Abstract: Provided is a method for treating or preventing cancer, containing, as an active ingredient, a compound having a specific chemical structure and an activity of inhibiting the formation of a c-Myc/Max/DNA complex, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Abstract: A transmittance-variable device is disclosed herein. In some embodiments, the transmittance-variable device includes a retardation film, a liquid crystal alignment film, and a liquid crystal layer configured to implement a twist orientation mode, wherein the retardation film, the liquid crystal alignment film and the liquid crystal layer are sequentially arranged, wherein a twist angle (T) is in a range of 50 degrees to 180 degrees, and wherein the smallest angle A between a slow axis of the retardation film and an alignment direction of the liquid crystal alignment film satisfies Equation 1 when a product (?nd) of a refractive index anisotropy (?n) and a thickness (d) is 0.7 ?m or less, and satisfies Equation 2 when the product (?nd) is more than 0.7 ?m. The transmittance-variable device can be applied to various applications without causing problems such as a crosstalk phenomenon, a rainbow phenomenon or a mirroring phenomenon.

Abstract: A transmittance-variable device is provided in the present application. The present application can provide a transmittance-variable device, which can be applied to various applications without causing problems such as a crosstalk phenomenon, a rainbow phenomenon or a mirroring phenomenon, while having excellent transmittance-variable characteristics.

Abstract: The present application relates to a polarization-variable element. The polarization-variable element of the present application has a fast response speed and excellent variable characteristics of polarization degree and transmittance. Such polarization-variable element may be applied to various applications including various architectural or vehicle materials requiring transmittance-variable characteristics, or eyewear such as goggles for augmented reality experience sports, sunglasses or helmets.

Abstract: The present invention relates to a Pt—N—C based electrochemical catalyst for chlorine evolution reaction and a production method thereof, and an aspect of the present invention provides a Pt—N—C based electrochemical catalyst including: a carbon support; and an organic compound including Pt and N distributed on the carbon support.

Abstract: The present application relates to a light modulating device and an eyewear. The present application can provide a light modulation device having both excellent mechanical properties and optical properties by applying a polymer film that is also optically anisotropic and mechanically anisotropic to a substrate.

Abstract: The present invention relates to: an antibody to T cell Immunoreceptor with Ig and Tyrosine-Based Inhibitory Motif Domains (TIGIT), or an antigen-binding fragment thereof; a nucleic acid encoding same; a vector carrying the nucleic acid; a cell transformed with the vector; a method for producing the antibody or the antigen-binding fragment thereof; and a composition and a composition for combined administration, which comprise same and are for preventing or treating cancer.

Abstract: The present invention relates to a pharmaceutical composition for the prophylaxis or treatment of cancer comprising a novel azolopyrimidine heterocyclic compound as an active ingredient, and the pharmaceutical composition for the prophylaxis or treatment of cancer of the present invention can be used as a small molecular immunotherapy anticancer agent which modulates an adenosine pathway by comprising the azolopyrimidine heterocyclic compound.

Abstract: A lens module is provided. The lens module includes at least one refractive index distribution lens; and a lens barrel configured to accommodate the at least one refractive index distribution lens, wherein the at least one refractive index distribution lens is composed of a single layer, and includes a plastic material.

Abstract: A light modulation element that can vary between a bright transparent mode and a dark scattering mode is provided. The light modulation element has a first light modulation layer and a second light modulation layer comprising nematic liquid crystals and a dichroic dye in a scattering mode when a voltage is applied. The first light modulation layer and the second light modulation layer are disposed to overlap each other. The light modulation element has an improved contrast ratio and haze-variable characteristics, without precipitation of dichroic dyes and an increase in power consumption.

Abstract: A bispecific anti-GPNMB/anti-CD3 antibody specifically binds to CD3 (cluster of differentiation 3) and GPNMB (glycoprotein non-metastatic melanoma protein B) and uses thereof are disclosed. The bispecific antibody shows high affinity and specificity to CD3 and GPNMB and thus can induce death of cancer cells expressing GPNMB and inhibit proliferation thereof. Therefore, the bispecific antibody can be used as an effective therapeutic agent for cancers expressing GPNMB.

Abstract: A light modulation device is disclosed herein. In some embodiments, a light modulation device includes a first polymer film substrate, a second polymer film substrate, an active liquid crystal layer disposed between the first and second polymer film substrates, wherein the active liquid crystal layer is capable of switching between a first orientation state and a second orientation state when a voltage is applied, and a polarizer, wherein each of the first and second polymer film substrates have in-plane retardation of 4,000 nm or more for light having a wavelength of 550 nm, a ratio of an elongation (E1) in a first direction to an elongation (E2) in a second direction perpendicular to the first direction of 3 or more, and wherein an angle formed by the first directions of the first and second polymer film substrates is in a range of 0 degrees to 10 degrees.

Abstract: The present application relates to a light modulation device and a use thereof. The present application can provide a light modulation device having both excellent mechanical properties and optical properties by applying a polymer film that is also optically anisotropic and mechanically anisotropic to a substrate.

Abstract: The present invention relates to a compound which inhibits the binding of Yes associated protein (YAP) and transcriptional enhancer associate domain (TEAD), a prodrug of same, a hydrate of same, a solvate of same or a pharmaceutically acceptable salt of same, and a composition comprising same as an active ingredient, the compound according to the present invention being able to be applied as an inhibitor which can directly inhibit YAP-TEAD binding in the Hippo pathway which plays a crucial role in the occurrence of cancer.

Abstract: A light modulation element and the use thereof are provided. The light modulation element can suppress a surface waviness phenomenon upon surface reflection visual observation by improving surface waviness of a base film caused by a spacer. Such light modulation element can be applied to various flexible display devices to improve the quality of products.

Abstract: Provided is a method for treating or preventing cancer, containing, as an active ingredient, a compound having a specific chemical structure and an activity of inhibiting the formation of a c-Myc/Max/DNA complex, or a pharmaceutically acceptable salt thereof.

Abstract: A transmittance-variable device is disclosed herein. In some embodiments, the transmittance-variable device includes a retardation film, a liquid crystal alignment film, and a liquid crystal layer configured to implement a twist orientation mode, wherein the retardation film, the liquid crystal alignment film and the liquid crystal layer are sequentially arranged, wherein a twist angle (T) is in a range of 50 degrees to 180 degrees, and wherein the smallest angle A between a slow axis of the retardation film and an alignment direction of the liquid crystal alignment film satisfies Equation 1 when a product (?nd) of a refractive index anisotropy (?n) and a thickness (d) is 0.7 ?m or less, and satisfies Equation 2 when the product (?nd) is more than 0.7 ?m. The transmittance-variable device can be applied to various applications without causing problems such as a crosstalk phenomenon, a rainbow phenomenon or a mirroring phenomenon.

Abstract: The present application relates to an optical element, a driving method of the optical element, a transmittance-variable device and a use thereof. In one example, the present application may provide a driving method suppressing a back-flow phenomenon caused by a bulk liquid crystal compound even when a cell gap of a liquid crystal layer becomes thick. The driving method may ensure excellent response speeds and driving characteristics.

Abstract: A transmittance-variable device is disclosed herein. In some embodiments, a transmittance-variable device includes first and second guest host layers, the first and second guest host layers are superposed, wherein each of the first and second guest host layers comprise a liquid crystal host and a dichroic dye guest, and wherein the device is capable of switching between a transparent mode and a black mode. The transmittance-variable device can exhibit high transmittance in the transparent state and a high shielding rate in the black state, and can exhibit a high contrast ratio even at the inclination angle, and exhibit excellent viewing angle symmetry in all directions. Such a transmittance-variable device can be applied to various applications including various architectural or automotive materials which need to adjust the transmittance, or eyewear such as goggles for augmented reality experience or sports, sunglasses or helmets.