Abstract: The present disclosure provides methods and compositions for controlling the localization of proteins in lipid structures. The disclosure also provides methods for selecting appropriate proteins for desired localization and distribution in lipid structures based on hydrophobic thickness.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.

Abstract: A sampling interface may comprise an inlet port, an outlet port, and a sampling chamber between the inlet port and the outlet port. The apparatus may also comprise a sampling port and at least one split seal between the sampling port and the sampling chamber. The split seal may comprise a first sealing member and a second sealing member that converge to a sealing line. The apparatus may additionally include at least one fluid collection channel disposed interior to the split seal. A lateral flow strip for sampling fluid removed from a tissue site may comprise an acquisition surface and a migration medium fluidly coupled to the acquisition surface. At least one test medium may be fluidly coupled to the migration medium, and a liquid-impermeable cover may enclose the migration medium and the test medium. The acquisition surface is preferably not enclosed.

Abstract: A surgical retractor assembly for providing surgical exposure. The surgical retractor assembly consists of two frame segments connected by adjustable ratchet mechanisms to form a retractor frame. The ratchet mechanisms can be attached to tissue retractor blades that provide exposure of the wound when expanded, without the requirement of a direct connection/attachment to an operating table or bed frame. The tissue retractor blades are attached in a manner that is adjustable and facilitates the ability of the overall surgical retractor assembly to be raised or lowered with respect to the patient. The retractor frame also allows attachments of additional retractor blades or other surgical retractor accessories for additional surgical exposure.

Abstract: A device receives current vehicle data that describes a current state of each of a plurality of components of the vehicle. The device accesses historical data describing prior services previously performed on the vehicle and applies the current vehicle data and the historical vehicle data to a trained machine learning model to obtain a set of recommended services, where the model was trained using labeled training data associated with additional vehicles having a threshold similarity to the vehicle. The machine learning model is trained to output a set of recommended services to be performed for a given vehicle based on inputs of given current vehicle data and given historical vehicle data for the given vehicle. The device outputs for display the set of recommended services to be performed on the vehicle to a user.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.

Abstract: Systems, apparatuses, and methods for providing negative pressure and/or instillation fluids to a tissue site are disclosed. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure and/or therapeutic solution of fluids to a tissue site, which can be used in conjunction with sensing properties of fluids extracted from a tissue site and/or instilled at a tissue site. For example, an apparatus may comprise a dressing interface or connector that includes a pH sensor, a humidity sensor, a temperature sensor and/or a pressure sensor embodied on a single pad within the connector and proximate the tissue site to provide data indicative of acidity, humidity, temperature and pressure. Such apparatus may further comprise an ambient port for providing the pressure sensor and the humidity sensor with access to the ambient environment providing readings relative to the atmospheric pressure and humidity.

Abstract: A surgical retractor assembly for providing surgical exposure. The surgical retractor assembly consists of two frame segments connected by adjustable ratchet mechanisms to form a retractor frame. The ratchet mechanisms can be attached to tissue retractor blades that provide exposure of the wound when expanded, without the requirement of a direct connection/attachment to an operating table or bed frame. The tissue retractor blades are attached in a manner that is adjustable and facilitates the ability of the overall surgical retractor assembly to be raised or lowered with respect to the patient. The retractor frame also allows attachments of additional retractor blades or other surgical retractor accessories for additional surgical exposure.

Abstract: This disclosure includes negative pressure wound therapy dressings with local oxygen generation for topical wound therapy. The dressings (18) for facilitating delivery of oxygen and application of negative pressure to target tissue include a manifold (46) that defines a plurality of gas passageways (50) and is configured to allow communication of oxygen to the target tissue; an oxygen-generating material (146) that is configured to release oxygen when exposed to water; a gas-occlusive layer (74) configured to be disposed over the manifold and the oxygen-generating material and coupled to tissue surrounding the target tissue such that an interior volume containing the manifold and the oxygen-generating material is defined between the gas-occlusive layer and the target tissue; and a port (94) coupled to the gas-occlusive layer and configured to be coupled to a negative pressure source.

Abstract: A dressing for treating tissue may be a composite of dressing layers, including a contact layer, a manifold layer, and an adhesive drape. The manifold layer may include one or more layers of felted open-cell foam in some examples. The manifold layer may be relatively thin to reduce the dressing profile and increase flexibility, which can enable it to conform to difficult geometry and other tissue sites under negative pressure. The dressing may have a length and a width less than the length. The manifold layer may include a population of holes extending at least partially therethrough, wherein the holes may be configured to promote anisotropic contraction of the dressing parallel to its width. The population of holes may have a circular, ovoid, triangular, square, hexagonal, irregular, or morphous shape. The dressing may be a bolster that may anisotropically contract to provide a closing force to a linear wound.

Abstract: A negative pressure wound therapy device includes a piezoelectric pump, a state detector configured to detect a state of the pump, and a control circuit configured to transmit a first control signal for a first period having a first RMS voltage greater than or equal to a threshold voltage at which driving the pump for a second period greater than the first period can cause the pump to emit sound at a magnitude greater than a sound threshold; receive a first indication of the state; determine if the pump is in a leak condition; transmit, responsive to the pump not being in the leak condition, a second control signal having a second RMS voltage less than the first RMS voltage; and transmit, responsive to the pump being in the leak condition, a third control signal having a third RMS voltage greater than the second RMS voltage.

Abstract: Systems, apparatuses, and methods for providing negative pressure and/or instillation fluids to a tissue site are disclosed. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure and/or therapeutic solution of fluids to a tissue site, which can be used in conjunction with sensing properties of fluids extracted from a tissue site and/or instilled at a tissue site. For example, an apparatus may comprise a dressing interface or connector that includes a pH sensor, a humidity sensor, a temperature sensor and/or a pressure sensor embodied on a single pad within the connector and proximate the tissue site to provide data indicative of acidity, humidity, temperature and pressure. Such apparatus may further comprise algorithms for processing such data for detecting leakage and blockage as well as providing information relating to the progression of healing of wounds at the tissue site.

Abstract: An apparatus for treating a tissue site includes a dressing, an oxygen source, a valve, and a negative-pressure source. The dressing is configured to be sealed around the tissue site. The oxygen source is fluidly coupled to the dressing and configured to provide a low flow of oxygen. A first port of the valve is fluidly coupled to the dressing and the valve moves between a closed position preventing flow through the valve and an open position permitting flow through the valve. The negative-pressure source is fluidly coupled to a second port of the valve and provides negative pressure to the second port of the valve at a non-therapeutic level. The valve separates the negative-pressure source from the dressing and selectively opens when a positive pressure is applied on an upstream side of the valve.

Abstract: This disclosure includes wound dressings and systems with high-flow therapeutic gas sources for topical wound therapy and related methods. Some dressings, which are configured to be coupled to tissue to facilitate delivery of therapeutic gas to the tissue, comprise a manifold that defines a plurality of gas passageways, the manifold configured to allow communication of therapeutic gas to the tissue; and a gas-occlusive layer configured to be disposed over the manifold and coupled to the tissue such that an interior volume containing the manifold is defined between the gas-occlusive layer and the tissue and the gas-occlusive layer limits escape of therapeutic gas from the interior volume; wherein the gas-occlusive layer includes: a first opening configured to allow communication of therapeutic gas into the interior volume; and one or more second openings configured to allow communication of therapeutic gas out of the interior volume.

Abstract: Dressings and kits for use in wound therapy and negative-pressure therapy comprising a manifold layer comprising porous open-cell liquid permeable foam and a polymer composition The polymer composition comprises a polymer and an active agent, such as collagen and oxidized regenerated cellulose. The foam may be felted. Methods of making and using the dressings are also provided.

Abstract: Disclosed embodiments may relate to a fluid bridge configured to facilitate negative -pressure therapy when used in a vertical orientation and/or under compression, and to systems and methods related thereto. In some embodiments, the fluid bridge may comprise an open-cell foam support manifold within an envelope. The support manifold may be configured to reduce negative-pressure drop across the length of the fluid bridge and/or to maintain therapeutic levels of negative pressure, for example despite vertical orientation and/or use under a compression garment.

Abstract: This disclosure describes devices, systems, and methods related to oxygenated hemoglobin, the generation thereof, and the use thereof. An exemplary oxygenated hemoglobin therapy system includes an oxygen source configured to provide oxygen and a hemoglobin source configured to provide topical hemoglobin. The therapy system may also include a mixer which has a first inlet, a second inlet, and an outlet. The mixer is configured to mix the oxygen and the topical hemoglobin to form a mixture and to provide the mixture to a dressing via the outlet. The therapy system may further include the dressing. The oxygenated hemoglobin therapy systems described herein are suitable for use in medical devices, such as bandages, drapes, dressings, and wound closures.

Abstract: A physical lock interface system facilitates secure and remote control of assignment and enablement of physical lock systems. The system receives a request to enable a user to disable a physical lock during a particular range of time. The lock is associated with a geofence boundary defined by a geofence. During the range of time, the system monitors for a presence of the user within the geofence. In response to determining that the user is within the geofence during the range of time, the system transmits a communication to an application of a client device of the user. The application is configured to interact electronically with the physical lock and to cause the client device to display information identifying the physical lock based on the communication. The system detects an electronic signal initiated by the application while the user is within the geofence and disables the physical lock.

Abstract: The present application relates to compounds of Formula I or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

Abstract: The present invention provides compositions comprising phase separated nanoparticles, as well as methods of making the nanoparticles and uses thereof. The nanoparticles can be conjugated to therapeutics and used to treat diseases or to screen compounds.