Abstract: This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.

Abstract: A core apparatus connectable to at least one sensor and to at least one fluid delivery device which includes a base housing, a connection hub to couple to the at least one sensor and to the at least one fluid delivery device, and a controller disposed within the base housing to communicate with the at least one sensor and to the at least one fluid delivery device, wherein the controller forms a continuous feedback loop with the at least one sensor and the at least one fluid delivery device.

Abstract: This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.

Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.

Abstract: The present invention provides a process for direct hydroxylation of aromatic hydrocarbons like benzene to phenol, toluene to cresols and anisole to methoxy phenols by using hydrogen peroxide as environmentally benign oxidant in polar solvent like acetonitrile using vanadium phthalocyanine or its derivative as a catalyst, at a temperature in the range of 25-100° C.

Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.

Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.

Abstract: The present invention provides a process for direct hydroxylation of aromatic hydrocarbons like benzene to phenol, toluene to cresols and anisole to methoxy phenols by using hydrogen peroxide as environmentally benign oxidant in polar solvent like acetonitrile using vanadium phthalocyanine or its derivative as a catalyst, at a temperature in the range of 25-100° C.

Abstract: An apparatus and method for multidimensional forecasting. In one embodiment of the method a database is accessed to select a set of data objects each of which has a date field that contains a date that falls within a predefined time period. The data contained in a first field of each of the set of data objects is summed thereby generating a first total. The data contained in the first field of each of a first subset of the set of data objects is summed thereby generating a first subset total. A user interface is then displayed on a monitor of a computer system, wherein the user interface, when displayed, comprises graphical representations of the first total and the first subset total.

Abstract: A system for performing bone arthrodesis includes an implant for bone arthrodesis and a bone fastening device. The implant includes a fastener with an elongated shaft having a head at one end and a bone-piercing point at the opposite end. A first washer has structure for engaging the head of the shaft so as to be polyaxially pivotable with respect to the head. A locking member has structure for engaging the shaft. The locking member can have a second washer pivotally engaged thereto. The bone fastening device can include an elongated cannula with a collet for detachably engaging the first washer and for advancing the first washer. Structure is provided for engaging the fastener and for advancing and rotating the fastener through the collet and through the first washer. The bone arthrodesis device further includes a lower end portion extending from the cannula. The lower end portion has structure for detachably engaging the locking member.

Abstract: A wide angle viewing device comprising a viewing head, a plurality of sensors, and a detector. The sensors are connected to the viewing head with each sensor positioned facing a unique direction such that the combination of sensors effectively views and entire volume, such as an entire room. The sensors collect radiation from the volume and deliver it to the detector. In one embodiment, the viewing device is used in a flame detector for detecting the presence of a fire in the viewed volume.

Abstract: An infrared spectrometer is adapted to capture spectral data at high frequency and includes an aperture defining slit and tuning fork chopper for periodically admitting infrared radiation. A lens and a plurality of mirrors direct the infrared radiation through pair of calcium fluoride prisms that split the infrared radiation into spectral components. The spectral components are directed by an additional mirror and lens to an array of lead selenide pixels that generate a set of data indicative of the spectral component intensities. Data collection circuitry coupled to the pixel array and coupled to the tuning fork chopper collects the set of data at a selectable rate at least once during each opening of the aperture. A serial output on the data collection circuitry provides a list of data values representative of the spectral intensity at each pixel which can be then stored in a mass storage device as well as immediately analyzed based on selected criteria.

Abstract: Laser sheet tomography is employed to determine flow field statistics in non-steady and steady flow at high repetition rates. The laser sheet tomography system is divided into two independent optical portions, the laser illuminator and the laser imager. As an absorption instrument, the laser illuminator can be shone directly into the laser imager, or if desired, the two portions can be positioned orthogonally to each other with the laser imager observing the scattered light. The observed light is correlated with known variations in laser intensity of the imager to generate transmittance data from which asymmetry ratios and probability density functions of local absorption coefficients can be computed at time repetition rates of 200 Hz and greater.

Abstract: A fire and smoke detector utilizes a statistical analysis of the near infrared radiation incident on it. The spectral radiation intensities incident on the fire detector are continuously measured at two near-infrared wavelengths, and a time series of apparent source temperatures is obtained from these measurements. The power spectral density and the probability density function of the apparent source temperatures are sufficient to determine the presence of a fire in the vicinity of the detector. The detector can indicate the presence of a fire in an adjoining room from the radiation which is incident on it due to reflections from common building materials. The present invention relates to fire and/or smoke detection methodology and associated apparatus. The detector utilizes fiber optic as a viewing and absorption/scattering detection means.

Abstract: The invention is a method of treating chronic pain associated with muscle spasms, tendonitis and sciatica comprising administering to a human patient an effective amount of niacin.