Patents by Inventor Junjian Liu

Junjian Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140234208
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 21, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140220019
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140219912
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • PROSTAGLANDIN E2 BINDING PROTEINS AND USES THEREOF
    Publication number: 20140186377
    Abstract: The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
    Type: Application
    Filed: November 26, 2013
    Publication date: July 3, 2014
    Applicant: AbbVie, Inc.
    Inventors: Jijie Gu, Charles W. Hutchins, Rong-Rong Zhu, Jianwei Shen, Maria C. Harris, Eileen Belanger, Tariq Ghayur, Paul R. Hinton, Veronica M. Juan, John Mankovich, Junjian Liu
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 8735546
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: May 27, 2014
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Junjian Liu, Peter C. Isakson
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20140134171
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: October 17, 2013
    Publication date: May 15, 2014
    Applicant: ABBVIE INC.
    Inventors: Tariq Ghayur, Junjian Liu, Sharmila Manoj, Susan E. Brophy
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 8722855
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: May 13, 2014
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Jochen G. Salfeld, Michael J. McPherson, Maria C. Harris, Junjian Liu, Peter C. Isakson, Jijie Gu
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 8586714
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: November 19, 2013
    Assignee: ABBVIE, Inc.
    Inventors: Tariq Ghayur, Junjian Liu, Sharmila Manoj, Susan E. Brophy
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20130171059
    Abstract: Multivalent and multispecific binding proteins, methods of making, and their uses in the diagnosis, prevention, and/or treatment diseases are provided.
    Type: Application
    Filed: December 28, 2012
    Publication date: July 4, 2013
    Applicant: AbbVie Inc.
    Inventors: Tariq GHAYUR, Junjian Liu
  • Use of ursolic acid saponin,oleanolic acid saponin in preparation of increasing leucocytes and/or platelet medicine
    Patent number: 8394776
    Abstract: The invention provides the use of ursolic acid saponin and oleanolic acid saponin of formula (I) in preparing medicaments for increasing leucocytes and/or platelets. The invention also provides a pharmaceutical composition containing the same compound. The invention utilizes the cheap and accessible ursolic acid and oleanolic acid which are widely present in natural plants as raw materials, introduces monosaccharyls or oligosaccharyls by structural modification. It is proved by pharmacological tests that the compound of formula (I) have an activity of obviously increasing leucocytes and/or platelets.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: March 12, 2013
    Assignee: Chengdu Di'Ao Jiuhong Pharmaceutical Factor
    Inventors: Bing Guang, Junjian Liu, Guangxin Dong, Xiangyang Peng, Xiaoxia Gong, Zhen Huang, Meirong Zhou, Wei Zhan, Jufang Yan, Yu Huang, Dongguang Qin, Jianxin Ji, Bogang Li
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20120263722
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: November 3, 2011
    Publication date: October 18, 2012
    Inventors: Tariq Ghayur, Junjian Liu, Peter C. Isakson
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20120258108
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: November 1, 2011
    Publication date: October 11, 2012
    Inventors: Tariq Ghayur, Junjian Liu, Jijie Gu, Maria C. Harris
  • HALF IMMUNOGLOBULIN BINDING PROTEINS AND USES THEREOF
    Publication number: 20120201746
    Abstract: The invention provides compositions, methods, and kits related to half-Ig binding proteins that include a functional antibody binding site and a CH3 domain wherein the CH3 domain includes at least one mutation to inhibit CH3-CH3 dimerization.
    Type: Application
    Filed: December 21, 2011
    Publication date: August 9, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: JUNJIAN LIU, JIJIE GU, TARIQ GHAYUR, CHARLES W. HUTCHINS
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20120034160
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: August 2, 2011
    Publication date: February 9, 2012
    Inventors: Tariq Ghayur, Junjian Liu, Peter C. Isakson
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20120014957
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: July 8, 2011
    Publication date: January 19, 2012
    Inventors: Tariq Ghayur, Junjian Liu
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20110318349
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: June 23, 2011
    Publication date: December 29, 2011
    Inventors: Tariq Ghayur, Junjian Liu, James P. Jakway, Robert V. Talanian, Lorenzo Benatuil
  • Dual Variable Domain Immunnoglobulins and Uses Thereof
    Publication number: 20110263827
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 30, 2010
    Publication date: October 27, 2011
    Applicant: Abbott Laboratories
    Inventors: Tariq Ghayur, Junjian Liu, Gillian A. Kingsbury, Edward B. Reilly, Susan E. Morgan-lappe
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20110212094
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: October 28, 2010
    Publication date: September 1, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Jochen G. Salfeld, Michael J. McPherson, Maria C. Harris, Junjian Liu, Peter C. Isakson, Jijie Gu
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110091372
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: September 1, 2010
    Publication date: April 21, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Sharmila Manoj, Susan E. Brophy
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110044980
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: July 29, 2010
    Publication date: February 24, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Alexander Ibraghimov