angling down from a center towards a circumference of the second element, to engage the first end surface of the first element.