Patents by Inventor Junjian Liu

Junjian Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL INTERLEUKIN-2 AND USE THEREOF
    Publication number: 20210213102
    Abstract: The present invention relates to a novel interleukin-2 (IL-2) mutant protein. The present invention further provides a fusion protein and an immunoconjugate comprising the IL-2 mutant protein, a nucleic acid encoding the IL-2 mutant protein, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-2 mutant protein, a pharmaceutical composition comprising the IL-2 mutant protein, and therapeutic use of the mutant protein.
    Type: Application
    Filed: September 20, 2019
    Publication date: July 15, 2021
    Inventors: Lishan KANG, Fenggen FU, Shuaixiang ZHOU, Xinzhen SHI, Junjian LIU
  • Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
    Patent number: 11026975
    Abstract: The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: June 8, 2021
    Assignees: Nanjing IASO Biotherapeutics Co., Ltd., Innovent Biologics (Suzhou) Co., Ltd.
    Inventors: Jianfeng Zhou, Junjian Liu, Guang Hu, Yongkun Yang, Guangrong Meng, Wenjing Gao, Yuyu Wang, Panpan Niu
  • ANTI-IL-23P19 ANTIBODY AND USE THEREOF
    Publication number: 20210115130
    Abstract: The present invention relates to a novel antibody and an antibody fragment thereof that specifically bind to IL-23p19 and a composition comprising the antibody or the antibody fragment thereof. In addition, the present invention relates to a nucleic acid encoding the antibody or the antibody fragment thereof, a host cell comprising the nucleic acid, and related use. Furthermore, the present invention relates to therapeutic and diagnostic use of the antibody and the antibody fragment.
    Type: Application
    Filed: November 27, 2019
    Publication date: April 22, 2021
    Inventors: Junjian LIU, Min WU, Li LI, Shuaixiang ZHOU, Enkun ZHOU
  • ANTI-TIGIT ANTIBODY AND USE THEREOF
    Publication number: 20210040201
    Abstract: The present invention relates to a novel antibody and an antibody fragment thereof that specifically bind to TIGIT and a composition comprising the antibody or the antibody fragment. In addition, the present invention relates to a nucleic acid encoding the antibody or the antibody fragment thereof, a host cell comprising the nucleic acid, and related use. Furthermore, the present invention relates to therapeutic and diagnostic use of the antibody and the antibody fragment.
    Type: Application
    Filed: July 25, 2019
    Publication date: February 11, 2021
    Inventors: Xinzhen SHI, Pan ZHANG, Junjian LIU
  • CHIMERIC ANTIGEN RECEPTOR (CAR) BINDING TO BCMA, AND USES THEREOF
    Publication number: 20200376030
    Abstract: The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
    Type: Application
    Filed: January 31, 2019
    Publication date: December 3, 2020
    Inventors: Jianfeng ZHOU, Junjian LIU, Guang HU, Yongkun YANG, Guangrong MENG, Wenjing GAO, Yuyu WANG, Panpan NIU
  • ANTI-CD47 ANTIBODY AND USE THEREOF
    Publication number: 20200377593
    Abstract: The present invention relates to novel antibodies and antibody fragments thereof that specifically bind to integrin-associated proteins (IAP, or CD47), and a composition comprising the antibodies or the antibody fragments. The present invention also relates to a nucleic acid encoding the antibodies or the antibody fragments thereof, a host cell comprising the nucleic acid, and related use. Furthermore, the present invention also relates to therapeutic and diagnostic use of the antibodies and the antibody fragments.
    Type: Application
    Filed: March 26, 2019
    Publication date: December 3, 2020
    Inventors: Dandan LIU, Weifeng HUANG, Bingliang CHEN, Junjian LIU
  • ANTI-PD-L1 ANTIBODY AND USES THEREOF
    Publication number: 20200332009
    Abstract: The invention relates to a novel antibody and an antibody fragment that specifically bind to PD-L1 and a composition comprising the antibody or the antibody fragment. In addition, the invention relates to a nucleic acid encoding the antibody or the antibody fragment thereof, a host cell comprising the nucleic acid, and a related use. Furthermore, the invention relates to a therapeutic and diagnostic use of these antibodies and antibody fragments. Particularly, the invention relates to a combined treatment of these antibodies and antibody fragments with other therapies.
    Type: Application
    Filed: December 27, 2018
    Publication date: October 22, 2020
    Inventors: Xiaoniu Miao, Huajing Hu, Junjian Liu, Bingliang Chen, Li Li
  • CHIMERIC ANTIGEN RECEPTOR (CAR) BINDING TO BCMA, AND USES THEREOF
    Publication number: 20200246381
    Abstract: The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a costimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 6, 2020
    Inventors: Jianfeng ZHOU, Junjian LIU, Guang HU, Yongkun YANG, Guangrong MENG, Wenjing GAO, Yuyu WANG, Panpan NIU
  • ANTI-CD47 ANTIBODIES AND USES THEREOF
    Publication number: 20200181259
    Abstract: The present invention is directed to a novel antibody against CD47 and the antibody fragments thereof and a composition comprising the antibody or antibody fragments thereof. The present invention relates further to a nucleic acid encoding the antibodies or antibody fragments thereof and host cells comprise the same, as well as the relevant use of the same. In addition, the present invention is also directed to the use of these antibodies and antibody fragments in the therapy and diagnosis.
    Type: Application
    Filed: August 28, 2018
    Publication date: June 11, 2020
    Inventors: Andy TSUN, Dandan LIU, Bingliang CHEN, Junjian LIU
  • ANTI-OX40 ANTIBODY AND USE THEREOF
    Publication number: 20200140562
    Abstract: The present invention relates to a novel antibody and antibody fragment that specifically binds to OX40 and to a composition comprising said antibody or antibody fragment thereof. In addition, the present invention relates to a nucleic acid encoding the antibody or antibody fragment thereof and a host cell comprising the same, and to a related use thereof. In addition, the present invention relates to the use of the antibody and antibody fragment for treatment and diagnosis.
    Type: Application
    Filed: March 23, 2018
    Publication date: May 7, 2020
    Inventors: Andy Tsun, Hemanta Baruah, Xiaolin Liu, Cheng Chen, Junjian Liu, Bingliang Chen, Weifeng Huang
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20170226200
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: September 20, 2016
    Publication date: August 10, 2017
    Inventors: Tariq GHAYUR, Junjian Liu, Peter C. Isakson
  • Methods of selecting biologic-producing cell lines by next generation sequencing
    Patent number: 9506053
    Abstract: An optimized multi-step cell line screening method based on next generation sequencing (NGS) and mass spec (MS) is disclosed. The method helps reduce variants in the biologic-producing cell line and improve the efficiency of cell line development process.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: November 29, 2016
    Assignee: AbbVie Inc.
    Inventors: Junjian Liu, Dean Regier, Sheng Zhang, Gerald Carson, David Ouellette
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 9493560
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: November 15, 2016
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Junjian Liu, Peter C. Isakson
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20160319026
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 5, 2016
    Publication date: November 3, 2016
    Inventors: Tariq Ghayur, Junjian Liu, Gillian A. Kingsbury, Edward B. Reilly, Susan E. Morgan-Lappe, Jijie Gu
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20160046730
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: July 29, 2015
    Publication date: February 18, 2016
    Inventors: Tariq Ghayur, Junjian Liu
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 9029508
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: May 12, 2015
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Susan E. Morgan-Lappe, Edward B. Reilly, Gillian A. Kingsbury, Andrew Phillips, Jieyi Wang, Randy L. Bell, Suzanne M. Norvell, Yingchun Li, Junjian Liu, Hua Ying
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20150104452
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: June 10, 2014
    Publication date: April 16, 2015
    Inventors: Tariq Ghayur, Edward B. Reilly, Andrew Phillips, Randy L. Bell, Yingchun Li, Hua Ying, Susan E. Morgan-Lappe, Gillian A. Kingsbury, Jieyi Wang, Suzanne M. Norvell, Junjian Liu
  • METHODS OF SELECTING BIOLOGIC-PRODUCING CELL LINES BY NEXT GENERATION SEQUENCING
    Publication number: 20150038337
    Abstract: An optimized multi-step cell line screening method based on next generation sequencing (NGS) and mass spec (MS) is disclosed. The method helps reduce variants in the biologic-producing cell line and improve the efficiency of cell line development process.
    Type: Application
    Filed: July 30, 2014
    Publication date: February 5, 2015
    Inventors: Junjian Liu, Dean Regier, Sheng Zhang, Gerald Carson, David Ouellette
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20150017168
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 15, 2015
    Applicant: ABBVIE INC.
    Inventors: Tariq Ghayur, Junjian Liu, Gillian A. Kingsbury, Edward B. Reilly, Susan E. Morgan-Lappe
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140308286
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: March 19, 2014
    Publication date: October 16, 2014
    Applicant: AbbVie Inc.
    Inventors: Tariq Ghayur, Jochen G. Salfeld, Michael J. McPherson, Maria C. Harris, Junjian Liu, Peter C. Isakson, Jijie Gu