Patents by Inventor Jy-An Wang

Jy-An Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11931456
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: March 19, 2024
    Assignee: MegaPro Biomedical Co. Ltd.
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Publication number: 20240000978
    Abstract: A method of tracking immune cells to detect immune response. The method including steps of identifying a patient having a disease associated with an organ; administering biocompatible magnetic nanoparticles into the blood stream of the patient; and obtaining a magnetic resonance image of the organ. The presence of hyperintense or hypointense spots in the magnetic resonance image indicates immune response in the patient.
    Type: Application
    Filed: August 7, 2023
    Publication date: January 4, 2024
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Shian-Jy Wang
  • Publication number: 20230078391
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Application
    Filed: November 16, 2022
    Publication date: March 16, 2023
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Patent number: 11541007
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: January 3, 2023
    Assignee: MegaPro Biomedical Co., Ltd.
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Publication number: 20220080057
    Abstract: A biocompatible magnetic material containing an iron oxide nanoparticle and one or more biocompatible polymers, each having formula (I) below, covalently bonded to the iron oxide nanoparticle: in which each of variables R, L, x, and y is defined herein, the biocompatible magnetic material contains 4-15% Fe(II) ions relative to the total iron ions. Also disclosed in a method of preparing the biocompatible magnetic material.
    Type: Application
    Filed: November 24, 2021
    Publication date: March 17, 2022
    Inventors: Wen-Yuan Hsieh, Yuan-Hung Hsu, Chia-Wen Huang, Ming-Cheng Wei, Chih-Lung Chen, Shian-Jy Wang
  • Publication number: 20200360287
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Application
    Filed: May 16, 2019
    Publication date: November 19, 2020
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Patent number: 10641840
    Abstract: Systems, methods and piezoelectric patches are provided for monitoring the structural health of connectors in overhead transmission lines. A plurality of piezoelectric patches is mounted to different locations on the connector. At least one of the patches is actuated using an AC voltage and certain electrical properties either from the same patch or of a different patch are evaluated over time to determine the structural health of the connectors.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: May 5, 2020
    Assignee: UT-BATTELLE, LLC
    Inventors: Hong Wang, Jy-An Wang, Fei Ren
  • Publication number: 20190247522
    Abstract: A biocompatible magnetic material containing an iron oxide nanoparticle and one or more biocompatible polymers, each having formula (I) below, covalently bonded to the iron oxide nanoparticle: in which each of variables R, L, x, and y is defined herein, the biocompatible magnetic material contains 4-15% Fe(II) ions relative to the total iron ions. Also disclosed in a method of preparing the biocompatible magnetic material.
    Type: Application
    Filed: November 29, 2018
    Publication date: August 15, 2019
    Inventors: Wen-Yuan Hsieh, Yuan-Hung Hsu, Chia-Wen Huang, Ming-Cheng Wei, Chih-Lung Chen, Shian-Jy Wang
  • Publication number: 20180210024
    Abstract: Systems, methods and piezoelectric patches are provided for monitoring the structural health of connectors in overhead transmission lines. A plurality of piezoelectric patches is mounted to different locations on the connector. At least one of the patches is actuated using an AC voltage and certain electrical properties either from the same patch or of a different patch are evaluated over time to determine the structural health of the connectors.
    Type: Application
    Filed: January 25, 2018
    Publication date: July 26, 2018
    Inventors: Hong Wang, Jy-An Wang, Fei Ren
  • Patent number: 9492399
    Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: November 15, 2016
    Assignee: MegaPro Biomedical Co., Ltd.
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Su-Yo Lin, Shin-Yi Huang, Yuan-Hung Hsu, Shian-Jy Wang, Hsin Jung Huang
  • Patent number: 9413092
    Abstract: An electrical connector for connecting electrical power transmission lines where the electrical connector is capable of conducting 1×106 to 2.5×106 siemens per meter squared (S/m2), and includes a base metal having a surface layer doped with a conductive material dopant. The conductive dopant material improves the reliability and performance of the electrical connector. An electrical power transmission system includes electrical power transmission lines connected by the electrical connector, and a method of joining power transmission lines with the electrical connector.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: August 9, 2016
    Assignee: Electric Power Research Institute, Inc.
    Inventors: John K. Chan, Gary Charles Sibilant, Jy-An Wang, Fei Ren
  • Publication number: 20160008292
    Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Su-Yo Lin, Shin-Yi Huang, Yuan-Hung Hsu, Shian-Jy Wang, Hsin Jung Huang
  • Publication number: 20160008491
    Abstract: A method of tracking immune cells to detect immune response. The method including steps of identifying a patient having a disease associated with an organ; administering biocompatible magnetic nanoparticles into the blood stream of the patient; and obtaining a magnetic resonance image of the organ. The presence of hyperintense or hypointense spots in the magnetic resonance image indicates immune response in the patient.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Shian-Jy Wang
  • Publication number: 20140199349
    Abstract: Disclosed is a pH-sensitive hyaluronic acid derivative, comprising at least one repeat unit as shown in the following formula (I), wherein HA represents a unit comprising N-acetyl-D-glucosamine and D-glucuronic acid, q represents an integer of 2 to 10,000; A represents a biocleavable linkage comprising at least one of hydrazone, acetal, ketal and imine; M represents at least one of a hydrophobic fragment, a hydrophilic fragment, and an amphiphilic fragment, and p represents the number of [A-M] directly grafted onto each HA unit, p represents an integer of 0 to 4, and the p of each HA unit is not 0 at the same time.
    Type: Application
    Filed: December 29, 2011
    Publication date: July 17, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jean-Dean Yang, Ayi-Man Chou, Jui-Hsiang Chen, Hsia-Wei Liu, Shian-Jy Wang, Tse-Min Teng, Hsiang-Fa Liang, Ming-Cheng Wei, Maggie J.M. Lu
  • Publication number: 20140151117
    Abstract: An electrical connector for connecting electrical power transmission lines is provided. The electrical connector is capable of conducting 1×106 to 2.5×106 siemens per meter squared (S/m2), and includes a base metal having a surface layer doped with a conductive material dopant. The conductive dopant material improves the reliability and performance of the electrical connector. An electrical power transmission system including electrical power transmission lines connected by the electrical connector, and a method of joining power transmission lines with the electrical connector are also disclosed.
    Type: Application
    Filed: November 22, 2013
    Publication date: June 5, 2014
    Applicant: Electric Power Research Institute, Inc.
    Inventors: John K. CHAN, Gary Charles SIBILANT, Jy-An WANG, Fei REN
  • Patent number: 8664529
    Abstract: Disclosed are several examples of an apparatus for connecting the free ends of two electrical power transmission lines having conductor strands disposed around a central, reinforcing core. The examples include an inner sleeve having a body defining an inner bore passing through an axially-extending, central axis, an outer rim surface disposed radially outward from the central bore, and one or more axially-extending grooves penetrating the body at the outer rim surface. Also included is an outer splice having a tubular shaped body with a bore passing coaxially through the central axis, the bore defining an inner rim surface for accepting the inner sleeve. The inner bore of the inner sleeve accepts the reinforcement cores of the two conductors, and the grooves accept the conductor strands in an overlapping configuration so that a majority of the electrical current flows between the overlapped conductor strands when the conductors are transmitting electrical current.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: March 4, 2014
    Assignee: UT-Battelle, LLC
    Inventors: Jy-An Wang, Fei Ren, Dominic F. Lee, Hao Jiang
  • Patent number: 8586095
    Abstract: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: November 19, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Wen Hsiang Chang, Chao-Hung Kao, Chin-I Lin, Shian-Jy Wang
  • Patent number: 8562953
    Abstract: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is CH2CH2Ol, and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: October 22, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Dhakshanamurthy Thirumalai, Chin-I Lin, Shian-Jy Wang
  • Publication number: 20130192870
    Abstract: Disclosed are several examples of an apparatus for connecting the free ends of two electrical power transmission lines having conductor strands disposed around a central, reinforcing core. The examples include an inner sleeve having a body defining an inner bore passing through an axially-extending, central axis, an outer rim surface disposed radially outward from the central bore, and one or more axially-extending grooves penetrating the body at the outer rim surface. Also included is an outer splice having a tubular shaped body with a bore passing coaxially through the central axis, the bore defining an inner rim surface for accepting the inner sleeve. The inner bore of the inner sleeve accepts the reinforcement cores of the two conductors, and the grooves accept the conductor strands in an overlapping configuration so that a majority of the electrical current flows between the overlapped conductor strands when the conductors are transmitting electrical current.
    Type: Application
    Filed: January 30, 2012
    Publication date: August 1, 2013
    Applicant: UT-BATTELLE, LLC
    Inventors: Jy-An Wang, Fei Ren, Dominic F. Lee, Hao Jiang
  • Patent number: 8486299
    Abstract: The invention provides phosphors composed of Eu(1-x-w)MaxMbwMgMc10O17, wherein Ma is Yb, Sn, Ce, Tb, Dy, or combinations thereof, and 0<x<0.5, Mb is Ca, Sr, Ba, or combinations thereof, and 0?w?0.5, and Mc is Al, Ga, Sc, In, or combinations thereof. The blue phosphors emit blue light under the excitation of ultraviolet light or blue light, and the phosphors may be further collocated with different colored phosphors to provide a white light illumination device. The blue phosphors of the invention can efficiently utilize light in solar cells.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: July 16, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Tien-Heng Huang, Fang-Ching Chang, Yao-Tsung Yeh, Shian-Jy Wang