Abstract: [Problem to be Solved ] Provided is a nucleic acid complex, preferably a double-stranded nucleic acid complex, having an excellent effect of suppressing the expression of a target gene. [Solution] The problem is solved by using a nucleic acid complex, preferably a double-stranded nucleic acid complex, comprising an active moiety comprising an antisense nucleic acid complementary to a transcript, for example, a transcript of a target gene, and a carrier moiety comprising a nucleic acid complementary to the nucleic acid, and having at least one bulge structure.

Abstract: Provided is a nucleic acid complex, preferably a double-stranded nucleic acid complex, having an excellent effect of suppressing the expression of a target gene. Further provided is a nucleic acid complex, that is, a double-stranded nucleic acid complex, comprising an active moiety comprising an antisense nucleic acid complementary to a transcript, for example, a transcript of a target gene, and a carrier moiety comprising a nucleic acid comprising DNA, preferably a DNA-based nucleic acid, which is complementary to the above-described nucleic acid.

Abstract: A silencer for a leaf spring assembly. The silencer is disposed between end portions of leaf springs. The silencer has a two-layer structure which has a fixing layer and a sliding layer which are integrally formed. The fixing layer has a projection portion, and the projection portion has an engagement portion at a leading end portion thereof. The fixing layer, which is fixed at the fixing side leaf spring, has a tensile strength higher than the sliding layer. The sliding layer, which abuts the sliding side leaf spring, has a hardness lower than the fixing layer. The projection portion of the fixing layer can have sufficient strength to resist the shearing force. In the sliding layer, undesirable noise generation is difficult, and even when a load transmission portion of an end portion of the sliding side leaf spring partially abuts the sliding layer, undesirable noise generation can be prevented.

Abstract: A silencer for a leaf spring assembly. The silencer is disposed between end portions of leaf springs. The silencer has a two-layer structure which has a fixing layer and a sliding layer which are integrally formed. The fixing layer has a projection portion, and the projection portion has an engagement portion at a leading end portion thereof. The fixing layer, which is fixed at the fixing side leaf spring, has a tensile strength higher than the sliding layer. The sliding layer, which abuts the sliding side leaf spring, has a hardness lower than the fixing layer. The projection portion of the fixing layer can have sufficient strength to resist the shearing force. In the sliding layer, undesirable noise generation is difficult, and even when a load transmission portion of an end portion of the sliding side leaf spring partially abuts the sliding layer, undesirable noise generation can be prevented.

Abstract: A semiconductor integrated circuit includes a first transistor which is formed of a first gate extending in a first direction and a first diffusion region and which is capable of being active, a second transistor which is formed of a second gate extending in the first direction and a second diffusion region and which is arranged adjacent to the first transistor in a second direction intersected at a right angle with the first direction, and a third gate which extends in the first direction and which is arranged adjacent in the second direction to the first transistor on an opposite side to the second transistor. A space between the first gate and the second gate is larger than a space between the first gate and the third gate.

Abstract: There is provided an electrode structure for a polymer electrolyte fuel cell having excellent power generation performance and excellent durability and a method for manufacturing the same. Also provided is a polymer electrolyte fuel cell including the electrode structure and an electrical apparatus and a transport apparatus using the polymer electrolyte fuel cell. The electrode structure includes a polymer electrolyte membrane 2 sandwiched between a pair of electrode catalyst layers 1, 1 containing carbon particles supporting catalyst particles. The polymer electrolyte membrane 2 is made of a sulfonated polyarylene-based polymer. The sulfonated polyarylene-based polymer has an ion exchange capacity in the range of 1.7 to 2.3 meq/g, and the polymer contains a component insoluble in N-methylpyrrolidone in an amount of 70% or less relative to the total amount of the polymer, after the polymer is subjected to heat treatment for exposing it under a constant temperature atmosphere of 12° C. for 200 hours.

Abstract: In the present invention, a decoupling capacitance circuit, a first output terminal and a second output terminal are provided. The decoupling capacitance circuit comprises a TDDB control circuit consisting of a first Tr and a second Tr, and a third Tr. Conductivity types of the first and second Trs are different from each other. A source of the first Tr is connected to a first power supply wiring, and a drain of the first Tr is connected to a gate of the second Tr. A source of the second Tr is connected to a second power supply wiring, and a drain of the second Tr is connected to a gate of the first Tr. The third and first Trs have the same conductivity type. A source and a drain of the third Tr are connected to the first power supply wiring, and a gate of the third Tr is connected to the drain of the second Tr. The first output terminal is connected to the drain of the first Tr, and the second output terminal is connected to the drain of the second Tr.

Abstract: In the present invention, a decoupling capacitance circuit, a first output terminal and a second output terminal are provided. The decoupling capacitance circuit comprises a TDDB control circuit consisting of a first Tr and a second Tr, and a third Tr. Conductivity types of the first and second Trs are different from each other. A source of the first Tr is connected to a first power supply wiring, and a drain of the first Tr is connected to a gate of the second Tr. A source of the second Tr is connected to a second power supply wiring, and a drain of the second Tr is connected to a gate of the first Tr. The third and first Trs have the same conductivity type. A source and a drain of the third Tr are connected to the first power supply wiring, and a gate of the third Tr is connected to the drain of the second Tr. The first output terminal is connected to the drain of the first Tr, and the second output terminal is connected to the drain of the second Tr.

Abstract: In the present invention, a decoupling capacitance circuit, a first output terminal and a second output terminal are provided. The decoupling capacitance circuit comprises a TDDB control circuit consisting of a first Tr and a second Tr, and a third Tr. Conductivity types of the first and second Trs are different from each other. A source of the first Tr is connected to a first power supply wiring, and a drain of the first Tr is connected to a gate of the second Tr. A source of the second Tr is connected to a second power supply wiring, and a drain of the second Tr is connected to a gate of the first Tr. The third and first Trs have the same conductivity type. A source and a drain of the third Tr are connected to the first power supply wiring, and a gate of the third Tr is connected to the drain of the second Tr. The first output terminal is connected to the drain of the first Tr, and the second output terminal is connected to the drain of the second Tr.

Abstract: A semiconductor integrated circuit includes a first transistor which is formed of a first gate extending in a first direction and a first diffusion region and which is capable of being active, a second transistor which is formed of a second gate extending in the first direction and a second diffusion region and which is arranged adjacent to the first transistor in a second direction intersected at a right angle with the first direction, and a third gate which extends in the first direction and which is arranged adjacent in the second direction to the first transistor on an opposite side to the second transistor. A space between the first gate and the second gate is larger than a space between the first gate and the third gate.

Abstract: A semiconductor integrated circuit includes a first transistor which is formed of a first gate extending in a first direction and a first diffusion region and which is capable of being active, a second transistor which is formed of a second gate extending in the first direction and a second diffusion region and which is arranged adjacent to the first transistor in a second direction intersected at a right angle with the first direction, and a third gate which extends in the first direction and which is arranged adjacent in the second direction to the first transistor on an opposite side to the second transistor. A space between the first gate and the second gate is larger than a space between the first gate and the third gate.

Abstract: In a standard cell, at least one of transistors on either side of a transistor having gate length different from that of the other transistors are set to be always in the OFF state. This prevents influence to the operation of the standard cell even with variation in final gate dimension, suppressing variation in characteristics of the standard cell.

Abstract: The present invention provides a complex, which comprises a cationic liposome comprising 2-O-(2-diethylaminoethyl)carbamoyl-1,3-O-dioleoylglycerol and a phospholipid as main ingredients, and an oligo nucleic acid which is carried on the liposome. Also, the present invention provides a pharmaceutical composition containing the complex to be used for treating or preventing diseases caused by a target molecule of the oligo nucleic acid (target DNA, target RNA, target protein) since it is possible to administer the complex in vivo and to put the complex into practical use as a medicament because the complex can exhibit pharmacological efficacy in vivo.

Abstract: A membrane electrode assembly includes an anode, a cathode, and a solid polymer electrolyte membrane interposed between the anode and the cathode. The anode and the cathode include gas diffusion layers and electrode catalyst layers. Mixture layers are provided over predetermined areas H around surfaces of the electrode catalyst layers. The electrode catalyst layers and adhesive layers are mixed in the mixture layers, respectively.

Abstract: [The problems] In a semiconductor integrated circuit in which tilted wiring is used, the tilted wiring cannot be used effectively since the arrangement of blocks is restricted. [Means for solving] In the semiconductor integrated circuit consisting of at least a first block, a second block and a third block, the third block B5 is diagonally arranged between the first bock B1 and the second block B2 at a predetermined angle of approximately 45 degrees to the both blocks, the first block B1 includes at least a first output P1, the second block B2 includes at least a first input pin P2, the third block B5 includes at least a second input pin Q1 and a second output pin Q2, the first output pin P1 and the second input pin Q1 are connected by a first wiring L1, and the second output pin Q2 and the first input pin P2 are connected by a second wiring L2. Herewith, the degree of integration can be increased and the tilted wiring can be effectively used.

Abstract: The invention provides a manufacturing process for MEA that enables sufficient bond strength among an electrolyte membrane and electrode substrates even when the electrolyte membrane comprises a heat-resistant material such as an aromatic polymer. The process comprises pressure bonding an electrolyte membrane with catalyzed electrode substrates to form a membrane-electrode assembly, wherein a good solvent for the electrolyte membrane is applied to at least one of facing surfaces of the opposed electrode substrate and the electrolyte membrane prior to the pressure bonding. The electrolyte membrane may comprise a sulfonated aromatic polymer. The good solvent for the electrolyte membrane may be an aprotic dipolar solvent.

Abstract: The present invention relates to oligo double-stranded RNAs for use in knockdown of the expression of Bcl-2 protein known as a suppressor for apoptosis, and pharmaceutical compositions containing them. It is known that Bcl-2 protein is over-expressed in diseases such as cancer, and by this over-expression, the growth of cancer cells is continued and the drug resistance to anti-cancer agents is caused. The present invention provides highly active oligo double-stranded RNAs cleaving bcl-2 mRNA and further provides pharmaceutical compositions comprising a complex of the oligo double-stranded RNA and a suitable carrier for inhibiting the expression of Bcl-2 protein.

Abstract: A membrane-electrode structure having an electrode catalyst layer adhered to a diffusion electrode, wherein the structure is manufactured by applying a catalyst paste onto a sheet substrate, and then dried to form a plurality of electrode catalyst layers. The electrode catalyst layers are thermally transferred onto each side of a polymer electrolyte membrane to form a laminated body. A first slurry is applied on a carbon substrate layer, and dried to form a water-repellent layer, and then, a second slurry is applied on the water-repellent layer, and dried to form a hydrophilic layer to form a diffusion electrode. The diffusion electrode is then laminated on the electrode catalyst layer through the hydrophilic layer, and then pressed under heating to integrate the laminated body and the diffusion electrode.

Abstract: Leaf springs have improved durability in spite of using inexpensive spring steel such as SUP9 and SUP11 as materials. While a spring main body, made of the spring steel in which Brinell hardness is under 555 HBW and not less than 388 HBW (corresponding to a diameter of under 2.70 mm of hardness and not less than 3.10mm of hardness on a Brinell ball mark), is maintained at 150 to 400° C., the load is applied in the direction in which the spring main body is to be used, and the first shotpeening is performed at the plane where the tensile stress acts.

Abstract: In the present invention, a decoupling capacitance circuit, a first output terminal and a second output terminal are provided. The decoupling capacitance circuit comprises a TDDB control circuit consisting of a first Tr and a second Tr, and a third Tr. Conductivity types of the first and second Trs are different from each other. A source of the first Tr is connected to a first power supply wiring, and a drain of the first Tr is connected to a gate of the second Tr. A source of the second Tr is connected to a second power supply wiring, and a drain of the second Tr is connected to a gate of the first Tr. The third and first Trs have the same conductivity type. A source and a drain of the third Tr are connected to the first power supply wiring, and a gate of the third Tr is connected to the drain of the second Tr. The first output terminal is connected to the drain of the first Tr, and the second output terminal is connected to the drain of the second Tr.