Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.

Abstract: The present disclosure provides a method of bioprinting a 3-D structure comprising one or more biologically-relevant materials on a super-hydrophobic surface. In one embodiment, the method comprises providing a composition having one or more biologically-relevant materials dispersed within a biocompatible medium. A pattern comprising a hydrophilic material is deposited on a defined area of the super-hydrophobic surface, wherein the pattern is modeled after a biological structure. The composition having the one or more biologically-relevant materials is then bioprinted atop the hydrophilic surface to form a 3-D structure, wherein the hydrophilic surface maintains the 3-D structure in a desired position or shape on the super-hydrophobic surface.

Abstract: A fluid moving apparatus includes an electric motor having a rotor and a stator and a fluid displacement member. The rotor rotates relative to the stator on a common axis to generate a rotational output. The rotational output is provided to the fluid displacement member to power the fluid displacement member to one of move linearly along and rotate about the common axis. The stator includes one or more coils configured to power rotation of the rotor. The one or more coils extend circumferentially around and can be coaxial on the common axis.

Abstract: A variety of footed and leadless semiconductor packages, with either exposed or isolated die pads, are described. Some of the packages have leads with highly coplanar feet that protrude from a plastic body, facilitating mounting the packages on printed circuit boards using wave-soldering techniques.

Abstract: An ink composition includes a polymeric binder having an addition copolymer and a ketone aldehyde resin. The addition copolymer is chosen from acrylic resins, vinyl resins including copolymers of vinyl chloride and vinyl acetate, and mixtures and combinations thereof. The ink composition further includes a liquid carrier with at least one organic solvent.

Abstract: Software installed in the nodes in a communication network allows them to perform a “name server” function, which entails the management of a dynamic list of the client devices that are connected to the cloud, a “task” function, which entails the receipt and transmission of the packets, and an “authority” function, which entails the determination of the routes of the packets through the cloud. Each node is capable of performing only one function at a time. After completing a job, a node reverts to an undifferentiated, state awaiting its next performance request.

Abstract: A fuel dispenser comprises fuel flow piping defining a flow path from a source of fuel toward a fueling nozzle. A plurality of fuel handling components are disposed along the fuel flow piping. Control electronics are in operative communication with the fluid handling components. A payment system includes a PIN pad that transmits secure tokens which are preferably cryptographically unique and independent such as not to be a function or derivative of network keys or user PIN. The tokens are then received and acted upon by a second subsystem to render PIN entry display data.

Abstract: A fluid moving apparatus includes an electric motor having a rotor and a stator and a fluid displacement member. The rotor rotates relative to the stator on a common axis to generate a rotational output. The rotational output is provided to the fluid displacement member to power the fluid displacement member to one of move linearly along and rotate about the common axis. The stator includes one or more coils configured to power rotation of the rotor. The one or more coils extend circumferentially around and can be coaxial on the common axis.

Abstract: A fully autonomous smart contract authoring system capable of concurrently generating multiple smart contracts from a single source file for a variety of blockchain networks from a single source file is disclosed.

Abstract: A system and method of identifying and maintaining synchronization of components within a container carrier applicating machine includes connecting a plurality of point of use feedback devices to operative components of the applicating machine and providing visual feedback from the plurality of feedback devices of location of sychronized and or unsynchronized components.

Abstract: A tissue construct is provided that comprises a pancreas derived microvessel fragment and a pancreatic islet cell. The pancreas derived microvessel fragment and the pancreatic islet cell can be incorporated into a biocompatible medium. Tissue constructs can be comprised of other cells, such as stem cells, combined with the pancreas derived microvascular fragment. Methods for isolating microvessel fragments from a pancreas are also provided and include enzymatic digestion of pancreatic tissue and separation of microvessel fragments from endocrine and exocrine tissue. Methods for treating diabetes are further provided and include administration of the tissue constructs.

Abstract: A variety of footed and leadless semiconductor packages, with either exposed or isolated die pads, are described. Some of the packages have leads with highly coplanar feet that protrude from a plastic body, facilitating mounting the packages on printed circuit boards using wave-soldering techniques.

Abstract: A retail environment having retail terminals with data entry point devices selectively encrypts input received by the data entry point devices and passes the encrypted data to a security module. The selective encryption is based on whether or not sensitive or confidential information, such as a personal identification number (PIN) associated with a debit card, is being input. To prevent hacking of the software of the retail terminal, content destined for display on the retail terminal is authenticated prior to display. In this manner, the retail terminal may be assured that confidential information is input only when desired, and thus may be encrypted only as needed.

Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A spinal construct includes an existing spinal rod implant defining a rod dimension and having at least one mating surface. At least one extension includes a mating surface engageable with the at least one mating surface of the existing spinal rod implant to comprise a connection having a dimension the same as the rod dimension. A coupling member is configured to fix the existing spinal rod implant with the at least one extension. Systems, surgical instruments, implants and methods are disclosed.

Abstract: A method of making a spheroid is provided that includes the step of providing a suspension having one or more biologically-relevant materials dispersed within a biocompatible medium. An amount of a hydrophilic material is deposited on a defined area of a super-hydrophobic surface, and a droplet of the suspension is bioprinted onto the hydrophilic material positioned on the super-hydrophobic to thereby create the spheroid.

Abstract: The present invention provides compounds of Formula (I): wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorders, such as cancer in a subject (e.g., a human).

Abstract: A spine stabilization and fusion system includes a lateral cage having a lateral cage bore hole. The system also includes a lateral cage insertion shaft comprising a leading end, a mid-portion, and a terminal end. A shape of the leading end matches a shape of the lateral cage bore hole such that the leading end mates with the lateral cage bore hole via a friction fit. The system also includes a lateral plate having a lateral plate bore hole and a plurality of holes, where the lateral plate bore hole receives the mid-portion of the lateral cage insertion shaft, and where the plurality of holes receive fasteners to couple the lateral plate to one or more vertebra.

Abstract: A fuel dispenser comprises fuel flow piping defining a flow path from a source of fuel toward a fueling nozzle. A plurality of fuel handling components are disposed along the fuel flow piping. Control electronics are in operative communication with the fluid handling components. A payment system includes a PIN pad that transmits secure tokens which are preferably cryptographically unique and independent such as not to be a function or derivative of network keys or user PIN. The tokens are then received and acted upon by a second subsystem to render PIN entry display data.