Patents by Inventor Juswinder Singh

Juswinder Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4,6-disubstitued pyrimidines useful as kinase inhibitors
    Patent number: 7982036
    Abstract: The present invention provides compounds of formula I wherein Ring A, Ring B, m, Rx, Ry, W and R1 are as defined herein, pharmaceutically acceptable salts and compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: July 19, 2011
    Assignee: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
  • Protein Kinase Conjugates and Inhibitors
    Publication number: 20110117073
    Abstract: The invention relates to protein conjugates that contain a protein kinase containg a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
    Type: Application
    Filed: September 15, 2010
    Publication date: May 19, 2011
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Russell Colyn Petter, Deqiang Niu, Lixin Qiao, Arthur Kluge, Roy Lobb, Shomir Ghosh, Zhendong Zhu
  • HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20100249092
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 29, 2009
    Publication date: September 30, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Russell Petter, Richland Wayne Tester, Arthur F. Kluge, Hormoz Mazdiyasni, William Frederick Westlin, III, Deqiang Niu, Lixin Qiao
  • ALGORITHM FOR DESIGNING IRREVERSIBLE INHIBITORS
    Publication number: 20100185419
    Abstract: The invention is an algorithm and method for designing an inhibitor that covalently binds a target polypeptide. The algorithm and method can be used to rapidly and efficiently convert reversible inhibitors into irreversible inhibitors.
    Type: Application
    Filed: September 4, 2009
    Publication date: July 22, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Russell Colyn Petter, Dequiang Niu
  • Pyrazolopyridines and methods of making and using the same
    Patent number: 7691865
    Abstract: Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: April 6, 2010
    Assignee: Biogen Idec MA Inc.
    Inventors: Wen-Cherng Lee, Mary Beth Carter, Lihong Sun, Paul Lyne, Claudio Chuaqui, Zhongli Zheng, Juswinder Singh, Paula Boriack-Sjodin
  • HCV PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20100069294
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 2, 2009
    Publication date: March 18, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Russell C. Petter, Juswinder Singh, Arthur F. Kluge, Deqiang Niu, Lixin Qiao, Shomir Ghosh
  • HCV PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20100041674
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 14, 2009
    Publication date: February 18, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Deqiang Niu, Russell C. Petter, Lixin Qiao, Juswinder Singh
  • HCV PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20100041591
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 2, 2009
    Publication date: February 18, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Deqiang Niu, Russell C. Petter, Juswinder Singh, Arthur F. Kluge, Lixin Qiao
  • Heteroaryl Compounds and Uses Thereof
    Publication number: 20100029610
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 26, 2009
    Publication date: February 4, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Russell Petter, Richland Wayne Tester, Arthur F. Kluge, Hormoz Mazdiyasni, William Frederick Westlin, III, Deqiang Niu, Lixin Qiao
  • HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20100016296
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: April 20, 2009
    Publication date: January 21, 2010
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
  • HCV PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20090306085
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 19, 2008
    Publication date: December 10, 2009
    Applicant: Avila Therapeutics, Inc.
    Inventors: Russell C. Petter, Juswinder Singh, Arthur F. Kluge, Deqiang Niu, Lixin Qiao, Shomir Ghosh
  • HCV PROTEASE INHIBITORS AND USES THEREOF
    Publication number: 20090176858
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 19, 2008
    Publication date: July 9, 2009
    Applicant: Avila Therapeutics, Inc.
    Inventors: Deqiang Niu, Russell C. Petter, Juswinder Singh, Arthur F. Kluge, Lixin Qiao
  • HETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20090137588
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 17, 2008
    Publication date: May 28, 2009
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
  • HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20080300268
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 3, 2008
    Publication date: December 4, 2008
    Applicant: Avila Therapeutics, Inc.
    Inventors: Juswinder SINGH, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter
  • Pyrimidinylpyrazoles as Tgf-Beta Inhibitors
    Publication number: 20080171755
    Abstract: The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).
    Type: Application
    Filed: August 24, 2005
    Publication date: July 17, 2008
    Inventors: Wen-Cherng Lee, Lihong Sun, Claudio Chuaqui, Mark Comebise, Juswinder Singh, Feng Shan
  • Structural interaction fingerprint
    Publication number: 20070134662
    Abstract: Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning to each information unit a calculated value to represent the characteristic of a set of intermolecular interactions occurring at each selected position (i.e., a position on the target molecule at which intermolecular interaction occurs), a SIFt of the target molecule-ligand complex is constructed.
    Type: Application
    Filed: July 1, 2004
    Publication date: June 14, 2007
    Inventors: Juswinder Singh, Claudio Chuaqui, Zhan Deng
  • Detecting protein similarity
    Publication number: 20070088506
    Abstract: The disulfide bridges in a protein sequence can be described by a disulfide signature that includes information about cysteine spacing and disulfide topology. Proteins with similar disulfide signatures can be structurally similar despite low overall sequence homology. A database of disulfide signatures can be compiled from publicly available sequence data.
    Type: Application
    Filed: November 23, 2004
    Publication date: April 19, 2007
    Applicant: Biogen Idec MA Inc.
    Inventors: Juswinder Singh, Herman Van Vlijmen, Abhas Gupta
  • Structural interaction fingerprint
    Publication number: 20070020642
    Abstract: Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning to each information unit a calculated value to represent the characteristic of a set of intermolecular interactions occurring at each selected position (i.e., a position on the target molecule at which intermolecular interaction occurs), a SIFt of the target molecule-ligand complex is constructed.
    Type: Application
    Filed: August 18, 2005
    Publication date: January 25, 2007
    Inventors: Zhan Deng, Claudio Chuaqui, Juswinder Singh
  • Pyrazoles and methods of making and using the same
    Publication number: 20060264440
    Abstract: The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).
    Type: Application
    Filed: February 12, 2004
    Publication date: November 23, 2006
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Wen-Cherng Lee, Lihong Sun, Feng Shan, Claudio Chuaqui, Mark Cornebise, Timothy Pontz, Mary Carter, Juswinder Singh, Paula Boriack-Sjodin, Leona Ling, Russell Petter
  • Cell adhesion inhibitors
    Publication number: 20060166866
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Application
    Filed: October 7, 2003
    Publication date: July 27, 2006
    Inventors: Steven Adams, Ko-Chung Lin, Wen-Cherng Lee, Alfredo Castro, Craig Zimmerman, Charles Hammond, Yu-Sheng Liao, Julio Cuervo, Juswinder Singh