Abstract: A gaming system, a network gaming architecture, and related methods are disclosed that provides game content to server-based gaming platforms. Players access game content and place wagers on through a client server. The client server may act as a thin client to the gaming platform such that the client server establishes the communication link to a remote gaming engine that performs game play processing. The gaming system includes the remote gaming engine, which may comprise a game rules server configured to administer a set of game rules for the wagering game, and a deck server that randomly selects game pieces according to the set of game rules. A network gaming architecture includes separating functions that require regulation on one set of regulated servers, and functions that do not require regulation on at least one unregulated server.

Abstract: Embodiments of methods that are useful to avoid overflow in fixed-length buffers. In one embodiment, the methods dynamically adjust parameters (e.g., sample time) and reconfigure data in the buffer to allow new data samples to fit in the buffer. These embodiments allow data collection to automatically adapt, e.g., by adjusting the sample rate to allow the data to fit in the limited buffer size. These embodiments can configure hardware and/or software on a valve positioner of a valve assembly to improve data collection for use in on-line valve diagnostics and other data processing techniques.

Abstract: Many pathogens, including Mycobacterium tuberculosis and Yersinia pestis, rely on an iron acquisition system based on siderophores, secreted iron-chelating compounds with extremely high Fe(III) affinity. The compounds of the invention are inhibitors of domain salicylation enzymes, which catalyze the salicylation of an aroyl carrier protein (ArCP) domain to form a salicyl-ArCP domain thioester intermediate via a two-step reaction. The compounds include the intermediate mimic 5?-O—[N-(salicyl)sulfamoyl]-adenosine (salicyl-AMS) and analogs thereof. These compounds are inhibitors of the salicylate activity of MbtA, YbtE, PchD, and other domain salicylation enzymes involved in the biosynthesis of siderophores. Therefore, these compounds may be used in the treatment of infection caused by microorganisms which rely on siderphore-based iron acquisition systems.

Abstract: Systems, devices and methods are provided for neuromonitoring, particularly neuromonitoring to reduce the risks of contacting or damaging nerves or causing patient discomfort during and after surgical procedures, including spinal surgeries. The neuromonitoring procedures include monitoring for the presence of or damage to sensory nerves, and optionally includes additional monitoring for motor nerves. In some systems, including systems that monitor for both sensory and motor nerves, components of the monitoring systems (e.g., stimulating electrodes and response sensors), may be combined with one or more surgical instruments. The systems, devices, and methods provide for pre-surgical assessment of neural anatomy and surgical planning, intraoperative monitoring of nerve condition, and post-operative assessment of nerve position and health.

Abstract: A punctal plug or lacrimal insert comprising a microelectromechanical system pump and associated reservoir may be utilized to deliver precise dosages of an active agent into the eye though the tear film. The microelectromechanical system pump comprises four main components; namely, a reservoir, a pump, a series of valves and a vent. The microelectromechanical system pump is positioned within a cavity in the punctal plug. The microelectromechanical system pump is positioned with a cavity in the punctal plug.

Abstract: Systems, devices, and methods are described for neuromonitoring. In certain embodiments, a signal includes components of a neuromuscular response detected by a sensor attached to a muscle in communication with a nerve being monitored in connection with a surgical procedure. A first component of the neuromuscular response corresponding to a first time period and a second component of the neuromuscular response corresponding to the first time period are extracted from the output signal, wherein the first and second components are different. A first display device and a second display device are configured to display the first component and the second component, respectively, in a substantially simultaneous fashion during the surgical procedure.

Abstract: Many pathogens, including Mycobacterium tuberculosis and Yersinia pestis, rely on an iron acquisition system based on siderophores, secreted iron-chelating compounds with extremely high Fe(III) affinity. The compounds of the invention are inhibitors of domain salicylation enzymes, which catalyze the salicylation of an aroyl carrier protein (ArCP) domain to form a salicyl-ArCP domain thioester intermediate via a two-step reaction. The compounds include the intermediate mimic 5?-O—[N-(salicyl)sulfamoyl]-adenosine (salicyl-AMS) and analogs thereof. These compounds are inhibitors of the salicylate activity of MbtA, YbtE, PchD, and other domain salicylation enzymes involved in the biosynthesis of siderophores. Therefore, these compounds may be used in the treatment of infection caused by microorganisms which rely on siderphore-based iron acquisition systems.

Abstract: Methods and apparatuses, including computer program products, are described for applying service based on classification and grouping of traffic flows. The method includes receiving a traffic flow, and matching the traffic flow to classification groups. The matching includes determining a first event associated with the traffic flow, comparing attributes of the first event with entry criteria of the classification groups, and assigning the first event to one or more classification groups where the first event meets the entry criteria of the one or more classification groups. The method includes identifying one or more service definitions for the traffic flow based on the classification groups assigned to the traffic flow, reconciling the one or more service definitions for the traffic flow, and providing a service to the traffic flow based on the reconciled service definitions.

Abstract: A gaming system, a network gaming architecture, and related methods are disclosed that provides game content to server-based gaming platforms. Players access game content and place wagers on through a client server. The client server may act as a thin client to the gaming platform such that the client server establishes the communication link to a remote gaming engine that performs game play processing. The gaming system includes the remote gaming engine, which may comprise a game rules server configured to administer a set of game rules for the wagering game, and a deck server that randomly selects game pieces according to the set of game rules. A network gaming architecture includes separating functions that require regulation on one set of regulated servers, and functions that do not require regulation on at least one unregulated server.

Abstract: A punctal plug or lacrimal insert comprising a microelectromechanical system pump and associated reservoir may be utilized to deliver precise dosages of an active agent into the eye though the tear film. The microelectromechanical system pump comprises four main components; namely, a reservoir, a pump, a series of valves and a vent. The microelectromechanical system pump is positioned within a cavity in the punctal plug. The microelectromechanical system pump is positioned with a cavity in the punctal plug.

Abstract: Many pathogens, including Mycobacterium tuberculosis and Yersinia pestis, rely on an iron acquisition system based on siderophores, secreted iron-chelating compounds with extremely high Fe(III) affinity. The compounds of the invention are inhibitors of domain salicylation enzymes, which catalyze the salicylation of an aroyl carrier protein (ArCP) domain to form a salicyl-ArCP domain thioester intermediate via a two-step reaction. The compounds include the intermediate mimic 5?-O—[N-(salicyl)sulfamoyl]-adenosine (salicyl-AMS) and analogs thereof. These compounds are inhibitors of the salicylate activity of MbtA, YbtE, PchD, and other domain salicylation enzymes involved in the biosynthesis of siderophores. Therefore, these compounds may be used in the treatment of infection caused by microorganisms which rely on siderphore-based iron acquisition systems.

Abstract: Methods and apparatuses, including computer program products, are described for applying service based on classification and grouping of traffic flows. The method includes receiving a traffic flow, and matching the traffic flow to classification groups. The matching includes determining a first event associated with the traffic flow, comparing attributes of the first event with entry criteria of the classification groups, and assigning the first event to one or more classification groups where the first event meets the entry criteria of the one or more classification groups. The method includes identifying one or more service definitions for the traffic flow based on the classification groups assigned to the traffic flow, reconciling the one or more service definitions for the traffic flow, and providing a service to the traffic flow based on the reconciled service definitions.

Abstract: A percussion drilling assembly for drilling a borehole, the assembly including a tubular casing having a central axis defined therethrough and a lower end, a driver sub having an upper end threadingly engaged with the lower end of the tubular casing, and an annular locking member disposed between the tubular easing and the driver sub. The annular locking member is configured to engage the tubular casing and the driver sub, and is configured to prevent separation of the driver sub from the tubular casing. The annular locking member includes a deformable elongate member.

Abstract: Methods and apparatuses, including computer program products, are described for sharing the status of S-CSCF nodes across a plurality of I-CSCF nodes in a communications network. The system includes a first I-CSCF node of the plurality of I-CSCF nodes configured to monitor status of one or more S-CSCF nodes connected to the first I-CSCF node, wherein the one or more S-CSCF nodes connected to the first I-CSCF node comprise a subset of the S-CSCF nodes in the network, and transmit the monitored status of the one or more S-CSCF nodes connected to the first I-CSCF node to a second I-CSCF node. The second I-SCSF node is configured to monitor status of one or more S-CSCF nodes connected to the second I-CSCF node, wherein the one or more S-CSCF nodes connected to the second I-CSCF node comprise a subset of the S-CSCF nodes in the network.

Abstract: Methods and apparatuses, including computer program products, are described for applying service based on classification and grouping of traffic flows. The method includes receiving a traffic flow, and matching the traffic flow to classification groups. The matching includes determining a first event associated with the traffic flow, comparing attributes of the first event with entry criteria of the classification groups, and assigning the first event to one or more classification groups where the first event meets the entry criteria of the one or more classification groups. The method includes identifying one or more service definitions for the traffic flow based on the classification groups assigned to the traffic flow, reconciling the one or more service definitions for the traffic flow, and providing a service to the traffic flow based on the reconciled service definitions.

Abstract: Methods and apparatuses, including computer program products, are described for applying service based on classification and grouping of traffic flows. The method includes receiving a traffic flow, and matching the traffic flow to classification groups. The matching includes determining a first event associated with the traffic flow, comparing attributes of the first event with entry criteria of the classification groups, and assigning the first event to one or more classification groups where the first event meets the entry criteria of the one or more classification groups. The method includes identifying one or more service definitions for the traffic flow based on the classification groups assigned to the traffic flow, reconciling the one or more service definitions for the traffic flow, and providing a service to the traffic flow based on the reconciled service definitions.

Abstract: Systems and methods are provided for location tracking and filtering or hiding electronic communications. In one implementation, a method is provided for location tracking for electronic communications. The method includes receiving a location ID for a location from a user who desires to follow the location within a social networking environment, and associating the location ID with the user. The method also includes providing instructions to display a representation of the location in a list of the user's contacts.

Abstract: Systems and methods are provided for filtering electronic communications. One exemplary method includes receiving a first message directed to a user, the first message including a plurality of messaging data; and receiving from the user a selection of the messaging data within the first message. The method further includes adding the selected messaging data to a database in relation to one or more contacts of the user, and receiving a second message directed to the user from at least one of the one or more contacts. The method further includes scanning the second message for the selected messaging data, and filtering, with at least one processor, the second message from delivery to the user if the second message contains the selected messaging data.