Abstract: Embodiments of three-dimensional (3D) memory devices formed by bonded semiconductor devices and methods for forming the same are disclosed. In an example, a method for forming a bonded semiconductor device includes the following operations. First, a first wafer and a second wafer are formed. The first wafer can include a functional layer over a substrate. Single-crystalline silicon may not be essential to the substrate and the substrate may not include single-crystalline silicon. The first wafer can be flipped to bond onto the second wafer to form the bonded semiconductor device so the substrate is on top of the functional layer. At least a portion of the substrate can be removed to form a top surface of the bonded semiconductor device. Further, bonding pads can be formed over the top surface.

Abstract: A method and a terminal device for providing a suspend button display are disclosed in order to improve display flexibility of a suspend button. In the solutions, when a terminal device detects that a tap operation or a second touch and hold operation, the terminal device may the suspend button to present an effect that the graphic displayed in the suspend button is zoomed in or zoomed out, and then display the suspend button restored to the default state. Therefore, according to the method, the display flexibility of the suspend button can be improved, so that visual experience of a user is improved.

Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

Abstract: Disclosed herein is a pharmaceutical combination for use in the prevention, delay of progression or treatment of cancer, wherein the pharmaceutical combination exhibits a synergistic efficacy. The pharmaceutical combination comprises a humanized antagonist monoclonal antibody against PD- and a RAF inhibitor. Also disclosed herein is a combination for use in the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject a therapeutically effective amount of a humanized antagonist monoclonal antibody against PD-1 and a therapeutically effective amount of a RAF inhibitor.

Abstract: A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.

Abstract: A lower limb exoskeleton system includes a back frame, hip joint movement mechanisms, telescopic thigh bars, knee joint movement mechanisms, shank bars, foot jump-down cushioning mechanisms, a waist binding frame, upper leg binding frames and lower leg binding frames. Two protruding ends of the back frame are connected with a top end of each of the telescopic thigh bars respectively via the hip joint movement mechanisms, bottom ends of the telescopic thigh bars are connected with a top end of the corresponding shank bars respectively via the knee joint movement mechanisms, and bottom ends of the shank bars are connected with the foot jump-down cushioning mechanisms. The waist binding frame is arranged on an inner side of a horizontal part of the back frame, and the upper leg binding frames and the lower leg binding frames are arranged on the telescopic thigh bars and the shank bars respectively.

Abstract: A process for the preparation of ultrafiltration and microfiltration polymeric flat sheet separation membranes is disclosed, the process comprising a unidirectional cooling step. Membranes prepared according to the process exhibit numerous advantages over ultrafiltration and microfiltration membranes prepared via conventional processes. In particular, the membranes prepared by the present process exhibit remarkable pure water flux, superior mechanical properties and increased anti-fouling characteristics. Also disclosed are particular PVDF ultrafiltration and microfiltration membranes having improved flux, mechanical and anti-fouling properties.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind to human OX40 (ACT35, CD134, or TNFRSF4), a pharmaceutical composition comprising said antibody, and use of the antibody or the composition for treating a disease, such as cancer. In particular, the anti-OX40 antibody of the present invention does not interfere with the binding of OX40-ligand to its receptor.

Abstract: A method and a terminal device for providing a suspend button display are disclosed in order to improve display flexibility of a suspend button. In the solutions, when a terminal device detects that a target object performs a sliding operation on a suspend button, the terminal device may control the suspend button to present an effect of a dynamic change. In this way, the suspend button may present a plurality of display forms. Therefore, according to the method, the display flexibility of the suspend button can be improved, so that visual experience of a user is improved.

Abstract: Disclosed herein is method for the prevention, delay of progression or treatment of hepatocellular carcinoma in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of an anti-PD-1 antibody, which is an antibody or a fragment antigen binding thereof, specifically binding to human PD-1.

Abstract: Search results can include, not only responsive content, typically in the form of documents, but can also include information regarding responsive entities, including tasks relevant to those entities, and can include identifications of individuals from whom additional information can be obtained, or who are otherwise relevant to the search. An association between entities and documents referencing those entities is identified and maintained. Documents responsive to a user's search query are identified utilizing existing algorithmic mechanisms and such identified responsive documents are referenced to determine whether they are associated with one or more entities. Additionally, a people/query mapping is maintained associating individual people with specific queries. User actions directed to one or more people in response to a query are utilized as a feedback loop.

Abstract: A long-distance FODAS amplification system includes a distributed amplification unit, which includes a LEAF, a pump, and a WDM; wherein the pump light passes through the WDM into the LEAF, so as to realize distributed amplification. A long-distance FODAS amplification method includes steps of: 1) modulating and amplifying a light source to obtain the probe pulse light; 2) guiding the pump light and the probe pulse light into LEAF; 3) combining the probe pulse light with the pump light to perform distributed amplification, so as to generate power-raised Rayleigh backscattered light; and 4) converting and demodulating the Rayleigh backscattered light after being output through the circulator, so as to complete distributed sensing.

Abstract: A staggered probe card and a conductive probe are provided. The staggered probe card includes an upper guide board, a lower guide board spaced apart from the upper guide board, and a plurality of conductive probes arranged in rows and passing through the upper and lower guide boards. Each of the conductive probes has an elongated structure defining a longitudinal direction, and includes a bottom surface and two long side surfaces respectively connected to two edges of the bottom surface. A distance between the two long side surfaces gradually decreases in a tapering direction that extends away from the bottom surface. In two of the rows of the conductive probes adjacent to each other, any two long side surfaces respectively belonging to the two adjacent rows and arranged adjacent to each other have a lateral interval along a direction that is non-parallel to the arrangement direction.

Abstract: Embodiments of three-dimensional (3D) memory devices formed by bonded semiconductor devices and methods for forming the same are disclosed. In an example, a method for forming a semiconductor device is disclosed. The method includes the following operations. First, an insulating material layer can be formed over a substrate. In an example, single-crystalline silicon is not essential to the substrate. The insulating material layer can be patterned to form an isolation structure and a plurality of trenches in the isolation structure. A semiconductor material can be deposited to fill up the plurality of trenches to form a plurality of array-base regions in the isolation structure, the isolation structure insulating the plurality of array-base regions from one another. Further, a plurality of memory arrays can be formed over the plurality of array-base regions, and an insulating structure can be formed to cover the plurality of memory arrays and the plurality of array-base regions.

Abstract: An image processing method and an apparatus relate to the field of image processing and add a diffuse reflection effect to a projection image in real time and reduce a calculation volume of adding the diffuse reflection effect. The method includes obtaining a first image that includes a diffuse reflection object, where the first image is an image obtained when the diffuse reflection object is illuminated by a light source, obtaining a mask image corresponding to the diffuse reflection object, obtaining orientation information of a terminal and obtaining a second image based on the orientation information, the first image, and the mask image, where the second image is an image that includes the diffuse reflection object and a diffuse reflection effect and that is generated by superposing the first image and the mask image moved based on the orientation information.

Abstract: A substrate and a method of manufacturing a catalytic substrate body arranged within the catalytic convertor such that a principal flow of fluid through the catalytic convertor flows along a surface of the substrate body, wherein said surface has a plurality of openings to micro-channels that extend away from said surface; and at least a portion of the surface of the substrate body comprises a catalytically active material, wherein the substrate body is in the form of a pellet; a sheet; solid elongated bodies; solid rods; a solid body having a plurality of bores; a non-tubular elongated body; a non-hollow body; a sheet curved in the form or a spiral; or a combination thereof.

Abstract: Disclosed herein is a pharmaceutical combination for use in the prevention, delay of progression or treatment of cancer, wherein the pharmaceutical combination exhibits a synergistic efficacy. The pharmaceutical combination comprises a humanized antagonist monoclonal antibody against PD- and a RAF inhibitor. Also disclosed herein is a combination for use in the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject a therapeutically effective amount of a humanized antagonist monoclonal antibody against PD-1 and a therapeutically effective amount of a RAF inhibitor.

Abstract: A linear joint includes a motor assembly includes a rotating shaft for outputting motion; a transmission mechanism including a screw and a nut threadedly connected to the screw, the nut being coaxial with respect to and securely connected to the rotating shaft so as to be rotatable together with the rotating shaft; and a rod connected to a first end of the screw so as to move together with the screw along a lengthwise direction of the screw.

Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.

Abstract: A method and system are provided that may centralize the management of applications that access the data of social networks via API calls. A central service may generate tokens at a generation rate that permit an application to access an API. The tokens may be distributed to queues associated with certain content types. The relative distribution of tokens to each queue may be determined by rules. A queue may release tokens to applications that function to access the content type associated with the queue. The token generation rate and rules may be selected to prevent violation of the rate limits for the API.