Abstract: A crystal controlled oscillator of the present disclosure includes: an oscillator circuit for oscillator output, a first oscillator circuit, a second oscillator circuit, a heating unit, a pulse generator, a frequency difference detector, an addition unit, a circuit unit, a frequency measuring unit, a determination unit, and a signal selector. The signal selector is configured to: select a control signal where electric power supplied to the heating unit is smaller than supplied electric power in the detection range in a case where a frequency in a set period at the train of pulses is out of the detection range at the high temperature side; select a control signal where electric power supplied to the heating unit becomes a preset value in a case where a frequency in the set period at the train of pulses is out of the detection range at the low temperature side.

Abstract: Provided is a technique that uses an established hepatocyte cell line in a method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 and in a method for evaluating a drug which interacts with a cytokine. The method for evaluating an effect of a cytokine on a metabolic activity of a cytochrome P450 includes: culturing an established hepatocyte cell line by using a culture chamber (10) including culture rooms (11), to thereby form spheroids (9); and evaluating the presence or absence of induction or attenuation of the cytochrome P450 after bringing a spheroid-shaped established hepatocyte cell line into contact with a test solution containing the cytokine in the culture chamber for one hour or more and less than 96 hours.

Abstract: A crystal oscillator includes: an oscillation circuit; first and second oscillation circuits connected to first and second temperature detection crystal units, respectively; a heating portion configured to constantly maintain an ambient temperature; a frequency difference detection portion that obtains, as a temperature detection value, “{(f2?f1)/f1}?{(f2r?f1r)/f1r}”, where “f1” and “f2” denote oscillation frequencies of the first and second oscillation circuits, respectively, and “f1r” and “f2r” denote oscillation frequencies of the first and second oscillation circuits, respectively, at a reference temperature; an accumulator that accumulates the temperature detection value; a rounding processing portion that performs rounding for the temperature detection value accumulated in the accumulator depending on a rounding factor designated independently from the accumulation number; and a heating control portion that controls power supplied to the heating portion based on the temperature detection value subjected

Abstract: In this winding structure for a rectangular wire, a coil is formed that is provided with: a core that forms a core main body; a teeth portion that is formed extending inwards in a radial direction from the core; and a jaw portion that is formed extending in a circumferential direction from a distal end on the inner side in the radial direction of the teeth portion, and in which a rectangular wire is wound in multiple layers around a slot that is formed surrounded by the teeth portion, the core, and the jaw portion. The ellipticity, which is a ratio of a width dimension relative to a thickness dimension of a cross-section of the rectangular wire, becomes larger as it is wound from inner layers of the coil towards outer layers thereof, and the ellipticity of the rectangular wire in each of the layers is set in accordance with the width dimension of the slot in each layer of the coil such that the generation of gaps between the slot and the rectangular wire is suppressed.

Abstract: A crystal oscillator includes: an oscillation circuit; first and second oscillation circuits connected to first and second temperature detection crystal units, respectively; a heating portion configured to constantly maintain an ambient temperature; a frequency difference detection portion that obtains, as a temperature detection value, “{(f2?f1)/f1}?{(f2r?f1r)/f1r}”, where “f1” and “f2” denote oscillation frequencies of the first and second oscillation circuits, respectively, and “f1r” and “f2r” denote oscillation frequencies of the first and second oscillation circuits, respectively, at a reference temperature; an accumulator that accumulates the temperature detection value; a rounding processing portion that performs rounding for the temperature detection value accumulated in the accumulator depending on a rounding factor designated independently from the accumulation number; and a heating control portion that controls power supplied to the heating portion based on the temperature detection value subjected

Abstract: An oscillation device corrects a setting value of an output frequency based on a detection result of an ambient temperature of a crystal unit. The oscillation device includes: an oscillation circuit; a temperature detection portion that detects the ambient temperature and outputs a digital value corresponding to the temperature detection value; an accumulator that accumulates the digital value; a rounding processing portion that performs rounding for the digital value accumulated in the accumulator; a digital filter that receives the digital value obtained from the rounding processing portion and obtains a step response gradually increasing from “0” and converging to a step value; and a correction value obtaining portion that obtains a frequency correction value of the oscillation frequency of the oscillation circuit caused by a difference between the ambient temperature and a reference temperature, wherein the setting value of the output frequency is corrected based on the frequency correction value.

Abstract: A crystal controlled oscillator of the present disclosure includes: an oscillator circuit for oscillator output, a first oscillator circuit, a second oscillator circuit, a heating unit, a pulse generator, a frequency difference detector, an addition unit, a circuit unit, a frequency measuring unit, a determination unit, and a signal selector. The signal selector is configured to: select a control signal where electric power supplied to the heating unit is smaller than supplied electric power in the detection range in a case where a frequency in a set period at the train of pulses is out of the detection range at the high temperature side; select a control signal where electric power supplied to the heating unit becomes a preset value in a case where a frequency in the set period at the train of pulses is out of the detection range at the low temperature side.

Abstract: An atmosphere temperature at which a quartz-crystal oscillator and an oscillation circuit are placed is controlled in high accuracy, and an output frequency with high stability is obtained. If oscillation outputs of first and second quartz-crystal oscillators are set to f1 and f2, and oscillation frequencies of the oscillation outputs at a reference temperature are set to f1r and f2r, respectively, {(f2?f1)/f1}?{(f2r?f1r)/f1r} is calculated by a frequency difference detection unit. A digital value can be obtained by representing this value by 34-bit digital value, corresponding to a temperature. Therefore, this value is treated as a temperature detection value, a difference with a temperature set value is supplied to the loop filter, and the digital value therefrom is converted into a direct-current voltage to control a heater.

Abstract: An oscillation device for reducing memory capacity includes a frequency difference detecting unit and a compensation value obtaining unit. When oscillation frequencies of the first and second oscillation circuits are respectively f1 and f2, and oscillation frequencies of the first and second oscillation circuits at a reference temperature are respectively f1r and f2r, the frequency difference detecting unit determines a difference corresponding value x corresponding to a difference value between a value corresponding to a difference between f1 and f1r, and a value corresponding to a difference between f2 and f2r. The compensation value obtaining unit obtains a frequency compensation value of f1 resulting from ambient temperature different from reference temperature based on the difference corresponding value x, and calculates the frequency compensation value of f1 by calculating nth-order polynomial for X being a value corresponding to x/k, where k is a divide coefficient specific to a device.

Abstract: A value corresponding to a difference value between a value corresponding to a difference between f1 and f1r and a value corresponding to a difference between f2 and f2r is treated as an instantaneous temperature, where f1 and f2 denote oscillation outputs of the first and second oscillation circuits, respectively, and f1r and f2r denote oscillation frequencies of the first and second oscillation circuits, respectively, at a reference temperature. A first correction value is obtained using an approximation formula of the frequency correction value of f1 based on the value corresponding to the difference value, and a second correction value for canceling a correction residual error is obtained from the correction residual error which is a difference between the first correction value and the frequency correction value actually measured. The frequency correction value is obtained from a sum of the first and second correction values.

Abstract: To perform, in an oscillation device compensating an output frequency based on a detection result of ambient temperature, temperature compensation of the output frequency with high accuracy. First and second quartz-crystal oscillators are structured by using a common quartz-crystal piece, and when oscillation outputs of first and second oscillation circuits respectively connected to these quartz-crystal oscillators are set to f1, f2, and oscillation frequencies of the first and the second oscillation circuits at a reference temperature are set to f1r, f2r, respectively, a frequency difference being a difference between a value corresponding to a difference between f1 and f1r and a value corresponding to a difference between f2 and f2r is treated as a temperature at that time. Further, based on the frequency difference, a frequency compensation value is determined through polynomial approximation.

Abstract: Provided is an oscillation device capable of obtaining a stable oscillation frequency by compensating for a change in oscillation frequency caused with an elapse of operating time of a quartz-crystal oscillator. A difference value ?F between a frequency difference between first and second quartz-crystal oscillators after a predetermined period of time has elapsed from a reference time and a frequency difference between the first and second quartz-crystal oscillators at the reference time is determined.

Abstract: An oscillation device for reducing memory capacity includes a frequency difference detecting unit and a compensation value obtaining unit. When oscillation frequencies of the first and second oscillation circuits are respectively f1 and f2, and oscillation frequencies of the first and second oscillation circuits at a reference temperature are respectively f1r and f2r, the frequency difference detecting unit determines a difference corresponding value x corresponding to a difference value between a value corresponding to a difference between f1 and f1r, and a value corresponding to a difference between f2 and f2r. The compensation value obtaining unit obtains a frequency compensation value of f1 resulting from ambient temperature different from reference temperature based on the difference corresponding value x, and calculates the frequency compensation value of f1 by calculating nth-order polynomial for X being a value corresponding to x/k, where k is a divide coefficient specific to a device.

Abstract: An atmosphere temperature at which a quartz-crystal oscillator and an oscillation circuit are placed is controlled in high accuracy, and an output frequency with high stability is obtained. If oscillation outputs of first and second quartz-crystal oscillators are set to f1 and f2, and oscillation frequencies of the oscillation outputs at a reference temperature are set to f1r and f2r, respectively, {(f2?f1)/f1}?{(f2r?f1r)/f1r} is calculated by a frequency difference detection unit. A digital value can be obtained by representing this value by 34-bit digital value, corresponding to a temperature. Therefore, this value is treated as a temperature detection value, a difference with a temperature set value is supplied to the loop filter, and the digital value therefrom is converted into a direct-current voltage to control a heater.

Abstract: Provided is an oscillation device capable of obtaining a stable oscillation frequency by compensating for a change in oscillation frequency caused with an elapse of operating time of a quartz-crystal oscillator. A difference value ?F between a frequency difference between first and second quartz-crystal oscillators after a predetermined period of time has elapsed from a reference time and a frequency difference between the first and second quartz-crystal oscillators at the reference time is determined.

Abstract: A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

Abstract: To perform, in an oscillation device compensating an output frequency based on a detection result of ambient temperature, temperature compensation of the output frequency with high accuracy. First and second quartz-crystal oscillators are structured by using a common quartz-crystal piece, and when oscillation outputs of first and second oscillation circuits respectively connected to these quartz-crystal oscillators are set to f1, f2, and oscillation frequencies of the first and the second oscillation circuits at a reference temperature are set to f1r, f2r, respectively, a frequency difference being a difference between a value corresponding to a difference between f1 and f1r and a value corresponding to a difference between f2 and f2r is treated as a temperature at that time. Further, based on the frequency difference, a frequency compensation value is determined through polynomial approximation.

Abstract: A signal processing unit and a wireless communication device are provided for making it possible to detect a frequency by means of a small scale operation circuit in a short time.

Abstract: There is provided a signal processing device and a wireless apparatus capable of not erroneously determining polarity, appropriately performing a spread modulation process, a carrier modulation process, and reception data demodulation process, improving reception accuracy, and miniaturizing a circuit, even when IF carrier frequency shift occurs.

Abstract: A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).