Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: A fixation device for folding a seal member includes a frame having a horizontal portion and an upright portion, a press assembly secured to the upright portion of the frame, and a nest assembly secured to the horizontal portion of the frame. The press assembly includes a handle assembly and an anvil assembly operably connected to the handle assembly. The nest assembly includes a clamping assembly, a folding assembly supported on the clamping assembly, a support assembly supported on the folding assembly, and a nest member. The support assembly includes a support plate and a seal clamp for securing a seal member.

Abstract: A surgical access device includes a tube and a housing coupled to the tube. The housing is configured for passage of a surgical instrument therethrough. The housing includes first and second chambers where the second chamber surrounds the first chamber. A seal is disposed in the first chamber. A port extends from the housing and is in fluid communication with the second chamber. A nozzle is defined between a distal portion of an outer wall of the first chamber and a wall of the housing. The nozzle is configured to direct fluid towards the second chamber.

Abstract: An access assembly includes an instrument valve housing defining a cavity, and a valve assembly. The valve assembly includes a flange seal member, a seal assembly, a centering mechanism, and a retainer frame assembly. The flange seal member includes an arcuate portion configured to adjustably engage first and second surfaces of the instrument valve housing in a sealing relation. The centering mechanism is configured to bias the valve assembly towards a generally centered position within the cavity. The centering mechanism includes a plurality of coils including inner coil portions operatively secured with the seal assembly, and outer coil portions configured to engage the first surface of the instrument valve housing. The retainer frame assembly includes first and second members. The inner coil portion of the centering mechanism is disposed between seal assembly and the second member of the retainer frame assembly.

Abstract: A non-transitory machine-readable medium having machine-executable instructions includes a translator, the machine-readable instructions for the translator being executable by a processor core to perform operations. The operations include translating records in model-based system engineering (MBSE) data for an MBSE platform to identify nodes and links for graph data of a graph database. The operations also include populating the graph data with the nodes and links from the translated nodes. A query to the graph data of the graph database reveals a subset of nodes of the nodes and links between the nodes of the subset of nodes and other nodes of the nodes of the graph data.

Abstract: An active plasma sterilizer (APS) system for sterilization/decontamination is provided, including a sterilization box and a plurality of compact portable plasma reactors (CPPRs) disposed in the sterilization box and configured for generating surface dielectric barrier discharge (SDBD) for generating and distributing reactive oxygen and nitrogen species (RONS) such as ozone. Each of the plurality of CPPRs includes a reactor panel and a power supply circuit. The reactor panel includes one or more electrodes separated by a dielectric medium. The active plasma sterilizer (APS) system may include an ozone decomposition module having a heating element connected to a power supply and configured to decompose ozone by heating ozonated air; a power supply module for supplying power to the heating element; connecting pipes for providing paths for ozonated air to travel through; and an air pump configured to circulate the ozonated air generated.

Abstract: Access assemblies includes an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a centering mechanism for maintaining the seal assembly and guard assembly centered within a cavity of the instrument valve. In embodiments, the seal assembly includes a plurality of seal sections that are movable from an unfolded configuration to folded configuration in which the seal assembly forms a hexagonal member defining an opening to facilitate sealed passage of a surgical instrument. The seal sections may include a tapered inner edge for engaging a surgical instrument inserted through the instrument valve housing.

Abstract: Included herein are manufacturing methods relating to water soluble substrates with particles and an apparatus to place the particles on the water soluble substrate.

Abstract: A method of manufacturing a non-fibrous water soluble product comprising particles, comprising: a) providing a first continuous water soluble non-fibrous substrate comprising a first side and moving in a first direction, b) providing a discretizing unit comprising one or more pockets comprising an opening; c) providing a continuous feed of first particles to at least one of the one or more pockets of the discretizing unit through the pocket opening at least partially filling the at least one of the one or more pockets, d) delivering the first particles from the pocket through the opening onto a portion of the first side of the first continuous water soluble non-fibrous substrate, and e) at least partially covering the first side of the first continuous water soluble non-fibrous substrate.

Abstract: Included herein are manufacturing methods relating to water soluble non-fibrous substrates with particles and an apparatus to place the particles on the water soluble non-fibrous substrate.

Abstract: Included herein are manufacturing methods relating to water soluble fibrous substrates with particles and an apparatus to place the particles on the water soluble fibrous substrate.

Abstract: An access assembly includes an instrument valve housing and a valve assembly disposed within the instrument valve housing. The instrument valve housing includes upper and lower housing sections. The valve assembly includes a centering mechanism, a seal assembly, and a guard assembly. The centering mechanism is configured to bias the valve assembly towards a generally centered position within the instrument valve housing. The centering mechanism includes a base seal member having an annular base and a flange portion. The flange portion includes an arcuate portion configured to adjustably engage first and second surfaces of the instrument valve housing in a sealing relation. The seal assembly is attachable to the centering mechanism. The seal assembly is configured to engage a surgical instrument inserted into the access assembly in a sealing relation. The guard assembly is attachable to the centering mechanism.

Abstract: The present disclosure provides methods of treating breast cancer with a combination of amcenestrant and palbociclib.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: A method of removing chemical contaminants from a composition comprising an active, a solvent, and a contaminant can include providing an initial feed supply, wherein the initial feed supply comprises the active, the solvent, and the contaminant, wherein the contaminant can include 1,4 dioxane, dimethyl dioxane, or a combination thereof; including filtering the initial feed stock through a nanofilter.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: A liquid dispensing system for dispensing two or more liquids of different composition, viscosity, solubility and/or miscibility at high filling speeds into a container through a unitary dispensing nozzle to improve homogeneous mixing of such liquids, while said nozzle is an integral piece free of any movable parts.

Abstract: An active plasma sterilizer (APS) system for sterilization/decontamination is provided, including a sterilization box and a plurality of compact portable plasma reactors (CPPRs) disposed in the sterilization box and configured for generating surface dielectric barrier discharge (SDBD) for generating and distributing reactive oxygen and nitrogen species (RONS) such as ozone. Each of the plurality of CPPRs includes a reactor panel and a power supply circuit. The reactor panel includes one or more electrodes separated by a dielectric medium. The active plasma sterilizer (APS) system may include an ozone decomposition module having a heating element connected to a power supply and configured to decompose ozone by heating ozonated air; a power supply module for supplying power to the heating element; connecting pipes for providing paths for ozonated air to travel through; and an air pump configured to circulate the ozonated air generated.

Abstract: A liquid dispensing system for dispensing two or more liquids of different composition, viscosity, solubility and/or miscibility at high filling speeds into a container through a unitary dispensing nozzle to improve homogeneous mixing of such liquids, while said nozzle is an integral piece free of any movable parts.