Patents by Inventor Junhu Zhang
Junhu Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230192720Abstract: The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.Type: ApplicationFiled: August 6, 2020Publication date: June 22, 2023Inventors: Junhu Zhang, Peter Qinhua Huang, Kevin Duane Bunker, Sobhana Babu Boga, Sunny Abraham, Brant Clayton Boren, Wanlong Jiang, Sunil Paliwal
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Publication number: 20220144854Abstract: Disclosed are macrocyclic compounds of formula (I) comprising a 2-carboxy indole ring. Such compounds, and their pharmaceutically acceptable salts, are useful as Mcl-1 (myeloid cell leukemia-1) inhibitors. The compounds may be used in treating a disease or condition, such as cancer.Type: ApplicationFiled: March 6, 2020Publication date: May 12, 2022Inventors: Junhu Zhang, Peter Qinhua Huang, Kevin Duane Bunker, Sobhana Babu Boga, Sunny Abraham, Brant Clayton Boren, Wanlong Jiang, Sunil Paliwal
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Patent number: 11230524Abstract: The present disclosure provides novel compounds capable of functioning as Myocyte Enhancer Factor 2 (MEF2) modulators, as well as compositions, pharmaceutical formulations, methods of synthesis and kits.Type: GrantFiled: August 17, 2018Date of Patent: January 25, 2022Assignee: STANDARD LLCInventor: Junhu Zhang
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Patent number: 10865216Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: GrantFiled: September 11, 2013Date of Patent: December 15, 2020Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Daniel Bensen, Allen Borchardt, Zhiyong Chen, John M. Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Leslie William Tari, Min Teng, Michael Trzoss, Junhu Zhang, Michael E. Jung, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
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Patent number: 10858360Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: GrantFiled: July 7, 2017Date of Patent: December 8, 2020Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Patent number: 10385055Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: GrantFiled: September 10, 2014Date of Patent: August 20, 2019Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: John Finn, Leslie William Tari, Zhiyong Chen, Junhu Zhang, Douglas Phillipson, Suk Joong Lee, Michael Trzoss, Daniel Bensen, Xiaoming Li, Min Teng, Voon Ong, Allen John Borchardt, Thanh To Lam, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
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Publication number: 20190241504Abstract: The present disclosure provides novel compounds capable of functioning as Myoctye Enhancer Factor 2 (MEF2) modulators, as well as compositions, pharmaceutical formulations, methods of synthesis and kits. Also provided are methods of treating a condition regulatable by MEF2 and/or MEF2 cofactors using the compounds, compositions, pharmaceutical formulations, and kits provided herein.Type: ApplicationFiled: August 17, 2018Publication date: August 8, 2019Inventor: Junhu Zhang
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Publication number: 20180362531Abstract: The present disclosure provides novel compounds capable of functioning as inhibitors of the kynurenine pathway and kits.Type: ApplicationFiled: June 18, 2018Publication date: December 20, 2018Inventor: Junhu ZHANG
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Patent number: 10047105Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.Type: GrantFiled: September 16, 2016Date of Patent: August 14, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Christopher J. Creighton, Leslie William Tari, Zhiyong Chen, Mark Hilgers, Thanh To Lam, Xiaoming Li, Michael Trzoss, Junhu Zhang, John Finn, Daniel Bensen
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Publication number: 20170369498Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: July 7, 2017Publication date: December 28, 2017Applicants: Merck Sharp & Dohme Corp., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Patent number: 9732083Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: GrantFiled: March 14, 2012Date of Patent: August 15, 2017Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Patent number: 9634273Abstract: Provided is a method for producing a highly efficient organic/inorganic hybrid solar cell using fully aqueous phase-synthesized semiconductor nanocrystals and conducting polymer. The method mainly includes three steps: synthesizing nanocrystals in an aqueous phase, synthesizing a conjugated polymer precursor in an aqueous phase, and producing a device of solar cell. The nanocrystal material required for producing a solar cell by the method is widely available, diversified and size-controlled, and the used conjugated polymer has regulated molecular structure and molecular weight, which contributes to increase the absorption of sunlight. The processing of cell device can be performed at room temperature in air, and has advantages of no pollution, short processing period, and low cost.Type: GrantFiled: May 13, 2011Date of Patent: April 25, 2017Assignee: JILIN UNIVERSITYInventors: Bai Yang, Weili Yu, Hao Zhang, Junhu Zhang, Haotong Wei, Zhanxi Fan
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Publication number: 20170037059Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.Type: ApplicationFiled: September 16, 2016Publication date: February 9, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Christopher J. Creighton, Leslie William Tari, Zhiyong Chen, Mark Hilgers, Thanh To Lam, Xiaoming Li, Michael Trzoss, Junhu Zhang, John Finn, Daniel Bensen
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Patent number: 9481675Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.Type: GrantFiled: September 10, 2010Date of Patent: November 1, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Christopher J Creighton, Leslie William Tari, Zhiyong Chen, Mark Hilgers, Thanh To Lam, Xiaoming Li, Michael Trzoss, Junhu Zhang, John Finn, Daniel Bensen
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Publication number: 20160222015Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: September 10, 2014Publication date: August 4, 2016Applicants: Merck Sharp & Dohme Corp., Lawrence Livermore National Security, LLCInventors: John Finn, Leslie William Tari, Zhiyong Chen, Junhu Zhang, Douglas Phillipson, Suk Joong Lee, Michael Trzoss, Daniel Bensen, Xiaoming Li, Min Teng, Voon Ong, Allen John Borchardt, Thanh To Lam, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
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Publication number: 20150246934Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: September 11, 2013Publication date: September 3, 2015Inventors: Daniel Bensen, Allen Borchardt, Zhiyong Chen, John M. Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Leslie William Tari, Min Teng, Michael Trzoss, Junhu Zhang, Michael E. Jung, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
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Patent number: 8835445Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.Type: GrantFiled: June 2, 2011Date of Patent: September 16, 2014Assignee: Trius Therapeutics, Inc.Inventors: Zhiyong Chen, Christopher J. Creighton, Mark Cunningham, John Finn, Mark Hilgers, Michael Jung, Lucy Aguirre Kohnen, Thanh Lam, Xiaoming Li, Mark Stidham, Les Tari, Michael Trzoss, Junhu Zhang
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Patent number: 8598184Abstract: The present invention is directed to low molecular weight and orally bioavailable 3H-[1,2,3]triazolo[4,5-d]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the tyrosine kinase MET. The invention is also directed to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.Type: GrantFiled: February 28, 2009Date of Patent: December 3, 2013Assignee: Tiger PharmatechInventor: Junhu Zhang
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Patent number: 8530652Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.Type: GrantFiled: October 6, 2011Date of Patent: September 10, 2013Assignees: Agouron Pharmaceuticals, Inc., Pfizer Inc.Inventors: Junhu Zhang, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
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Publication number: 20130164881Abstract: Provided is a method for producing a highly efficient organic/inorganic hybrid solar cell using fully aqueous phase-synthesized semiconductor nanocrystals and conducting polymer. The method mainly includes three steps: synthesizing nanocrystals in an aqueous phase, synthesizing a conjugated polymer precursor in an aqueous phase, and producing a device of solar cell. The nanocrystal material required for producing a solar cell by the method is widely available, diversified and size-controlled, and the used conjugated polymer has regulated molecular structure and molecular weight, which contributes to increase the absorption of sunlight. The processing of cell device can be performed at room temperature in air, and has advantages of no pollution, short processing period, and low cost.Type: ApplicationFiled: May 13, 2011Publication date: June 27, 2013Applicant: JILIN UNIVERSITYInventors: Bai Yang, Weili Yu, Hao Zhang, Junhu Zhang, Haotong Wei, Zhanxi Fan