Patents by Inventor Junzo Tanaka

Junzo Tanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9315562
    Abstract: The object of the present invention is to provide a collagen fiber membrane, which has sufficient strength and can be used as a cell culture substrate, a scaffold material for regenerative medicine (for example, material for tissue engineering of cartilage, bone, ligament, corneal stroma, skin, or liver), an implantation material (for example, wound dressing material, bone grafting material, hemostatic material, anti-adhesive material) or a carrier for drug delivery. The object of the present invention can be solved by a fish-derived collagen fiber membrane, characterized in that (1) a tensile strength is 30 MPa or more, (2) a density determined by the gravimetric method, is 0.4 g/cm3 or more, and (3) an average membrane thickness is 1 ?m to 2 mm, and a variation in membrane thickness is plus or minus 30%, relative to the average membrane thickness.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: April 19, 2016
    Assignee: Tokyo Institute of Technology
    Inventors: Junzo Tanaka, Toshiyuki Ikoma, Tomohiko Yoshioka
  • Publication number: 20150359635
    Abstract: The invention provides a medical device in which a metallic porous body is joined to at least a part of a surface of the main body of a medical device, and a surface modification method for the medical device. The metallic porous body is formed in multilayers.
    Type: Application
    Filed: August 11, 2015
    Publication date: December 17, 2015
    Applicant: MITSUBISHI MATERIALS CORPORATION
    Inventors: Koichi KITA, Komei KATO, Akiko YAMAMOTO, Junzo TANAKA
  • Patent number: 9138301
    Abstract: The invention provides a medical device in which a metallic porous body is joined to at least a part of a surface of the main body of a medical device, and a surface modification method for the medical device. The metallic porous body is formed in multilayers.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: September 22, 2015
    Assignee: MITSUBISHI MATERIALS CORPORATION
    Inventors: Koichi Kita, Komei Kato, Akiko Yamamoto, Junzo Tanaka
  • Patent number: 9119903
    Abstract: The object of the present invention is to provide a calcium phosphate-collagen fiber composite which has an excellent mechanical property, can induce bone replacement by rapid bone remodeling, and can be used in a high-load region. The object can be solved by a porous composite comprising a calcium phosphate crystal and a collagen fiber at a weight ratio of 80:20 to 20:80, wherein (1) a bioabsorbability of the porous composite is graded, and (2) the density of the porous composite determined by gravimetric method is 300 to 1500 mg/cm3.
    Type: Grant
    Filed: July 4, 2012
    Date of Patent: September 1, 2015
    Assignee: TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Junzo Tanaka, Toshiyuki Ikoma, Tomohiko Yoshioka, Takashi Yoshida
  • Publication number: 20140142717
    Abstract: The object of the present invention is to provide a calcium phosphate-collagen fiber composite which has an excellent mechanical property, can induce bone replacement by rapid bone remodeling, and can be used in a high-load region. The object can be solved by a porous composite comprising a calcium phosphate crystal and a collagen fiber at a weight ratio of 80:20 to 20:80, wherein (1) a bioabsorbability of the porous composite is graded, and (2) the density of the porous composite determined by gravimetric method is 300 to 1500 mg/cm3.
    Type: Application
    Filed: July 4, 2012
    Publication date: May 22, 2014
    Applicant: TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Junzo Tanaka, Toshiyuki Ikoma, Tomohiko Yoshioka, Takashi Yoshida
  • Patent number: 8673640
    Abstract: A porous scaffold having pores for seeding cells characterized in that, in the outer peripheral face of the porous main body having the pores for seeding cells, a porous membrane having pores smaller than the cells is located. Thus, it is possible to provide a porous scaffold whereby the cells can be seeded at a high efficiency while preventing cell leakage and, moreover, even cells having little adhesiveness can be adhered.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: March 18, 2014
    Assignee: National Institute for Materials Science
    Inventors: Guoping Chen, Tetsuya Tateishi, Junzo Tanaka
  • Publication number: 20140044948
    Abstract: The object of the present invention is to provide a collagen fiber membrane, which has sufficient strength and can be used as a cell culture substrate, a scaffold material for regenerative medicine (for example, material for tissue engineering of cartilage, bone, ligament, corneal stroma, skin, or liver), an implantation material (for example, wound dressing material, bone grafting material, hemostatic material, anti-adhesive material) or a carrier for drug delivery. The object of the present invention can be solved by a fish-derived collagen fiber membrane, characterized in that (1) a tensile strength is 30 MPa or more, (2) a density determined by the gravimetric method, is 0.4 g/cm3 or more, and (3) an average membrane thickness is 1 ?m to 2 mm, and a variation in membrane thickness is plus or minus 30%, relative to the average membrane thickness.
    Type: Application
    Filed: November 28, 2011
    Publication date: February 13, 2014
    Applicant: Tokyo Institute of Technology
    Inventors: Junzo Tanaka, Toshiyuki Ikoma, Tomohiko Yoshioka
  • Publication number: 20130337227
    Abstract: The object of the present invention is to provide a non-fibrogenesis collagen material which has a sufficient strength and can be used as a cell culture substrate, a scaffold material for regenerative medicine (for example, material for tissue engineering of cartilage, bone, ligament, corneal stroma, skin, or liver), an implantation material (for example, wound dressing material, bone grafting material, hemostatic material, anti-adhesive material) or a carrier for drug delivery. The object of the present invention can be solved by a non-fibrogenesis collagen material characterized by comprising a fish-derived collagen.
    Type: Application
    Filed: November 28, 2011
    Publication date: December 19, 2013
    Applicant: Tokyo Institute of Technology
    Inventors: Junzo Tanaka, Toshiyuki Ikoma, Tomohiko Yoshioka
  • Patent number: 8609235
    Abstract: Provision of a porous ceramic material which rapidly induces bone tissue formation and has practical strength. A porous ceramic material 11 having substantially unidirectionally oriented pores 12, a porosity of 40-90%, and an average open area of one pore of 0.05×10?3-50×10?3 mm2 both in a first sectional surface perpendicular to the pore 12 orientation direction and a second sectional surface parallel to the first sectional surface and 5 mm distant from the first sectional surface in the pore 12 orientation direction. Using the material 11, when a cylindrical test piece (diameter 3 mm×height 5 mm, the pore 12 array direction as a height direction) made of the material is dipped in polyethylene glycol up to 1 mm from one end thereof, polyethylene glycol permeates through the whole test piece preferably within 30 seconds.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: December 17, 2013
    Assignees: Kuraray Co., Ltd., National Institute for Materials Science
    Inventors: Yuji Hotta, Yasushi Suetsugu, Masanori Kikuchi, Toshiyuki Ikoma, Tomoya Kuwayama, Takashi Makabe, Junzo Tanaka
  • Patent number: 8313767
    Abstract: Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: November 20, 2012
    Assignee: Independent Administrative Institution, National Institute for Materials Science
    Inventors: Yutaka Mizushima, Yasuaki Ogawa, Junzo Tanaka, Toshiyuki Ikoma
  • Patent number: 8207391
    Abstract: An adsorbent for radioelement-containing waste composed of the following spherical layered double hydroxide (A) or spherical metal hydroxide (B) is provided. (A) is a nonstoichiometric compound represented by general formula (a) or (b): [M2+1-xM3+x(OH)2]x+[An?x/n·mH2O]x? . . . (a), [Al2Li(OH)6]x+[An?x/n·mH2O]x? . . . (b) wherein 0.1?x?0.4, 0<m, n represents a natural number of 1 to 4, M2+ represents at least one divalent metal, M3+ represents at least one trivalent metal, and An? represents at least one n-valent ion-exchangeable anion, and (B) is a spherical metal hydroxide containing a metal selected from the group consisting of the metal atoms belonging to Group II, Group IV, Group V, Group VI, Group XI, Group XII, and Group XIII of the periodic table, and the group consisting of Mn, Fe, Co, Ni, Pb, and Bi.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: June 26, 2012
    Assignee: National Institute for Materials Science
    Inventors: Hirohisa Yamada, Kenji Tamura, Junzo Tanaka, Toshiyuki Ikoma, Yasushi Suetsugu, Yusuke Moriyoshi, Yujiro Watanabe
  • Patent number: 8168151
    Abstract: This invention provides organic/inorganic composite biomaterials constituted by composites of hydroxyapatite and collagen and having an average fiber length of 60 ?m or longer, and a process for producing the same in which the calcium ion and phosphate ion concentrations in the reaction vessel are optimized through regulation of the concentration of a starting material and the flow rate. The organic/inorganic composite biomaterials have mechanical strength and a biodegradation rate suitable for artificial bones through the introduction of crosslinking therein.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: May 1, 2012
    Assignee: Japan Science and Technology Agency
    Inventors: Junzo Tanaka, Masanori Kikuchi, Noriichi Ito, Yoshinobu Mandai
  • Patent number: 8039090
    Abstract: A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a molding die having a high thermal conductivity, (2) rapidly freezing and drying the slurry in the molding die, to form a porous body comprising a porous layer and a dense layer formed on the porous layer, (3) cross-linking collagen in the porous body, and (4) removing the dense layer except for a portion thereof on a surface coming into contact with a soft tissue when implanted in a human body, so that the porous layer is exposed.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: October 18, 2011
    Assignees: Hoya Corporation, National Institute for Materials Science
    Inventors: Katsumi Kawamura, Takehiko Nakajima, Daisuke Shoji, Junzo Tanaka, Masanori Kikuchi, Toshiyuki Ikoma
  • Patent number: 8008357
    Abstract: In the process of producing a porous body containing a fibrous apatite/collagen composite by gelating a dispersion comprising the fibrous apatite/collagen composite, collagen and water, freeze-drying the resultant gel to form a porous body, and cross-linking collagen in the porous body, a method for controlling the average pore diameter of the porous body by the solidification time of the gel in the freezing step.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: August 30, 2011
    Assignees: Hoya Corporation, National Institute for Materials Science
    Inventors: Daisuke Shoji, Katsumi Kawamura, Takehiko Nakajima, Junzo Tanaka, Masanori Kikuchi, Toshiyuki Ikoma, Naomi Mochizuki
  • Patent number: 7871638
    Abstract: This invention relates to a scaffold consisting of a biodegradable polymeric material with a composition gradient of calcium phosphate that is capable of effectively regenerating the hard/soft tissue interface and an implant for hard/soft tissue filling with the utilization of such scaffold.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: January 18, 2011
    Assignees: Japan Science and Technology Agency, National Institute for Materials Science
    Inventors: Junzo Tanaka, Tetsushi Taguchi
  • Publication number: 20100322902
    Abstract: Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound.
    Type: Application
    Filed: September 2, 2010
    Publication date: December 23, 2010
    Inventors: Yutaka Mizushima, Yasuaki Ogawa, Junzo Tanaka, Toshiyuki Ikoma
  • Publication number: 20100221835
    Abstract: This invention relates to a method for cartilage tissue engineering using scaffolds in simulated microgravity culture. This invention enables engineering of homogeneous cartilage tissue using bone marrow cells in a more rapid manner in a simulated microgravity environment, while allowing control of the configuration of the resulting cartilage tissue.
    Type: Application
    Filed: June 15, 2006
    Publication date: September 2, 2010
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Junzo Tanaka, Yoshito Ikada, Yoshimi Ohyabu, Toshimasa Uemura
  • Publication number: 20100191033
    Abstract: An adsorbent for radioelement-containing waste includes spherical layered double hydroxide (A) or spherical metal hydroxide (B). (A) is a nonstoichiometric compound represented by general formula (a) or (b): [M2+1-xM3+x(OH)2]x+[An?x/n.mH2O]x???(a), [Al2Li(OH)6]x+[An?x/n.mH2O]x???(b) where 0.1?x?0.4, 0<m. The n represents a natural number of 1 to 4, M2+ represents at least one divalent metal, M3+ represents at least one trivalent metal, and An? represents at least one n-valent ion-exchangeable anion. (B) contains a metal selected from the group of Group II, Group IV, Group V, Group VI, Group XI, Group XII, and Group XIII of the periodic table, and the group of Mn, Fe, Co, Ni, Pb, and Bi. This adsorbent efficiently adsorbs and collects volatile iodine, a radioactive anion in wastewater, etc. providing a crack-resistant solidified article after a solidification treatment, and effectively confines the radioelement-containing waste with long-term stability.
    Type: Application
    Filed: February 19, 2010
    Publication date: July 29, 2010
    Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Hirohisa Yamada, Kenji Tamura, Junzo Tanaka, Toshiyuki Ikoma, Yasushi Suetsugu, Yusuke Moriyoshi, Yujiro Watanabe
  • Patent number: 7741454
    Abstract: The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: June 22, 2010
    Assignees: National Institute for Materials Science, Furuuchi Chemical Corporation
    Inventors: Tetsushi Taguchi, Hisatoshi Kobayashi, Junzo Tanaka, Hirofumi Saito
  • Patent number: 7732573
    Abstract: A method for producing a porous body comprising apatite/collagen composite fibers comprising the steps of gelling a dispersion comprising long apatite/collagen composite fibers having an average length of 10-75 mm, short apatite/collagen composite fibers having an average length of 0.05-1 mm, and a liquid; freezing and drying the resultant gel to form a porous body; and cross-linking collagen in the porous body.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: June 8, 2010
    Assignees: National Institute for Materials Science, Hoya Corporation
    Inventors: Junzo Tanaka, Masanori Kikuchi, Toshiyuki Ikoma, Daisuke Shoji, Katsumi Kawamura, Takehiko Nakajima, Naomi Mochizuki