Patents by Inventor Junhua Wang

Junhua Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12655921
    Abstract: An explosion-proof spiral exhaust pressure relief device for mine is provided, relating to the technical field of explosion-proof pressure relief devices. A main structure of the explosion-proof spiral exhaust pressure relief device for mine includes an explosion-proof pressure relief housing and a first explosion-proof pressure relief inner core. An exhaust cavity is arranged inside the explosion-proof pressure relief housing in an axial direction. The exhaust cavity is open at one end of the explosion-proof pressure relief housing, and the other end of the explosion-proof pressure relief housing is provided with pressure relief holes communicating with the exhaust cavity. The first explosion-proof pressure relief inner core is arranged in the exhaust cavity. An outer wall of the first explosion-proof pressure relief inner core is provided with at least one explosion-proof spiral pressure relief channel.
    Type: Grant
    Filed: June 29, 2023
    Date of Patent: June 16, 2026
    Inventors: Junhua Wang, Rui Chen, Yandong Hou
  • Patent number: 12636363
    Abstract: Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.
    Type: Grant
    Filed: August 19, 2025
    Date of Patent: May 26, 2026
    Assignee: DENALI THERAPEUTICS INC.
    Inventors: Annie Arguello, Tina Giese, Gunasekaran Kannan, Mihalis S. Kariolis, Cathal S. Mahon, Junhua Wang
  • Publication number: 20260132197
    Abstract: Provided are an antibody or an antigen-binding fragment thereof that specifically recognizes CD47 and methods of making the same and using the same. The antibodies provided herein exhibit both induction of phagocytosis of cancer cells and have very low to no hemagglutination and phagocytosis of RBCs, showing improved efficacy to toxicity ratio for cancer treatment.
    Type: Application
    Filed: October 13, 2023
    Publication date: May 14, 2026
    Inventors: Shuai YANG, Xiaojie TU, Yanmin CHEN, Junhua WANG, Yunxiang WU, Xiaoxiao LIU, Shu WU
  • Publication number: 20260079170
    Abstract: The present disclosure provides methods and materials for screening a compound or monitoring a subject's response to a compound or dosing regimen for treating a PGRN-associated disorder. Methods and materials for identifying and treating a subject having a PGRN-associated disorder are also provided.
    Type: Application
    Filed: September 19, 2025
    Publication date: March 19, 2026
    Applicant: Denali Therapeutics Inc.
    Inventors: Giuseppe Astarita, Sarah L. Devos, Gilbert Di Paolo, Todd P. Logan, Junhua Wang
  • Publication number: 20260061413
    Abstract: Polymers based on poly(aryl alkylene) that are capable of crosslinking in a controlled manner are provided. Crosslinked anion exchange membranes or anion exchange ionomers formed from these polymers not only have superior chemical stability and hydroxide conductivity but also have decreased water uptake and improved mechanical stability.
    Type: Application
    Filed: June 12, 2025
    Publication date: March 5, 2026
    Inventors: Yushan Yan, Lan Wang, Hui Duan, Junhua Wang, Keda Hu
  • Publication number: 20260043727
    Abstract: Disclosed are a friction and wear test system and a friction and wear test method. To reduce the error of measured friction coefficients, the friction and wear test system of the present disclosure includes a rotating shaft, a dynamic specimen mounting structure mounted on the rotating shaft, a first static specimen mounting structure, a first loading module for applying a preset loading force to the first static specimen during the test, and a second static specimen mounting structure arranged directly opposite to the first static specimen mounting structure in the axial direction of the rotating shaft. The second static specimen mounting structure is configured with a second loading module for applying a preset loading force pointing at the dynamic specimen to the second static specimen during the test, so as to at least partially counterbalance the force loaded on the dynamic specimen by the first static specimen during the test.
    Type: Application
    Filed: July 1, 2025
    Publication date: February 12, 2026
    Applicant: HENAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Donglin LI, Fang YANG, Junhua WANG, Jianjun PENG, Shuai WANG, Yu WANG, Xiaoqiang WANG, Jubo LI, Feng ZHAO, Yinshui LIU
  • Publication number: 20260018644
    Abstract: A manifold assembly for a dual-stack fuel cell system includes a first manifold structure for delivering one of an oxidant and a coolant, the first manifold structure including a first branch channel and a first main manifold channel in fluid communication with the first branch channel and extending at least partially superposed over the first branch channel, wherein the first branch channel is open on a side opposite to the first main manifold channel for sealing connection to a surface of a stack end plate, such that one of the oxidant and coolant is guided along the surface of the stack end plate therein.
    Type: Application
    Filed: July 11, 2025
    Publication date: January 15, 2026
    Inventors: Lin Yang, Fengming Dai, Junhua Wang
  • Publication number: 20250387477
    Abstract: Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.
    Type: Application
    Filed: August 19, 2025
    Publication date: December 25, 2025
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Annie ARGUELLO, Tina GIESE, Gunasekaran KANNAN, Mihalis S. KARIOLIS, Cathal S. MAHON, Junhua WANG
  • Publication number: 20250367284
    Abstract: Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.
    Type: Application
    Filed: August 19, 2025
    Publication date: December 4, 2025
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Annie ARGUELLO, Tina GIESE, Gunasekaran KANNAN, Mihalis S. KARIOLIS, Cathal S. MAHON, Junhua WANG
  • Publication number: 20250314330
    Abstract: An explosion-proof spiral exhaust pressure relief device for mine is provided, relating to the technical field of explosion-proof pressure relief devices. A main structure of the explosion-proof spiral exhaust pressure relief device for mine includes an explosion-proof pressure relief housing and a first explosion-proof pressure relief inner core. An exhaust cavity is arranged inside the explosion-proof pressure relief housing in an axial direction. The exhaust cavity is open at one end of the explosion-proof pressure relief housing, and the other end of the explosion-proof pressure relief housing is provided with pressure relief holes communicating with the exhaust cavity. The first explosion-proof pressure relief inner core is arranged in the exhaust cavity. An outer wall of the first explosion-proof pressure relief inner core is provided with at least one explosion-proof spiral pressure relief channel.
    Type: Application
    Filed: June 29, 2023
    Publication date: October 9, 2025
    Applicant: WUJIANG TIANLONG ELECTRONIC MACHINERY EQPT CO., LTD.
    Inventors: Junhua WANG, Rui CHEN, Yandong HOU
  • Patent number: 12272958
    Abstract: The present invention relates to the technical field of power generation of power systems, and in particular to a power supply and energy storage system using carbon as a medium. The power supply and energy storage system generates energy by reacting carbon dioxide and air, collects carbon monoxide by providing a pressurizing apparatus and a gas storage apparatus, and sends the collected carbon monoxide back to an energy supply apparatus during power consumption peaks, thereby balancing power deficits of loads and renewable energy power generation, considering the stability, reliability, and economic efficiency of the power supply and energy storage system, and improving energy utilization efficiency.
    Type: Grant
    Filed: May 9, 2024
    Date of Patent: April 8, 2025
    Assignees: Ningbo Electric Power Design Institute Co. Ltd, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Ningbo Yongyao Power Investment Corporation Co., Ltd
    Inventors: Yan Yao, Wanbing Guan, Zixiang Pei, Junhua Wang, Puyan Wang, Yuzhe Xie, Xuanjun Chen, Yuting Liu, Jun Wu, Wei Xue, Tianchen Fan
  • Publication number: 20250041843
    Abstract: Polymers with piperidinium-functionalized groups are provided. The hydroxide (anion) exchange membranes or hydroxide (anion) exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties upon tuning the polymer structure the combination and ratios of various aromatic and ketone units.
    Type: Application
    Filed: July 25, 2024
    Publication date: February 6, 2025
    Inventors: Yushan Yan, Junhua Wang, Keda Hu, Lan Wang
  • Patent number: 12083456
    Abstract: An apparatus and method for purification and recovery of an organic liquid. The apparatus includes a distillation kettle and a receiver tank connected by a distillation pipe, and a vacuum pump, wherein a vacuum storage tank is arranged between the receiver tank and the vacuum pump; the vacuum storage tank is connected to the receiver tank by a vacuum regulating pipe, a first vacuum regulating valve being arranged on the vacuum regulating pipe; and the vacuum storage tank is connected to the vacuum pump by an evacuation pipe, a second vacuum regulating valve being arranged on the evacuation pipe. By arranging a vacuum storage tank between the receiver tank and the vacuum pump, the vacuum degree in the receiver tank is regulated by the vacuum storage tank, such that the organic liquid is recovered in a sealed environment under reduced pressure.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: September 10, 2024
    Inventors: Junhua Wang, Zhiliang Xu, Mingyuan Hua, Zhenzhong Yan, Tianze Wang
  • Publication number: 20240278227
    Abstract: Alkaline-stable cations were introduced to a polyolefin bearing phenyl side chains to enable manipulation of ion exchange capacity and hot pressing technique. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved device stability as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells and hydroxide exchange membrane electrolyzers comprising the polyolefin with pendant cation provide enhanced performance and durability at relatively high temperatures.
    Type: Application
    Filed: February 7, 2024
    Publication date: August 22, 2024
    Inventors: Yushan Yan, Junhua Wang, Hui Duan, Keda Hu, Lan Wang, Wenjuan Shi
  • Publication number: 20240246070
    Abstract: Poly(aryl alkylene) polymers with pendant piperidinium-functionalized groups are provided which have an alkaline-stable cation, such as imidazolium, introduced into a rigid aromatic polymer backbone free of ether bonds. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells and hydroxide exchange membrane electrolyzers comprising the poly(aryl alkylene) polymers with pendant piperidinium-functionalized groups exhibit enhanced performance and durability at relatively high temperatures.
    Type: Application
    Filed: December 19, 2023
    Publication date: July 25, 2024
    Inventors: Junhua Wang, Keda Hu, Lan Wang, Yushan Yan
  • Publication number: 20240148866
    Abstract: Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 9, 2024
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Annie ARGUELLO, Tina GIESE, Gunasekaran KANNAN, Mihalis S. KARIOLIS, Cathal S. MAHON, Junhua WANG
  • Publication number: 20240131477
    Abstract: Hydroxide-exchange membranes (HEMs) and hydroxide-exchange ionomers (HEIs) are provided which include polymers with oxidation resistant groups. The attachment of the oxidation resistant groups to the polymer backbone allows fine-tuning of the mechanical properties of the membrane and incorporation of alkaline stable cations, such as imidazoliums, phosphoniums and ammoniums, and provides enhanced stability to the polymer. HEMs/HEIs formed from these polymers exhibit superior chemical stability, anion conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional HEM/HEIs. The HEMs exhibit enhanced stability in a highly oxidative environment.
    Type: Application
    Filed: February 4, 2022
    Publication date: April 25, 2024
    Inventors: Yushan Yan, Keda Hu, Lan Wang, Brian Setzler, Wenjuan Shi, Junhua Wang
  • Patent number: 11951350
    Abstract: An upper limb rehabilitation training system in two-person standing type and an application method thereof are provided. The upper limb rehabilitation training system includes an upper limb rehabilitation training platform, two weight-reducing suspending support structures arranged oppositely, and two standing frames arranged oppositely; the upper limb rehabilitation training platform includes an all-in-one computer which includes a computer and a touch display screen, and a periphery of the touch display screen is provided with a grating structure; the upper limb rehabilitation training platform is provided with a two-person interactive upper limb training module including two control handles, a virtual training prop and a virtual training scene. The two control handles are suspended from the two weight-reducing suspending support structures, respectively; the grating structure is configured to identify the control handles and positions thereof.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: April 9, 2024
    Assignee: GUANGZHOU XIAOKANG MEDICAL TECHNOLOGY CO., LTD
    Inventors: Junhua Wang, Zhaokun Wang
  • Patent number: 11944599
    Abstract: A method of extracting myricetin from Xanthoceras sorbifolia Bunge is provided. The method includes: step 1, baking obtaining Xanthoceras sorbifolia Bunge crude powder; step 2, mixing the crude powder with a counter-current extraction solution to perform a counter-current extraction to obtain a filtrate and a filter residue; step 3, mixing the filter residue with a solvent to obtain a first mixture, and heating the first mixture to reflux for extraction to obtain an extraction liquid; step 4, mixing the extraction liquid and the filtrate, and concentrating under reduced pressure to obtain a concentrated solution; and step 5, separating and eluting the concentrated solution to obtain an eluent, then drying the eluent to obtain the myricetin.
    Type: Grant
    Filed: September 29, 2023
    Date of Patent: April 2, 2024
    Assignee: HEBEI RUILONG BIOTECHNOLOGY CO., LTD
    Inventors: Weijia Li, Jingmei Zheng, Jingyi Yan, Junhua Wang
  • Publication number: 20240075008
    Abstract: The disclosure relates to the technical field of extraction of an active ingredient from traditional Chinese medicine, and provides a method of extracting myricetin from Xanthoceras sorbifolia Bunge.
    Type: Application
    Filed: September 29, 2023
    Publication date: March 7, 2024
    Applicant: HEBEI RUILONG BIOTECHNOLOGY CO., LTD
    Inventors: Weijia LI, Jingmei ZHENG, Jingyi YAN, Junhua WANG