Abstract: Polymeric ligation clips and a clip applier for applying a polymeric ligation clip to tissue are disclosed herein. More particularly, the polymeric ligation clips include separate first and second beams that can be coupled to each other and are movable from a reduced diameter open position in which minimal strain is placed on the ligation clip to a clamped position and to a clip applier for delivering such a ligation clip to a surgical site.

Abstract: A liquid distribution system for a sprayer vehicle includes a product tank configured to contain a liquid and having a fluid inlet and a fluid outlet; a pump in fluid communication with the product tank; a plurality of nozzles carried by a boom; a recirculation line connecting the fluid outlet, the pump, at least some of the plurality of nozzles, and the fluid inlet; a bypass line connected at an upstream connection and a downstream connection to the recirculation line; and at least one water quality sensor configured to detect a water quality property of liquid flowing through the bypass line. Related vehicles and methods are also disclosed.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface asialoglycoprotein receptor (ASGPR). The cell surface ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface asialoglycoprotein receptor (ASGPR). The cell surface ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: Systems and methods are disclosed for presenting web application content. A method for presenting web application content includes executing a web application using a web browser, the web application configured to display a web page element in a web browser. The method includes identifying an application component requested by a user action. The method also includes querying a component registry database for the application component, the component registry database including one or more application components loadable by the web application. The method then includes obtaining, from a link in the component registry database, application component code for the application component. The method also includes incorporating the application component code into the web page element. The method also includes rendering the application component code and the web page element using the web browser so that the application component is displayed in the web browser as part of the web page element.

Abstract: Systems, methods, devices, and computer readable storage media described herein provide network storage acceleration techniques. In an aspect, a command is received from an application by a storage interface controller. The command is configured to establish a connection with a storage node of a storage service of a storage system. The command comprises a session token corresponding to a session between the application and the storage service. The session token is provided to a broker at a first endpoint. The broker is configured to manage a cluster of storage nodes. The cluster of storage nodes comprises the storage node. A response is received from the broker. The response comprises a second endpoint associated with the storage node. A connection with the second endpoint is established. The second endpoint is mapped to a storage object. In a further aspect, the storage interface controller is a non-volatile memory express (NVMe) controller.

Abstract: A surgical access assembly includes a housing, a tubular member, and a valve assembly. The tubular member extends from the housing. The valve assembly is positioned in the housing and includes a centering mechanism, a guard assembly disposed on a first side of the centering mechanism, and an instrument seal disposed on a second side of the centering mechanism. The instrument seal including petals that are arrange in an overlapping arrangement.

Abstract: A surgical access assembly includes a cannula, a valve housing attached to the cannula, and a valve assembly positioned in the valve housing. The valve assembly includes a centering mechanism with a hoop and fingers, a ring with a flange at one end of the ring, a retainer having first and second discs, a guard having a frame and flaps attached to the frame, and a seal with petals attached to a support. The guard is at least partially disposed in the first disc and the seal is at least partially disposed in the second disc.

Abstract: The present invention generally relates to soles in particular midsoles for sports shoes. According to an aspect, an additively manufactured sole is provided. The sole comprises a lattice structure, the lattice structure comprising a plurality of cell elements. The sole further comprises a heel element, three-dimensionally encompassing the heel. Moreover, the sole comprises a base portion interconnecting the heel element and the lattice structure, wherein the base portion has an extension arranged to connect to a plurality of adjacent cell elements, wherein the plurality of adjacent cell elements is not positioned along an edge of the lattice structure.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: A surgical access assembly includes a cannula, a valve housing attached to the cannula, and a valve assembly positioned in the valve housing. The valve assembly includes a centering mechanism with a hoop and fingers, a ring with a flange at one end of the ring, a retainer having first and second discs, a guard having a frame and flaps attached to the frame, and a seal with petals attached to a support. The guard is at least partially disposed in the first disc and the seal is at least partially disposed in the second disc.

Abstract: A surgical access assembly includes a housing, a tubular member, and a valve assembly. The tubular member extends from the housing. The valve assembly is positioned in the housing and includes a centering mechanism, a guard assembly disposed on a first side of the centering mechanism, and an instrument seal disposed on a second side of the centering mechanism. The instrument seal including petals that are arrange in an overlapping arrangement.

Abstract: The present invention generally relates to soles in particular midsoles for sports shoes. According to an aspect, an additively manufactured sole is provided. The sole comprises a lattice structure, the lattice structure comprising a plurality of cell elements. The sole further comprises a heel element, three-dimensionally encompassing the heel. Moreover, the sole comprises a base portion interconnecting the heel element and the lattice structure, wherein the base portion has an extension arranged to connect to a plurality of adjacent cell elements, wherein the plurality of adjacent cell elements is not positioned along an edge of the lattice structure.

Abstract: An intraoperative clip loading device includes an elongate body that can be positioned at a surgical site through a cannula during an endoscopic surgical procedure to provide a supply of ligation clips to the clip applier. The elongate body includes structure for supporting and advancing the ligation clips within the elongate body.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface mannose-6-phosphate receptor (M6PR). The M6PR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the M6PR. Also provided are compound that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific target proteins from the cell surface or the extracellular milieu. For example, the conjugates described herein may sequester and/or degrade a target molecule of interest in a cell's lysosome. Also provided are methods of using the conjugates to target a protein for sequestration and/or lysosomal degradation.

Abstract: A method for reducing false positives of a metal detector in detecting a target, including transmitting a transmit magnetic field; receiving a receive magnetic field to produce a receive signal; processing the receive signal using at least two different functions to produce a first signal and a second signal; the at least two different functions are configured such that the first signal is sensitive to at least one characteristic of the target, and such that the second signal is a representation of a likelihood function of the first signal, the representation of the likelihood function taking into consideration an effect of an environment upon the first signal; and classifying the receive signal into a classification of one of at least three possible classes based on at least the second signal; and producing an indicator output signal based on the classification. The indicator output signal is different for different classifications and the indicator output signal includes an audio signal.

Abstract: A patient support apparatus for patients. The patient support apparatus comprises a base having a base frame and an intermediate frame. The patient support further comprises a litter configured to be docked to and undocked from a trolley that is configured to slidably translate along the intermediate frame between a plurality of positions including a trolley forward position and a trolley docking position. The litter includes a lower pin and an upper pin. The trolley is configured to receive the upper pin and the lower pin and includes a lower pin stop and an upper pin stop. The lower pin is configured to abut the lower pin stop and the upper pin is configured to abut the upper pin stop to dock the litter to the base.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: A fixation device for folding a seal member includes a frame having a horizontal portion and an upright portion, a press assembly secured to the upright portion of the frame, and a nest assembly secured to the horizontal portion of the frame. The press assembly includes a handle assembly and an anvil assembly operably connected to the handle assembly. The nest assembly includes a clamping assembly, a folding assembly supported on the clamping assembly, a support assembly supported on the folding assembly, and a nest member. The support assembly includes a support plate and a seal clamp for securing a seal member.

Abstract: A surgical access device includes a tube and a housing coupled to the tube. The housing is configured for passage of a surgical instrument therethrough. The housing includes first and second chambers where the second chamber surrounds the first chamber. A seal is disposed in the first chamber. A port extends from the housing and is in fluid communication with the second chamber. A nozzle is defined between a distal portion of an outer wall of the first chamber and a wall of the housing. The nozzle is configured to direct fluid towards the second chamber.