Patents by Inventor Kaoru Kobayashi

Kaoru Kobayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220205011
    Abstract: The present invention makes it possible to simply, rapidly, and with high sensitivity detect periodontopathic bacteria at room temperature and in under ten minutes (approximately 2-8 minutes). The arginine-specific peptidase activity of three strains of periodontopathic bacteria, i.e., Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, are analyzed at room temperature, in under ten minutes, and with high sensitivity. A first compound that has an anti-oxidizing effect and/or a second compound that protects SH groups (mercapto groups) and has a disulfide bond-cleaving effect are present during analysis of a sample. The first compound is at least one among L-ascorbic acid, L-cysteine hydrochloride, and glutathione, and the second compound is at least one among DTT, thioglycolic acid, thioglycerol, mercaptoethanol, and TCEP.
    Type: Application
    Filed: April 13, 2020
    Publication date: June 30, 2022
    Inventors: Yuri YAMASHITA, Hatsue ITAGAKI, Senta MORIWAKA, Kaoru KOBAYASHI, Yukuharu KOBAYASHI
  • Patent number: 11191507
    Abstract: Provided are: a device (1) and a system (100) for quantitatively calculating bone density by using an X-ray image of a bone pail, in particular, an alveolar bone; and an imaging assisting tool (4) for accurately and easily performing X-ray imaging of an alveolar bone. This bone density measurement device (1) comprises: an image display unit (101) for displaying X-ray images for an imaged bone part and a reference body on the same screen; a reference body density measurement unit (103) for measuring the density of the displayed X-ray image for the reference body; a bone part density measurement unit (105) for measuring the density of the displayed X-ray image for the bone part; and a bone density calculation unit (106) for calculating the hone density of the bone part by comparing the density of the X-ray image for the bone part with the density of the X-ray image for the reference body.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: December 7, 2021
    Assignee: MEDIA CO., LTD.
    Inventors: Shinji Shimoda, Kaoru Kobayashi, Akitoshi Katsumata, Hironobu Tsuji, Yosuke Tsuji, Tatsuro Hayashi
  • Patent number: 10967907
    Abstract: A vehicle front end structure includes an engine cradle and a force receiving structure. The engine cradle has a front corner and an engine mounted to the engine cradle. The force receiving structure has a force receiving surface extending laterally outboard from proximate the front corner of the engine cradle and a force directing section located rearward of the force receiving surface. The force receiving structure is installed to the engine cradle by a vertically oriented first mechanical fastener designed and structured such that during an impact event where an impacting force is applied to the force receiving surface, the force receiving structure pivots about the first mechanical fastener with an outboard portion of the force receiving surface initially moving rearward relative to the engine cradle and the force directing section initially moving laterally inboard contacting the engine and imparting a portion of the impacting force thereto.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: April 6, 2021
    Assignee: Nissan North America, Inc.
    Inventors: Kaoru Kobayashi, Naoya Kodama, Masaya Innami, Tadahiro Kawano, Jason Lyman
  • Publication number: 20210052537
    Abstract: To provide a novel colitis ameliorating agent. A colitis ameliorating agent comprising a trans-astaxanthin derivative of formula (I), geometric isomers thereof, a mixture of the geometric isomers, an optical isomer thereof, or a salt thereof; (wherein m1, m2, n1, and n2 are each the same or different and mean an integer of 1 to 6).
    Type: Application
    Filed: February 12, 2019
    Publication date: February 25, 2021
    Applicant: ASTA PHARMACEUTICALS, CO., LTD.
    Inventors: Michinori TAKASHINA, Makoto OGAWA, Kaoru KOBAYASHI, Yasuhiro NISHIDA, Akiko NAKAGAWA, Takashi FUJITA, Satoshi KOBAYASHI, Ryoma SHINOHARA, Yuji IWANO, Kiyotaka MORIIZUMI, Sachi MAEDA, Ryo SAKATA, Tomihisa YOKOYAMA
  • Publication number: 20200256850
    Abstract: Provided is a technique that uses an established hepatocyte cell line in a method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 and in a method for evaluating a drug which interacts with a cytokine. The method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 includes: culturing an established hepatocyte cell line by using a culture chamber (10) including culture rooms (11), to thereby form spheroids (9); and evaluating the presence or absence of induction or attenuation of the cytochrome P450 after bringing a spheroid-shaped established hepatocyte cell line into contact with a test solution containing the cytokine in the culture chamber for one hour or more and less than 96 hours.
    Type: Application
    Filed: April 27, 2020
    Publication date: August 13, 2020
    Inventors: Satoru Ayano, Kan Chiba, Yoko Ejiri, Masaya Hosoda, Kaoru Kobayashi, Hanaka Mimura
  • Patent number: 10677783
    Abstract: Provided is a technique that uses an established hepatocyte cell line in a method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 and in a method for evaluating a drug which interacts with a cytokine. The method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 includes: culturing an established hepatocyte cell line by using a culture chamber (10) including culture rooms (11), to thereby form spheroids (9); and evaluating the presence or absence of induction or attenuation of the cytochrome P450 after bringing a spheroid-shaped established hepatocyte cell line into contact with a test solution containing the cytokine in the culture chamber for one hour or more and less than 96 hours.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: June 9, 2020
    Assignee: Corning Incorporated
    Inventors: Kaoru Kobayashi, Hanaka Mimura, Kan Chiba, Yoko Ejiri, Masaya Hosoda, Satoru Ayano
  • Publication number: 20200114971
    Abstract: A vehicle front and structure in an engine cradle and a force receiving structure. The engine cradle has a front corner and an engine mounted to the engine cradle. The force receiving structure has a force receiving surface extending laterally outboard from proximate the front corner of the engine cradle and a force directing section located rearward of the force receiving surface. The force receiving structure is installed to the engine cradle by a vertically oriented first mechanical fastener designed and structured such that during an impact event where an impacting force is applied to the force receiving surface, the force receiving structure pivots about the first mechanical listener with an outboard portion of the force receiving surface initially moving rearward relative to the engine cradle and the force directing section initially moving laterally inboard contacting the engine and imparting a portion of the impacting force thereto.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 16, 2020
    Inventors: Kaoru KOBAYASHI, Naoya KODAMA, Masaya INNAMI, Tadahiro KAWANO, Jason LYMAN
  • Publication number: 20200036455
    Abstract: An angular error detecting device detects an angular error in a receiving direction of a frequency signal from a tracking target with respect to a front direction of an antenna based on a phase difference of a first reception signal received at a first receiving unit of the antenna and a second reception signal received at a second receiving unit having a receiving position in the antenna different from a receiving position of the first receiving unit. The angular error detecting device includes a reception signal output unit, a pilot signal supply unit, a pilot phase difference detection unit, a correction unit, and an angular error detection unit. The angular error detection unit detects the angular error based on the one side corrected at the correction unit and the other side that is not corrected of the sum signal and the difference signal.
    Type: Application
    Filed: July 25, 2019
    Publication date: January 30, 2020
    Applicant: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Kaoru KOBAYASHI, Naoki ONISHI
  • Patent number: 10541762
    Abstract: An angular error detecting device detects an angular error in a receiving direction of a frequency signal from a tracking target with respect to a front direction of an antenna based on a phase difference of a first reception signal received at a first receiving unit of the antenna and a second reception signal received at a second receiving unit having a receiving position in the antenna different from a receiving position of the first receiving unit. The angular error detecting device includes a reception signal output unit, a pilot signal supply unit, a pilot phase difference detection unit, a correction unit, and an angular error detection unit. The angular error detection unit detects the angular error based on the one side corrected at the correction unit and the other side that is not corrected of the sum signal and the difference signal.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 21, 2020
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Kaoru Kobayashi, Naoki Onishi
  • Publication number: 20190343475
    Abstract: Provided are: a device (1) and a system (100) for quantitatively calculating bone density by using an X-ray image of a bone pail, in particular, an alveolar bone; and an imaging assisting tool (4) for accurately and easily performing X-ray imaging of an alveolar bone. This bone density measurement device (1) comprises: an image display unit (101) for displaying X-ray images for an imaged bone part and a reference body on the same screen; a reference body density measurement unit (103) for measuring the density of the displayed X-ray image for the reference body; a bone part density measurement unit (105) for measuring the density of the displayed X-ray image for the bone part; and a bone density calculation unit (106) for calculating the hone density of the bone part by comparing the density of the X-ray image for the bone part with the density of the X-ray image for the reference body.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 14, 2019
    Applicant: MEDIA CO., LTD.
    Inventors: Shinji SHIMODA, Kaoru KOBAYASHI, Akitoshi KATSUMATA, Hironobu TSUJI, Yosuke TSUJI, Tatsuro HAYASHI
  • Patent number: 10423666
    Abstract: A semiconductor device that writes, into respective memory spaces of a plurality of separate memories constituting a search memory mat, an entry address corresponding to key data to be written. In this semiconductor device, pieces of divided data are assigned respectively to the separate memories, and, by employing each divided data as an address, entry addresses corresponding to the divided data are written sequentially into memory spaces specified by memory addresses of the separate memories (first writing process). In this first writing process, if another entry address is already written in an accessed memory space, no entry address is written into that memory space. If an entry address corresponding to a single one of the plurality of pieces of divided data is successfully written into a memory space, the first writing process is ended. Second write processing to a verification memory may also be performed. Key data may be written to a backup memory when a whole collision occurs.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: September 24, 2019
    Assignee: NAGASE & CO., LTD.
    Inventors: Masato Nishizawa, Kaoru Kobayashi, Kanji Otsuka, Yoichi Sato, Toshiyuki Kouchi, Minoru Uwai
  • Patent number: 10164571
    Abstract: An crystal resonator includes a first oscillating circuit that oscillates a crystal resonator at a first frequency, a first impedance adjusting circuit that adjusts an impedance of a first oscillating system including the crystal resonator and the first oscillating circuit, a second oscillating circuit that oscillates the crystal resonator at a second frequency that is different from the first frequency, a second impedance adjusting circuit that adjusts an impedance of a second oscillating system including the crystal resonator and the second oscillating circuit, and a controlling circuit that controls the first impedance adjusting circuit and the second impedance adjusting circuit.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: December 25, 2018
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Takashi Nakaoka, Kazuo Akaike, Hiroshi Hoshigami, Kaoru Kobayashi
  • Patent number: 10153776
    Abstract: The present invention provides a frequency synthesizer that is switchable at a high speed and includes a few unnecessary frequency components in an output frequency signal. In a frequency synthesizer 1, a DDS 2 operates based on a clock signal to generate a reference frequency signal with a predetermined reference frequency, and clock signal supply units 41 and 42 switch the clock signals that have different clock frequencies to supply to the DDS 2. When the clock signals are switched to operate the DDS 2, the storage unit 12 stores a combination of a clock frequency fclk, a reference frequency fc, and a dividing number N in association with an output frequency fVCO of the frequency synthesizer 1 such that a spurious frequency does not exist within a predetermined frequency range and a dividing number of a variable frequency divider 302 disposed on a PLL circuit 3 is minimum. Setting units 11 and 24 read setting items stored in the storage unit 12 to set respective units.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: December 11, 2018
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Hiroyuki Demura, Kaoru Kobayashi
  • Publication number: 20180129756
    Abstract: Disclosed is a semiconductor device that writes, into respective memory spaces of a plurality of divisional memories constituting a search memory mat, an entry address corresponding to key data to be written. In this semiconductor device, pieces of divisional data are assigned respectively to the divisional memories, and, by employing each divisional data as an address, an entry address corresponding to said divisional data is written sequentially into a memory space specified by a memory address of each said divisional memory (first writing process). In this first writing process, if another entry address is already written in an accessed memory space, no entry address is written into that memory space. If an entry address corresponding to one of the plurality of pieces of divisional data is successfully written into a memory space, the first writing process is ended.
    Type: Application
    Filed: April 18, 2016
    Publication date: May 10, 2018
    Applicant: NAGASE & CO., LTD.
    Inventors: Masato NISHIZAWA, Kaoru KOBAYASHI, Kanji OTSUKA, Yoichi SATO, Toshiyuki KOUCHI, Minoru UWAI
  • Publication number: 20170310331
    Abstract: The present invention provides a frequency synthesizer that is switchable at a high speed and includes a few unnecessary frequency components in an output frequency signal. In a frequency synthesizer 1, a DDS 2 operates based on a clock signal to generate a reference frequency signal with a predetermined reference frequency, and clock signal supply units 41 and 42 switch the clock signals that have different clock frequencies to supply to the DDS 2. When the clock signals are switched to operate the DDS 2, the storage unit 12 stores a combination of a clock frequency fclk, a reference frequency fc, and a dividing number N in association with an output frequency fVCO of the frequency synthesizer 1 such that a spurious frequency does not exist within a predetermined frequency range and a dividing number of a variable frequency divider 302 disposed on a PLL circuit 3 is minimum. Setting units 11 and 24 read setting items stored in the storage unit 12 to set respective units.
    Type: Application
    Filed: September 24, 2015
    Publication date: October 26, 2017
    Applicant: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Hiroyuki DEMURA, Kaoru KOBAYASHI
  • Publication number: 20160322936
    Abstract: An crystal resonator includes a first oscillating circuit that oscillates a crystal resonator at a first frequency, a first impedance adjusting circuit that adjusts an impedance of a first oscillating system including the crystal resonator and the first oscillating circuit, a second oscillating circuit that oscillates the crystal resonator at a second frequency that is different from the first frequency, a second impedance adjusting circuit that adjusts an impedance of a second oscillating system including the crystal resonator and the second oscillating circuit, and a controlling circuit that controls the first impedance adjusting circuit and the second impedance adjusting circuit.
    Type: Application
    Filed: July 14, 2016
    Publication date: November 3, 2016
    Applicant: NIHON DEMPA KOGYO CO., LTD.
    Inventors: TAKASHI NAKAOKA, KAZUO AKAIKE, HIROSHI HOSHIGAMI, KAORU KOBAYASHI
  • Patent number: 9225342
    Abstract: An oscillation device corrects a setting value of an output frequency based on a detection result of an ambient temperature of a crystal unit. The oscillation device includes: an oscillation circuit; a temperature detection portion that detects the ambient temperature and outputs a digital value corresponding to the temperature detection value; an accumulator that accumulates the digital value; a rounding processing portion that performs rounding for the digital value accumulated in the accumulator; a digital filter that receives the digital value obtained from the rounding processing portion and obtains a step response gradually increasing from “0” and converging to a step value; and a correction value obtaining portion that obtains a frequency correction value of the oscillation frequency of the oscillation circuit caused by a difference between the ambient temperature and a reference temperature, wherein the setting value of the output frequency is corrected based on the frequency correction value.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: December 29, 2015
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Kazuo Akaike, Kaoru Kobayashi
  • Patent number: 9154139
    Abstract: A crystal controlled oscillator of the present disclosure includes: an oscillator circuit for oscillator output, a first oscillator circuit, a second oscillator circuit, a heating unit, a pulse generator, a frequency difference detector, an addition unit, a circuit unit, a frequency measuring unit, a determination unit, and a signal selector. The signal selector is configured to: select a control signal where electric power supplied to the heating unit is smaller than supplied electric power in the detection range in a case where a frequency in a set period at the train of pulses is out of the detection range at the high temperature side; select a control signal where electric power supplied to the heating unit becomes a preset value in a case where a frequency in the set period at the train of pulses is out of the detection range at the low temperature side.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: October 6, 2015
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Kazuo Akaike, Kaoru Kobayashi
  • Publication number: 20150276716
    Abstract: Provided is a technique that uses an established hepatocyte cell line in a method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 and in a method for evaluating a drug which interacts with a cytokine. The method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 includes: culturing an established hepatocyte cell line by using a culture chamber (10) including culture rooms (11), to thereby form spheroids (9); and evaluating the presence or absence of induction or attenuation of the cytochrome P450 after bringing a spheroid-shaped established hepatocyte cell line into contact with a test solution containing the cytokine in the culture chamber for one hour or more and less than 96 hours.
    Type: Application
    Filed: September 27, 2013
    Publication date: October 1, 2015
    Applicant: KURARAY Co., Ltd.
    Inventors: Kaoru Kobayashi, Hanaka Mimura, Kan Chiba, Yoko Ejiri, Masaya Hosoda, Satoru Ayano
  • Patent number: 9100023
    Abstract: A crystal oscillator includes: an oscillation circuit; first and second oscillation circuits connected to first and second temperature detection crystal units, respectively; a heating portion configured to constantly maintain an ambient temperature; a frequency difference detection portion that obtains, as a temperature detection value, “{(f2?f1)/f1}?{(f2r?f1r)/f1r}”, where “f1” and “f2” denote oscillation frequencies of the first and second oscillation circuits, respectively, and “f1r” and “f2r” denote oscillation frequencies of the first and second oscillation circuits, respectively, at a reference temperature; an accumulator that accumulates the temperature detection value; a rounding processing portion that performs rounding for the temperature detection value accumulated in the accumulator depending on a rounding factor designated independently from the accumulation number; and a heating control portion that controls power supplied to the heating portion based on the temperature detection value subjected
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: August 4, 2015
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Kazuo Akaike, Kaoru Kobayashi