Patents by Inventor Junhu Zhang

Junhu Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GYRASE INHIBITORS
    Publication number: 20130079323
    Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 28, 2013
    Applicant: TRIUS THERAPEUTICS, INC.
    Inventors: Christopher J. Creighton, Leslie William Tari, Zhiyong Chen, Mark Hilgers, Thanh To Lam, Xiaoming Li, Michael Trzoss, Junhu Zhang, John Finn, Daniel Bensen
  • PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
    Publication number: 20120264751
    Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Application
    Filed: October 6, 2011
    Publication date: October 18, 2012
    Inventors: Junhu ZHANG, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
  • TRICYCLIC GYRASE INHIBITORS
    Publication number: 20120238751
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Application
    Filed: March 14, 2012
    Publication date: September 20, 2012
    Applicant: TRIUS THERAPEUTICS, INC.
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • DIHYDROFOLATE REDUCTASE INHIBITORS
    Publication number: 20120136014
    Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.
    Type: Application
    Filed: June 2, 2011
    Publication date: May 31, 2012
    Applicant: TRIUS THERAPEUTICS, INC.
    Inventors: Zhiyong Chen, Christopher J. Creghton, Mark Cunningham, John Finn, Mark Hilgers, Michael Jung, Lucy Aguirre Kohnen, Thanh Lam, Xiaoming Li, Mark Stidham, Les Tari, Michael Trzoss, Junhu Zhang
  • Pyrrolopyrazole, potent kinase inhibitors
    Patent number: 8067591
    Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: November 29, 2011
    Assignees: Agouron Pharmaceuticals, Inc., Pfizer Inc.
    Inventors: Junhu Zhang, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
  • Protein Kinase Inhibitors
    Publication number: 20100324074
    Abstract: The present invention is directed to low molecular weight and orally bioavailable 3H-[1,2,3]triazolo[4,5-d]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the tyrosine kinase MET. The invention is also directed to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: February 28, 2009
    Publication date: December 23, 2010
    Inventor: Junhu Zhang
  • PYRROLOPYRAZOLE, POTENT KINASE INHIBITORS
    Publication number: 20100222342
    Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Application
    Filed: December 28, 2005
    Publication date: September 2, 2010
    Inventors: Junhu Zhang, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
  • INHIBITORS OF THE HIV INTEGRASE ENZYME
    Publication number: 20100137283
    Abstract: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
    Type: Application
    Filed: February 1, 2010
    Publication date: June 3, 2010
    Inventors: Klaus Ruprecht Dress, Qiyue Hu, Ted William Johnson, Michael Bruno Plewe, Steven Paul Tanis, Huichun Zhu, Junhu Zhang
  • Inhibitors of the HIV integrase enzyme
    Patent number: 7692014
    Abstract: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: April 6, 2010
    Assignee: Pfizer, Inc.
    Inventors: Klaus Ruprecht Dress, Qiyue Hu, Ted William Johnson, Michael Bruno Plewe, Steven Paul Tanis, Huichun Zhu, Junhu Zhang
  • CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
    Publication number: 20090318440
    Abstract: Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
    Type: Application
    Filed: December 12, 2006
    Publication date: December 24, 2009
    Inventors: Junhu Zhang, Anle Yang, Susan Elizabeth Kephart, Liming Dong, Chuangxing Guo, Yufeng Hong, Mary Catherine Johnson, Indrawan James Mc Alpine, Jayashree Tikhe, Haitao Li
  • Inhibitors of the HIV integrase enzyme
    Patent number: 7468375
    Abstract: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: December 23, 2008
    Assignee: Pfizer Inc.
    Inventors: Klaus Ruprecht Dress, Qiyue Hu, Ted William Johnson, Michael Bruno Plewe, Steven Paul Tanis, Hai Wang, Anle Yang, Chunfeng Yin, Junhu Zhang
  • HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE
    Publication number: 20080221154
    Abstract: Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
    Type: Application
    Filed: March 6, 2008
    Publication date: September 11, 2008
    Inventors: Qiyue HU, Ted William Johnson, Atsuo Kuki, Michael Bruno Plewe, Dawn Marie Nowlin, Hai Wang, Junhu Zhang
  • HIV-Integrase inhibitors, pharmaceutical compositions and methods for their use
    Patent number: 7368571
    Abstract: Bicycling hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: May 6, 2008
    Assignee: Pfizer Inc
    Inventors: Qiyue Hu, Atsuo Kuki, Dawn Marie Nowlin, Michael Bruno Plewe, Hai Wang, Junhu Zhang
  • Inhibitors of the Hiv Integrase Enzyme
    Publication number: 20070232644
    Abstract: The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions comprising compounds of formula (I), and their methods of use in treating HIV-infected mammals.
    Type: Application
    Filed: August 26, 2005
    Publication date: October 4, 2007
    Inventors: Klaus Dress, Jon Kuehler, Michael Plewe, Anle Yang, Junhu Zhang
  • HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE
    Publication number: 20070004768
    Abstract: Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
    Type: Application
    Filed: September 6, 2006
    Publication date: January 4, 2007
    Inventors: Qiyue Hu, Atsuo Kuki, Michael Plewe, Dawn Nowlin, Hai Wang, Junhu Zhang
  • HIV integrase inhibitors, pharmaceutical compositions and methods for their use
    Patent number: 7138408
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: November 21, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Bruno Plewe, Hai Wang, Junhu Zhang
  • HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
    Patent number: 7135482
    Abstract: Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: November 14, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Qiyue Hu, Ted William Johnson, Atsuo Kuki, Michael Bruno Plewe, Dawn Marie Nowlin, Hai Wang, Junhu Zhang
  • HIV integrase inhibitors, pharmaceutical compositions and methods for their use
    Publication number: 20060122211
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Application
    Filed: October 14, 2005
    Publication date: June 8, 2006
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Plewe, Hai Wang, Junhu Zhang
  • HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
    Patent number: 7001912
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: February 21, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Bruno Plewe, Hai Wang, Junhu Zhang
  • Inhibitors of the HIV integrase enzyme
    Publication number: 20050277662
    Abstract: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
    Type: Application
    Filed: April 25, 2005
    Publication date: December 15, 2005
    Inventors: Klaus Dress, Qiyue Hu, Ted Johnson, Michael Plewe, Steven Tanis, Hai Wang, Anle Yang, Chunfeng Yin, Junhu Zhang