Patents by Inventor Kai Rossen

Kai Rossen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of fexofenadine and of intermediates used therein
    Patent number: 10696633
    Abstract: A new process for the preparation of fexofenadine and of related intermediates, which can be used in the preparation of fexofenadine, is provided.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 30, 2020
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Hermut Wehlan, Kai Rossen, Guenter Billen
  • Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
    Patent number: 10336698
    Abstract: A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: July 2, 2019
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Hermut Wehlan, Kai Rossen, Alexander Schaefer
  • Process for the preparation of ramipril
    Patent number: 10112973
    Abstract: An enantioselective process for the production of (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid and its conversion into Ramipril is provided.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: October 30, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Gerhard Kretzschmar, Jan Oehme, Kai Rossen
  • PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN
    Publication number: 20180297951
    Abstract: A new process for the preparation of fexofenadine and of related intermediates, which can be used in the preparation of fexofenadine, is provided.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 18, 2018
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Hermut WEHLAN, Kai ROSSEN, Guenter BILLEN
  • PROCESS FOR THE PRODUCTION OF 2-[4-(CYCLOPROPANECARBONYL)PHENYL]-2-METHYL-PROPANENITRILE
    Publication number: 20170369440
    Abstract: A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.
    Type: Application
    Filed: January 21, 2016
    Publication date: December 28, 2017
    Inventors: Hermut WEHLAN, Kai ROSSEN, Alexander SCHAEFER
  • PROCESS FOR THE PREPARATION OF RAMIPRIL
    Publication number: 20170158733
    Abstract: An enantioselective process for the production of (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid and its conversion into Ramipril is provided.
    Type: Application
    Filed: June 8, 2015
    Publication date: June 8, 2017
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Gerhard KRETZSCHMAR, Jan OEHME, Kai ROSSEN
  • Salt of (R)-3-(6-amino-pyridin-3-yl)-2-(1-Cyclohexyl-1H-imidazol-4-yl) ethyl propionate
    Patent number: 9156815
    Abstract: The invention relates to the salt of naphthalene-1,5-disulfonic acid with (R)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)ethyl propionate, which can be represented by the following structural formula of formula (I), to methods for the production thereof, to drugs containing said salt, and to the use of said drugs to treat diseases that are accompanied by thromboses, embolisms, hypercoagulability, or fibrotic changes.
    Type: Grant
    Filed: November 22, 2012
    Date of Patent: October 13, 2015
    Assignee: Sanofi
    Inventors: Kai Rossen, Hermut Wehlan
  • Salt Of (R)-3-(6-Amino-Pyridin-3-Yl)-2-(1-Cyclohexyl-1H-Imidazol-4-Yl) Ethyl Propionate
    Publication number: 20140336226
    Abstract: The invention relates to the salt of naphthalene-1,5-disulfonic acid with (R)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)ethyl propionate, which can be represented by the following structural formula of formula (I), to methods for the production thereof, to drugs containing said salt, and to the use of said drugs to treat diseases that are accompanied by thromboses, embolisms, hypercoagulability, or fibrotic changes.
    Type: Application
    Filed: November 22, 2012
    Publication date: November 13, 2014
    Inventors: Kai Rossen, Hermut Wehlan
  • Process for the preparation of a compound useful as an inhibitor of TAFIa
    Patent number: 8865906
    Abstract: The present invention relates to a process for the preparation of a compound of the formula I, which comprises reacting a compound of the formula IV with an oxalic acid diester and to novel intermediate compounds used therein.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: October 21, 2014
    Assignee: Sanofi
    Inventors: Kai Rossen, Volker Kraft, Hermut Wehlan, Antony Bigot, Veronique Crocq-Stuerga
  • Process for the preparation of 6-substituted-1-(2H)-isoquinolinones
    Patent number: 8716481
    Abstract: The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: May 6, 2014
    Assignee: Sanofi
    Inventors: Kai Rossen, Hermut Wehlan, Oliver Plettenburg, Volker Kraft, Guenter Billen, Simon Gessler
  • Process for the production of benzofurans
    Patent number: 8674121
    Abstract: A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: March 18, 2014
    Assignee: SANOFI
    Inventors: Gerhard Kretzschmar, Volker Kraft, Thomas Olpp, Kai Rossen
  • Process for the production of dronedarone intermediates
    Patent number: 8658808
    Abstract: A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: February 25, 2014
    Assignee: Sanofi
    Inventors: Gerhard Kretzschmar, Volker Kraft, Kai Rossen, Joachim Graeser
  • Process for preparing n-protected 4-ketoproline derivatives
    Patent number: 8618310
    Abstract: The present invention is concerned with a process for preparing compounds of the general formula (I). These compounds can preferably be used to prepare bioactive agents. The reaction of the invention starts from the corresponding hydroxy compounds which are oxidized, with Ru catalysis, in a one-phase aqueous system.
    Type: Grant
    Filed: February 19, 2005
    Date of Patent: December 31, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Kai Rossen, Martin Sarich
  • Process for the production of artemisinin intermediates
    Patent number: 8334392
    Abstract: This application relates to a process for the production of (2R)-dihydroartemisinic acid or (2R)-dihydroartemisinic acid esters from artemisinic acid or artemisinic acid esters, respectively, by diimine hydrogenation of the exocyclic CC-double bond, and use of said process in the production of the antimalarial drug artemisinin.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: December 18, 2012
    Assignee: Sanofi
    Inventors: Volker Kraft, Gerhard Kretzschmar, Kai Rossen
  • METHOD FOR PRODUCING PYRAZOLE GLYCOSIDE DERIVATIVES
    Publication number: 20120264925
    Abstract: A process for preparing pyrazole-glycoside derivatives of the general Formula (I) in which the meanings are R1 H and R2 F; or R1 F and R2 H; or R1 F and R2 F; R3 (C1-C8)-alkyl, where one, more than one or all hydrogen(s) may be replaced by fluorine; X (C1-C3)-alkylene, (C2-C3)-alkenylene.
    Type: Application
    Filed: August 26, 2010
    Publication date: October 18, 2012
    Applicant: SANOFI
    Inventors: Michael Podeschwa, David Rigal, Kai Rossen, Bernhard Otto, Hermut Wehlan, Theodor Andreas Wollmann, Bernd Becker, Berndt Kulitzscher, Alexander Schaefer
  • PROCESS FOR THE PREPARATION OF A COMPOUND USEFUL AS AN INHIBITOR OF TAFIA
    Publication number: 20120245358
    Abstract: The present invention relates to a process for the preparation of a compound of the formula I, which comprises reacting a compound of the formula IV with an oxalic acid diester and to novel intermediate compounds used therein.
    Type: Application
    Filed: May 11, 2010
    Publication date: September 27, 2012
    Applicant: SANOFI
    Inventors: Kai Rossen, Volker Kraft, Hermut Wehlan, Antony Bigot, Veronique Crocq-Stuerga
  • PROCESS FOR THE PRODUCTION OF DRONEDARONE INTERMEDIATES
    Publication number: 20120077995
    Abstract: A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 29, 2012
    Applicant: SANOFI
    Inventors: Gerhard Kretzschmar, Volker Kraft, Kai Rossen, Joachim Graser
  • PROCESS FOR THE PRODUCTION OF BENZOFURANS
    Publication number: 20120065411
    Abstract: A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 15, 2012
    Applicant: SANOFI
    Inventors: Gerhard Kretzschmar, Volker Kraft, Thomas Olpp, Kai Rossen
  • PROCESS FOR THE PRODUCTION OF ARTEMISININ INTERMEDIATES
    Publication number: 20110230669
    Abstract: This application relates to a process for the production of (2R)-dihydroartemisinic acid or (2R)-dihydroartemisinic acid esters from artemisinic acid or artemisinic acid esters, respectively, by diimine hydrogenation of the exocyclic CC-double bond, and use of said process in the production of the antimalarial drug artemisinin.
    Type: Application
    Filed: September 10, 2010
    Publication date: September 22, 2011
    Inventors: VOLKER KRAFT, GERHARD KRETZSCHMAR, KAI ROSSEN
  • PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES
    Publication number: 20110021779
    Abstract: The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.
    Type: Application
    Filed: June 17, 2010
    Publication date: January 27, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Kai ROSSEN, Hermut WEHLAN, Oliver PLETTENBURG, Volker KRAFT, Guenter BILLEN, Simon GESSLER