Abstract: Provided herein are cell-free systems comprising two-component systems including a histidine kinase and a response regulator. In embodiments, the systems further include synthetic membranes. Also provided are methods for using the systems to detect analytes and synthesize target molecules.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.

Abstract: A device receives current vehicle data that describes a current state of each of a plurality of components of the vehicle. The device accesses historical data describing prior services previously performed on the vehicle and applies the current vehicle data and the historical vehicle data to a trained machine learning model to obtain a set of recommended services, where the model was trained using labeled training data associated with additional vehicles having a threshold similarity to the vehicle. The machine learning model is trained to output a set of recommended services to be performed for a given vehicle based on inputs of given current vehicle data and given historical vehicle data for the given vehicle. The device outputs for display the set of recommended services to be performed on the vehicle to a user.

Abstract: This disclosure includes wound dressings (18) and systems (10) with therapeutic gas and negative pressure sources for incision management. The dressing, which are configured to be coupled to tissue to facilitate delivery of oxygen to the tissue, comprise a manifold configured to permit communication of oxygen to the tissue the manifold (46) defining: a plurality of gas passageways (50); and a plurality of openings (62), one or more of which comprises a length (66) and a width (70) that is at least 50 percent less than the length; and a gas-occlusive layer (86) configured to be disposed over the manifold and coupled to the tissue such that an interior volume containing the manifold is defined between the gas-occlusive layer and the tissue and the gas-occlusive layer limits escape of oxygen from the interior volume.

Abstract: A document management system manages documents. The documents are managed such that the documents may be shared with one or more users during an online sharing session for electronic signing. During the online sharing session, one or more documents are collaboratively reviewed by one or more participants of the online sharing session. The one or more documents are e-signed at least one of the participants of the online sharing session.

Abstract: An evaporative bridge dressing that may be used with negative-pressure treatment of tissue. The evaporative bridge dressing may have one or more fluid transfer layers comprised of high-density wicking material enclosed between layers of film having high moisture-vapor transfer rates to reduce liquid storage and minimize pressure drop.

Abstract: This disclosure includes wound dressings and systems for effluent management of topical wound therapy and related methods. Some devices, which are configured to dilute therapeutic gas effluent flowing from a dressing, comprise a therapeutic gas source configured to provide therapeutic gas to the dressing; a container comprising a sidewall that defines a chamber configured to receive therapeutic gas effluent from the dressing; a negative pressure source configured to be coupled to the container such that the negative pressure source can be activated to draw fluid from the dressing through the chamber of the container; and a diluent gas source configured to deliver a diluent gas to dilute therapeutic gas effluent before the therapeutic gas effluent enters the negative pressure source.

Abstract: Systems and methods of providing a collaborative interface with real-time permission management for configuring an API based on inputs received through interface elements presented within a GUI.

Abstract: An evaporative bridge dressing that may be used with negative-pressure treatment of tissue. The evaporative bridge dressing may have one or more fluid transfer layers comprised of high-density wicking material enclosed between layers of film having high moisture-vapor transfer rates to reduce liquid storage and minimize pressure drop.

Abstract: A surgical retractor assembly for providing surgical exposure. The surgical retractor assembly consists of two frame segments connected by adjustable ratchet mechanisms to form a retractor frame. The ratchet mechanisms can be attached to tissue retractor blades that provide exposure of the wound when expanded, without the requirement of a direct connection/attachment to an operating table or bed frame. The tissue retractor blades are attached in a manner that is adjustable and facilitates the ability of the overall surgical retractor assembly to be raised or lowered with respect to the patient. The retractor frame also allows attachments of additional retractor blades or other surgical retractor accessories for additional surgical exposure.

Abstract: This disclosure includes wound dressings and systems with remote oxygen generation for topical wound therapy and related methods.

Abstract: A wound therapy system having a wound dressing for treating a wound includes a sensor that measures a pH level at a wound area. The sensor has a circuit that includes a first electrode and one or more second electrodes. The first electrode has a changeable conductivity that changes according to a hydrogen ion concentration level. The one or more second electrodes are configured with a fixed conductivity that does not change with the hydrogen ion concentration level. The first electrode is coated with a porous protective membrane formed from a sulfonated and/or carboxylated copolymer.

Abstract: This disclosure includes wound dressings and systems with remote oxygen generation for topical wound therapy and related methods.

Abstract: A device receives current vehicle data that describes a current state of each of a plurality of components of the vehicle. The device accesses historical data describing prior services previously performed on the vehicle and applies the current vehicle data and the historical vehicle data to a trained machine learning model to obtain a set of recommended services, where the model was trained using labeled training data associated with additional vehicles having a threshold similarity to the vehicle. The machine learning model is trained to output a set of recommended services to be performed for a given vehicle based on inputs of given current vehicle data and given historical vehicle data for the given vehicle. The device outputs for display the set of recommended services to be performed on the vehicle to a user.

Abstract: A system for providing a force to a desired area on a curved body part of a person includes a dressing assembly shaped and configured to be placed on the desired area of the person, a releaseable circumferential member surrounding the curved body part that holds the dressing assembly against the desired area, a sealing subsystem for providing a fluid seal over the dressing assembly and the person's skin, and a reduced-pressure subsystem for providing a reduced pressure to the dressing assembly. When reduced pressure is supplied, the system generates the force against the desired area on the curved body part.

Abstract: A wound therapy system having a wound dressing for treating a wound includes a sensor that measures a pH level at a wound area. The sensor has a circuit that includes a first electrode and one or more second electrodes. The first electrode has a changeable conductivity that changes according to a hydrogen ion concentration level. The one or more second electrodes are configured with a fixed conductivity that does not change with the hydrogen ion concentration level. The first electrode is coated with a porous protective membrane formed from a sulfonated and/or carboxylated copolymer.

Abstract: A negative pressure wound therapy system includes at least one sensor coupled to a wound dressing for a wound of a patient, and a control circuit. The at least one sensor is configured to output an indication of a displacement of the wound dressing. The control circuit is configured to receive the indication of the displacement of the wound dressing, calculate a therapy parameter corresponding to the indication of the displacement, and output the therapy parameter.

Abstract: Systems, apparatuses, and methods for providing negative pressure and/or instillation fluids to a tissue site. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure and/or therapeutic solution of fluids to a tissue site, which can be used in conjunction with sensing properties of fluids extracted from a tissue site and/or instilled at a tissue site. For example, an apparatus includes a dressing interface or connector that includes a pH sensor, a humidity sensor, a temperature sensor and/or a pressure sensor embodied on a single pad within the connector and proximate the tissue site to provide data indicative of acidity, humidity, temperature and pressure. Such apparatus includes algorithms for processing such data for detecting leakage and blockage as well as providing information relating to the progression of healing of wounds at the tissue site.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.