Abstract: The invention relates to the detection of the cofactor reduced nicotinamide adenine dinucleotide phosphate (NADPH). Provided is a sensor molecule for the resonance energy transfer (RET)-based detection of NADPH, the sensor comprising a segment A connected via a linker to a segment B, wherein each of segment A and segment B comprises a member of a RET pair comprising a donor moiety and an acceptor moiety, further characterized in that (i) segment A comprises a binding protein (BP) for NADPH, the BP being dihydrofolate reductase (DHFR; EC 1.5.1.3) or a functional homolog, fragment, derivative or variant thereof, showing the desired NADPH binding properties, and wherein the BP comprises a heterologous protein domain inserted at or replacing at least part of the region corresponding to positions (20) to (27) of E.

Abstract: Methods and systems for image generation include generating a latent representation of an image, modifying the latent representation of the image based on a trained attribute classifier and a specified attribute input, and decoding the modified latent representation to generate an output image that matches the specified attribute input.

Abstract: Methods and systems for training a model include training an encoder in an unsupervised fashion based on a backward latent flow between a reference frame and a driving frame taken from a same video. A diffusion model is trained that generates a video sequence responsive to an input image and a text condition, using the trained encoder to determine a latent flow sequence and occlusion map sequence of a labeled training video.

Abstract: In one example, a continuous-wave radar circuit receives reflection signals, computer processing circuitry processes data corresponding to the reflection signals, and emulation circuitry introduces a plurality of diagnostic data sets into the radar circuit to cause the radar circuit to process simulated reflection signals as though the simulated reflection signals are reflections from objects remote from the apparatus. The radar circuit may receive the reflection signals in response to chirp sequences actually transmitted as reflections from objects.

Abstract: A method for distributing symmetric encryption keys in a communication system comprising a plurality of nodes is disclosed. Each node comprises information about printer control settings and printer jobs and a printing device configured for generating encryption keys. The method comprises: providing to each node an initial session key information that comprises an initial printer control setting and an initial printer job setting; providing to each node as a one-time pad an initial session key package encrypted with the initial session key information and comprising items of first session key information, wherein any two nodes have a common item of first session key information; generating at each node second session key information that is different for each of the other nodes; and sending from one of the nodes to another node a message encrypted with the first session key information and comprising the second session key information.

Abstract: A computer implemented method for controlling a synthesis process for a chemical or biological product, comprising the steps of at a processing device of a synthesis specification control module receiving via a communication interface a synthesis specification for the synthesis process, deriving a set of experimental requirements from the synthesis specification, receiving via the communication interface device laboratory equipment data associated with at least one laboratory equipment device deriving a set of equipment properties from the laboratory equipment data associated with at least one laboratory equipment device, comparing the set of experimental requirements with the set of equipment properties, generating control data based on the comparison providing with the processing device the control data suitable for controlling the synthesis process.

Abstract: The claimed invention is directed to a novel composite half shaft. More specifically, the claimed invention provides for the integration of a continuous velocity joint within the hollow tubular portion of the axle shaft, which permits for a longer lightweight composite hollow shaft. The use of the lightweight material over additional length results in an overall weight reduction. Additional benefits include reduced unsprung weight in vehicles, improved mileage for gas powered vehicles and increased range for electric vehicles. The use of composite materials in place of a solid or hollow metal axle bar results in improved noise, vibration and harshness (“NVH”) characteristics over conventional half shafts..

Abstract: In one example, a continuous-wave radar circuit receives reflection signals, computer processing circuitry processes data corresponding to the reflection signals, and emulation circuitry introduces a plurality of diagnostic data sets into the radar circuit to cause the radar circuit to process simulated reflection signals as though the simulated reflection signals are reflections from objects remote from the apparatus. The radar circuit may receive the reflection signals in response to chirp sequences actually transmitted as reflections from objects.

Abstract: A method of generating at least one encryption key (130) for encrypting data (142), a method of 5 data transmission between at least two communication systems (136, 138), a method of encrypting data (142) and a method of decrypting encrypted data (144) are disclosed. Further disclosed are an encryption key generating device (110), a system (134), a data encryption system (148) and a data decryption system (150). The method of generating at least one encryption key (130) for encrypting data (142), specifically for data transmission over an insecure channel, comprises: i. blending at least two materials (114) according to at least one item of blending in-formation by using a blending device (112), thereby generating at least one blend (120); ii. detecting at least one material property (124) of the blend (120) by using at least one detector (126); and iii.

Abstract: A composite vehicle driveshaft is provided with a composite tube and a welded joint system(s) at one or both ends of the composite tube for connecting the composite vehicle driveshaft to driveline components. Each welded joint system may include a sleeve that is bonded to an end of the composite tube and a joint assembly that is welded to the sleeve.

Abstract: A composite vehicle driveshaft is provided with a crash collapse system that allows for a controlled longitudinal collapse of the driveshaft by facilitating telescopic movement of various components with respect to each other during a crash event. The crash collapse system may include a collapsible joint with a sleeve that is concentrically bonded in an end of a composite tube and a stub end assembly that is spline-engaged and interference fit within the sleeve, such as by way of a press-fit and/or a thermal shrink-fit procedure. This relationship may rotationally lock and axially fix the stub end assembly to the sleeve unless, during a crash event, the composite vehicle driveshaft experiences a compression or push-type force that exceeds a minimum breakaway or collapse force value that longitudinally and telescopically collapses the composite vehicle driveshaft.

Abstract: The invention relates to the detection of the cofactor reduced nicotinamide adenine dinucleotide phosphate (NADPH). Provided is a sensor molecule for the resonance energy transfer (RET)-based detection of NADPH, the sensor comprising a segment A connected via a linker to a segment B, wherein each of segment A and segment B comprises a member of a RET pair comprising a donor moiety and an acceptor moiety, further characterized in that (i) segment A comprises a binding protein (BP) for NADPH, the BP being dihydrofolate reductase (DHFR; EC 1.5.1.3) or a functional homolog, fragment, derivative or variant thereof, showing the desired NADPH binding properties, and wherein the BP comprises a heterologous protein domain inserted at or replacing at least part of the region corresponding to positions (20) to (27) of E.

Abstract: A connector assembly (1) comprises an outer housing (300); and a latch (330), which is carried by the outer housing (300), to allow a coupling of the connector assembly to a corresponding counter connector. Further, the outer housing (300) is configured to receive at least one of two different types of cables (100) through a first end and at least one of two different module mating interfaces (430, 432, 434) at a second end. In another embodiment the outer housing (300) is arranged movable on an inner housing (200), and the latch (330) is rotatably arranged on the outer housing (300).

Abstract: A composite vehicle driveshaft is provided with a composite tube and a welded joint system(s) at one or both ends of the composite tube for connecting the composite vehicle driveshaft to driveline components. Each welded joint system may include a sleeve that is bonded to an end of the composite tube and a joint assembly that is welded to the sleeve.

Abstract: A composite vehicle driveshaft is provided with a crash collapse system that allows for a controlled longitudinal collapse of the driveshaft by facilitating telescopic movement of various components with respect to each other during a crash event. The crash collapse system may include a collapsible joint with a sleeve that is concentrically bonded in an end of a composite tube and a stub end assembly that is spline-engaged and interference fit within the sleeve, such as by way of a press-fit and/or a thermal shrink-fit procedure. This relationship may rotationally lock and axially fix the stub end assembly to the sleeve unless, during a crash event, the composite vehicle driveshaft experiences a compression or push-type force that exceeds a minimum breakaway or collapse force value that longitudinally and telescopically collapses the composite vehicle driveshaft.

Abstract: The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Provided is a sensor molecule for fluorescence- or luminescence-based detection of a nicotinamide adenine dinucleotide analyte, in particular for detecting the concentrations of NAD+, NADP+ and/or the ratios of the concentrations of NAD+/NADH and NADP+/NADPH, the sensor comprising (i) a binding protein (BP) for the nicotinamide adenine dinucleotide analyte, the BP being derived from sepiapterin reductase (SPR; EC 1.1.1.153) (ii) an SPR ligand (SPR-L) capable of intramolecular binding to said BP in the presence of the oxidized form of said analyte; and (iii) at least one fluorophore.

Abstract: A remote antenna system is provided. The remote antenna system comprises an antenna controller circuit and a remote antenna circuit coupled to the antenna controller circuit by a cable. The remote antenna system further comprises a bidirectional data signal path for carrying transmit and received data signals between the antenna controller circuit and the remote antenna circuit; and a control path for carrying control information between the antenna controller circuit and the remote antenna circuit. The control path is a bidirectional control path. The control path comprises a transmit circuit comprising an input to receive control information and configured to convert the control information into a series of pulses; and a receive circuit comprising a comparator circuit configure to receive the series of pulses and reconstruct them to the control signal.

Abstract: A remote antenna system is provided. The remote antenna system comprises an antenna controller circuit and a remote antenna circuit coupled to the antenna controller circuit by a cable. The remote antenna system further comprises a bidirectional data signal path for carrying transmit and received data signals between the antenna controller circuit and the remote antenna circuit; and a control path for carrying control information between the antenna controller circuit and the remote antenna circuit. The control path is a bidirectional control path. The control path comprises a transmit circuit comprising an input to receive control information and configured to convert the control information into a series of pulses; and a receive circuit comprising a comparator circuit configure to receive the series of pulses and reconstruct them to the control signal.

Abstract: Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.

Abstract: The invention relates to the field of in vitro detection methods using luminescence. Provided is a sensor molecule for detecting an analyte of interest in a sample using bioluminescence resonance energy transfer (BRET), the sensor molecule comprising a proteinaceous moiety tethered to a synthetic regulatory molecule. Also provided is an analytical device comprising a sensor and methods using the sensor molecule.