Patents by Inventor Kai Rossen

Kai Rossen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-Benzyl-2-hydroxy-1, 4-oxazine-3-one and polymorphic forms thereof
    Publication number: 20020042510
    Abstract: The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
    Type: Application
    Filed: June 8, 2001
    Publication date: April 11, 2002
    Inventors: Louis S. Crocker, Karel M. Jos Brands, Todd D. Nelson, Philip J. Pye, Jonathan D. Rosen, Kai Rossen
  • Process for making diaryl pyridines useful as cox-2 inhibitors
    Patent number: 6369275
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: April 9, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Ian W. Davies, Michel Journet, Linda Gerena, Robert D. Larsen, Philip J. Pye, Kai Rossen
  • Process for the preparation of hydroxylactones
    Publication number: 20020038040
    Abstract: The present invention is directed towards a process for the preparation of enantiomerically enriched 4-hydroxymethyl-&ggr;-butyrolactone (I).
    Type: Application
    Filed: August 24, 2001
    Publication date: March 28, 2002
    Inventors: Kai Rossen, Stefan Eils
  • Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5- BIS (trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
    Publication number: 20020016458
    Abstract: The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1 -[3.5-bis(trifluoromethyl)phenyl]ethenyl] oxy]-3-(4-fluorophenyl)-4-(phenylmethyl)mopholine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
    Type: Application
    Filed: June 8, 2001
    Publication date: February 7, 2002
    Inventors: Philip J. Pye, Kai Rossen
  • PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES, AND COMPOUNDS PRODUCED
    Publication number: 20010025103
    Abstract: An efficient method for the synthesis of a compound of formula 2: 1
    Type: Application
    Filed: April 15, 1999
    Publication date: September 27, 2001
    Inventors: PHILIP J. PYE, PAUL J. REIDER, KAI ROSSEN, RALPH P. VOLANTE
  • Intermediates useful in a process for synthesizing COX-2 inhibitors
    Patent number: 6252116
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: June 26, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Edward G. Corley, Ian W. Davies, Robert D. Larsen, Philip J. Pye, Kai Rossen
  • Process for making diaryl pyridines useful as COX-2 inhibitors
    Patent number: 6204387
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: March 20, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Ian W. Davies, Linda Gerena, Michel Journet, Robert D. Larsen, Philip J. Pye, Kai Rossen
  • Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide
    Patent number: 6156895
    Abstract: An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxamide, an intermediate for an HIV protease inhibitor.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: December 5, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Philip J. Pye, Ralph P. Volante, Paul J. Reider
  • Intermediates for making heterocycles useful as COX-2 inhibitors
    Patent number: 6153787
    Abstract: The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: November 28, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Guo-Jie Ho, Ralph P. Volante, Roger N. Farr, David J. Mathre
  • Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
    Patent number: 6130334
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: October 10, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Philip J. Pye, Ashok Maliakal, Kai Rossen, Ralph P. Volante, Jess Sager
  • Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
    Patent number: 6127545
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: October 3, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Philip J. Pye, Kai Rossen, Ashok Maliakal, Ralph P. Volante, Jess Sager, Jean-Francois Marcoux, Ian Davies, Edward G. Corley, Daniel Richard Sidler, Robert D. Larsen
  • Chiral bisphosphines
    Patent number: 6043387
    Abstract: New chiral biphosphines, e.g., ##STR1## are useful as key components in catalysts for asymmetric reactions, providing desirably high enantiomeric excess (ee).
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: March 28, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Philip Pye, Ralph P. Volante, Kai Rossen
  • Process for making diaryl pyridines useful as cox-2-inhibitors
    Patent number: 6040450
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: March 21, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Ian W. Davies, Michel Journet, Linda Gerena, Robert D. Larsen, Philip J. Pye, Kai Rossen
  • Process for synthesizing COX-2 inhibitors
    Patent number: 6040319
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: March 21, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Edward G. Corley, Ian W. Davies, Robert D. Larsen, Philip J. Pye, Kai Rossen
  • Process for indinavir intermediate
    Patent number: 5981759
    Abstract: An intermediate in the synthesis of indinavir is prepared by iodohydroxylating an allyl acetonide by hypoiodous acid generated in situ from sodium hypochlorite and sodium iodide.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: November 9, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Yongku Sun, Frank P. Gortsema, Carl Leblond, Kai Rossen
  • Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide
    Patent number: 5977364
    Abstract: An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxaimide, an intermediate for an HIV protease inhibitor.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: November 2, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Philip J. Pye, Ralph P. Volante, Paul J. Reider
  • Process for making phenyl heterocycles useful as cox-2 inhibitors
    Patent number: 5883267
    Abstract: The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: March 16, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Ralph P. Volante, Guo-Jie Ho, Roger N. Farr, David J. Mathre
  • Chiral bisphosphines
    Patent number: 5874629
    Abstract: New chiral biphosphines, e.g., ##STR1## are useful as key components in catalysts for asymmetric reactions, providing desirably high enantiomeric excess (ee).
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: February 23, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Philip Pye, Kai Rossen, Ralph P. Volante
  • Process for making HIV protese inhibitors
    Patent number: 5861512
    Abstract: Intermediates of structural formula ##STR1## can be made by reacting a primary or secondary amine with glycosidol or an activated derivative thereof. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: January 19, 1999
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kai Rossen, Paul Reider, Richard J. Varsolona, Ralph P. Volante, Kenneth M. Wells
  • Process for making an epoxide
    Patent number: 5728840
    Abstract: A process for synthesizing the epoxide of the formula ##STR1## consists of, at a minimum, formation of a halohydrin from the allyl acetonide reactat, followed by base-induced cyclization, the epoxide product I being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: March 17, 1998
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kan K. Eng, Peter E. Maligres, Paul J. Reider, Kai Rossen, Ralph P. Volante, Veena Upadhyay, Steven A. Weissman