Patents by Inventor Jurgen Stoltefuss

Jurgen Stoltefuss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4935409
    Abstract: Animal growth promoters of the formula ##STR1## The intermediates of the formula ##STR2## are also new.
    Type: Grant
    Filed: April 27, 1988
    Date of Patent: June 19, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hartmund Wollweber, Jurgen Stoltefuss, Friedrich Berschauer
  • Patent number: 4904679
    Abstract: Pyrrolophenylalkanolamines of the formula ##STR1## R.sup.1 and R.sup.2 represent hydrogen or various radicals, R.sup.3 represents hydrogen, acyl or trialkylsilyl,R.sup.4 represents hydrogen or alkyl,R.sup.5 represents hydrogen, or, together with R.sup.3, represents ##STR2## wherein R.sup.7 represents hydrogen or alkyl, andR.sup.6 represents branched or cyfclic alkyl, which is optionally substituted,and salts thereof promote the yield of animals. Many new intermediates are also shown.
    Type: Grant
    Filed: April 22, 1988
    Date of Patent: February 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hartmund Wollweber, Jurgen Stoltefuss, Friedrich Berschauer, Ann de Jong, Martin Scheer
  • Patent number: 4895855
    Abstract: A composition effective for treating circulation disorders comprises a mixture of ##STR1## wherein the variables can have varied meetings. I are inotropic and II are vasodilating but, whereas the ingredients in the combination would be expected to be antagonistic, they are reinforcing.
    Type: Grant
    Filed: December 6, 1985
    Date of Patent: January 23, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Goldmann, Horst Boshagen, Friedrich Bossert, Gerhard Franckowiak, Horst Meyer, Jurgen Stoltefuss, Rainer Gross, Matthias Schramm, Gunter Thomas
  • Patent number: 4822798
    Abstract: Circulatory system-active novel dihydropyrimidines of the formula ##STR1## in which R.sup.1 and R.sup.6 are diverse organic radicals, and pharmacologically acceptable addition salts thereof.
    Type: Grant
    Filed: August 26, 1983
    Date of Patent: April 18, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Horst Boshagen, Matthias Schramm, Gunter Thomas
  • Patent number: 4806667
    Abstract: A method for promoting production of useful livestock comprising administering to such livestock an amount effective therefor of a monosilylated aminopheylethylamine derivative of the formula ##STR1## in which X and Y are identical or different and represent hydrogen or CN,R.sup.2 represents hydrogen or methyl,R.sup.3 represents t-butyl, isopropyl, monofluoro-t-butyl or 1-cyclohexyl-ethyl, andR.sup.4, R.sup.5 and R.sup.6 denote a straight-chain or branched alkyl rdical,or a physiologically tolerated salt thereof.Those compounds wherein R.sup.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: February 21, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Jurgen Stoltefuss, Friedrich Berschauer, Anno de Jong, Martin Scheer
  • Patent number: 4791122
    Abstract: 5-Aryl-1,4-dihydropyridines of the formula ##STR1## in which Rrepresents cycloalkyl,heteroaryl oraryl which is optionally substituted by at least one substituent independently selected from the group consisting of halogen, nitro, hydroxyl, amino, carboxyl, alkoxycarbonyl, cyano, acyl, acyloxy, acylthio, by alkyl, alkyloxy, alkylthio or alkylsulphonyl, each of which is optionally substituted by one or more halogens, by aryl which is optionally substituted by alkyl, alkoxy, halogen or nitro, or optionally by the group --Z--CH.sub.2 --R.sup.4,whereZ represents oxygen or sulphur, andR.sup.4represents cycloalkyl,heteroaryl oraryl which is optionally substituted by halogen, cyano, nitro, hydroxyl, carboxyl, alkoxycarbonyl or by alkyl or alkoxy, each of which is optionally substituted by one or more halogens,R.sup.1 and R.sup.2are identical or different andrepresent straight-chain or branched alkyl which is optionally substituted by aryl, carboxyl, alkoxycarbonyl or by hydroxyl,R.sup.
    Type: Grant
    Filed: January 8, 1986
    Date of Patent: December 13, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Rainer Gross, Matthias Schramm, Gunter Thomas, Michael Kayser, Bernd Pelster
  • Patent number: 4772611
    Abstract: Novel cardioactive compounds of the formula ##STR1## in which R.sup.1 is alkyl, aryl or heterocyclic, preferably substituted phenyl,R.sup.2 is alkyl, preferably methyl,R.sup.3 is hydrogen, halogen, acyloxy or alkyl, preferably hydrogen, andR.sup.4 is phenyl, carbalkoxy or together with R.sup.3 forms a ring, preferably carbalkoxy,are produced by reducing the corresponding nitro compounds.
    Type: Grant
    Filed: April 28, 1987
    Date of Patent: September 20, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Fred R. Heiker, Martin Bechem, Rainer Gross, Michael Kayser, Matthias Schramm, Gunter Thomas
  • Patent number: 4772612
    Abstract: Novel circulation active dihydropyridines of the formula ##STR1## in which X is CO, SO.sub.2 or CONH,R.sup.4 is H, OH, alkyl, halogen, acyloxy, alkoxyalkoxy, aralkyloxy, or together with R.sup.5 forms a heterocyclic ring, andthe other radicals are conventional in the dihydropyridine art,and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 3, 1986
    Date of Patent: September 20, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Goldmann, Jurgen Stoltefuss, Gerhard Franckowiak, Rainer Gross, Matthias Schramm, Gunter Thomas
  • Patent number: 4670423
    Abstract: Monosilylated aminophenylethylamine derivative of the formula ##STR1## in which X and Y each independently is hydrogen or halogen,R.sub.1 is the radical ##STR2## R.sub.2 is hydrogen or an aliphatic hydrocarbon radical having up to 10 C atoms,R.sub.3 is hydrogen, an aliphatic hydrocarbon radical which can optionally be substituted by halogen, a phenyl radical which can optionally be substituted by halogen, hydroxyl, alkyl, aryl, alkoxy, alkylthio, optionally substituted phenoxy, optionally substituted phenylthio, cyano or trifluoromethyl, or a heterocyclic radical, or, together with R.sub.2 is a nitrogen-containing saturated heterocyclic radical, andR.sub.4, R.sub.5 and R.sub.6 each independently is an alkyl radical,or physiologically tolerated salts thereof, promote the growth of animals.
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: June 2, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Jurgen Stoltefuss, Friedrich Berschauer, Anno de Jong, Martin Scheer
  • Patent number: 4645775
    Abstract: Novel 3-nitro-dihydropyridine derivatives of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkylmercapto, ##STR2## Z is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkoxy or nitro, orR.sub.1 and R.sub.2, together with 2 C atoms of the phenyl ring form the ring ##STR3## X is oxygen or sulphur, A is a hydrocarbon radical with up to 12 C atoms which optionally contains one or two identical or different chain members from the group comprising O, S and CO and/or which is optionally substituted by hydroxyl or aliphatic acyloxy with up to 4 C atoms,R.sub.3 is --O--COR.sub.6, --S--CO--R.sub.6, SH, OH , NH.sub.2, ##STR4## NH--COR.sub.6, COOR.sub.6, NR.sub.7 R.sub.8 or CONR.sub.7 R.
    Type: Grant
    Filed: May 15, 1985
    Date of Patent: February 24, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Fred R. Heiker, Gerhard Franckowiak, Matthias Schramm, Gunter Thomas, Rainer Gross
  • Patent number: 4540684
    Abstract: A 1,4-dihydropyridine derivative of the formula ##STR1## in which R and R.sub.1 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 to C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, trifluoromethyl, ##STR2## X is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, trifluoromethyl, amino or nitro, andR.sub.2 and R.sub.3 each independently is hydrogen, a C.sub.1 -C.sub.10 -alkyl, C.sub.2 -C.sub.10 -alkenyl or C.sub.3 -C.sub.10 -alkinyl radical which is optionally substituted by halogen, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, mono- and di-C.sub.1 -C.sub.4 -alkylamino, carbo-C.sub.1 -C.sub.6 -alkoxy and/or nitro, a C.sub.3 to C.sub.6 -membered cycloalkyl radical, a phenyl radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, amino and/or nitro, or a phenyl-C.sub.1 -C.sub.3 -alkyl radical, or a carbohydrate radical which is optionally bonded via a C.
    Type: Grant
    Filed: May 18, 1984
    Date of Patent: September 10, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Gerhard Franckowiak, Horst Boshagen, Siegfried Goldmann, Matthias Schramm, Gunter Thomas, Rainer Gross
  • Patent number: 4537881
    Abstract: Novel 1,4-dihydropyridines of the fomula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkylmercapto, ##STR2## in which Z is oxygen or sulphur, andR.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkoxy or nitro, orR.sub.1 and R.sub.2, together with 2 C atoms of the phenyl ring, form the ring ##STR3## X is oxygen, sulphur or the radical NR.sub.6, R.sub.6 is a C.sub.1 -C.sub.6 -alkyl group,A is a C.sub.2 -C.sub.10 -alkylene group, it being necessary that at least two C atoms are located in the alkylene chain which connects the carbonyloxy group to X, andR.sub.
    Type: Grant
    Filed: July 3, 1984
    Date of Patent: August 27, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Fred R. Heiker, Jurgen Stoltefuss, Gerhard Franckowiak, Matthias Schramm, Gunter Thomas, Rainer Gross
  • Patent number: 4532248
    Abstract: 1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, andR.sup.1 to R.sup.7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca.sup.++ into cells, particularly in combatting coronary and vascular diseases, hypertension swelling in the mucous membranes and diseases involving increased blood sugar or an incorrect salt and fluid balance.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: July 30, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Franckowiak, Horst Boshagen, Friedrich Bossert, Siegfried Goldmann, Horst Meyer, Egbert Wehinger, Jurgen Stoltefuss, Matthias Schramm, Gunter Thomas, Robertson Towart
  • Patent number: 4492703
    Abstract: 1,4-Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.4, R.sup.5, R.sup.6 and Y are hydrogen or various organic radicals,R.sup.2 and R.sup.3 are various organic radicals, ##STR2## is phenyl, naphthyl or various heterocyclic radicals, X is a direct bond, O, S or SO, andB is a direct bond or alkylene,or pharmaceutically acceptable addition salts thereof exhibit hypotensive, vasodilating and coronary activities.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: January 8, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Goldmann, Horst Boshagen, Jurgen Stoltefuss, Matthias Schramm, Gunter Thomas, Stanislav Kazda
  • Patent number: 4465684
    Abstract: The invention relates, inter alia, to 3,4,5-trihydroxypiperidine compounds of Formula (I), infra, to methods for the manufacture of said compounds, to pharmaceutical compositions containing said compounds and to methods for the use of said compounds and compositions. Also included in the invention are concentrates, premixes and feedstuffs containing said compounds.
    Type: Grant
    Filed: November 20, 1981
    Date of Patent: August 14, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Bodo Junge, Jurgen Stoltefuss, Delf Schmidt, Hans P. Krause, Walter Puls
  • Patent number: 4407809
    Abstract: The invention relates to 3,4,5-trihydroxypiperidine compound of Formula (I) as methods for the preparation of said compounds. Also included in the invention are compositions containing said piperidine compounds and methods for the use of said piperidine compounds and compositions. The invention further includes veterinary compositions containing said piperidine compounds and their use in animal nutrition.The piperidine compounds of Formula (I) are useful as agents against prediabetes, gastritis, constipation, infections of the gastro-intestinal tract, meteorism, flatulence, caries, arteriosclerosis and hypertension and in particular against diabetes, hyperlipaemia and adiposity, and also in animal nutrition for influencing the meat/fat ratio in favor of the meat content.
    Type: Grant
    Filed: February 5, 1981
    Date of Patent: October 4, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Jurgen Stoltefuss, Lutz Muller, Hans-Peter Krause, Rudiger Sitt
  • Patent number: 4278683
    Abstract: The invention relates to 3,4,5-trihydroxypiperidines, processes for their producion, compositions containing them and methods for the use of said 3,4,5-trihydroxypiperidines and compositions containing them. The compounds and compositions of the invention are useful, inter alia, for their saccharase inhibiting activity in warm-blooded animals as well as their ability to improve feed utilization in warm-blooded and cold-blooded animals.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: July 14, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Lutz Muller, Walter Puls, Rudiger Sitt
  • Patent number: 4220782
    Abstract: The invention relates to a process for the production of a compound of the formula ##STR1## in which R denotes a hydrogen atom or an alkyl, aralkyl or aryl group and comprises deblocking a compound of the general formula ##STR2## in which R has the meaning indicated above, by treatment with a strong mineral acid and isolating the intermediate product in the form of a salt thereof and then hydrogenating said salt with a suitable hydrogen donor, or, in a one-pot process, first deblocking the starting material by treatment with a strong mineral acid and, after controlled addition of a base, hydrogenating directly.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: September 2, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventor: Jurgen Stoltefuss
  • Patent number: 4219552
    Abstract: The invention relates to new (4-phenoxy-phenyl)-1,3,5-triazine derivatives of the formula ##STR1## in which R.sup.1 represents halogenoalkylthio, halogenalkylsulphinyl or halogenoalkylsulphonyl,R.sup.2 represents hydrogen, alkyl, alkoxy, alkoxyalkyl, alkylmercapto, halogen, halogenalkyl or an optionally substituted sulphamoyl, such as dialkyl, sulphamoyl, radical,R.sup.3 and R.sup.4 can be identical or different and represent hydrogen, alkyl, alkenyl or alkinyl andX is O or S,and their physiologically acceptable salts. The compounds have a very good coccidiostatic action and an excellent growth promoting action.Also included in the invention are compositions containing said compounds and methods for their preparation and use.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: August 26, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Axel Haberkorn, Martin Scheer, Jurgen Stoltefuss
  • Patent number: 4175123
    Abstract: The present invention provides amino-sugar derivatives of the general formula ##STR1## in which n and m independently of each other represent an integer from 0 to 8 and the sum n+m has a value of 0 to 8, andX designates a group --OR, --SH, --SR, --NH.sub.2, --NHR or NRR.sub.1,in whichR designates an alkyl, alkenyl, cycloalkyl, aralkyl, aryl or heterocyclic radical, which can be substituted, andR.sub.1 designates an alkyl, cycloalkyl, aralkyl or aryl radical, which can be substituted, orR and R.sub.1 together with the nitrogen atom to which they are bonded, form a heterocyclic ring.It has been found that the compounds of the formula (II) are highly active inhibitors for glycoside hydrolases of the digestive tract.Also included in the invention are methods of preparing the amino-sugar derivatives of the invention, compositions containing said amino-sugar derivatives and methods for the use of said amino-sugar derivatives and compositions containing them.
    Type: Grant
    Filed: December 15, 1977
    Date of Patent: November 20, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Hans-Peter Krause, Lutz Muller, Walter Puls, Jurgen Stoltefuss