Patents by Inventor Junji Hamuro

Junji Hamuro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human IL-2 receptor .gamma. chain molecule
    Patent number: 5510259
    Abstract: The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: April 23, 1996
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Kazuo Sugamura, Toshikazu Takeshita, Hironobu Asao, Masataka Nakamura, Toshiro Shimamura, Manabu Suzuki, Junji Hamuro
  • Ligand for the neu gene product
    Patent number: 5464751
    Abstract: A purified proteinaceous substance bindable with p185, the translation product of the neu oncogene is disclosed. The purified proteinaceous substance may be characterized in that it increases the activity of the tyrosine kinase contained in the neu oncogene product but does not increase the activity of tyrosine kinase of epidermal growth factor receptor; induces p185 dimerization and internalization; affects the growth of cells which express p185 in a dose dependent manner; is heat stable from about 56.degree. C. to about 100.degree. C.; is degradable by protease; and has a molecular weight of from about 7,000 to about 14,000 daltons in its smallest active form as determined by gel filtration and ultrafiltration membrane analysis. Methods of detecting p185 on the surfaces of tumor cells are also disclosed.
    Type: Grant
    Filed: September 24, 1992
    Date of Patent: November 7, 1995
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Kunio Dobashi, James G. Davis, Junji Hamuro
  • Interleukin-2 polypeptides
    Patent number: 5399669
    Abstract: Recombinantly produced interleukin-2 exhibits human IL-2 activity, has a molecular weight of about 15,000 daltons, is activity stable at a pH of 2-9 and is resistant to elevated temperatures. The recombinant IL-2 has the principal biological activity of human IL-2, promotion of proliferation of cytotoxic T lymphocytes.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: March 21, 1995
    Assignees: Ajinomoto Co., Inc., Japanese Foundation For Cancer Research
    Inventors: Tadatsugu Taniguchi, Masami Muramatsu, Haruo Sugano, Hiroshi Matsui, Nobukazu Kashima, Junji Hamuro
  • Immunoprophylactic and immunotherapeutic agents
    Patent number: 4789658
    Abstract: An immunopropylactic and immunotherapeutic agent comprising human interleukin 2 of human cellular origin is disclosed along with a method of producing the agent.
    Type: Grant
    Filed: June 9, 1986
    Date of Patent: December 6, 1988
    Assignee: Ajinomoto Company, Incorporated
    Inventors: Ryota Yoshimoto, Nobukazu Kashima, Junji Hamuro, Koji Mitsugi
  • Hybridomas and monoclonal antibodies to human IL-2
    Patent number: 4772572
    Abstract: Certain hybridomas preparing monoclonal antibodies to human interleukin-2 (IL-2) which do not cross react with rator mouse IL-2 are disclosed. The secreted monoclonal antibody can be used in immunoassays for human IL-2.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: September 20, 1988
    Assignee: Ajinomoto Co., Inc.
    Inventors: Ryota Yoshimoto, Yoshiaki Hanzawa, Junji Hamuro
  • Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell
    Patent number: 4738927
    Abstract: A gene coded for a polypeptide which possesses interleukin-2 activity is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.
    Type: Grant
    Filed: February 3, 1983
    Date of Patent: April 19, 1988
    Assignee: Ajinomoto Co. Inc.
    Inventors: Tadatsugu Taniguchi, Masami Muramatsu, Haruo Sugano, Hiroshi Matsui, Nobukazu Kashima, Junji Hamuro
  • Stable aqueous solutions of glucans and glucan derivatives capable of inhibiting sarcoma in mice
    Patent number: 4207312
    Abstract: The glucans and glucan derivatives which inhibit the growth of sarcoma 180 in mice are only sparingly soluble in water, and their aqueous solutions are unstable. In the presence of 0.1 to 1.0 g/dl water soluble dextran, hydroxyethyl starch, carboxymethyl cellulose, or polyethylene glycol, they form relatively concentrated and stable solutions, particularly in the presence of hexoses, pentoses or sugar alcohols having 5 or 6 carbon atoms.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: June 10, 1980
    Assignees: Ajinomoto Co. Ltd., Morishita Pharmaceuticals Co. Ltd.
    Inventors: Mitsuharu Fujii, Tatsuo Kuoka, Tatsuo Setsuta, Yutaka Iwao, Yasumi Yugari, Tsuyoshi Shiio, Takashi Yoshihama, Junji Hamuro
  • Sulfates of hydroxyethyl starch
    Patent number: 3951949
    Abstract: Sulfates of hydroxyethyl starch are useful as anti-inflammatory, anti-lipaemic, anti-arteriosclerosis, anti-ulcer or hypocholesterolic agents. They are manufactured by sulfation of hydroxyethyl starch.
    Type: Grant
    Filed: July 3, 1974
    Date of Patent: April 20, 1976
    Assignee: Ajinomoto Co., Inc.
    Inventors: Junji Hamuro, Yayoi Yoshinari