Patents by Inventor Karen E. Linder

Karen E. Linder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gastrin releasing peptide compounds
    Patent number: 7611692
    Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: November 3, 2009
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
  • Gastrin Releasing Peptide Compounds
    Publication number: 20090175786
    Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Application
    Filed: June 11, 2008
    Publication date: July 9, 2009
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael F. Tweedle, Mary Ellen Maddalena
  • Radiopharmaceutical formulations
    Patent number: 7556795
    Abstract: Radiopharmaceutical compounds are disclosed having a radionuclide chelating moiety and a targeting ligand, and optionally a linker. Formulations of compositions useful for making the radiopharmaceutical compounds contain a chelating ligand, a reducing agent, an exchange ligand and a stabilizer.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: July 7, 2009
    Assignee: Bracco Imaging S.p.A.
    Inventors: Jianqing Chen, Karen E. Linder, Nannan Wang, Aldo Cagnolini
  • CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES
    Publication number: 20090062509
    Abstract: A method is disclosed for the syntheses of thiol-containing radiopharmaceuticals without the need for purification starting from chelators containing disulfide bonds. This is done by providing a method that reduces disulfide bonds on a precursor molecule or a precursor compound in the presence of phosphine compounds, thus freeing thiols for metal complexation.
    Type: Application
    Filed: March 14, 2007
    Publication date: March 5, 2009
    Inventors: Aldo Cagnolini, Karen E. Linder, Kondareddiar Ramalingam, Hong Helen Fan
  • Gastrin Releasing Peptide Compounds
    Publication number: 20080247946
    Abstract: New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
    Type: Application
    Filed: August 25, 2006
    Publication date: October 9, 2008
    Applicant: BRACCO IMAGING S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf E. Swenson, Michael Tweedle
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 7399460
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the ?, ?, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: July 15, 2008
    Assignee: Bracco International B.V.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Nataranjan Raju, Michael F. Tweedle
  • Multivalent constructs for therapeutic and diagnostic applications
    Patent number: 7261876
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: August 28, 2007
    Assignees: Bracco International BV, Dyax Corp.
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron Sato, Sharon Michele Walker, Daniel T. Dransfield
  • Gastrin releasing peptide compounds
    Patent number: 7226577
    Abstract: New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N-O-P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N-O-P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: June 5, 2007
    Assignee: Bracco Imaging, S. p. A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf E. Swenson, Michael Tweedle
  • Multivalent constructs for therapeutic and diagnostic applications
    Patent number: 7211240
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: May 1, 2007
    Assignees: Bracco International B.V., Dyax Corp
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sybille Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron Sato, Sharon Michele Walker, Daniel T. Dransfield
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 7186397
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the ?, ?, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: December 30, 2000
    Date of Patent: March 6, 2007
    Assignee: Bracco International B.V.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Gastrin releasing peptide compounds
    Publication number: 20040253225
    Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
    Type: Application
    Filed: April 20, 2004
    Publication date: December 16, 2004
    Inventors: Enrico Cappelleti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
  • Multivalent constructs for therapeutic and diagnostic applications
    Publication number: 20040210041
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Application
    Filed: March 22, 2004
    Publication date: October 21, 2004
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron Sato, Sharon Michele Walker, Daniel T. Dransfield
  • Gastrin releasing peptide compounds
    Publication number: 20040136906
    Abstract: New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
    Type: Application
    Filed: January 13, 2003
    Publication date: July 15, 2004
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Ed Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf E. Swenson, Michael Tweedle
  • Multivalent constructs for therapeutic and diagnostic applications
    Publication number: 20040018974
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Application
    Filed: March 3, 2003
    Publication date: January 29, 2004
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron Sato, Sharon Michele Walker, Daniel T. Dransfield
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Publication number: 20010004454
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Application
    Filed: December 30, 2000
    Publication date: June 21, 2001
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 6221334
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: April 24, 2001
    Assignee: Bracco Research USA, Inc.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 6093382
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: May 16, 1998
    Date of Patent: July 25, 2000
    Assignee: Bracco Research USA Inc.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group
    Patent number: 5387409
    Abstract: Boronic acid adducts of technetium-99m and radioactive rhenium dioxime complexes, each of which include biochemically active groups, are useful as diagnostic and therapeutic agents, respectively.
    Type: Grant
    Filed: January 7, 1992
    Date of Patent: February 7, 1995
    Assignee: Bracco International B.V.
    Inventors: Adrian D. Nunn, Karen E. Linder, Silvia Jurisson, William C. Eckelman
  • Metal-isonitrile adducts for preparing radionuclide complexes
    Patent number: 5324824
    Abstract: A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrite.
    Type: Grant
    Filed: March 12, 1991
    Date of Patent: June 28, 1994
    Assignee: The DuPont Merck Pharmaceutical Co.
    Inventors: Alan B. Carpenter, Jr., Leo J. Maheu, Michael A. Patz, Thomas H. Tulip, Karen E. Linder, Vinayakam Subramanyam, Jeffery S. Thompson
  • Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds
    Patent number: 5183653
    Abstract: Boronic acid adducts of metal dioxime complexes are useful as reagents for labeling proteins and other amine-containing compounds.
    Type: Grant
    Filed: April 13, 1990
    Date of Patent: February 2, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karen E. Linder, Adrian D. Nunn, Kondareddiar Ramalingam