Abstract: The present disclosure relates to methods and apparatus that collect data regarding malware threats, that organizes this collected malware threat data, and that provides this data to computers or people such that damage associated with these software threats can be quantified and reduced. The present disclosure is also directed to preventing the spread of malware before that malware can damage computers or steal computer data. Methods consistent with the present disclosure may optimize tests performed at different levels of a multi-level threat detection and prevention system. As such, methods consistent with the present disclosure may collect data from various sources that may include endpoint computing devices, firewalls/gateways, or isolated (e.g. “sandbox”) computers. Once this information is collected, it may then be organized, displayed, and analyzed in ways that were not previously possible.

Abstract: In some embodiments, the present invention provides an exemplary computer system that includes at least the following components: at least one processor; a non-transitory memory storing software instructions; and where, when executing the software instructions by the processor, the computer system is configured to perform at least: controlling a plurality of first software objects; controlling a plurality of second software objects; controlling a plurality of third software object; where each software object includes at least one property programmed with at least one trigger condition and at least one programmed action; where the at least one pre-programmed action is configured to dynamically change a value of at least one property of at least one other software object based on: i) the at least one trigger condition; and ii) a value of at least one other property.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: An actuator for use in a surgical instrument, the actuator includes an upper portion configured to be actuated by one or more fingers, wherein the upper portion has an upper distal portion for operating the surgical instrument in a first mode of operation, and an upper proximal portion for operating the surgical instrument in a second mode of operation, and wherein the upper distal portion and the upper proximal portion have different respective tactile configurations for informing the user of the first and second modes of operation, respectively.

Abstract: Inserts and features to reduce or prevent spline crash in surgical staplers and/or to minimize damage resulting from spline crash in surgical staplers. An insert for a surgical stapler includes a body and spline covers. The body is configured to fit within a bore of a shell assembly and the spline covers extend inward from the body. Each of the spline covers are sized and dimensioned to cap a distal portion of splines of the shell assembly. A shell assembly for a surgical stapler includes shell splines that are disposed on an inner wall of an inner housing portion that defines a bore. The shell splines include a lead spline that has a leading end positioned distal of a leading end of each of the other shell splines.

Abstract: A surgical stapling apparatus (stapler) including a housing, elongated member, and a reload is disclosed. A cartridge is configured to selectively couple to a first jaw member of the reload and includes one or more resilient members thereon. An anvil operably supported on a second jaw member of the reload is configured to compress one or more fasteners ejected from the cartridge. The anvil includes one or more locking members thereon. A knife is configured to translate through the cartridge and anvil when the first and second jaw members are in a closed configuration. Engagement between the knife and the resilient member(s) causes the resilient member(s) to move from an initial configuration that allows the knife to travel distally past the locking member(s) to a final configuration that allows the locking member(s) to engage the knife.

Abstract: This invention is directed toward a system which can “step into the shoes” of a user and learn the perspective of that user, regarding photographs or other content, to the point where the system can learn, using criteria it has developed through its interaction with the user, to select photographs it predicts the user will find meaningful from large sets of photographs. The “meaningfulness” of various content from a multitude of users is a constantly improving system made up of four basic elements: a General Content Perspective, an Individual Content Perspective, a Natural Language Generation and Content Presentation, and a Hypersphere element.

Abstract: Some examples include a portable support pad constructed of nonwoven needlefelt, such as for relieving physical stress and fatigue endured from extended kneeling, sitting, lying and/or standing on rigid, flat, irregular, and/or un-even surfaces. The support pad constructed of the nonwoven needlefelt is flexible porous, absorptive, and chemically resistant to corrosive substances.

Abstract: Responsive to the request for a security fabric report, an upper-level node transits a request to a lower-level node for a subtree security report. If there are additional network gateways at lower hierarchical levels, the next level down repeats the process. A root level network gateway will transmit the first request, as the high level of the hierarchy, and a last leaf receives the last request, as the lowest level. An overall security fabric report is returned from the root node.

Abstract: An electromechanical surgical device includes an end effector configured to perform at least one function, the end effector including an input drive axle projecting therefrom; and a shaft assembly. The shaft assembly includes a rotatable drive shaft; a proximal neck housing supported at a distal end of an outer tube; a distal neck housing pivotally connected to the proximal neck housing; a pivot pin interconnecting the proximal neck housing and the distal neck housing; and a gear train supported in the proximal neck housing, on the pivot pin, and in the distal neck housing. The gear train includes a proximal gear; an intermediate gear; a distal gear; and a pair of output gears, wherein each output gear defines a coupling socket each configured to selectively receive the drive axle of the end effector.

Abstract: The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.

Abstract: A surgical grasper includes an articulation assembly configured to enable a tool assembly to pivot in a first plane and articulate in a second plane orthogonal to the first plane. The surgical grasper eliminates the center line pivot joint used in conventional articulation mechanism, which, in turn, enables use of thicker cable that provides greater clamping force of first and second jaws of the tool assembly.

Abstract: The present disclosure provides TGF? inhibitor therapy for treating immunosuppressive conditions, cancer, and fibrosis, either as a monotherapy or combination/adjunct therapy. Selection of suitable therapy and patients who are likely to benefit from such therapy are also disclosed, as well as methods of treating cancer and fibrosis and methods of predicting and monitoring therapeutic response. Related compositions, methods and therapeutic use are also disclosed.

Abstract: Electrical stimulation of specific facial and lingual nerves creates a more sustained pulsatility activity compared to stimulation of other cranial nerves. Pulsatility of arteries has intrinsic time constraints related to the time for vasodilation/constriction and time to return to baseline (TBL) after electrical stimulation which may affect the pulsatility response. Control of temporal patterning and the stimulation waveform maximizes the physiological response to cerebral pulsatility and its resulting effects on cerebral spinal fluid penetration into the brain parenchyma for a multitude of therapeutic uses including clearing misfolded proteins and/or administered pharmacological agents, diluting endogenous neurochemical concentrations within the brain, and reducing non-synaptic coupling.

Abstract: Inserts and features to reduce or prevent spline crash in surgical staplers and/or to minimize damage resulting from spline crash in surgical staplers. An insert for a surgical stapler includes a body and spline covers. The body is configured to fit within a bore of a shell assembly and the spline covers extend inward from the body. Each of the spline covers are sized and dimensioned to cap a distal portion of splines of the shell assembly. A shell assembly for a surgical stapler includes shell splines that are disposed on an inner wall of an inner housing portion that defines a bore. The shell splines include a lead spline that has a leading end positioned distal of a leading end of each of the other shell splines.

Abstract: This invention is directed toward a system which can “step into the shoes” of a user and learn the perspective of that user, regarding photographs or other content, to the point where the system can learn, using criteria it has developed through its interaction with the user, to select photographs it predicts the user will find meaningful from large sets of photographs. The “meaningfulness” of various content from a multitude of users is a constantly improving system made up of four basic elements: a General Content Perspective, an Individual Content Perspective, a Natural Language Generation and Content Presentation, and a Hypersphere element.

Abstract: An apparatus includes a crossbar to which a plurality of accessories using different mechanical interfaces may be attached and detached. The crossbar is instrumented and provides information, such as a weight change due to addition to, or removal of, items from an accessory on the crossbar. An extensible bracket attaches the crossbar to a supporting structure, decreasing mechanical strain on the crossbar due to minor misalignment of the supporting structure. Accessories such as wire hooks, shelves, bins, and so forth may be supported by the crossbar. A tether device, locking cam device, or clip device may be used to prevent lateral movement of components such as the accessories or the entire crossbar relative to its supporting structure. A baffle may be affixed to the crossbar to constrain airflow for operation in a temperature-controlled case.

Abstract: Densified textile aggregates are co-fed with a fuel into a partial oxidation gasifier. High solids concentrations in the feedstock composition can be obtained without significant impact on the feedstock composition stability and pumpability. A consistent quality of densified textile derived syngas can be continuously produced, including generation of carbon dioxide and a carbon monoxide/hydrogen ratio while stably operating the gasifier and avoiding the high tar generation of fluidized bed or fixed bed waste gasifiers and without impacting the operations of the gasifier. The densified textile derived syngas quality, composition, and throughput are suitable for produce a wide range of chemicals and polymers, including methanol, acetic acid, methyl acetate, acetic anhydride, and cellulose esters through a variety of reaction schemes in which at least a portion of the chemical or polymer originates with densified textile derived syngas.