Abstract: RNA molecules for RNA interference to target a mutant allele with a point mutation, wherein the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and when counted from the base at the 5?-end in the nucleotide sequence complementary to the sequence of the mutant allele: a base at position 5 or 6 is mismatched with a base in the mutant allele; a base at position 10 or 11 is at the position of the point mutation and is identical to the base at the position of the point mutation in the mutant allele; the group at the 2?-position of the pentose in the ribonucleotide at position 8 is modified with OCH3, halogen, or LNA; and the group at the 2?-position of the pentose in the ribonucleotide at position 7 is not modified with any of OCH3, halogen, and LNA.

Abstract: A system performs a first analysis operation in which an operation history of an image forming apparatus and input information are analyzed, an issuance operation in which, in a case where a result of an analysis of the first analysis operation satisfies notification conditions, a second analysis operation in which a confidence for the result of the analysis of the first analysis operation is obtained, a transmission operation in which, in a case where the confidence is less than a threshold, a message requesting further input of input information is transmitted, and a control operation in which the notification conditions are controlled based on the input information obtained as a response to the message.

Abstract: The present invention makes it possible to simply, rapidly, and with high sensitivity detect periodontopathic bacteria at room temperature and in under ten minutes (approximately 2-8 minutes). The arginine-specific peptidase activity of three strains of periodontopathic bacteria, i.e., Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, are analyzed at room temperature, in under ten minutes, and with high sensitivity. A first compound that has an anti-oxidizing effect and/or a second compound that protects SH groups (mercapto groups) and has a disulfide bond-cleaving effect are present during analysis of a sample. The first compound is at least one among L-ascorbic acid, L-cysteine hydrochloride, and glutathione, and the second compound is at least one among DTT, thioglycolic acid, thioglycerol, mercaptoethanol, and TCEP.

Abstract: Provided are: a device (1) and a system (100) for quantitatively calculating bone density by using an X-ray image of a bone pail, in particular, an alveolar bone; and an imaging assisting tool (4) for accurately and easily performing X-ray imaging of an alveolar bone. This bone density measurement device (1) comprises: an image display unit (101) for displaying X-ray images for an imaged bone part and a reference body on the same screen; a reference body density measurement unit (103) for measuring the density of the displayed X-ray image for the reference body; a bone part density measurement unit (105) for measuring the density of the displayed X-ray image for the bone part; and a bone density calculation unit (106) for calculating the hone density of the bone part by comparing the density of the X-ray image for the bone part with the density of the X-ray image for the reference body.

Abstract: A vehicle front end structure includes an engine cradle and a force receiving structure. The engine cradle has a front corner and an engine mounted to the engine cradle. The force receiving structure has a force receiving surface extending laterally outboard from proximate the front corner of the engine cradle and a force directing section located rearward of the force receiving surface. The force receiving structure is installed to the engine cradle by a vertically oriented first mechanical fastener designed and structured such that during an impact event where an impacting force is applied to the force receiving surface, the force receiving structure pivots about the first mechanical fastener with an outboard portion of the force receiving surface initially moving rearward relative to the engine cradle and the force directing section initially moving laterally inboard contacting the engine and imparting a portion of the impacting force thereto.

Abstract: To provide a novel colitis ameliorating agent. A colitis ameliorating agent comprising a trans-astaxanthin derivative of formula (I), geometric isomers thereof, a mixture of the geometric isomers, an optical isomer thereof, or a salt thereof; (wherein m1, m2, n1, and n2 are each the same or different and mean an integer of 1 to 6).

Abstract: Provided is a technique that uses an established hepatocyte cell line in a method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 and in a method for evaluating a drug which interacts with a cytokine. The method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 includes: culturing an established hepatocyte cell line by using a culture chamber (10) including culture rooms (11), to thereby form spheroids (9); and evaluating the presence or absence of induction or attenuation of the cytochrome P450 after bringing a spheroid-shaped established hepatocyte cell line into contact with a test solution containing the cytokine in the culture chamber for one hour or more and less than 96 hours.

Abstract: Provided is a technique that uses an established hepatocyte cell line in a method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 and in a method for evaluating a drug which interacts with a cytokine. The method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 includes: culturing an established hepatocyte cell line by using a culture chamber (10) including culture rooms (11), to thereby form spheroids (9); and evaluating the presence or absence of induction or attenuation of the cytochrome P450 after bringing a spheroid-shaped established hepatocyte cell line into contact with a test solution containing the cytokine in the culture chamber for one hour or more and less than 96 hours.

Abstract: A vehicle front and structure in an engine cradle and a force receiving structure. The engine cradle has a front corner and an engine mounted to the engine cradle. The force receiving structure has a force receiving surface extending laterally outboard from proximate the front corner of the engine cradle and a force directing section located rearward of the force receiving surface. The force receiving structure is installed to the engine cradle by a vertically oriented first mechanical fastener designed and structured such that during an impact event where an impacting force is applied to the force receiving surface, the force receiving structure pivots about the first mechanical listener with an outboard portion of the force receiving surface initially moving rearward relative to the engine cradle and the force directing section initially moving laterally inboard contacting the engine and imparting a portion of the impacting force thereto.

Abstract: An angular error detecting device detects an angular error in a receiving direction of a frequency signal from a tracking target with respect to a front direction of an antenna based on a phase difference of a first reception signal received at a first receiving unit of the antenna and a second reception signal received at a second receiving unit having a receiving position in the antenna different from a receiving position of the first receiving unit. The angular error detecting device includes a reception signal output unit, a pilot signal supply unit, a pilot phase difference detection unit, a correction unit, and an angular error detection unit. The angular error detection unit detects the angular error based on the one side corrected at the correction unit and the other side that is not corrected of the sum signal and the difference signal.

Abstract: An angular error detecting device detects an angular error in a receiving direction of a frequency signal from a tracking target with respect to a front direction of an antenna based on a phase difference of a first reception signal received at a first receiving unit of the antenna and a second reception signal received at a second receiving unit having a receiving position in the antenna different from a receiving position of the first receiving unit. The angular error detecting device includes a reception signal output unit, a pilot signal supply unit, a pilot phase difference detection unit, a correction unit, and an angular error detection unit. The angular error detection unit detects the angular error based on the one side corrected at the correction unit and the other side that is not corrected of the sum signal and the difference signal.

Abstract: Provided are: a device (1) and a system (100) for quantitatively calculating bone density by using an X-ray image of a bone pail, in particular, an alveolar bone; and an imaging assisting tool (4) for accurately and easily performing X-ray imaging of an alveolar bone. This bone density measurement device (1) comprises: an image display unit (101) for displaying X-ray images for an imaged bone part and a reference body on the same screen; a reference body density measurement unit (103) for measuring the density of the displayed X-ray image for the reference body; a bone part density measurement unit (105) for measuring the density of the displayed X-ray image for the bone part; and a bone density calculation unit (106) for calculating the hone density of the bone part by comparing the density of the X-ray image for the bone part with the density of the X-ray image for the reference body.

Abstract: A semiconductor device that writes, into respective memory spaces of a plurality of separate memories constituting a search memory mat, an entry address corresponding to key data to be written. In this semiconductor device, pieces of divided data are assigned respectively to the separate memories, and, by employing each divided data as an address, entry addresses corresponding to the divided data are written sequentially into memory spaces specified by memory addresses of the separate memories (first writing process). In this first writing process, if another entry address is already written in an accessed memory space, no entry address is written into that memory space. If an entry address corresponding to a single one of the plurality of pieces of divided data is successfully written into a memory space, the first writing process is ended. Second write processing to a verification memory may also be performed. Key data may be written to a backup memory when a whole collision occurs.

Abstract: An crystal resonator includes a first oscillating circuit that oscillates a crystal resonator at a first frequency, a first impedance adjusting circuit that adjusts an impedance of a first oscillating system including the crystal resonator and the first oscillating circuit, a second oscillating circuit that oscillates the crystal resonator at a second frequency that is different from the first frequency, a second impedance adjusting circuit that adjusts an impedance of a second oscillating system including the crystal resonator and the second oscillating circuit, and a controlling circuit that controls the first impedance adjusting circuit and the second impedance adjusting circuit.

Abstract: The present invention provides a frequency synthesizer that is switchable at a high speed and includes a few unnecessary frequency components in an output frequency signal. In a frequency synthesizer 1, a DDS 2 operates based on a clock signal to generate a reference frequency signal with a predetermined reference frequency, and clock signal supply units 41 and 42 switch the clock signals that have different clock frequencies to supply to the DDS 2. When the clock signals are switched to operate the DDS 2, the storage unit 12 stores a combination of a clock frequency fclk, a reference frequency fc, and a dividing number N in association with an output frequency fVCO of the frequency synthesizer 1 such that a spurious frequency does not exist within a predetermined frequency range and a dividing number of a variable frequency divider 302 disposed on a PLL circuit 3 is minimum. Setting units 11 and 24 read setting items stored in the storage unit 12 to set respective units.

Abstract: Disclosed is a semiconductor device that writes, into respective memory spaces of a plurality of divisional memories constituting a search memory mat, an entry address corresponding to key data to be written. In this semiconductor device, pieces of divisional data are assigned respectively to the divisional memories, and, by employing each divisional data as an address, an entry address corresponding to said divisional data is written sequentially into a memory space specified by a memory address of each said divisional memory (first writing process). In this first writing process, if another entry address is already written in an accessed memory space, no entry address is written into that memory space. If an entry address corresponding to one of the plurality of pieces of divisional data is successfully written into a memory space, the first writing process is ended.

Abstract: The present invention provides a frequency synthesizer that is switchable at a high speed and includes a few unnecessary frequency components in an output frequency signal. In a frequency synthesizer 1, a DDS 2 operates based on a clock signal to generate a reference frequency signal with a predetermined reference frequency, and clock signal supply units 41 and 42 switch the clock signals that have different clock frequencies to supply to the DDS 2. When the clock signals are switched to operate the DDS 2, the storage unit 12 stores a combination of a clock frequency fclk, a reference frequency fc, and a dividing number N in association with an output frequency fVCO of the frequency synthesizer 1 such that a spurious frequency does not exist within a predetermined frequency range and a dividing number of a variable frequency divider 302 disposed on a PLL circuit 3 is minimum. Setting units 11 and 24 read setting items stored in the storage unit 12 to set respective units.

Abstract: An crystal resonator includes a first oscillating circuit that oscillates a crystal resonator at a first frequency, a first impedance adjusting circuit that adjusts an impedance of a first oscillating system including the crystal resonator and the first oscillating circuit, a second oscillating circuit that oscillates the crystal resonator at a second frequency that is different from the first frequency, a second impedance adjusting circuit that adjusts an impedance of a second oscillating system including the crystal resonator and the second oscillating circuit, and a controlling circuit that controls the first impedance adjusting circuit and the second impedance adjusting circuit.

Abstract: An oscillation device corrects a setting value of an output frequency based on a detection result of an ambient temperature of a crystal unit. The oscillation device includes: an oscillation circuit; a temperature detection portion that detects the ambient temperature and outputs a digital value corresponding to the temperature detection value; an accumulator that accumulates the digital value; a rounding processing portion that performs rounding for the digital value accumulated in the accumulator; a digital filter that receives the digital value obtained from the rounding processing portion and obtains a step response gradually increasing from “0” and converging to a step value; and a correction value obtaining portion that obtains a frequency correction value of the oscillation frequency of the oscillation circuit caused by a difference between the ambient temperature and a reference temperature, wherein the setting value of the output frequency is corrected based on the frequency correction value.

Abstract: A crystal controlled oscillator of the present disclosure includes: an oscillator circuit for oscillator output, a first oscillator circuit, a second oscillator circuit, a heating unit, a pulse generator, a frequency difference detector, an addition unit, a circuit unit, a frequency measuring unit, a determination unit, and a signal selector. The signal selector is configured to: select a control signal where electric power supplied to the heating unit is smaller than supplied electric power in the detection range in a case where a frequency in a set period at the train of pulses is out of the detection range at the high temperature side; select a control signal where electric power supplied to the heating unit becomes a preset value in a case where a frequency in the set period at the train of pulses is out of the detection range at the low temperature side.